{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:25:16Z","timestamp":1761513916540,"version":"3.37.3"},"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Forschungsgemeinschaft (DFG, Germany)","award":["Br1860\/8"],"award-info":[{"award-number":["Br1860\/8"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, Germany)","award":["SFB854 TP14"],"award-info":[{"award-number":["SFB854 TP14"]}]},{"name":"Forschungsgemeinschaft (DFG, Germany)","award":["Br1860\/11"],"award-info":[{"award-number":["Br1860\/11"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166633","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T19:14:01Z","timestamp":1480360441000},"page":"e0166633","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca2+ Influx"],"prefix":"10.1371","volume":"11","author":[{"given":"Kristin","family":"Schmiedeberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hardy","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich-Wilhelm","family":"R\u00f6hl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Hartig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Jorch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-3568","authenticated-orcid":true,"given":"Monika C.","family":"Brunner-Weinzierl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy","volume":"10","author":"E von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2567.1998.00507.x","article-title":"Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells","volume":"94","author":"S Kilpinen","year":"1998","journal-title":"Immunology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e25690","DOI":"10.1371\/journal.pone.0025690","article-title":"Fluorescent cell barcoding as a tool to assess the age-related development of intracellular cytokine production in small amounts of blood from infants","volume":"6","author":"J Stam","year":"2011","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3476(97)70200-2","article-title":"Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations","volume":"130","author":"WM Comans-Bitter","year":"1997","journal-title":"J Pediatr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaci.2003.07.003","article-title":"Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study","volume":"112","author":"WT Shearer","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1182\/blood.V94.9.3101","article-title":"Reduced NFAT1 protein expression in human umbilical cord blood T lymphocytes","volume":"94","author":"S Kadereit","year":"1999","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1182\/blood-2009-10-233585","article-title":"NFAT pulls the strings during CD4+ T helper cell effector functions","volume":"115","author":"N Hermann-Kleiter","year":"2010","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1182\/blood-2003-05-1732","article-title":"Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation","volume":"102","author":"BA Kaminski","year":"2003","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1182\/blood-2008-09-181156","article-title":"microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells","volume":"113","author":"RP Weitzel","year":"2009","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1182\/blood-2008-02-139154","article-title":"Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets","volume":"113","author":"S Kohler","year":"2009","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"F Sallusto","year":"1999","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1073\/pnas.96.1.185","article-title":"A two-step, two-signal model for the primary activation of precursor helper T cells","volume":"96","author":"PA Bretscher","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nri1248","article-title":"CD28-mediated co-stimulation: a quantitative support for TCR signalling","volume":"3","author":"O Acuto","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1182\/blood.V86.9.3479.bloodjournal8693479","article-title":"Critical role of CD28\/B7 costimulation in the development of human Th2 cytokine-producing cells","volume":"86","author":"LM Webb","year":"1995","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1182\/blood.V75.7.1531.1531","article-title":"CD28 ligation in T-cell activation: evidence for two signal transduction pathways","volume":"75","author":"JA Ledbetter","year":"1990","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jim.2016.01.007","article-title":"Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-kappaB, NFAT and AP-1","volume":"430","author":"S Jutz","year":"2016","journal-title":"J Immunol Methods"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1128\/MCB.17.7.4051","article-title":"CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites","volume":"17","author":"VS Shapiro","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1016\/S0021-9258(18)42696-8","article-title":"AU RNA-binding factors differ in their binding specificities and affinities","volume":"267","author":"PR Bohjanen","year":"1992","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.4049\/jimmunol.1300485","article-title":"CD28 sensitizes TCR Ca(2)(+) signaling during Ag-independent polarization of plasma membrane rafts","volume":"191","author":"JN Byrum","year":"2013","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/386855a0","article-title":"Differential activation of transcription factors induced by Ca2+ response amplitude and duration","volume":"386","author":"RE Dolmetsch","year":"1997","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.4049\/jimmunol.1003998","article-title":"IL-1beta and TGF-beta act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells","volume":"187","author":"K Hebel","year":"2011","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.4049\/jimmunol.1302539","article-title":"CD4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program","volume":"192","author":"K Hebel","year":"2014","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2249.2005.02928.x","article-title":"Cytokine responses correlate differentially with age in infancy and early childhood","volume":"142","author":"C Hartel","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1182\/blood.V93.3.1120","article-title":"Intracellular cytokine profiles of cord and adult blood lymphocytes","volume":"93","author":"J Chipeta","year":"1999","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.humimm.2006.02.040","article-title":"Similar potential to become activated and proliferate but differential kinetics and profiles of cytokine production of umbilical cord blood T cells and adult blood naive and memory T cells","volume":"67","author":"FM Kloosterboer","year":"2006","journal-title":"Hum Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20011756","article-title":"Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood","volume":"195","author":"S Kimmig","year":"2002","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1002\/eji.200636976","article-title":"Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children","volume":"37","author":"S Junge","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.180.3.1499","article-title":"Homeostasis of the naive CD4+ T cell compartment during aging","volume":"180","author":"RD Kilpatrick","year":"2008","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/intimm\/dxq063","article-title":"T-lymphocyte calcium influx characteristics and their modulation by Kv1.3 and IKCa1 channel inhibitors in the neonate","volume":"22","author":"G Toldi","year":"2010","journal-title":"Int Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.coi.2008.04.004","article-title":"Calcium signaling in lymphocytes","volume":"20","author":"M Oh-hora","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2249.2008.03677.x","article-title":"Intracellular calcium signalling patterns reflect the differentiation status of human T cells","volume":"153","author":"HP Arrol","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.4049\/jimmunol.1202534","article-title":"Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a","volume":"190","author":"AC Palin","year":"2013","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0092-8674(02)00767-5","article-title":"Transcriptional mechanisms underlying lymphocyte tolerance","volume":"109","author":"F Macian","year":"2002","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0301-472X(01)00662-2","article-title":"Cyclosporin A effects during primary and secondary activation of human umbilical cord blood T lymphocytes","volume":"29","author":"S Kadereit","year":"2001","journal-title":"Exp Hematol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1478-811X-7-25","article-title":"Novel inhibitors of the calcineurin\/NFATc hub\u2014alternatives to CsA and FK506?","volume":"7","author":"M Sieber","year":"2009","journal-title":"Cell Commun Signal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1097-2765(00)00053-8","article-title":"Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity","volume":"6","author":"H Okamura","year":"2000","journal-title":"Mol Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx","volume":"15","author":"J Liou","year":"2005","journal-title":"Curr Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/emboj.2011.495","article-title":"STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation","volume":"31","author":"MF Ritchie","year":"2012","journal-title":"EMBO J"},{"issue":"Suppl 1","key":"ref39","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1136\/thorax.55.suppl_1.S2","article-title":"Family size, infection and atopy: the first decade of the &quot;hygiene hypothesis&quot;","volume":"55","author":"DP Strachan","year":"2000","journal-title":"Thorax"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"DP Strachan","year":"1989","journal-title":"BMJ"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00281-003-0142-2","article-title":"Effects of intestinal microflora and the environment on the development of asthma and allergy","volume":"25","author":"B Bjorksten","year":"2004","journal-title":"Springer Semin Immunopathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1365-2222.2006.02463.x","article-title":"Too clean, or not too clean: the hygiene hypothesis and home hygiene","volume":"36","author":"SF Bloomfield","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e1478","DOI":"10.1542\/peds.2007-2749","article-title":"Head covering and the risk for SIDS: findings from the New Zealand and German SIDS case-control studies","volume":"121","author":"EA Mitchell","year":"2008","journal-title":"Pediatrics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0140-6736(03)15323-8","article-title":"Sudden unexplained infant death in 20 regions in Europe: case control study","volume":"363","author":"RG Carpenter","year":"2004","journal-title":"Lancet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jpeds.2008.04.022","article-title":"Sudden infant death syndrome: changing epidemiologic patterns in California 1989\u20132004","volume":"153","author":"RK Chang","year":"2008","journal-title":"J Pediatr"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.4049\/jimmunol.1100978","article-title":"Reversible senescence in human CD4+CD45RA+CD27- memory T cells","volume":"187","author":"D Di Mitri","year":"2011","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0165-2478(97)00056-4","article-title":"CD45RA-expressing memory\/effector Th cells committed to production of interferon-gamma lack expression of CD31","volume":"57","author":"A Thiel","year":"1997","journal-title":"Immunol Lett"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1038\/srep07760","article-title":"Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus","volume":"5","author":"SN Christo","year":"2015","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bbamem.2013.07.009","article-title":"The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux","volume":"1838","author":"N Joseph","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e0159248","DOI":"10.1371\/journal.pone.0159248","article-title":"Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism","volume":"11","author":"CA Rivet","year":"2016","journal-title":"PLoS One"},{"key":"ref51","article-title":"Novel STIM1-dependent control of Ca2+ clearance regulates NFAT activity during T-cell activation","author":"E Samakai","year":"2016","journal-title":"FASEB J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/ni1574","article-title":"Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance","volume":"9","author":"M Oh-Hora","year":"2008","journal-title":"Nat Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2567.2009.03155.x","article-title":"Efficiency of T-cell costimulation by CD80 and CD86 cross-linking correlates with calcium entry","volume":"129","author":"M Thiel","year":"2009","journal-title":"Immunology"},{"key":"ref54","article-title":"Control of T cell antigen reactivity via programmed TCR downregulation","author":"AM Gallegos","year":"2016","journal-title":"Nat Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.4049\/jimmunol.1102376","article-title":"Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity","volume":"188","author":"Q Li","year":"2012","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.4049\/jimmunol.1290068","article-title":"Comment on &quot;constitutive nuclear localization of NFAT in Foxp3(+) regulatory T cells independent of calcineurin activity&quot;","volume":"189","author":"T Scheel","year":"2012","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.imlet.2014.10.020","article-title":"TCR and CD28 activate the transcription factor NF-kappaB in T-cells via distinct adaptor signaling complexes","volume":"163","author":"YR Thaker","year":"2015","journal-title":"Immunol Lett"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/art.37714","article-title":"Impact of the CTLA-4\/CD28 axis on the processes of joint inflammation in rheumatoid arthritis","volume":"65","author":"D Kormendy","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e1708","DOI":"10.1371\/journal.pone.0001708","article-title":"Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies","volume":"3","author":"Z Waibler","year":"2008","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/eji.201444513","article-title":"CD28 signals the differential control of regulatory T cells and effector T cells","volume":"44","author":"N Mikami","year":"2014","journal-title":"Eur J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/eji.201343967","article-title":"Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412\/TAB08","volume":"44","author":"P Tabares","year":"2014","journal-title":"Eur J Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.1073\/pnas.0701705104","article-title":"More genes underwent positive selection in chimpanzee evolution than in human evolution","volume":"104","author":"MA Bakewell","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood.V98.9.2745","article-title":"Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life","volume":"98","author":"HW Schroeder Jr.","year":"2001","journal-title":"Blood"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.1501997","article-title":"TLR-Mediated Innate Production of IFN-gamma by CD8+ T Cells Is Independent of Glycolysis","volume":"196","author":"F Salerno","year":"2016","journal-title":"J Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1126\/science.1196509","article-title":"Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans","volume":"330","author":"JE Mold","year":"2010","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"DH Munn","year":"1998","journal-title":"Science"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.4049\/jimmunol.151.9.4562","article-title":"Synthesis of T helper 2-type cytokines at the maternal-fetal interface","volume":"151","author":"H Lin","year":"1993","journal-title":"J Immunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1182\/blood-2011-02-334698","article-title":"Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8alpha(+) semi-invariant T cells","volume":"118","author":"CJ Turtle","year":"2011","journal-title":"Blood"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1182\/blood.V98.5.1480","article-title":"Regulation of interferon-gamma gene expression by nuclear factor of activated T cells","volume":"98","author":"A Kiani","year":"2001","journal-title":"Blood"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"RA Seder","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1182\/blood-2002-11-3591","article-title":"Homeostatic control of T-cell generation in neonates","volume":"102","author":"SO Schonland","year":"2003","journal-title":"Blood"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.4049\/jimmunol.154.11.5757","article-title":"Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response","volume":"154","author":"PJ Lucas","year":"1995","journal-title":"J Immunol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.156.12.4576","article-title":"CD28 is required for germinal center formation","volume":"156","author":"SE Ferguson","year":"1996","journal-title":"J Immunol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.4049\/jimmunol.181.11.7445","article-title":"Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses","volume":"181","author":"EB Wilson","year":"2008","journal-title":"J Immunol"},{"key":"ref75","article-title":"Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants","author":"D Gibbons","year":"2014","journal-title":"nature medicine"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1684\/ecn.2009.0149","article-title":"Age-related changes in intracellular cytokine expression in healthy children","volume":"20","author":"V Wiegering","year":"2009","journal-title":"Eur Cytokine Netw"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000073638","article-title":"Age-related changes in intracellular TH1\/TH2 cytokine production, immunoproliferative T lymphocyte response and natural killer cell activity in newborns, children and adults","volume":"84","author":"A Gasparoni","year":"2003","journal-title":"Biol Neonate"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1182\/blood.V92.1.11.413a39_11_18","article-title":"Intracellular cytokine profile of cord and adult blood lymphocytes","volume":"92","author":"IM Chalmers","year":"1998","journal-title":"Blood"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/S0140-6736(08)60774-6","article-title":"Sudden unexpected death in infancy: evidence of infection","volume":"371","author":"JA Morris","year":"2008","journal-title":"Lancet"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/S0140-6736(08)60798-9","article-title":"Infection and sudden unexpected death in infancy: a systematic retrospective case review","volume":"371","author":"MA Weber","year":"2008","journal-title":"Lancet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:49:27Z","timestamp":1692586167000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166633"}},"subtitle":[],"editor":[{"given":"Stephen J","family":"Turner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":80,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166633","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,11,28]]}}}