{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:35:50Z","timestamp":1791570950033,"version":"4.3.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006146","name":"F\u00f6rdergemeinschaft Kinderkrebs-Zentrum Hamburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166690","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T19:22:02Z","timestamp":1480533722000},"page":"e0166690","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium"],"prefix":"10.1371","volume":"11","author":[{"given":"Nils W.","family":"Engel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ahlfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika K.","family":"Wefers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Merk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Ohli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-1121","authenticated-orcid":true,"given":"Ulrich","family":"Sch\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01206454","article-title":"Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons","volume":"8","author":"PP Graziadei","year":"1979","journal-title":"J Neurocytol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ar.10047","article-title":"Neural regeneration and the peripheral olfactory system","volume":"269","author":"JE Schwob","year":"2002","journal-title":"Anat Rec"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.brainresrev.2008.10.004","article-title":"Neurogliogenesis in the mature olfactory system: a possible protective role against infection and toxic dust","volume":"59","author":"E Loseva","year":"2009","journal-title":"Brain Res Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/cne.22316","article-title":"Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: cell proliferation, neuronal differentiation, and cell death","volume":"518","author":"K Kondo","year":"2010","journal-title":"J Comp Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/jcs.080580","article-title":"Canonical Wnt signaling promotes the proliferation and neurogenesis of peripheral olfactory stem cells during postnatal development and adult regeneration","volume":"124","author":"YZ Wang","year":"2011","journal-title":"J Cell Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"8268","DOI":"10.1523\/JNEUROSCI.0240-14.2014","article-title":"Wnt-responsive Lgr5(+) globose basal cells function as multipotent olfactory epithelium progenitor cells","volume":"34","author":"M Chen","year":"2014","journal-title":"J Neurosci"},{"key":"ref7","first-page":"1344","article-title":"Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas","volume":"58","author":"J Palacios","year":"1998","journal-title":"Cancer Res"},{"key":"ref8","first-page":"3526","article-title":"Beta-catenin mutation in carcinoma of the uterine endometrium","volume":"58","author":"T Fukuchi","year":"1998","journal-title":"Cancer Res"},{"key":"ref9","first-page":"4257","article-title":"Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer","volume":"59","author":"WS Park","year":"1999","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1097>3.0.CO;2-9","article-title":"Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma","volume":"30","author":"N Sunaga","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1038\/sj.onc.1209556","article-title":"Dysregulation of growth factor signaling in human hepatocellular carcinoma","volume":"25","author":"K Breuhahn","year":"2006","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nature09587","article-title":"Subtypes of medulloblastoma have distinct developmental origins","volume":"468","author":"P Gibson","year":"2010","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrc3002","article-title":"Wilms&apos; tumours: about tumour suppressor genes, an oncogene and a chameleon gene","volume":"11","author":"V Huff","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/1270","article-title":"Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4","volume":"19","author":"V Korinek","year":"1998","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1073\/pnas.2536800100","article-title":"Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1","volume":"101","author":"F Kuhnert","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.2296722","article-title":"A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse","volume":"247","author":"AR Moser","year":"1990","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"ER Fearon","year":"1990","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"PJ Morin","year":"1997","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e23012","DOI":"10.1371\/journal.pone.0023012","article-title":"Wnt\/beta-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum","volume":"6","author":"HJ Selvadurai","year":"2011","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1128\/MCB.05718-11","article-title":"Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors","volume":"31","author":"A Lorenz","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1126\/science.1074192","article-title":"Regulation of cerebral cortical size by control of cell cycle exit in neural precursors","volume":"297","author":"A Chenn","year":"2002","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ydbio.2012.12.001","article-title":"Constitutive activation of beta-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system","volume":"374","author":"J Poschl","year":"2013","journal-title":"Dev Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.expneurol.2013.01.027","article-title":"Signals that regulate the oncogenic fate of neural stem cells and progenitors","volume":"260","author":"FJ Swartling","year":"2014","journal-title":"Exp Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","article-title":"Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice","volume":"9","author":"K Arnold","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"L Madisen","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1093\/emboj\/18.21.5931","article-title":"Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene","volume":"18","author":"N Harada","year":"1999","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccr.2008.07.005","article-title":"Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma","volume":"14","author":"U Schuller","year":"2008","journal-title":"Cancer Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/modpathol.2008.118","article-title":"MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma","volume":"21","author":"J Ralston","year":"2008","journal-title":"Mod Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1002\/cne.22463","article-title":"Expression of pax6 and sox2 in adult olfactory epithelium","volume":"518","author":"Z Guo","year":"2010","journal-title":"J Comp Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1242\/dev.124.8.1611","article-title":"Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors","volume":"124","author":"E Cau","year":"1997","journal-title":"Development"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yexcr.2005.03.027","article-title":"Identification and molecular regulation of neural stem cells in the olfactory epithelium","volume":"306","author":"CL Beites","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10735-007-9141-2","article-title":"Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology","volume":"38","author":"B Murdoch","year":"2007","journal-title":"J Mol Histol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.hoc.2012.08.005","article-title":"Esthesioneuroblastoma: a contemporary review of diagnosis and management","volume":"26","author":"M Bak","year":"2012","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1083\/jcb.152.1.87","article-title":"WNT-1 Signaling Inhibits Apoptosis by Activating \u03b2-Catenin\/T Cell Factor\u2013Mediated Transcription","volume":"152","author":"S Chen","year":"2001","journal-title":"J Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"38239","DOI":"10.1074\/jbc.M206402200","article-title":"Wnt Signaling Protects 3T3-L1 Preadipocytes from Apoptosis through Induction of Insulin-like Growth Factors","volume":"277","author":"KA Longo","year":"2002","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1046\/j.1365-2168.2002.02120.x","article-title":"The colorectal adenoma-carcinoma sequence","volume":"89","author":"A Leslie","year":"2002","journal-title":"Br J Surg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2645","article-title":"Genetic prognostic and predictive markers in colorectal cancer","volume":"9","author":"A Walther","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/cea.12472","article-title":"Pathogenesis of nasal polyposis","volume":"45","author":"KE Hulse","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e0141722","DOI":"10.1371\/journal.pone.0141722","article-title":"Human Papillomavirus (HPV) Prevalence in Nasal and Antrochoanal Polyps and Association with Clinical Data","volume":"10","author":"M Kn\u00f6r","year":"2015","journal-title":"PLoS ONE"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4193\/Rhino09.171","article-title":"Nasal polyps do not contain olfactory structures","volume":"49","author":"MF Bhutta","year":"2011","journal-title":"Rhinology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e48997","DOI":"10.1371\/journal.pone.0048997","article-title":"A global analysis of tandem 3&apos;UTRs in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"7","author":"P Tian","year":"2012","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01054767","article-title":"Expression of the human Achaete-scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma)","volume":"26","author":"ME Carney","year":"1995","journal-title":"J Neurooncol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/PAP.0b013e3181b544cf","article-title":"Olfactory neuroblastoma: a review and update","volume":"16","author":"H Faragalla","year":"2009","journal-title":"Adv Anat Pathol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nec.2012.08.005","article-title":"Esthesioneuroblastoma","volume":"24","author":"TJ Ow","year":"2013","journal-title":"Neurosurg Clin N Am"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/his.12452","article-title":"Phenotypical and molecular distinctness of sinonasal haemangiopericytoma compared to solitary fibrous tumour of the sinonasal tract.","volume":"65","author":"A Agaimy","year":"2014","journal-title":"Histopathology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/modpathol.2014.161","article-title":"Nuclear expression and gain-of-function beta-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker","volume":"28","author":"J Lasota","year":"2015","journal-title":"Mod Pathol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ajpath.2014.10.019","article-title":"Recurrent mutations within the amino-terminal region of beta-catenin are probable key molecular driver events in sinonasal hemangiopericytoma","volume":"185","author":"F Haller","year":"2015","journal-title":"Am J Pathol"},{"key":"ref48","first-page":"65","article-title":"WHO\/IARC Classification of Tumours Pathology &amp; Genetics of Head and Neck Tumours","volume":"9","author":"BM Wenig","year":"2005"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T18:44:21Z","timestamp":1657910661000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166690"}},"subtitle":[],"editor":[{"given":"Chunming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166690","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}