{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:46:31Z","timestamp":1768992391956,"version":"3.49.0"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["H302040"],"award-info":[{"award-number":["H302040"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0167388","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T20:13:02Z","timestamp":1481314382000},"page":"e0167388","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Genome-Wide Association of Heroin Dependence in Han Chinese"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-7176","authenticated-orcid":true,"given":"Gursharan","family":"Kalsi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Euesden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R. I.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazil","family":"Aliev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Newhouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiehe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Asherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1176\/appi.ajp.160.4.687","article-title":"Specificity of genetic and environmental risk factors for use and abuse\/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins","volume":"160","author":"KS Kendler","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/(SICI)1096-8628(19960920)67:5<473::AID-AJMG6>3.0.CO;2-L","article-title":"Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs","volume":"67","author":"MT Tsuang","year":"1996","journal-title":"Am J Med Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.278.5335.58","article-title":"Molecular and cellular basis of addiction","volume":"278","author":"EJ Nestler","year":"1997","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00439-012-1172-4","article-title":"The genetics of the opioid system and specific drug addictions","volume":"131","author":"O Levran","year":"2012","journal-title":"Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-2999(00)00819-0","article-title":"Opioid receptor and peptide gene polymorphisms: potential implications for addictions","volume":"410","author":"KS LaForge","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molmed.2004.12.006","article-title":"Are mu-opioid receptor polymorphisms important for clinical opioid therapy?","volume":"11","author":"J Lotsch","year":"2005","journal-title":"Trends Mol Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10519-015-9737-3","article-title":"Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts","volume":"46","author":"TH Schwantes-An","year":"2016","journal-title":"Behav Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.57.1.1","article-title":"Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments","volume":"57","author":"MJ Kreek","year":"2005","journal-title":"Pharmacol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1601-183X.2008.00410.x","article-title":"Genetic susceptibility to heroin addiction: a candidate gene association study","volume":"7","author":"O Levran","year":"2008","journal-title":"Genes Brain Behav"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1749-6632.2009.05275.x","article-title":"Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment","volume":"1187","author":"V Yuferov","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.mp.4002147","article-title":"Genotype patterns that contribute to increased risk for or protection from developing heroin addiction","volume":"13","author":"DA Nielsen","year":"2008","journal-title":"Mol Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/YPG.0b013e32833a2106","article-title":"Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction","volume":"20","author":"DA Nielsen","year":"2010","journal-title":"Psychiatr Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biopsych.2013.08.034","article-title":"Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways","volume":"76","author":"J Gelernter","year":"2014","journal-title":"Biol Psychiatry"},{"key":"ref14","article-title":"Evidence of CNIH3 involvement in opioid dependence","author":"EC Nelson","year":"2015","journal-title":"Mol Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"SE Hyman","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1371\/journal.pcbi.0040002","article-title":"Genes and (common) pathways underlying drug addiction","volume":"4","author":"CY Li","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19407","DOI":"10.1073\/pnas.1112052108","article-title":"Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors","volume":"108","author":"H Shen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1093\/bioinformatics\/bts479","article-title":"zCall: a rare variant caller for array-based genotyping: genetics and population analysis","volume":"28","author":"JI Goldstein","year":"2012","journal-title":"Bioinformatics"},{"key":"ref19","article-title":"Quality control, imputation and analysis of genome-wide genotyping data from the Illumina HumanCoreExome microarray","author":"JR Coleman","year":"2015","journal-title":"Brief Funct Genomics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"CC Chang","year":"2015","journal-title":"Gigascience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/gepi.20297","article-title":"Estimation of significance thresholds for genomewide association scans","volume":"32","author":"F Dudbridge","year":"2008","journal-title":"Genet Epidemiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature08250","article-title":"Targeted capture and massively parallel sequencing of 12 human exomes","volume":"461","author":"SB Ng","year":"2009","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/bioinformatics\/btu704","article-title":"minimac2: faster genotype imputation","volume":"31","author":"C Fuchsberger","year":"2015","journal-title":"Bioinformatics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1017\/thg.2014.79","article-title":"VEGAS2: Software for More Flexible Gene-Based Testing","volume":"18","author":"A Mishra","year":"2015","journal-title":"Twin Res Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajhg.2010.06.009","article-title":"A versatile gene-based test for genome-wide association studies","volume":"87","author":"JZ Liu","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.drugalcdep.2005.04.005","article-title":"Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA)","volume":"80","author":"A Pierucci-Lagha","year":"2005","journal-title":"Drug Alcohol Depend"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"A Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"CA de Leeuw","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"A Auton","year":"2015","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate\u2014a Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B-Methodological"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1003348","DOI":"10.1371\/journal.pgen.1003348","article-title":"Power and predictive accuracy of polygenic risk scores","volume":"9","author":"F Dudbridge","year":"2013","journal-title":"PLoS Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"SM Purcell","year":"2009","journal-title":"Nature"},{"key":"ref34","article-title":"PRSice: Polygenic Risk Score software","author":"J Euesden","year":"2014","journal-title":"Bioinformatics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","year":"2013","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/mp.2012.21","article-title":"A mega-analysis of genome-wide association studies for major depressive disorder","volume":"18","author":"S Ripke","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jaac.2010.06.007","article-title":"Case-control genome-wide association study of attention-deficit\/hyperactivity disorder","volume":"49","author":"BM Neale","year":"2010","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng.943","article-title":"Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4","volume":"43","year":"2011","journal-title":"Nat Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ng.2742","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia","volume":"45","author":"S Ripke","year":"2013","journal-title":"Nat Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ng.573","article-title":"Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior","volume":"42","author":"TE Thorgeirsson","year":"2010","journal-title":"Nat Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/2167702613497473","article-title":"The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?","volume":"2","author":"A Caspi","year":"2014","journal-title":"Clin Psychol Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/add.12491","article-title":"Polygenic risk scores for smoking: predictors for alcohol and cannabis use?","volume":"109","author":"JM Vink","year":"2014","journal-title":"Addiction"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molcel.2014.02.017","article-title":"Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis","volume":"54","author":"H Kim","year":"2014","journal-title":"Mol Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","article-title":"Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet&apos;s disease","volume":"42","author":"EF Remmers","year":"2010","journal-title":"Nat Genet"},{"key":"ref45","first-page":"1078","article-title":"Criteria for diagnosis of Behcet&apos;s disease. International Study Group for Behcet&apos;s Disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuron.2006.03.018","article-title":"SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release","volume":"50","author":"E Inoue","year":"2006","journal-title":"Neuron"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1073\/pnas.1321990111","article-title":"SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems","volume":"111","author":"BN Lilley","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0896-6273(01)00184-2","article-title":"The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination","volume":"29","author":"JG Crump","year":"2001","journal-title":"Neuron"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1242\/dev.055376","article-title":"Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo","volume":"138","author":"S Baas","year":"2011","journal-title":"Development"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"S Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"A Hall","year":"1998","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/jcs.064964","article-title":"Rho GTPases and their role in organizing the actin cytoskeleton","volume":"124","author":"ST Sit","year":"2011","journal-title":"J Cell Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e1004635","DOI":"10.1371\/journal.pgen.1004635","article-title":"An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs","volume":"10","author":"KJ Ekenstedt","year":"2014","journal-title":"PLoS Genet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1086\/378159","article-title":"Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10","volume":"73","author":"K Verhoeven","year":"2003","journal-title":"Am J Hum Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.conb.2013.01.027","article-title":"Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin&apos;?","volume":"23","author":"A Rothenfluh","year":"2013","journal-title":"Curr Opin Neurobiol"},{"issue":"Suppl 1","key":"ref56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","article-title":"Structural plasticity associated with exposure to drugs of abuse","volume":"47","author":"TE Robinson","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.ne.17.030194.002013","article-title":"Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function","volume":"17","author":"KM Harris","year":"1994","journal-title":"Annu Rev Neurosci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0166-2236(03)00162-0","article-title":"Structure-stability-function relationships of dendritic spines","volume":"26","author":"H Kasai","year":"2003","journal-title":"Trends Neurosci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn1301","article-title":"Structural plasticity and memory","volume":"5","author":"R Lamprecht","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.physiol.64.081501.160008","article-title":"Structure and function of dendritic spines","volume":"64","author":"EA Nimchinsky","year":"2002","journal-title":"Annu Rev Physiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/syn.10146","article-title":"Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult rats","volume":"46","author":"TE Robinson","year":"2002","journal-title":"Synapse"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2011.07.114","article-title":"Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese","volume":"412","author":"F Gao","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2009.08.004","article-title":"Potential association of DRD2 and DAT1 genetic variation with heroin dependence","volume":"464","author":"QF Hou","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/ajmg.10200","article-title":"Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects","volume":"114","author":"T Li","year":"2002","journal-title":"Am J Med Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/13556210050003775","article-title":"Association analysis of polymorphisms in the mu opioid gene and heroin abuse in Chinese subjects","volume":"5","author":"T Li","year":"2000","journal-title":"Addict Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/sj.mp.4000310","article-title":"Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects","volume":"2","author":"T Li","year":"1997","journal-title":"Mol Psychiatry"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/1096-8628(20001009)96:5<616::AID-AJMG6>3.0.CO;2-7","article-title":"Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects","volume":"96","author":"T Li","year":"2000","journal-title":"Am J Med Genet"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/ajmg.b.30429","article-title":"Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population","volume":"144B","author":"EW Loh","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00213-006-0375-6","article-title":"Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese","volume":"186","author":"C Shao","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/humu.9026","article-title":"Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin","volume":"19","author":"J Shi","year":"2002","journal-title":"Hum Mutat"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/00001756-200105080-00011","article-title":"Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts","volume":"12","author":"CY Szeto","year":"2001","journal-title":"Neuroreport"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.61.6.597","article-title":"Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations","volume":"61","author":"K Xu","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ajmg.10374","article-title":"Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case\/control sample","volume":"110","author":"K Xu","year":"2002","journal-title":"Am J Med Genet"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pnpbp.2012.12.011","article-title":"The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence","volume":"43","author":"TY Wang","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0167388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:22:01Z","timestamp":1718940121000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0167388"}},"subtitle":[],"editor":[{"given":"Brion","family":"Maher","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,9]]},"references-count":74,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0167388","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,9]]}}}