{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:00:58Z","timestamp":1783418458793,"version":"3.54.6"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0167386","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T19:24:54Z","timestamp":1480620294000},"page":"e0167386","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["Detection of Human Papillomavirus Infection in Patients with Vaginal Intraepithelial Neoplasia"],"prefix":"10.1371","volume":"11","author":[{"given":"Cristina","family":"Lamos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mihaljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Aulmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Domschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wallwiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Paringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Fluhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dinkic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Brucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Golatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gensthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eichbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Rom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00404-005-0022-1","article-title":"Vaginal intraepithelial neoplasia: clinical-therapeutic analysis of 33 cases","volume":"272","author":"EF Murta","year":"2005","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3802\/jgo.2009.20.4.232","article-title":"The utility of the human papillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia","volume":"20","author":"KA So","year":"2009","journal-title":"J Gynecol Oncol"},{"key":"ref3","first-page":"210","article-title":"World Health Organization Classification of Tumours of the female reproductive Organs","author":"A Ferenczy","year":"2014"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/gyno.2001.6502","article-title":"A population-based study of squamous cell vaginal cancer: HPV and cofactors","volume":"84","author":"JR Daling","year":"2002","journal-title":"Gynecol Oncol"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ijc.25384","article-title":"Human papillomavirus genotype in cervical intraepithelial neoplasia grades 2 and 3 of Taiwanese women","volume":"128","author":"A Chao","year":"2011","journal-title":"Int J Cancer"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/AOG.0b013e31819bd6e0","article-title":"Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors","volume":"113","author":"JS Smith","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/ijc.24116","article-title":"Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis","volume":"124","author":"H De Vuyst","year":"2009","journal-title":"Int J Cancer"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1128\/JCM.42.7.3176-3184.2004","article-title":"Detection and typing of human papillomavirus by e6 nested multiplex PCR","volume":"42","author":"K Sotlar","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jmv.20153","article-title":"Detection of high-risk human papillomavirus E6 and E7 oncogene transcripts in cervical scrapes by nested RT-polymerase chain reaction","volume":"74","author":"K Sotlar","year":"2004","journal-title":"J Med Virol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00428-007-0437-0","article-title":"Inter-laboratory validation of PCR-based HPV detection in pathology specimens","volume":"451","author":"I Petersen","year":"2007","journal-title":"Virchows Arch"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/jcp.2008.056275","article-title":"Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status","volume":"61","author":"S Aulmann","year":"2008","journal-title":"J Clin Pathol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"P Peduzzi","year":"1996","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0090-8258(90)90180-S","article-title":"Vaginal intraepithelial neoplasia","volume":"36","author":"P Audet-Lapointe","year":"1990","journal-title":"Gynecol Oncol"},{"key":"ref14","article-title":"Human papillomavirus in vaginal intraepithelial neoplasia","author":"A Chao","year":"2011","journal-title":"Int J Cancer"},{"issue":"5","key":"ref15","first-page":"457","article-title":"Vaginal intraepithelial neoplasia: report of 102 cases","volume":"23","author":"E Diakomanolis","year":"2002","journal-title":"Eur J Gynaecol Oncol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/gyno.2001.6401","article-title":"Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia","volume":"83","author":"JA Dodge","year":"2001","journal-title":"Gynecol Oncol"},{"issue":"5 Pt 1","key":"ref17","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0029-7844(97)00069-0","article-title":"Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus","volume":"89","author":"MA Chiasson","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00006254-199902000-00023","article-title":"Lower genital tract intraepithelial neoplasia in HIV-infected women: guidelines for evaluation and management","volume":"54","author":"M Spitzer","year":"1999","journal-title":"Obstet Gynecol Surv"},{"issue":"2","key":"ref19","first-page":"205","article-title":"Anal and cervical human papillomavirus infection and risk of anal and cervical epithelial abnormalities in human immunodeficiency virus-infected women","volume":"83","author":"AB Williams","year":"1994","journal-title":"Obstet Gynecol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00432-006-0162-0","article-title":"Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile","volume":"133","author":"M Hampl","year":"2007","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.1174","article-title":"Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","volume":"92","author":"R Klaes","year":"2001","journal-title":"Int J Cancer"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0738-081X(96)00152-6","article-title":"Therapy of anogenital HPV-induced lesions","volume":"15","author":"G Gross","year":"1997","journal-title":"Clin Dermatol"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/ijc.23446","article-title":"Risk factors for invasive squamous cell carcinoma of the vulva and vagina\u2014population-based case-control study in Denmark","volume":"122","author":"BS Madsen","year":"2008","journal-title":"Int J Cancer"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bpobgyn.2005.10.007","article-title":"Worldwide burden of gynaecological cancer: the size of the problem","volume":"20","author":"R Sankaranarayanan","year":"2006","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00404-011-1850-9","article-title":"Epidemiology of vulvar and vaginal cancer in Germany","volume":"284","author":"C Dittmer","year":"2011","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/1097-0142(19910701)68:1<195::AID-CNCR2820680135>3.0.CO;2-L","article-title":"Natural history of vaginal intraepithelial neoplasia","volume":"68","author":"M Aho","year":"1991","journal-title":"Cancer"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"113.e1","DOI":"10.1016\/j.ajog.2008.02.026","article-title":"Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study","volume":"199","author":"S Schockaert","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref28","first-page":"188","article-title":"Vaginal intraepithelial neoplasia (VAIN) following hysterectomy in patients treated for carcinoma in situ of the cervix","volume":"18","author":"D Kalogirou","year":"1997","journal-title":"Eur J Gynaecol Oncol"},{"issue":"1","key":"ref29","first-page":"43","article-title":"Prognostic factors for the development of vaginal intraepithelial neoplasia","volume":"29","author":"E Gonzalez Bosquet","year":"2008","journal-title":"Eur J Gynaecol Oncol"},{"issue":"5","key":"ref30","first-page":"699","article-title":"Vaginal cancer after hysterectomy for benign disease: value of cytologic screening","volume":"64","author":"J Bell","year":"1984","journal-title":"Obstet Gynecol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.canlet.2006.09.003","article-title":"Prediction of persistent vaginal intraepithelial neoplasia in previously hysterectomized women by high-risk HPV DNA detection","volume":"249","author":"A Frega","year":"2007","journal-title":"Cancer Lett"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00006250-198609000-00008","article-title":"Vaginal intraepithelial neoplasia: biologic aspects and management","volume":"68","author":"PM Lenehan","year":"1986","journal-title":"Obstet Gynecol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0167386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:08:51Z","timestamp":1589008131000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0167386"}},"subtitle":[],"editor":[{"given":"Anthony W.I.","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0167386","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}