{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:50:53Z","timestamp":1790247053023,"version":"4.1.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry Economy and Competitiveness","award":["RD12\/0036\/0002"],"award-info":[{"award-number":["RD12\/0036\/0002"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2015-64556-R"],"award-info":[{"award-number":["SAF2015-64556-R"]}]},{"DOI":"10.13039\/501100007287","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["14-1248"],"award-info":[{"award-number":["14-1248"]}],"id":[{"id":"10.13039\/501100007287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008054","name":"Fundaci\u00f3n Ram\u00f3n Areces","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100008054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008431","name":"Consejer\u00eda de Educaci\u00f3n, Junta de Castilla y Le\u00f3n","doi-asserted-by":"crossref","award":["CSI049U16"],"award-info":[{"award-number":["CSI049U16"]}],"id":[{"id":"10.13039\/501100008431","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","award":["GC16173472GARC"],"award-info":[{"award-number":["GC16173472GARC"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166715","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T18:32:11Z","timestamp":1478889131000},"page":"e0166715","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation"],"prefix":"10.1371","volume":"11","author":[{"given":"Antonio","family":"Castro-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-6072","authenticated-orcid":true,"given":"Xos\u00e9 R.","family":"Bustelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bies.20558","article-title":"GTP-binding proteins of the Rho\/Rac family: regulation, effectors and functions in vivo","volume":"29","author":"XR Bustelo","year":"2007","journal-title":"Bioessays"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.21.020604.150721","article-title":"Rho GTPases: biochemistry and biology","volume":"21","author":"AB Jaffe","year":"2005","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.molcel.2011.03.017","article-title":"Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size","volume":"42","author":"A Saci","year":"2011","journal-title":"Molecular cell"},{"key":"ref4","first-page":"1","article-title":"Deregulation of Rho GTPases in cancer","volume":"2016","author":"AP Porter","journal-title":"Small GTPases"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/bies.201200041","article-title":"Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho\/Rac GTPases, epithelial-mesenchymal transitions, and more","volume":"34","author":"XR Bustelo","year":"2012","journal-title":"Bioessays"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrc725","article-title":"RHO-GTPases and cancer","volume":"2","author":"E Sahai","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/sgtp.19111","article-title":"Rac-ing to the plasma membrane. The long and complex work commute of Rac1 during cell signaling","volume":"3","author":"XR Bustelo","year":"2012","journal-title":"Small Gtpases"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tcb.2005.05.001","article-title":"GDIs: central regulatory molecules in Rho GTPase activation","volume":"15","author":"C DerMardirossian","year":"2005","journal-title":"Trends in cell biology"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2007.05.018","article-title":"GEFs and GAPs: critical elements in the control of small G proteins","volume":"129","author":"JL Bos","year":"2007","journal-title":"Cell"},{"issue":"41","key":"ref10","doi-asserted-by":"crossref","first-page":"39413","DOI":"10.1074\/jbc.M302083200","article-title":"Calcium signaling regulates translocation and activation of Rac","volume":"278","author":"LS Price","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.0908326107","article-title":"Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI","volume":"107","author":"F Chianale","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1091\/mbc.E06-06-0533","article-title":"Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling","volume":"17","author":"C DerMardirossian","year":"2006","journal-title":"Molecular biology of the cell"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.molcel.2004.05.019","article-title":"Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase","volume":"15","author":"C DerMardirossian","year":"2004","journal-title":"Molecular cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2091-11-48","article-title":"The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor alpha with the small GTPase Rac","volume":"11","author":"F Fei","year":"2010","journal-title":"BMC Biochem"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1091\/mbc.E07-12-1248","article-title":"Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI","volume":"20","author":"H Abramovici","year":"2009","journal-title":"Molecular biology of the cell"},{"issue":"35","key":"ref16","doi-asserted-by":"crossref","first-page":"26206","DOI":"10.1016\/S0021-9258(19)74301-4","article-title":"Biologically active lipids are regulators of Rac.GDI complexation","volume":"268","author":"TH Chuang","year":"1993","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1128\/MCB.18.2.762","article-title":"Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex","volume":"18","author":"KF Tolias","year":"1998","journal-title":"Molecular and cellular biology"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ncb759","article-title":"Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI","volume":"4","author":"MA Del Pozo","year":"2002","journal-title":"Nature cell biology"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/emboj\/19.9.2008","article-title":"Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK","volume":"19","author":"MA del Pozo","year":"2000","journal-title":"The EMBO journal"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ncb2112","article-title":"SUMOylation of the GTPase Rac1 is required for optimal cell migration","volume":"12","author":"S Castillo-Lluva","year":"2010","journal-title":"Nature cell biology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1074\/jbc.275.1.423","article-title":"Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1","volume":"275","author":"T Kwon","year":"2000","journal-title":"The Journal of biological chemistry"},{"issue":"Pt 11","key":"ref22","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1242\/jcs.062919","article-title":"Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway","volume":"123","author":"M Nethe","year":"2010","journal-title":"Journal of cell science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ncomms1243","article-title":"The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility","volume":"2","author":"M de la Vega","year":"2011","journal-title":"Nat Commun"},{"issue":"5804","key":"ref24","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1126\/science.1134389","article-title":"PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane","volume":"314","author":"WD Heo","year":"2006","journal-title":"Science"},{"issue":"5860","key":"ref25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1152066","article-title":"Membrane phosphatidylserine regulates surface charge and protein localization","volume":"319","author":"T Yeung","year":"2008","journal-title":"Science"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/ncb1657","article-title":"Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts","volume":"9","author":"N Balasubramanian","year":"2007","journal-title":"Nature cell biology"},{"issue":"5659","key":"ref27","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1092571","article-title":"Integrins regulate Rac targeting by internalization of membrane domains","volume":"303","author":"MA del Pozo","year":"2004","journal-title":"Science"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ncb1293","article-title":"Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization","volume":"7","author":"MA del Pozo","year":"2005","journal-title":"Nature cell biology"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1083\/jcb.200509096","article-title":"Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix","volume":"172","author":"JP ten Klooster","year":"2006","journal-title":"The Journal of cell biology"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1083\/jcb.200911110","article-title":"Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation","volume":"190","author":"WT Chao","year":"2010","journal-title":"The Journal of cell biology"},{"issue":"Pt 14","key":"ref31","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1242\/jcs.080630","article-title":"The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration","volume":"124","author":"BJ de Kreuk","year":"2011","journal-title":"Journal of cell science"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"e28587","DOI":"10.1371\/journal.pone.0028587","article-title":"Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading","volume":"6","author":"F Chang","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ni1232","article-title":"An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis","volume":"6","author":"J Zhang","year":"2005","journal-title":"Nature immunology"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2008.05.034","article-title":"Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration","volume":"134","author":"A Palamidessi","year":"2008","journal-title":"Cell"},{"issue":"19","key":"ref35","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1038\/emboj.2011.310","article-title":"Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation","volume":"30","author":"A Castro-Castro","year":"2011","journal-title":"The EMBO journal"},{"issue":"3\u20134","key":"ref36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ejcb.2005.10.007","article-title":"AlphaPIX and betaPIX and their role in focal adhesion formation","volume":"85","author":"G Rosenberger","year":"2006","journal-title":"European journal of cell biology"},{"issue":"16","key":"ref37","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1091\/mbc.E15-01-0052","article-title":"The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects","volume":"26","author":"V Ojeda","year":"2015","journal-title":"Molecular biology of the cell"},{"issue":"18","key":"ref38","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1128\/MCB.00347-14","article-title":"Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output","volume":"34","author":"V Ojeda","year":"2014","journal-title":"Molecular and cellular biology"},{"issue":"Pt 16","key":"ref39","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1242\/jcs.080804","article-title":"Phosphorylated filamin A regulates actin-linked caveolae dynamics","volume":"124","author":"O Muriel","year":"2011","journal-title":"J Cell Sci"},{"issue":"51","key":"ref40","doi-asserted-by":"crossref","first-page":"43902","DOI":"10.1074\/jbc.M111.301382","article-title":"The WD40 repeat protein WDR26 binds Gbetagamma and promotes Gbetagamma-dependent signal transduction and leukocyte migration","volume":"286","author":"Z Sun","year":"2011","journal-title":"The Journal of biological chemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/978-0-387-09595-0_7","article-title":"Coronin: the double-edged sword of actin dynamics","volume":"48","author":"M Gandhi","year":"2008","journal-title":"Sub-cellular biochemistry"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.7439","article-title":"Upregulated WDR26 serves as a scaffold to coordinate PI3K\/ AKT pathway-driven breast cancer cell growth, migration, and invasion","author":"Y Ye","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/1873-3468.12180","article-title":"WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway","volume":"590","author":"T Goto","year":"2016","journal-title":"FEBS letters"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e557","DOI":"10.1038\/tp.2015.49","article-title":"Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins","volume":"5","author":"A Cordova-Palomera","year":"2015","journal-title":"Transl Psychiatry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.plantsci.2015.09.024","article-title":"An Arabidopsis WDR protein coordinates cellular networks involved in light, stress response and hormone signals","volume":"241","author":"HW Chuang","year":"2015","journal-title":"Plant Sci"},{"issue":"23","key":"ref46","doi-asserted-by":"crossref","first-page":"16715","DOI":"10.1074\/jbc.M113.462564","article-title":"WDR26 functions as a scaffolding protein to promote Gbetagamma-mediated phospholipase C beta2 (PLCbeta2) activation in leukocytes","volume":"288","author":"Z Sun","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4161\/cam.22940","article-title":"WD40-repeat proteins control the flow of Gbetagamma signaling for directional cell migration","volume":"7","author":"C Runne","year":"2013","journal-title":"Cell adhesion & migration"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"e75217","DOI":"10.1371\/journal.pone.0075217","article-title":"Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin\/RanBPM\/CTLH complex","volume":"8","author":"O Francis","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3109\/10715762.2012.678840","article-title":"A novel WD-repeat protein, WDR26, inhibits apoptosis of cardiomyocytes induced by oxidative stress","volume":"46","author":"Y Feng","year":"2012","journal-title":"Free Radic Res"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2009.05.024","article-title":"A novel WD-40 repeat protein WDR26 suppresses H2O2-induced cell death in neural cells","volume":"460","author":"J Zhao","year":"2009","journal-title":"Neurosci Lett"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jcb.20175","article-title":"WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway","volume":"93","author":"Y Zhu","year":"2004","journal-title":"J Cell Biochem"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/jb\/mvv127","article-title":"Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners","volume":"159","author":"T Muramatsu","year":"2016","journal-title":"Journal of biochemistry"},{"issue":"3\u20134","key":"ref53","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.biochi.2004.09.023","article-title":"EMMPRIN\/CD147, an MMP modulator in cancer, development and tissue repair","volume":"87","author":"EE Gabison","year":"2005","journal-title":"Biochimie"},{"issue":"8","key":"ref54","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1074\/mcp.M400207-MCP200","article-title":"Metabolic activation-related CD147-CD98 complex","volume":"4","author":"D Xu","year":"2005","journal-title":"Mol Cell Proteomics"},{"issue":"18","key":"ref55","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1091\/mbc.E11-04-0361","article-title":"Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling","volume":"22","author":"A Norambuena","year":"2011","journal-title":"Molecular biology of the cell"},{"issue":"42","key":"ref56","doi-asserted-by":"crossref","first-page":"13784","DOI":"10.1021\/bi00042a009","article-title":"Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor","volume":"34","author":"U Klein","year":"1995","journal-title":"Biochemistry"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"K Simons","year":"2000","journal-title":"Nature reviews"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.92.1.79","article-title":"Action of cytochalasin D on cytoskeletal networks","volume":"92","author":"M Schliwa","year":"1982","journal-title":"J Cell Biol"},{"key":"ref59","first-page":"75","article-title":"Interfering with Ras signaling using membrane-permeable peptides or drugs","volume":"189","author":"H Maruta","year":"2002","journal-title":"Methods Mol Biol"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.141.4.905","article-title":"Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains","volume":"141","author":"PA Orlandi","year":"1998","journal-title":"The Journal of cell biology"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1083\/jcb.127.5.1199","article-title":"Regulated internalization of caveolae","volume":"127","author":"RG Parton","year":"1994","journal-title":"The Journal of cell biology"},{"issue":"6635","key":"ref62","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/42961","article-title":"C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases","volume":"387","author":"YQ Gosser","year":"1997","journal-title":"Nature"},{"issue":"Pt 2","key":"ref63","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/bj20030979","article-title":"An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells","volume":"378","author":"PN Gandhi","year":"2004","journal-title":"The Biochemical journal"},{"issue":"Pt 2","key":"ref64","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/bj3040525","article-title":"Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3","volume":"304","author":"WJ Mawby","year":"1994","journal-title":"Biochem J"},{"issue":"Pt 1","key":"ref65","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1083\/jcb.111.6.2785","article-title":"Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins","volume":"111","author":"E Brown","year":"1990","journal-title":"J Cell Biol"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1091\/mbc.9.4.865","article-title":"The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells","volume":"9","author":"XQ Wang","year":"1998","journal-title":"Mol Biol Cell"},{"issue":"8","key":"ref67","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tcb.2006.06.002","article-title":"Coronins: the return of the crown","volume":"16","author":"AC Uetrecht","year":"2006","journal-title":"Trends in cell biology"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jmb.2007.12.007","article-title":"Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament","volume":"376","author":"VE Galkin","year":"2008","journal-title":"Journal of molecular biology"},{"issue":"11","key":"ref69","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/ni.1662","article-title":"The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency","volume":"9","author":"LR Shiow","year":"2008","journal-title":"Nature immunology"},{"issue":"8","key":"ref70","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1091\/mbc.E04-01-0019","article-title":"Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42","volume":"15","author":"M Miyashita","year":"2004","journal-title":"Molecular biology of the cell"},{"issue":"48","key":"ref71","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1523\/JNEUROSCI.3981-06.2006","article-title":"CD47 promotes neuronal development through Src- and FRG\/Vav2-mediated activation of Rac and Cdc42","volume":"26","author":"T Murata","year":"2006","journal-title":"J Neurosci"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcp.20379","article-title":"Novel CD47-dependent intercellular adhesion modulates cell migration","volume":"205","author":"RA Rebres","year":"2005","journal-title":"J Cell Physiol"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1182\/blood.V96.1.234","article-title":"Integrin-associated protein\/CD47 regulates motile activity in human B-cell lines through CDC42","volume":"96","author":"H Yoshida","year":"2000","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T04:55:46Z","timestamp":1657688146000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166715"}},"subtitle":[],"editor":[{"given":"Mirjam M","family":"Zegers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,11]]},"references-count":73,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166715","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,11]]}}}