{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:09:00Z","timestamp":1759032540342,"version":"3.37.3"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["NIH5R21DC014335-02"],"award-info":[{"award-number":["NIH5R21DC014335-02"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166346","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T18:35:39Z","timestamp":1478889339000},"page":"e0166346","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats"],"prefix":"10.1371","volume":"11","author":[{"given":"Edward","family":"Pace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bobian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Panekkad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"issue":"193 Pt 1","key":"ref1","first-page":"1","article-title":"Current estimates from the National Health Interview Survey, 1994","author":"PF Adams","year":"1995","journal-title":"Vital and health statistics Series 10, Data from the National Health Survey"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","article-title":"Prevalence and characteristics of tinnitus among US adults","volume":"123","author":"J Shargorodsky","year":"2010","journal-title":"The American journal of medicine"},{"issue":"6","key":"ref3","first-page":"339","article-title":"Tinnitus and suicide","volume":"13","author":"JE Lewis","year":"2002","journal-title":"JAmAcadAudiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/qhw.v7i0.19540","article-title":"Learning from tinnitus patients&apos; narratives\u2014a case study in the psychodynamic approach","volume":"7","author":"N Dauman","year":"2012","journal-title":"International journal of qualitative studies on health and well-being"},{"issue":"1","key":"ref5","first-page":"19","article-title":"Tinnitus characteristics in tinnitus complainers and noncomplainers","volume":"27","author":"LR Hallberg","year":"1993","journal-title":"BrJAudiol"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000251916","article-title":"Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety","volume":"15","author":"N Oishi","year":"2010","journal-title":"Audiol Neurootol"},{"issue":"3","key":"ref7","first-page":"242","article-title":"Pattern of brain blood perfusion in tinnitus patients using technetium-99m SPECT imaging","volume":"17","author":"S Mahmoudian","year":"2012","journal-title":"Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences"},{"key":"ref8","unstructured":"VBA. Annual Benefits Report\u2014Veterans Benefits Administration. In: Affairs USDoV, editor. 810 Vermont Avenue N. W. Washington, D.C., 204202013."},{"issue":"1","key":"ref9","first-page":"188","article-title":"Gap detection deficits in rats with tinnitus: a potential novel screening tool","volume":"120","author":"JG Turner","year":"2006","journal-title":"BehavNeurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fneur.2015.00088","article-title":"Gap-Prepulse Inhibition of the Acoustic Startle Reflex (GPIAS) for Tinnitus Assessment: Current Status and Future Directions","volume":"6","author":"A Galazyuk","year":"2015","journal-title":"Front Neurol"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10162-014-0500-x","article-title":"Partial to complete suppression of unilateral noise-induced tinnitus in rats after cyclobenzaprine treatment","volume":"16","author":"E Lobarinas","year":"2015","journal-title":"J Assoc Res Otolaryngol"},{"key":"ref12","article-title":"The gap-startle paradigm for tinnitus screening in animal models: Limitations and optimization","author":"E Lobarinas","year":"2012","journal-title":"Hear Res"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10162-011-0276-1","article-title":"Development of tinnitus in CBA\/CaJ mice following sound exposure","volume":"12","author":"RJ Longenecker","year":"2011","journal-title":"J Assoc Res Otolaryngol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.heares.2012.05.011","article-title":"Gap detection deficits in humans with tinnitus as assessed with the acoustic startle paradigm: does tinnitus fill in the gap?","volume":"295","author":"P Fournier","year":"2013","journal-title":"Hear Res"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1097\/AUD.0000000000000156","article-title":"The Gap Detection Test: Can It Be Used to Diagnose Tinnitus?","volume":"36","author":"K Boyen","year":"2015","journal-title":"Ear Hear"},{"issue":"67","key":"ref16","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4103\/1463-1741.121232","article-title":"Does tinnitus &quot;fill in&quot; the silent gaps?","volume":"15","author":"J Campolo","year":"2013","journal-title":"Noise Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fneur.2015.00031","article-title":"Salicylate-induced hearing loss and gap detection deficits in rats","volume":"6","author":"KE Radziwon","year":"2015","journal-title":"Front Neurol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1152\/jn.00184.2013","article-title":"Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?","volume":"111","author":"AE Hickox","year":"2014","journal-title":"J Neurophysiol"},{"issue":"6","key":"ref19","first-page":"811","article-title":"Phantom auditory sensation in rats: an animal model for tinnitus","volume":"102","author":"PJ Jastreboff","year":"1988","journal-title":"BehavNeurosci"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jneumeth.2013.07.021","article-title":"A novel behavioral assay for the assessment of acute tinnitus in rats optimized for simultaneous recording of oscillatory neural activity","volume":"219","author":"D Stolzberg","year":"2013","journal-title":"J Neurosci Methods"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuroscience.2011.02.040","article-title":"Acoustic trauma that can cause tinnitus impairs impulsive control but not performance accuracy in the 5-choice serial reaction time task in rats","volume":"180","author":"Y Zheng","year":"2011","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"ref22","first-page":"39","article-title":"A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus","volume":"180","author":"L Ruttiger","year":"2003","journal-title":"HearRes"},{"issue":"1\u20132","key":"ref23","first-page":"83","article-title":"Tinnitus in hamsters following exposure to intense sound","volume":"170","author":"HE Heffner","year":"2002","journal-title":"HearRes"},{"issue":"1","key":"ref24","first-page":"54","article-title":"Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model","volume":"2","author":"CA Bauer","year":"2001","journal-title":"JAssocResOtolaryngol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3758\/s13428-011-0061-4","article-title":"A two-choice sound localization procedure for detecting lateralized tinnitus in animals","volume":"43","author":"HE Heffner","year":"2011","journal-title":"Behav Res Methods"},{"issue":"3","key":"ref26","first-page":"734","article-title":"Tinnitus and hearing loss in hamsters (Mesocricetus auratus) exposed to loud sound","volume":"119","author":"HE Heffner","year":"2005","journal-title":"BehavNeurosci"},{"year":"2012","author":"HE Heffner","key":"ref27"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"e75011","DOI":"10.1371\/journal.pone.0075011","article-title":"Noise-Induced Tinnitus Using Individualized Gap Detection Analysis and Its Relationship with Hyperacusis, Anxiety, and Spatial Cognition","volume":"8","author":"EZ Pace","year":"2013","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"ref29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.heares.2012.03.015","article-title":"Isoflurane blocks temporary tinnitus","volume":"290","author":"M Norman","year":"2012","journal-title":"Hear Res"},{"issue":"6","key":"ref30","first-page":"1404","article-title":"The effect of isoflurane, halothane and pentobarbital on noise-induced hearing loss in mice","volume":"104","author":"JW Chung","year":"2007","journal-title":"AnesthAnalg"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1097\/01.mlg.0000180173.81034.4d","article-title":"Protective effect of isoflurane anesthesia on noise-induced hearing loss in mice","volume":"115","author":"JU Kim","year":"2005","journal-title":"Laryngoscope"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuroscience.2006.11.067","article-title":"Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1\/arc in auditory neurons following acoustic trauma","volume":"145","author":"J Tan","year":"2007","journal-title":"Neuroscience"},{"issue":"6","key":"ref33","first-page":"1503","article-title":"Study of tinnitus induced temporarily by noise","volume":"44","author":"GR Atherley","year":"1968","journal-title":"JAcoustSocAm"},{"issue":"2","key":"ref34","first-page":"453","article-title":"Relation of induced tinnitus to physical characteristics of the inducing stimuli","volume":"42","author":"M Loeb","year":"1967","journal-title":"JAcoustSocAm"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fneur.2015.00060","article-title":"Cannabinoid CB1 Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats","volume":"6","author":"Y Zheng","year":"2015","journal-title":"Front Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"724195","DOI":"10.1155\/2014\/724195","article-title":"The effects of acute stress-induced sleep disturbance on acoustic trauma-induced tinnitus in rats","volume":"2014","author":"Y Zheng","year":"2014","journal-title":"BioMed research international"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fneur.2012.00127","article-title":"Evidence that Memantine Reduces Chronic Tinnitus Caused by Acoustic Trauma in Rats","volume":"3","author":"Y Zheng","year":"2012","journal-title":"Front Neurol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"80904","DOI":"10.1155\/2007\/80904","article-title":"Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma","volume":"2007","author":"MJ Guitton","year":"2007","journal-title":"Neural Plast"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuroscience.2010.02.071","article-title":"Noise trauma impairs neurogenesis in the rat hippocampus","volume":"167","author":"KS Kraus","year":"2010","journal-title":"Neuroscience"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"e57247","DOI":"10.1371\/journal.pone.0057247","article-title":"The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats","volume":"8","author":"L Ruttiger","year":"2013","journal-title":"PLoS One"},{"key":"ref41","article-title":"Seasonal affective disorder in patients with chronic tinnitus","author":"YH Kim","year":"2015","journal-title":"Laryngoscope"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"e64726","DOI":"10.1371\/journal.pone.0064726","article-title":"Tinnitus, unipolar brush cells, and cerebellar glutamatergic function in an animal model","volume":"8","author":"CA Bauer","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10162-006-0067-2","article-title":"Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model","volume":"8","author":"TJ Brozoski","year":"2007","journal-title":"J Assoc Res Otolaryngol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejphar.2015.05.007","article-title":"The anti-inflammatory selective melanocortin receptor subtype 4 agonist, RO27-3225, fails to prevent acoustic trauma-induced tinnitus in rats","volume":"761","author":"Y Zheng","year":"2015","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuroscience.2009.08.026","article-title":"Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus","volume":"164","author":"H Wang","year":"2009","journal-title":"Neuroscience"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnsys.2012.00028","article-title":"Salicylate toxicity model of tinnitus","volume":"6","author":"D Stolzberg","year":"2012","journal-title":"Front Syst Neurosci"},{"issue":"1\u20132","key":"ref47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.heares.2010.05.015","article-title":"The effects of the synthetic cannabinoid receptor agonists, WIN55,212\u20132 and CP55,940, on salicylate-induced tinnitus in rats","volume":"268","author":"Y Zheng","year":"2010","journal-title":"Hear Res"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0194-5998(99)70237-8","article-title":"Behavioral model of chronic tinnitus in rats","volume":"121","author":"CA Bauer","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"51","key":"ref49","first-page":"12","article-title":"Generalization of conditioned suppression during salicylate-induced phantom auditory perception in rats","author":"JF Brennan","year":"1991","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.neuroscience.2009.11.048","article-title":"Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats","volume":"165","author":"K Kizawa","year":"2010","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"ref51","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.heares.2006.06.013","article-title":"Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats","volume":"226","author":"G Yang","year":"2007","journal-title":"Hear Res"},{"issue":"1\u20132","key":"ref52","first-page":"109","article-title":"A novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC)","volume":"190","author":"E Lobarinas","year":"2004","journal-title":"HearRes"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003","article-title":"Salicylate induces tinnitus through activation of cochlear NMDA receptors","volume":"23","author":"MJ Guitton","year":"2003","journal-title":"JNeurosci"},{"issue":"1\u20132","key":"ref54","first-page":"244","article-title":"Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats","volume":"226","author":"G Yang","year":"2007","journal-title":"HearRes"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.heares.2015.01.013","article-title":"Forward acoustic masking enhances the auditory brainstem response in a diotic, but not dichotic, paradigm in salicylate-induced tinnitus","volume":"323","author":"XP Liu","year":"2015","journal-title":"Hear Res"},{"key":"ref56","article-title":"Effects of Salicylate on the Inflammatory Genes Expression and Synaptic Ultrastructure in the Cochlear Nucleus of Rats","author":"SS Hu","year":"2013","journal-title":"Inflammation"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jneumeth.2012.12.023","article-title":"A novel behavioural approach to detecting tinnitus in the guinea pig","volume":"213","author":"JI Berger","year":"2013","journal-title":"J Neurosci Methods"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1044\/1059-0889(2008\/08-0006)","article-title":"Gap detection methods for assessing salicylate-induced tinnitus and hyperacusis in rats","volume":"17","author":"JG Turner","year":"2008","journal-title":"Am J Audiol"},{"key":"ref59","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-3728-4_2","article-title":"Behavioral tests for tinnitus in animals","author":"LE Heffner","year":"2012"},{"key":"ref60","first-page":"150","article-title":"Tinnitus: facts, theories, and treatments","volume":"xi","author":"D McFadden","year":"1982"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1177\/0194599812473554","article-title":"Is the degree of discomfort caused by tinnitus in normal-hearing individuals correlated with psychiatric disorders?","volume":"148","author":"RC Granjeiro","year":"2013","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/00016480510027565","article-title":"Assessment and amelioration of hyperacusis in tinnitus patients","volume":"125","author":"R Dauman","year":"2005","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"ref63","first-page":"162","article-title":"Tinnitus Retraining Therapy (TRT) as a method for treatment of tinnitus and hyperacusis patients","volume":"11","author":"PJ Jastreboff","year":"2000","journal-title":"JAmAcadAudiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fneur.2014.00179","article-title":"Behavioral models of tinnitus and hyperacusis in animals","volume":"5","author":"SH Hayes","year":"2014","journal-title":"Front Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:15:24Z","timestamp":1588968924000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166346"}},"subtitle":[],"editor":[{"given":"Manuel S.","family":"Malmierca","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,11]]},"references-count":64,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166346","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,11,11]]}}}