{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:04:49Z","timestamp":1790528689101,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166725","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T18:45:22Z","timestamp":1479494722000},"page":"e0166725","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of Fibrinolytic Inhibitors: Alpha-2-Antiplasmin and Plasminogen Activator Inhibitor 1 in Patients with Obstructive Sleep Apnoea"],"prefix":"10.1371","volume":"11","author":[{"given":"Maciej","family":"Zakrzewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Zakrzewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Kici\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Przybylska-Ku\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Dyba\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"My\u015bli\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Pastryk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Tomaszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Mosiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"ref1","unstructured":"P\u0142ywaczewski R. The frequency and severity of obstructive sleep apnea among the adult population of right-bank Warsaw. Postdoctoral dissertation, Institute of Tuberculosis and Lung Diseases of Warsaw. 2003."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1001\/jama.290.14.1906","article-title":"Obstructive sleep apnea. Implications for cardiac and vascular disease","volume":"290","author":"AS Shamsuzzaman","year":"2003","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/smrv.2002.0260","article-title":"Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms","volume":"7","author":"A Jordan","year":"2003","journal-title":"Sleep Med Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4158\/EP.13.4.355","article-title":"Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus","volume":"13","author":"D Einhorn","year":"2007","journal-title":"Endocr Pract"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1378\/chest.102.6.1663","article-title":"The relationship between sleep apnea syndrome and hypothyroidism","volume":"102","author":"C Lin","year":"1992","journal-title":"Chest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.2109080","article-title":"Epidemiology of obstructive sleep apnea. A population health perspective","volume":"165","author":"T Young","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/01.CIR.0000136587.68725.8E","article-title":"Association of atrial fibrillation and obstructive sleep apnea","volume":"110","author":"AS Gami","year":"2004","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/rccm.200509-1442OC","article-title":"Association of nocturnal arrhythmias with sleep-disordered breathing. The Sleep Heart Health Study","volume":"173","author":"R Mehra","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0140-6736(90)91799-G","article-title":"Association of sleep apnea with myocardial infarction in men","volume":"336","author":"J Hung","year":"1990","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/ajrccm.162.1.9905035","article-title":"Respiratory disturbance index: an independent predictor of mortality in coronary artery disease","volume":"162","author":"Y Peker","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/01.STR.27.3.401","article-title":"Investigating the relationship between stroke and obstructive sleep apnea","volume":"27","author":"ME Dyken","year":"1996","journal-title":"Stroke"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/sleep\/22.2.217","article-title":"Sleep apnea in acute cerebrovascular diseases: final report on 128 patients","volume":"22","author":"C Bassetti","year":"1999","journal-title":"Sleep"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm.163.1.2001008","article-title":"Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study","volume":"163","author":"E Shahar","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1378\/chest.128.2.624","article-title":"Mortality in obstructive sleep apnea-hypopnea patients treated with positive airway pressure","volume":"128","author":"F Campos-Rodriguez","year":"2005","journal-title":"Chest"},{"key":"ref15","first-page":"164","article-title":"Dysfunction of the plasminogen system in patients with cancer","volume":"81","author":"A Thielemann","year":"2012","journal-title":"Nowiny Lekarskie"},{"key":"ref16","first-page":"93","article-title":"Deep venous thrombosis and occult cancer","volume":"2","author":"MZ Wojtukiewicz","year":"1998","journal-title":"Onkol Pol"},{"key":"ref17","first-page":"105","article-title":"Prothrombotic mechanisms in cancer","volume":"12","author":"J Ko\u0142odziejczyk","year":"2009","journal-title":"Onkol Pol"},{"key":"ref18","first-page":"46","article-title":"Sleep and stroke","volume":"157","author":"P Clarenbach","year":"2001","journal-title":"Rev Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11325-006-0060-3","article-title":"Association between sleep apnea severity and blood coagulability: treatment effects of nasal continuous positive airway pressure","volume":"10","author":"R von K\u00e4nel","year":"2006","journal-title":"Sleep Breath"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000086729","article-title":"Altered blood rheology in obstructive sleep apnea as a mediator of cardiovascular risk","volume":"104","author":"S Steiner","year":"2005","journal-title":"Cardiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/qjmed\/91.9.627","article-title":"Improvement of factor VII clotting activity following long-term NCPAP treatment in obstructive sleep apnoea syndrome","volume":"91","author":"K Chin","year":"1998","journal-title":"Q J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.jbchem.a122920","article-title":"Expression and characterization of pro alpha-2-antiplasmin inhibitor","volume":"106","author":"Y Sumi","year":"1989","journal-title":"J Biochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1042\/bj2910623","article-title":"Different N-terminal forms of a2-plasmin inhibitor in human plasma","volume":"291","author":"K Bangert","year":"1993","journal-title":"Biochem J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jpeds.2006.04.008","article-title":"Pediatric reference intervals for uncommon bleeding and thrombotic disorders","volume":"149","author":"MM Flanders","year":"2006","journal-title":"J Pediatr"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107881","article-title":"Activation of markers of inflammation, coagulation and fibrinolysis in musculoskeletal trauma","volume":"9","author":"O Reikeras","year":"2014","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/bmj.291.6495.573","article-title":"Plasminogen activator inhibitor in the blood of patients with coronary artery disease","volume":"291","author":"JA Paramo","year":"1985","journal-title":"Br Med J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0049-3848(87)90147-2","article-title":"Elevated levels of the rapid inhibitor of plasminogen activator (t-PAI) in acute myocardial infarction","volume":"47","author":"L Aimer","year":"1987","journal-title":"Thromb Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0049-3848(87)90264-7","article-title":"Relationship between age and plasma t-PA, PA-inhibitor, and PA activity","volume":"46","author":"Y Hashimoto","year":"1987","journal-title":"Thromb Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1055\/s-0038-1649834","article-title":"Environmental and genetic factors in relation to elevated circulating levels of plasminogen activator inhibitor-1 in Caucasian patients with non-insulin-dependend diabetes mellitus","volume":"74","author":"MW Mansfield","year":"1995","journal-title":"Thromb Haemost"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2337\/diab.41.8.1009","article-title":"Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose","volume":"41","author":"M Maiello","year":"1992","journal-title":"Diabetes"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/01.ATV.13.12.1822","article-title":"Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis","volume":"13","author":"TK Nordt","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1538-7836.2004.01055.x","article-title":"Discovery of alpha-2-palsmin inhibitor ant its congenital deficiency","volume":"3","author":"N Aoki","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref33","first-page":"15","article-title":"Evaluation of platelet activation, plasma antithrombin III and alpha2-antiplasmin activities in hypertensive patients","volume":"58","author":"M Tomczykowska","year":"2003","journal-title":"Ann Univ Mariae Curie-Sklodowska Med"},{"key":"ref34","first-page":"1","article-title":"Evaluation of plasminogen activator inhibitor 1 concentration in patients with simple obesity","volume":"8","author":"P Bogda\u0144ski","year":"2012","journal-title":"Endokr, Oty\u0142o\u015b\u0107 Zab Przem Mat"},{"key":"ref35","first-page":"158","article-title":"The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study)","volume":"19","author":"Y Surjawan","year":"2009","journal-title":"Med J Indones"},{"key":"ref36","first-page":"311","article-title":"Tissue plasminogen activator (t-PA) and its inhibitor type 1 (PAI-1) in recent myocardial infarction","volume":"9","author":"R Bujak","year":"2002","journal-title":"Cardiol J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/sleep\/18.3.188","article-title":"Platelet function and fibrinolytic activity in hypertensive and normotensive sleep apnea patients","volume":"18","author":"C Rangemark","year":"1995","journal-title":"Sleep"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1378\/chest.06-2006","article-title":"Association between polysomnographic measures of disrupted sleep and prothrombotic factors","volume":"131","author":"R von K\u00e4nel","year":"2007","journal-title":"Chest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"E285","DOI":"10.25011\/cim.v32i6.10664","article-title":"Hypertension and hemostatic\/fibrinolytic balance disorders","volume":"32","author":"O Tabak","year":"2009","journal-title":"Clin Invest Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/CEH-120017736","article-title":"Increased plasma plasminogen activator inhibitor-1 levels: a possible marker of hypertensive target organ damage","volume":"25","author":"EJ Diamantopoulos","year":"2003","journal-title":"Clin Exp Hypertens"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00408-008-9076-8","article-title":"Plasminogen activator inhibitor-1 in obstructive sleep apnea patients with and without hypertension","volume":"186","author":"C Zamarr\u00f3n","year":"2008","journal-title":"Lung"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"20443","DOI":"10.1016\/S0021-9258(17)30524-0","article-title":"Oxygen radicals generated during anoxia followed by reoxygenation reduce the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in human endothelial cell culture","volume":"265","author":"MA Shatos","year":"1990","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T04:18:20Z","timestamp":1657772300000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166725"}},"subtitle":[],"editor":[{"given":"Xianwu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166725","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,18]]}}}