{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:45:39Z","timestamp":1790693139043,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166474","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T18:55:33Z","timestamp":1478804133000},"page":"e0166474","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex"],"prefix":"10.1371","volume":"11","author":[{"given":"Yen-Lung","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunn-Guang","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Huei","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Ling","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Huey","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"ref1","first-page":"v","year":"2012"},{"issue":"9966","key":"ref2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"MG Guzman","year":"2015","journal-title":"Lancet"},{"key":"ref3","author":"DM Knipe","year":"2013"},{"issue":"21","key":"ref4","doi-asserted-by":"crossref","first-page":"12019","DOI":"10.1128\/JVI.00300-07","article-title":"Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking","volume":"81","author":"HM van der Schaar","year":"2007","journal-title":"J Virol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1371\/journal.ppat.0040017","article-title":"The mannose receptor mediates dengue virus infection of macrophages","volume":"4","author":"JL Miller","year":"2008","journal-title":"PLoS pathogens"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells","volume":"197","author":"B Tassaneetrithep","year":"2003","journal-title":"J Exp Med"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jmb.2013.11.023","article-title":"Innate immunity to dengue virus infection and subversion of antiviral responses","volume":"426","author":"AM Green","year":"2014","journal-title":"J Mol Biol"},{"issue":"7195","key":"ref8","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nature07013","article-title":"CLEC5A is critical for dengue-virus-induced lethal disease","volume":"453","author":"ST Chen","year":"2008","journal-title":"Nature"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"e1002655","DOI":"10.1371\/journal.ppat.1002655","article-title":"CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality","volume":"8","author":"ST Chen","year":"2012","journal-title":"PLoS pathogens"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1172\/JCI57682","article-title":"Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice","volume":"121","author":"R Cheung","year":"2011","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1182\/blood-2012-05-430090","article-title":"CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages","volume":"121","author":"MF Wu","year":"2013","journal-title":"Blood"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/femsre\/fuu004","article-title":"Receptors and routes of dengue virus entry into the host cells","volume":"39","author":"C Cruz-Oliveira","year":"2015","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cell.2015.07.005","article-title":"Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control","volume":"162","author":"MS Diamond","year":"2015","journal-title":"Cell"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/v6010069","article-title":"Flavivirus entry receptors: an update","volume":"6","author":"M Perera-Lecoin","year":"2014","journal-title":"Viruses"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.nano.2014.03.009","article-title":"Nanostructured electrochemical biosensor for th0065 detection of the weak binding between the dengue virus and the CLEC5A receptor","volume":"10","author":"YT Tung","year":"2014","journal-title":"Nanomedicine: nanotechnology, biology, and medicine"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"e106882","DOI":"10.1371\/journal.pone.0106882","article-title":"Kinetic titration series with biolayer interferometry","volume":"9","author":"D Frenzel","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ab.2008.03.035","article-title":"Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet","volume":"377","author":"Y Abdiche","year":"2008","journal-title":"Anal Biochem"},{"issue":"50","key":"ref18","doi-asserted-by":"crossref","first-page":"34479","DOI":"10.1074\/jbc.M109.065961","article-title":"Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins","volume":"284","author":"TL Hsu","year":"2009","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/glycob\/cwq193","article-title":"Survey of immune-related, mannose\/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities","volume":"21","author":"RT Lee","year":"2011","journal-title":"Glycobiology"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1128\/JCM.38.9.3306-3310.2000","article-title":"Quantitative competitive reverse transcription-PCR for quantification of dengue virus RNA","volume":"38","author":"WK Wang","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1128\/JCM.40.12.4472-4478.2002","article-title":"Detection of dengue virus replication in peripheral blood mononuclear cells from dengue virus type 2-infected patients by a reverse transcription-real-time PCR assay","volume":"40","author":"WK Wang","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"13","key":"ref22","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1073\/pnas.0400983101","article-title":"Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria","volume":"101","author":"FA Verreck","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.atherosclerosis.2010.11.023","article-title":"Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: implication in atherosclerosis","volume":"214","author":"I Brocheriou","year":"2011","journal-title":"Atherosclerosis"},{"issue":"6","key":"ref24","first-page":"L721","article-title":"Differential regulation of the mannose and SP-A receptors on macrophages","volume":"269","author":"Z Chroneos","year":"1995","journal-title":"Am J Physiol"},{"issue":"1\u20132","key":"ref25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jim.2011.10.013","article-title":"Systematic validation of specific phenotypic markers for in vitro polarized human macrophages","volume":"375","author":"CA Ambarus","year":"2012","journal-title":"J Immunol Methods"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/cyto.a.22629","article-title":"Statistical analysis of molecule colocalization in bioimaging","volume":"87","author":"T Lagache","year":"2015","journal-title":"Cytometry A"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1083\/jcb.200306112","article-title":"Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells","volume":"164","author":"A Cambi","year":"2004","journal-title":"J Cell Biol"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1073\/pnas.0438057100","article-title":"Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes","volume":"100","author":"G Panyi","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1073\/pnas.97.11.6013","article-title":"Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts","volume":"97","author":"G Vereb","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/infdis\/jir173","article-title":"Lectin switching during dengue virus infection","volume":"203","author":"W Dejnirattisai","year":"2011","journal-title":"J Infect Dis"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.vaccine.2015.01.047","article-title":"Site-specific characterization of envelope protein N-glycosylation on Sanofi Pasteur's tetravalent CYD dengue vaccine","volume":"33","author":"J Dubayle","year":"2015","journal-title":"Vaccine"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2005.11.042","article-title":"Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN","volume":"124","author":"E Pokidysheva","year":"2006","journal-title":"Cell"},{"issue":"12","key":"ref33","doi-asserted-by":"crossref","first-page":"e1000244","DOI":"10.1371\/journal.ppat.1000244","article-title":"Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells","volume":"4","author":"HM van der Schaar","year":"2008","journal-title":"PLoS pathogens"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T07:07:45Z","timestamp":1601190465000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166474"}},"subtitle":[],"editor":[{"given":"Stefan","family":"P\u00f6hlmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,10]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166474","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,10]]}}}