{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:46:02Z","timestamp":1791395162402,"version":"4.3.3"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["1005882"],"award-info":[{"award-number":["1005882"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166523","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T19:12:13Z","timestamp":1479237133000},"page":"e0166523","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":108,"title":["A Microbiological Map of the Healthy Equine Gastrointestinal Tract"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-7269","authenticated-orcid":true,"given":"Aaron C.","family":"Ericsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja C.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Lanter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1128\/AEM.66.11.5030-5034.2000","article-title":"Colonization of the stratified squamous epithelium of the nonsecreting area of horse stomach by lactobacilli","volume":"66","author":"N Yuki","year":"2000","journal-title":"Appl Environ Microbiol"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.2527\/jas.2006-182","article-title":"Postprandial kinetics of some biotic and abiotic characteristics of the gastric ecosystem of horses fed a pelleted concentrate meal","volume":"85","author":"M Varloud","year":"2007","journal-title":"Journal of animal science"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S1357729800059038","article-title":"Characterization of the microbial and biochemical profile of the different segments ofthe digestive tract in horses given two distinct diets","volume":"77","author":"A de Fombelle","year":"2003","journal-title":"ANIMAL SCIENCE-GLASGOW THEN PENICUIK"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.livprodsci.2005.04.008","article-title":"Passage rate of digesta through the equine gastrointestinal tract: A review","volume":"99","author":"S Van Weyenberg","year":"2006","journal-title":"Livest Sci"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1128\/AEM.54.9.2155-2160.1988","article-title":"Enumeration of anaerobic bacterial microflora of the equine gastrointestinal tract","volume":"54","author":"RI Mackie","year":"1988","journal-title":"Appl Environ Microbiol"},{"issue":"7415","key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"CL Maynard","year":"2012","journal-title":"Nature"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ni.2640","article-title":"Commensal bacteria at the interface of host metabolism and the immune system","volume":"14","author":"JR Brestoff","year":"2013","journal-title":"Nat Immunol"},{"issue":"Suppl 1","key":"ref8","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"JG Caporaso","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"e0116704","DOI":"10.1371\/journal.pone.0116704","article-title":"Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice","volume":"10","author":"AC Ericsson","year":"2015","journal-title":"PloS one"},{"key":"ref10","article-title":"Comparative evaluation of DNA extraction methods from feces of multiple host species for downstream next-generation sequencing","author":"ML Hart","year":"2015","journal-title":"PloS one"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"T Magoc","year":"2011","journal-title":"Bioinformatics"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1007s36","article-title":"Using QIIME to analyze 16S rRNA gene sequences from microbial communities","author":"J Kuczynski","year":"2011","journal-title":"Current protocols in bioinformatics \/ editoral board, Andreas D Baxevanis"},{"issue":"17","key":"ref13","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"TZ DeSantis","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"ref15","unstructured":"Tsugawa H. Platform for Riken Metabolomics 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/prime.psc.riken.jp\/Metabolomics_Software\/StatisticalAnalysisOnMicrosoftExcel\/index.html\" xlink:type=\"simple\">http:\/\/prime.psc.riken.jp\/Metabolomics_Software\/StatisticalAnalysisOnMicrosoftExcel\/index.html<\/ext-link>."},{"key":"ref16","unstructured":"Hammer O. Past 3.x 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/folk.uio.no\/ohammer\/past\/\" xlink:type=\"simple\">http:\/\/folk.uio.no\/ohammer\/past\/<\/ext-link>."},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2460\/javma.2001.219.67","article-title":"Estimate of the national incidence of and operation-level risk factors for colic among horses in the United States, spring 1998 to spring 1999","volume":"219","author":"JL Traub-Dargatz","year":"2001","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2746\/042516401776249499","article-title":"A cross-sectional study of colic in horses on thoroughbred training premises in the British Isles in 1997","volume":"33","author":"MH Hillyer","year":"2001","journal-title":"Equine veterinary journal"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-5877(96)01102-6","article-title":"Risk factors for colic in the Michigan (USA) equine population","volume":"30","author":"JB Kaneene","year":"1997","journal-title":"Preventive veterinary medicine"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.2042-3306.1997.tb03157.x","article-title":"Prospective study of equine colic incidence and mortality","volume":"29","author":"MK Tinker","year":"1997","journal-title":"Equine veterinary journal"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2460\/javma.1999.215.01.53","article-title":"Dietary and other management factors associated with colic in horses","volume":"215","author":"ND Cohen","year":"1999","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/1746-6148-8-231","article-title":"Pyrosequencing of 16S rRNA genes in fecal samples reveals high diversity of hindgut microflora in horses and potential links to chronic laminitis","volume":"8","author":"SM Steelman","year":"2012","journal-title":"BMC veterinary research"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1111\/j.1462-2920.2007.01327.x","article-title":"Fluorescence in situ hybridization analysis of hindgut bacteria associated with the development of equine laminitis","volume":"9","author":"GJ Milinovich","year":"2007","journal-title":"Environmental microbiology"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2527\/jas.2010-3108","article-title":"Dietary supplementation with short-chain fructo-oligosaccharides improves insulin sensitivity in obese horses","volume":"89","author":"F Respondek","year":"2011","journal-title":"Journal of animal science"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2746\/042516409X447806","article-title":"Changes in faecal bacteria associated with concentrate and forage-only diets fed to horses in training","volume":"41","author":"B Willing","year":"2009","journal-title":"Equine veterinary journal"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1574-6968.2011.02434.x","article-title":"Characterization of the fecal bacteria communities of forage-fed horses by pyrosequencing of 16S rRNA V4 gene amplicons","volume":"326","author":"ML Shepherd","year":"2012","journal-title":"FEMS Microbiol Lett"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"e77660","DOI":"10.1371\/journal.pone.0077660","article-title":"Identification of a core bacterial community within the large intestine of the horse","volume":"8","author":"K Dougal","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1574-6941.2012.01441.x","article-title":"A comparison of the microbiome and the metabolome of different regions of the equine hindgut","volume":"82","author":"K Dougal","year":"2012","journal-title":"FEMS microbiology ecology"},{"key":"ref29","article-title":"Effects of transport, fasting and anaesthesia on the faecal microbiota of healthy adult horses","author":"A Schoster","year":"2015","journal-title":"Equine veterinary journal"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tvjl.2015.03.018","article-title":"Characterization and comparison of the bacterial microbiota in different gastrointestinal tract compartments in horses","volume":"205","author":"MC Costa","year":"2015","journal-title":"Veterinary journal"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/evj.12361","article-title":"Changes in the faecal microbiota of mares precede the development of post partum colic","volume":"47","author":"JS Weese","year":"2015","journal-title":"Equine veterinary journal"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1128\/AEM.06252-11","article-title":"Equine stomachs harbor an abundant and diverse mucosal microbiota","volume":"78","author":"GA Perkins","year":"2012","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"e41484","DOI":"10.1371\/journal.pone.0041484","article-title":"Comparison of the fecal microbiota of healthy horses and horses with colitis by high throughput sequencing of the V3-V5 region of the 16S rRNA gene","volume":"7","author":"MC Costa","year":"2012","journal-title":"PloS one"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12917-015-0335-7","article-title":"Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs","volume":"11","author":"MC Costa","year":"2015","journal-title":"BMC veterinary research"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/lam.12137","article-title":"The core faecal bacterial microbiome of Irish Thoroughbred racehorses","volume":"57","author":"OD MM","year":"2013","journal-title":"Letters in applied microbiology"},{"issue":"6123","key":"ref36","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"JG Markle","year":"2013","journal-title":"Science"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2013.08.013","article-title":"Gender bias in autoimmunity is influenced by microbiota","volume":"39","author":"L Yurkovetskiy","year":"2013","journal-title":"Immunity"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age","volume":"9","author":"D Mariat","year":"2009","journal-title":"BMC microbiology"},{"issue":"6052","key":"ref39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"GD Wu","year":"2011","journal-title":"Science"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu7010017","article-title":"The impact of diet and lifestyle on gut microbiota and human health","volume":"7","author":"MA Conlon","year":"2015","journal-title":"Nutrients"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T16:21:54Z","timestamp":1718900514000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166523"}},"subtitle":[],"editor":[{"given":"Hauke","family":"Smidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166523","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}