{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:54:31Z","timestamp":1768319671055,"version":"3.49.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166661","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T18:31:10Z","timestamp":1482258670000},"page":"e0166661","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Drug Resistance and Virological Failure among HIV-Infected Patients after a Decade of Antiretroviral Treatment Expansion in Eight Provinces of China"],"prefix":"10.1371","volume":"11","author":[{"given":"Zhongbao","family":"Zuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scottie","family":"Bussell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebing","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"issue":"9534","key":"ref1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0140-6736(06)69152-6","article-title":"HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis","volume":"368","author":"MT May","year":"2006","journal-title":"Lancet (London, England)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"18797","DOI":"10.7448\/IAS.17.1.18797","article-title":"Disease patterns and causes of death of hospitalized HIV-positive adults in West Africa: a multicountry survey in the antiretroviral treatment era","volume":"17","author":"C Lewden","year":"2014","journal-title":"Journal of the International AIDS Society"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1365-3156.2008.02078.x","article-title":"Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America","volume":"13","author":"O Keiser","year":"2008","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1097\/QAI.0b013e31829ceb14","article-title":"Reduction in early mortality on antiretroviral therapy for adults in rural South Africa since change in CD4+ cell count eligibility criteria","volume":"65","author":"RJ Lessells","year":"2014","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"14","key":"ref5","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1097\/QAD.0b013e32833d45c5","article-title":"Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002\u20132007","volume":"24","author":"M Cornell","year":"2010","journal-title":"AIDS (London, England)"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/ije\/dyp233","article-title":"Cohort profile: the Chinese national free antiretroviral treatment cohort","volume":"39","author":"Y Ma","year":"2010","journal-title":"International journal of epidemiology"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1086\/590945","article-title":"The effect of highly active antiretroviral therapy on mortality among HIV-infected former plasma donors in China","volume":"47","author":"F Zhang","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1097\/QAI.0b013e3182948d82","article-title":"Decreasing excess mortality of HIV-infected patients initiating antiretroviral therapy: comparison with mortality in general population in China, 2003\u20132009","volume":"63","author":"H Zhu","year":"2013","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S1473-3099(11)70097-4","article-title":"Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study","volume":"11","author":"F Zhang","year":"2011","journal-title":"The Lancet Infectious diseases"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/0003-4819-151-4-200908180-00006","article-title":"Five-year outcomes of the China National Free Antiretroviral Treatment Program","volume":"151","author":"F Zhang","year":"2009","journal-title":"Ann Intern Med"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/QAI.0b013e31824c3d9f","article-title":"Association between missed early visits and mortality among patients of china national free antiretroviral treatment cohort","volume":"60","author":"Y Zhang","year":"2012","journal-title":"Journal of acquired immune deficiency syndromes"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1097\/QAD.0b013e3283611931","article-title":"Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China","volume":"27","author":"L Liao","year":"2013","journal-title":"AIDS (London, England)"},{"issue":"19","key":"ref13","first-page":"3514","article-title":"Expansion of China&apos;s free antiretroviral treatment program","volume":"125","author":"DC Zhao","year":"2012","journal-title":"Chinese medical journal"},{"key":"ref14","first-page":"87","article-title":"Update on the AIDS\/STD epidemic in China and main response in control and prevention in December, 2014","volume":"21","author":"N NCAIDS","year":"2015","journal-title":"Chin J AIDS STD"},{"issue":"Suppl 1","key":"ref15","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/QAI.0b013e3181c7d363","article-title":"The prevalence of transmitted antiretroviral drug resistance in treatment-naive HIV-infected individuals in China","volume":"53","author":"L Liao","year":"2010","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/jac\/dkv078","article-title":"Reductions in virological failure and drug resistance in Chinese antiretroviral-treated patients due to lamivudine-based regimens, 2003\u201312","volume":"70","author":"H Xing","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1086\/503914","article-title":"Web resources for HIV type 1 genotypic-resistance test interpretation","volume":"42","author":"TF Liu","year":"2006","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/QAD.0b013e328011e691","article-title":"HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance","volume":"21","author":"RW Shafer","year":"2007","journal-title":"AIDS (London, England)"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"e88305","DOI":"10.1371\/journal.pone.0088305","article-title":"Virological outcomes and drug resistance in Chinese patients after 12 months of 3TC-based first-line antiretroviral treatment, 2011\u20132012","volume":"9","author":"J Wang","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/157016211795569122","article-title":"Factors associated with HIV virologic failure among patients on HAART for one year at three sentinel surveillance sites in China","volume":"9","author":"X Wang","year":"2011","journal-title":"Current HIV research"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/cid\/ciu590","article-title":"Emerging trends of HIV drug resistance in Chinese HIV-infected patients receiving first-line highly active antiretroviral therapy: a systematic review and meta-analysis","volume":"59","author":"H Liu","year":"2014","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"e72680","DOI":"10.1371\/journal.pone.0072680","article-title":"Population-based monitoring of emerging HIV-1 drug resistance on antiretroviral therapy and associated factors in a sentinel site in Cameroon: low levels of resistance but poor programmatic performance","volume":"8","author":"SC Billong","year":"2013","journal-title":"PloS one"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/QAI.0000000000000509","article-title":"Population-based surveillance of HIV drug resistance emerging on treatment and associated factors at sentinel antiretroviral therapy sites in Namibia","volume":"68","author":"SY Hong","year":"2015","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"Suppl 4","key":"ref24","doi-asserted-by":"crossref","first-page":"S355","DOI":"10.1093\/cid\/cis004","article-title":"A retrospective survey of HIV drug resistance among patients 1 year after initiation of antiretroviral therapy at 4 clinics in Malawi","volume":"54","author":"N Wadonda-Kabondo","year":"2012","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fpubh.2015.00244","article-title":"Low Virologic Failure and Drug Resistance among HIV-Infected Patients Receiving Hospital-Based ART While Care and Outreach through Community in Guangxi, China","volume":"3","author":"S Liang","year":"2015","journal-title":"Frontiers in public health"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"e62408","DOI":"10.1371\/journal.pone.0062408","article-title":"Incidence and associated factors of HIV drug resistance in Chinese HIV-infected patients receiving antiretroviral treatment","volume":"8","author":"H Xing","year":"2013","journal-title":"PloS one"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"e005886","DOI":"10.1136\/bmjopen-2014-005886","article-title":"HIV virological failure and drug resistance among injecting drug users receiving first-line ART in China","volume":"4","author":"X Leng","year":"2014","journal-title":"BMJ Open"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1073\/pnas.90.12.5653","article-title":"Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3&apos;-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase","volume":"90","author":"M Tisdale","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1097\/00002030-200001280-00001","article-title":"Non-nucleoside reverse transcriptase inhibitor resistance among patients failing a nevirapine plus protease inhibitor-containing regimen","volume":"14","author":"JL Casado","year":"2000","journal-title":"AIDS (London, England)"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"e54917","DOI":"10.1371\/journal.pone.0054917","article-title":"HIV drug resistance and its impact on antiretroviral therapy in Chinese HIV-infected patients","volume":"8","author":"H Xing","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11908-008-0083-y","article-title":"Strategies for promoting adherence to antiretroviral therapy: a review of the literature","volume":"10","author":"JM Simoni","year":"2008","journal-title":"Curr Infect Dis Rep"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1037\/0278-6133.26.4.488","article-title":"A randomized controlled trial of a peer support intervention targeting antiretroviral medication adherence and depressive symptomatology in HIV-positive men and women","volume":"26","author":"JM Simoni","year":"2007","journal-title":"Health Psychol"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/01.aids.0000232238.28415.d2","article-title":"Cognitive-behavioral intervention to enhance adherence to antiretroviral therapy: a randomized controlled trial (CCTG 578)","volume":"20","author":"GJ Wagner","year":"2006","journal-title":"AIDS (London, England)"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.drugalcdep.2006.09.019","article-title":"Voucher reinforcement improves medication adherence in HIV-positive methadone patients: a randomized trial","volume":"88","author":"JL Sorensen","year":"2007","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/003335490712200408","article-title":"Modified directly observed therapy for antiretroviral therapy: a primer from the field","volume":"122","author":"K Goggin","year":"2007","journal-title":"Public Health Rep"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1086\/432877","article-title":"A programmable prompting device improves adherence to highly active antiretroviral therapy in HIV-infected subjects with memory impairment","volume":"41","author":"AS Andrade","year":"2005","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"e64459","DOI":"10.1371\/journal.pone.0064459","article-title":"Comparison of tenofovir, zidovudine, or stavudine as part of first-line antiretroviral therapy in a resource-limited-setting: a cohort study","volume":"8","author":"K Velen","year":"2013","journal-title":"PloS one"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/QAD.0b013e32835b0f59","article-title":"Tenofovir-based regimens associated with less drug resistance in HIV-1-infected Nigerians failing first-line antiretroviral therapy","volume":"27","author":"MA Etiebet","year":"2013","journal-title":"AIDS (London, England)"},{"key":"ref39","article-title":"Superior effectiveness of zidovudine compared to tenofovir when combined with nevirapine-based antiretroviral therapy in a large Nigerian Cohort","author":"KK Scarsi","year":"2015","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1179\/1945577115Y.0000000004","article-title":"Comparative effectiveness of tenofovir in treatment-naive HIV-infected patients: systematic review and meta-analysis","volume":"16","author":"LG Hemkens","year":"2015","journal-title":"HIV Clin Trials"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T16:23:29Z","timestamp":1658247809000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166661"}},"subtitle":[],"editor":[{"given":"Dimitrios","family":"Paraskevis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166661","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}