{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:04:54Z","timestamp":1770332694467,"version":"3.49.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["25-A-12"],"award-info":[{"award-number":["25-A-12"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0167186","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T20:16:03Z","timestamp":1479932163000},"page":"e0167186","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Diagnostic Utility of Pleural Fluid Cell Block versus Pleural Biopsy Collected by Flex-Rigid Pleuroscopy for Malignant Pleural Disease: A Single Center Retrospective Analysis"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-7897","authenticated-orcid":true,"given":"Shion","family":"Miyoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Sasada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0025-6196(11)60848-3","article-title":"Recent advances in the diagnosis and management of malignant pleural effusions","volume":"83","author":"JE Heffner","year":"2008","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1440-1843.2007.01154.x","article-title":"Diagnosis and management of malignant pleural effusions","volume":"13","author":"JE Heffner","year":"2008","journal-title":"Respirology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1164\/ajrccm.162.5.ats8-00","article-title":"Management of malignant pleural effusions","volume":"162","author":"S American Thoracic","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/thx.43.4.327","article-title":"Thoracoscopy: assessment of a physician service and comparison of a flexible bronchoscope used as a thoracoscope with a rigid thoracoscope","volume":"43","author":"AC Davidson","year":"1988","journal-title":"Thorax"},{"issue":"1","key":"ref5","first-page":"45","article-title":"Thoracoscopy. A safe, accurate diagnostic procedure using the rigid thoracoscope and local anesthesia","volume":"75","author":"FA Oldenburg Jr.","year":"1979","journal-title":"Chest"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1183\/09031936.00101706","article-title":"The autoclavable semirigid thoracoscope: the way forward in pleural disease?","volume":"29","author":"M Munavvar","year":"2007","journal-title":"Eur Respir J"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1378\/chest.114.1.150","article-title":"Investigation of pleural effusion: an evaluation of the new Olympus LTF semiflexible thoracofiberscope and comparison with Abram&apos;s needle biopsy","volume":"114","author":"AN McLean","year":"1998","journal-title":"Chest"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1378\/chest.122.5.1530","article-title":"A novel instrument for the evaluation of the pleural space: an experience in 34 patients","volume":"122","author":"A Ernst","year":"2002","journal-title":"Chest"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1309\/G035-P2MM-D1TM-T5QE","article-title":"Cell block cytology. Improved preparation and its efficacy in diagnostic cytology","volume":"114","author":"NA Nathan","year":"2000","journal-title":"Am J Clin Pathol"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/cncy.21342","article-title":"The diagnosis of malignant mesothelioma in effusion cytology: a reappraisal and results of a multi-institution survey","volume":"121","author":"A Paintal","year":"2013","journal-title":"Cancer Cytopathol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1378\/chest.13-1187","article-title":"Diagnostic accuracy and safety of semirigid thoracoscopy in exudative pleural effusions: a meta-analysis","volume":"144","author":"R Agarwal","year":"2013","journal-title":"Chest"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2478\/raon-2013-0068","article-title":"Semirigid thoracoscopy: an effective method for diagnosing pleural malignancies","volume":"48","author":"A Rozman","year":"2014","journal-title":"Radiol Oncol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/LBR.0b013e3181e6a2e7","article-title":"Utility of semirigid thoracoscopy in the diagnosis of pleural effusions: a systematic review","volume":"17","author":"A Mohan","year":"2010","journal-title":"J Bronchology Interv Pulmonol"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/LBR.0b013e3181f9ebca","article-title":"Performance characteristics of semirigid thoracoscopy in pleural effusions of undetermined etiology","volume":"17","author":"A Mohan","year":"2010","journal-title":"J Bronchology Interv Pulmonol"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/jjco\/hyu078","article-title":"Flex-rigid pleuroscopy under local anesthesia in patients with dry pleural dissemination on radiography","volume":"44","author":"Y Watanabe","year":"2014","journal-title":"Japanese journal of clinical oncology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0970-9371.93210","article-title":"Diagnostic utility of the cell block method versus the conventional smear study in pleural fluid cytology","volume":"29","author":"U Shivakumarswamy","year":"2012","journal-title":"J Cytol"},{"issue":"4","key":"ref17","first-page":"403","article-title":"Fine needle aspiration minibiopsies","volume":"30","author":"WH Kern","year":"1986","journal-title":"Acta Cytol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ajcp\/86.3.281","article-title":"Fine-needle aspiration of the liver. A comparison of smear and rinse preparations in the detection of cancer","volume":"86","author":"SR Axe","year":"1986","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"ref19","first-page":"773","article-title":"Comparison of smears and cell blocks in the fine needle aspiration diagnosis of recurrent gynecologic malignancies","volume":"35","author":"EM Wojcik","year":"1991","journal-title":"Acta Cytol"},{"issue":"5","key":"ref20","first-page":"630","article-title":"Simple miniblock technique for cytology","volume":"6","author":"SW Leung","year":"1993","journal-title":"Mod Pathol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000354960","article-title":"Efficacy of CytoLyt(R) hemolytic action on ThinPrep(R) LBC using cultured osteosarcoma cell line LM8","volume":"58","author":"Y Norimatsu","year":"2014","journal-title":"Acta Cytol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/cncr.21425","article-title":"Comparison of the effectiveness of two liquid-based Papanicolaou systems in the handling of adverse limiting factors, such as excessive blood","volume":"108","author":"BJ Sweeney","year":"2006","journal-title":"Cancer"},{"issue":"Suppl 5","key":"ref23","doi-asserted-by":"crossref","first-page":"v31","DOI":"10.1093\/annonc\/mdv199","article-title":"Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"26","author":"P Baas","year":"2015","journal-title":"Ann Oncol"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/cncr.23034","article-title":"Accuracy of pleural biopsy using thoracoscopy for the diagnosis of histologic subtype in patients with malignant pleural mesothelioma","volume":"110","author":"L Greillier","year":"2007","journal-title":"Cancer"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/1097-0142(19930715)72:2<389::AID-CNCR2820720213>3.0.CO;2-V","article-title":"Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. Part 1: Diagnosis","volume":"72","author":"C Boutin","year":"1993","journal-title":"Cancer"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1155\/DTE.3.147","article-title":"Thoracoscopy in pleural malignant mesothelioma diagnosis","volume":"3","author":"GF Tassi","year":"1997","journal-title":"Diagn Ther Endosc"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00464-008-0263-8","article-title":"A new electrocautery pleural biopsy technique using an insulated-tip diathermic knife during semirigid pleuroscopy","volume":"23","author":"S Sasada","year":"2009","journal-title":"Surg Endosc"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.5858\/arpa.2012-0214-OA","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group","volume":"137","author":"AN Husain","year":"2013","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/dc.2840090106","article-title":"Cytopathology of malignant mesothelioma: a study of its patterns and histological bases","volume":"9","author":"L DiBonito","year":"1993","journal-title":"Diagn Cytopathol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1378\/chest.111.1.106","article-title":"The role of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma","volume":"111","author":"AA Renshaw","year":"1997","journal-title":"Chest"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1378\/chest.122.6.1875","article-title":"A pulmonary myth unmasked?","volume":"122","author":"MH Baumann","year":"2002","journal-title":"Chest"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1378\/chest.09-0641","article-title":"Prospective study to determine the volume of pleural fluid required to diagnose malignancy","volume":"137","author":"J Swiderek","year":"2010","journal-title":"Chest"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0012-3692(15)50413-3","article-title":"Proinflammatory cytokines, transforming growth factor-beta1, and fibrinolytic enzymes in loculated and free-flowing pleural exudates","volume":"128","author":"CL Chung","year":"2005","journal-title":"Chest"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1378\/chest.126.6.2022","article-title":"Diagnostically significant variations in pleural fluid pH in loculated parapneumonic effusions","volume":"126","author":"NA Maskell","year":"2004","journal-title":"Chest"},{"issue":"30","key":"ref35","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1200\/JCO.2015.62.1342","article-title":"Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update","volume":"33","author":"GA Masters","year":"2015","journal-title":"J Clin Oncol"},{"issue":"Suppl 3","key":"ref36","doi-asserted-by":"crossref","first-page":"iii27","DOI":"10.1093\/annonc\/mdu199","article-title":"Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"25","author":"M Reck","year":"2014","journal-title":"Ann Oncol"},{"issue":"18","key":"ref37","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJMoa1006448","article-title":"Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer","volume":"363","author":"EL Kwak","year":"2010","journal-title":"N Engl J Med"},{"issue":"16","key":"ref38","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1056\/NEJMoa052122","article-title":"Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer","volume":"353","author":"EH Romond","year":"2005","journal-title":"N Engl J Med"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1200\/JCO.2008.19.9844","article-title":"Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review","volume":"28","author":"S Dawood","year":"2010","journal-title":"J Clin Oncol"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1378\/chest.09-1951","article-title":"Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology","volume":"138","author":"S Savic","year":"2010","journal-title":"Chest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1749-8090-7-121","article-title":"Fluorescence in situ hybridization as adjunct to cytology improves the diagnosis and directs estimation of prognosis of malignant pleural effusions","volume":"7","author":"J Han","year":"2012","journal-title":"Journal of cardiothoracic surgery"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cncy.21510","article-title":"Detection of ALK rearrangements in malignant pleural effusion cell blocks from patients with advanced non-small cell lung cancer: a comparison of Ventana immunohistochemistry and fluorescence in situ hybridization","volume":"123","author":"W Wang","year":"2015","journal-title":"Cancer Cytopathol"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/his.12560","article-title":"Cell block samples from malignant pleural effusion might be valid alternative samples for anaplastic lymphoma kinase detection in patients with advanced non-small-cell lung cancer","volume":"66","author":"J Zhou","year":"2015","journal-title":"Histopathology"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/jclinpath-2013-201728","article-title":"The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies","volume":"66","author":"X Liu","year":"2013","journal-title":"J Clin Pathol"},{"issue":"18","key":"ref45","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1056\/NEJMoa1411817","article-title":"AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer","volume":"372","author":"PA Janne","year":"2015","journal-title":"N Engl J Med"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1158\/1078-0432.CCR-10-2277","article-title":"Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay","volume":"17","author":"ME Arcila","year":"2011","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1158\/2159-8290.CD-15-0399","article-title":"Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor","volume":"5","author":"Z Piotrowska","year":"2015","journal-title":"Cancer discovery"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1158\/1078-0432.CCR-15-1031","article-title":"Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses","volume":"22","author":"TK Sundaresan","year":"2016","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"31","key":"ref49","doi-asserted-by":"crossref","first-page":"30850","DOI":"10.18632\/oncotarget.5068","article-title":"Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples","volume":"6","author":"H Ishii","year":"2015","journal-title":"Oncotarget"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0167186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T19:40:04Z","timestamp":1718912404000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0167186"}},"subtitle":[],"editor":[{"given":"Hyun-Sung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0167186","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}