{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:45:07Z","timestamp":1789505107096,"version":"build-2803163510"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2012\/09130-1"],"award-info":[{"award-number":["2012\/09130-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2011\/14550-7"],"award-info":[{"award-number":["2011\/14550-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2013\/10661-4"],"award-info":[{"award-number":["2013\/10661-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2012\/09494-3"],"award-info":[{"award-number":["2012\/09494-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166845","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T20:00:41Z","timestamp":1479931241000},"page":"e0166845","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism"],"prefix":"10.1371","volume":"11","author":[{"given":"Karla","family":"Reichert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helison Rafael","family":"Pereira do Carmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anali","family":"Galluce Torina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Di\u00f3genes de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Carvalho Sposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlos Alexandre","family":"de Souza Vilarinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindemberg","family":"da Mota Silveira-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Paulo","family":"Martins de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-7155","authenticated-orcid":true,"given":"Orlando","family":"Petrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"issue":"25","key":"ref1","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"MG Sutton","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"ref2","first-page":"150","article-title":"Ventricular remodeling after myocardial infarction: concepts and clinical implications","volume":"92","author":"LA Zornoff","year":"2009","journal-title":"Arquivos brasileiros de cardiologia"},{"issue":"18","key":"ref3","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/hc4301.097193","article-title":"Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction","volume":"104","author":"JI Nwogu","year":"2001","journal-title":"Circulation"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/dvdy.20095","article-title":"Organization of fibroblasts in the heart","volume":"230","author":"EC Goldsmith","year":"2004","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"issue":"14","key":"ref5","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1161\/CIRCULATIONAHA.109.912774","article-title":"Circulating biomarkers of collagen metabolism in cardiac diseases","volume":"121","author":"B Lopez","year":"2010","journal-title":"Circulation"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1111\/j.1755-5922.2011.00276.x","article-title":"Matricellular proteins: new molecular targets to prevent heart failure","volume":"30","author":"H Okamoto","year":"2012","journal-title":"Cardiovascular therapeutics"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12471-011-0226-x","article-title":"Monitoring cardiac fibrosis: a technical challenge","volume":"20","author":"S de Jong","year":"2012","journal-title":"Netherlands heart journal: monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"H194","DOI":"10.1152\/ajpheart.2000.278.1.H194","article-title":"Structural and mechanical factors influencing infarct scar collagen organization","volume":"278","author":"SD Zimmerman","year":"2000","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e25320","DOI":"10.1371\/journal.pone.0025320","article-title":"Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction","volume":"6","author":"XL Tang","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"ref10","first-page":"24","article-title":"Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond","volume":"26","author":"N Kaludercic","year":"2008","journal-title":"Cardiovascular therapeutics"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5507\/bp.2005.031","article-title":"Matrix metalloproteinases and their function in myocardium","volume":"149","author":"J Kukacka","year":"2005","journal-title":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia"},{"issue":"23","key":"ref12","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/01.CIR.99.23.3063","article-title":"Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice","volume":"99","author":"LE Rohde","year":"1999","journal-title":"Circulation"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2174\/1568026611208011181","article-title":"Matrix metallopropteinases in heart failure","volume":"12","author":"D Tousoulis","year":"2012","journal-title":"Current topics in medicinal chemistry"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/01.fjc.0000200989.23987.b8","article-title":"Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling","volume":"47","author":"KA Apple","year":"2006","journal-title":"Journal of cardiovascular pharmacology"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3349\/ymj.2012.53.3.501","article-title":"Correlations between serum inflammation factors and left ventricular remodeling in acute ST segment elevation myocardial infarction","volume":"53","author":"J Tan","year":"2012","journal-title":"Yonsei medical journal"},{"issue":"4\u20135","key":"ref16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10741-011-9266-y","article-title":"Tissue inhibitor of metalloproteinases (TIMPs) in heart failure","volume":"17","author":"L Moore","year":"2012","journal-title":"Heart failure reviews"},{"issue":"Pt 19","key":"ref17","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1242\/jcs.00063","article-title":"Metalloproteinase inhibitors: biological actions and therapeutic opportunities","volume":"115","author":"AH Baker","year":"2002","journal-title":"Journal of cell science"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00005-009-0024-y","article-title":"The role of IL-1 in the pathogenesis of heart disease","volume":"57","author":"M Bujak","year":"2009","journal-title":"Archivum immunologiae et therapiae experimentalis"},{"issue":"18","key":"ref19","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.jacc.2011.06.058","article-title":"New targets to treat the structural remodeling of the myocardium","volume":"58","author":"A Gonzalez","year":"2011","journal-title":"Journal of the American College of Cardiology"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1253\/circj.CJ-13-0013","article-title":"Post-infarction inflammation and left ventricular remodeling- a double-edged sword","volume":"77","author":"T Anzai","year":"2013","journal-title":"Circulation journal: official journal of the Japanese Circulation Society"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1440-1681.2005.04256.x","article-title":"In vitro inhibitory effects of atorvastatin on cardiac fibroblasts: implications for ventricular remodelling","volume":"32","author":"J Martin","year":"2005","journal-title":"Clinical and experimental pharmacology & physiology"},{"issue":"25","key":"ref22","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1161\/01.CIR.0000023397.12047.03","article-title":"Statin therapy: beyond cholesterol lowering and antiinflammatory effects","volume":"105","author":"AC Yeung","year":"2002","journal-title":"Circulation"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.3760\/cma.j.issn.0366-6999.20123223","article-title":"Atorvastatin reduces myocardial fibrosis in a rat model with post-myocardial infarction heart failure by increasing the matrix metalloproteinase-2\/tissue matrix metalloproteinase inhibitor-2 ratio","volume":"126","author":"Z An","year":"2013","journal-title":"Chinese medical journal"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.7150\/ijms.8.564","article-title":"Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response","volume":"8","author":"XJ Song","year":"2011","journal-title":"International journal of medical sciences"},{"issue":"1\u20133","key":"ref25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2011.04.061","article-title":"Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat","volume":"666","author":"A Garjani","year":"2011","journal-title":"European journal of pharmacology"},{"issue":"4","key":"ref26","first-page":"434","article-title":"Experimental myocardium infarction in rats: analysis of the model","volume":"93","author":"LA Zornoff","year":"2009","journal-title":"Arquivos brasileiros de cardiologia"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"e64986","DOI":"10.1371\/journal.pone.0064986","article-title":"Left and right ventricle late remodeling following myocardial infarction in rats","volume":"8","author":"I Stefanon","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"e0121842","DOI":"10.1371\/journal.pone.0121842","article-title":"Diacerein improves left ventricular remodeling and cardiac function by reducing the inflammatory response after myocardial infarction","volume":"10","author":"AG Torina","year":"2015","journal-title":"PloS one"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yjmcc.2011.11.005","article-title":"Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium","volume":"52","author":"AB Stein","year":"2012","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10741-010-9192-4","article-title":"Myocardial remodeling, an overview","volume":"16","author":"DV Cokkinos","year":"2011","journal-title":"Heart failure reviews"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/hc0702.104164","article-title":"Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction","volume":"105","author":"S Hayashidani","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1472-8206.2004.00299.x","article-title":"Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update","volume":"19","author":"M Schachter","year":"2005","journal-title":"Fundamental & clinical pharmacology"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2174\/1568026611208011214","article-title":"Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease","volume":"12","author":"A Briasoulis","year":"2012","journal-title":"Current topics in medicinal chemistry"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.0000013290.12884.A3","article-title":"Matrix metalloproteinases: regulation and dysregulation in the failing heart","volume":"90","author":"FG Spinale","year":"2002","journal-title":"Circulation research"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11936-009-0034-4","article-title":"Matrix metalloproteinase therapy in heart failure","volume":"11","author":"FG Spinale","year":"2009","journal-title":"Current treatment options in cardiovascular medicine"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.yjmcc.2009.09.013","article-title":"TIMPs and cardiac remodeling: 'Embracing the MMP-independent-side of the family'","volume":"48","author":"D Vanhoutte","year":"2010","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.biocel.2005.10.007","article-title":"Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosterone","volume":"38","author":"G Kessler-Icekson","year":"2006","journal-title":"The international journal of biochemistry & cell biology"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"NG Frangogiannis","year":"2012","journal-title":"Physiological reviews"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.yjmcc.2009.06.018","article-title":"Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC)","volume":"48","author":"S McCurdy","year":"2010","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cardiores.2004.06.006","article-title":"Matricellular proteins in the heart: possible role during stress and remodeling","volume":"64","author":"MW Schellings","year":"2004","journal-title":"Cardiovascular research"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/01.hjh.0000165625.79933.9a","article-title":"Left ventricular hypertrophy as a predictor of cardiovascular risk","volume":"23","author":"P Gosse","year":"2005","journal-title":"Journal of hypertension Supplement: official journal of the International Society of Hypertension"},{"issue":"3","key":"ref42","first-page":"365","article-title":"Atorvastatin attenuating down-regulation of peroxisome proliferator-activated receptor gamma in preventing cardiac hypertrophy of rats in vitro and in vivo","volume":"9","author":"P Ye","year":"2006","journal-title":"Journal of pharmacy & pharmaceutical sciences: a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques"},{"issue":"2","key":"ref43","first-page":"140","article-title":"Simvastatin activates the PPARgamma-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling","volume":"40","author":"C Zou","year":"2013","journal-title":"Texas Heart Institute journal \/ from the Texas Heart Institute of St Luke's Episcopal Hospital, Texas Children's Hospital"},{"issue":"1\u20133","key":"ref44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbalip.2004.11.004","article-title":"Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation","volume":"1687","author":"A Planavila","year":"2005","journal-title":"Biochimica et biophysica acta"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3892\/etm.2013.1208","article-title":"Effects of long-term atorvastatin treatment on cardiac aging","volume":"6","author":"L Han","year":"2013","journal-title":"Experimental and therapeutic medicine"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.amjcard.2013.01.287","article-title":"Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]","volume":"111","author":"A Abbate","year":"2013","journal-title":"The American journal of cardiology"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.yjmcc.2009.07.015","article-title":"The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction","volume":"48","author":"M Dobaczewski","year":"2010","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3181\/0707-MR-196","article-title":"Nuclear factor-kappaB activation: from bench to bedside","volume":"233","author":"G Sethi","year":"2008","journal-title":"Experimental biology and medicine (Maywood, NJ)"},{"issue":"51","key":"ref49","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","article-title":"Introduction to NF-kappaB: players, pathways, perspectives","volume":"25","author":"TD Gilmore","year":"2006","journal-title":"Oncogene"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"RE1","DOI":"10.1126\/stke.1999.5.re1","article-title":"The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus","volume":"1999","author":"DM Rothwarf","year":"1999","journal-title":"Science's STKE: signal transduction knowledge environment"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/smim.2000.0210","article-title":"The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling","volume":"12","author":"M Karin","year":"2000","journal-title":"Seminars in immunology"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.arcmed.2011.06.002","article-title":"Body weight loss after myocardial infarction in rats as a marker of early heart failure development","volume":"42","author":"O Faria Tde","year":"2011","journal-title":"Archives of medical research"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0735-1097(01)01377-8","article-title":"Nuclear factor kappa-B and the heart","volume":"38","author":"G Valen","year":"2001","journal-title":"Journal of the American College of Cardiology"},{"issue":"11","key":"ref54","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1096\/fj.05-5133fje","article-title":"Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction","volume":"20","author":"S Frantz","year":"2006","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"539","DOI":"10.5551\/jat.2956","article-title":"Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes","volume":"17","author":"E Mandosi","year":"2010","journal-title":"Journal of atherosclerosis and thrombosis"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"e53882","DOI":"10.1371\/journal.pone.0053882","article-title":"A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation","volume":"8","author":"E van der Meij","year":"2013","journal-title":"PloS one"},{"issue":"1\u20132","key":"ref57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11010-010-0572-9","article-title":"Statins attenuate high mobility group box-1 protein induced vascular endothelial activation: a key role for TLR4\/NF-kappaB signaling pathway","volume":"345","author":"J Yang","year":"2010","journal-title":"Molecular and cellular biochemistry"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0021-9150(99)00193-8","article-title":"Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells","volume":"147","author":"M Ortego","year":"1999","journal-title":"Atherosclerosis"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/CIRCINTERVENTIONS.112.968495","article-title":"On the edge: targeting Toll-like receptor 2 in ischemia\/reperfusion injury","volume":"5","author":"PM Lepper","year":"2012","journal-title":"Circulation Cardiovascular interventions"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2011.38","article-title":"Innate immune signaling in cardiac ischemia","volume":"8","author":"F Arslan","year":"2011","journal-title":"Nature reviews Cardiology"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCULATIONAHA.109.880187","article-title":"Myocardial ischemia\/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody","volume":"121","author":"F Arslan","year":"2010","journal-title":"Circulation"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1007\/s11033-010-9970-z","article-title":"The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4","volume":"38","author":"J Yang","year":"2011","journal-title":"Molecular biology reports"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"170352","DOI":"10.4061\/2011\/170352","article-title":"Toll-like receptors and myocardial inflammation","volume":"2011","author":"Y Feng","year":"2011","journal-title":"International journal of inflammation"},{"issue":"3","key":"ref64","doi-asserted-by":"crossref","first-page":"H1072","DOI":"10.1152\/ajpheart.00255.2009","article-title":"Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice","volume":"298","author":"T Nishioka","year":"2010","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"5","key":"ref65","first-page":"635","article-title":"Relevance of the ventricular remodeling pattern in the model of myocardial infarction in rats","volume":"95","author":"MF Minicucci","year":"2010","journal-title":"Arquivos brasileiros de cardiologia"},{"issue":"6","key":"ref66","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/ALN.0b013e31828744c0","article-title":"Xenon and isoflurane reduce left ventricular remodeling after myocardial infarction in the rat","volume":"118","author":"AB Roehl","year":"2013","journal-title":"Anesthesiology"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0172453","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T19:38:48Z","timestamp":1718912328000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166845"}},"subtitle":[],"editor":[{"given":"Vincenzo","family":"Lionetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":66,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166845","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0172453","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}