{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:25:19Z","timestamp":1788009919236,"version":"build-2784847793"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T00:00:00Z","timestamp":1479340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166429","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T18:31:41Z","timestamp":1479407501000},"page":"e0166429","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["High Prevalence of Obesity, Hypertension, Hyperlipidemia, and Diabetes Mellitus in Japanese Outpatients with Schizophrenia: A Nationwide Survey"],"prefix":"10.1371","volume":"11","author":[{"given":"Takuro","family":"Sugai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yasui-Furukori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitake","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurefu","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyoaki","family":"Sagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Someya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/070674379103600401","article-title":"Mortality in a cohort of patients with schizophrenia: a record linkage study","volume":"36","author":"SC Newman","year":"1991","journal-title":"Can J Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.schres.2006.09.025","article-title":"Cardiovascular and metabolic risk in outpatients with schizophrenia treated with antipsychotics: results of the CLAMORS Study","volume":"90","author":"J Bobes","year":"2007","journal-title":"Schizophr Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.schres.2005.12.855","article-title":"Prevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medication","volume":"83","author":"MA De Hert","year":"2006","journal-title":"Schizophr Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.schres.2005.07.014","article-title":"Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III","volume":"80","author":"JP McEvoy","year":"2005","journal-title":"Schizophr Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.schres.2009.12.016","article-title":"Prevalence of cardiovascular risk factors and disease in people with schizophrenia: a population-based study","volume":"117","author":"LC Bresee","year":"2010","journal-title":"Schizophr Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0447.2009.01401.x","article-title":"Prevalence of metabolic syndrome among patients with schizophrenia or schizoaffective disorder in Taiwan","volume":"120","author":"MC Huang","year":"2009","journal-title":"Acta Psychiatr Scand"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.schres.2005.05.001","article-title":"Serum lipid profiles and schizophrenia: effects of conventional or atypical antipsychotic drugs in Taiwan","volume":"80","author":"TL Huang","year":"2005","journal-title":"Schizophr Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute\/American Heart Association conference on scientific issues related to definition","volume":"109","author":"SM Grundy","year":"2004","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/j.2051-5545.2009.tb00199.x","article-title":"Metabolic syndrome in people with schizophrenia: a review","volume":"8","author":"M De Hert","year":"2009","journal-title":"World Psychiatry"},{"key":"ref10","unstructured":"Ministry of Health, Labour and Welfare. (2009) Patient Survey. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncnp.go.jp\/nimh\/keikaku\/vision\/630data.html\" xlink:type=\"simple\">http:\/\/www.ncnp.go.jp\/nimh\/keikaku\/vision\/630data.html<\/ext-link>."},{"key":"ref11","unstructured":"Ministry of Health, Labour and Welfare. (2008) Patient Survey. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncnp.go.jp\/nimh\/keikaku\/vision\/630data.html\" xlink:type=\"simple\">http:\/\/www.ncnp.go.jp\/nimh\/keikaku\/vision\/630data.html<\/ext-link>."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4093\/dmj.2011.35.6.561","article-title":"Obesity and metabolic syndrome in Korea","volume":"35","author":"SW Oh","year":"2011","journal-title":"Diabetes Metab J"},{"key":"ref13","unstructured":"Ministry of Health, Labour and Welfare. (2011) National Health and Nutrition Examination Survey. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.mhlw.go.jp\/bunya\/kenkou\/eiyou\/h23-houkoku.html\" xlink:type=\"simple\">http:\/\/www.mhlw.go.jp\/bunya\/kenkou\/eiyou\/h23-houkoku.html<\/ext-link>."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.schres.2009.04.003","article-title":"Prevalence of diabetes in patients with schizophrenia in Taiwan: a population-based National Health Insurance study","volume":"111","author":"IC Chien","year":"2009","journal-title":"Schizophr Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/oxfordjournals.schbul.a033504","article-title":"Prevalence and correlates of diabetes in national schizophrenia samples","volume":"26","author":"L Dixon","year":"2000","journal-title":"Schizophr Bull"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/sj.ijo.0801840","article-title":"Increased visceral fat distribution in drug-na\u00efve and drug free patients with schizophrenia","volume":"26","author":"JH Thakore","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.schres.2006.06.026","article-title":"Low rates of treatment for hypertension, dyslipidaemia and diabetes in schizophrenia: data from the CATIE schizophrenia trial sample at baseline","volume":"86","author":"HA Nasrallah","year":"2006","journal-title":"Schizophr Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-244X-8-84","article-title":"Relative risk of diabetes, dyslipidaemia, hypertension and the metabolic syndrome in people with severe mental illnesses: systematic review and meta-analysis","volume":"8","author":"DP Osborn","year":"2008","journal-title":"BMC Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4088\/JCP.v66n0205","article-title":"Medical morbidity and mortality in schizophrenia: guidelines for psychiatrists","volume":"66","author":"DC Goff","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treat-ment of high blood cholesterol in adults (Adult treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1001\/jama.285.19.2481","article-title":"Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease","volume":"285","author":"PM Ridker","year":"2001","journal-title":"JAMA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.schres.2005.05.001","article-title":"Serum lipid profiles and schizophrenia: Effects of conventional or atypical antipsychotic drugs in Taiwan","volume":"80","author":"LH Tiao","year":"2005","journal-title":"Schizophr Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/hrt.2006.110171","article-title":"Inequalities in the primary care of patients with coronary heart disease and serious mental health problems: a cross sectional study","volume":"93","author":"J Hippisley-Cox","year":"2007","journal-title":"Heart"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.288.14.1723","article-title":"Prevalence and trends in obesity among US adults: 1999\u20132000","volume":"288","author":"KM Flegal","year":"2002","journal-title":"JAMA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4088\/PCC.v07n0307","article-title":"The relation between body fat distribution and cardiovascular risk factors in patients with schizophrenia: a cross-sectional pilot study","volume":"7","author":"MM Kato","year":"2005","journal-title":"Prim Care Companion. J Clin Psychiatry"},{"key":"ref26","first-page":"205","article-title":"Relationship between smoking status and cardiovascular disease risk factors in young adult males in Taiwan","volume":"3","author":"NF Chu","year":"1996","journal-title":"J Cardiovasc Risk"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0091-7435(02)00045-2","article-title":"Awareness of hypertension and dyslipidemia in a semirural population of young adults: the Bogalusa Heart Study","volume":"36","author":"MG Frontini","year":"2003","journal-title":"Prev Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/JCP.0b013e318166c4f7","article-title":"Dyslipidemia independent of body mass in antipsychotic-treated patients under real-life conditions","volume":"28","author":"AB Birkenaes","year":"2008","journal-title":"J Clin Psychopharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1503\/cmaj.051455","article-title":"A comprehensive view of sex-specific issues related to cardiovascular disease","volume":"176","author":"L Pilote","year":"2007","journal-title":"Can Med Assoc J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4088\/JCP.v68n0711","article-title":"Metabolic syndrome among persons with schizophrenia and other psychotic disorders in a general population survey","volume":"68","author":"JM Suvisaari","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s40279-013-0110-5","article-title":"Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations","volume":"44","author":"S Mann","year":"2014","journal-title":"Sports Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T18:25:40Z","timestamp":1568571940000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166429"}},"subtitle":[],"editor":[{"given":"Nanette H","family":"Bishopric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,17]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166429","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,17]]}}}