{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:34:37Z","timestamp":1776504877031,"version":"3.51.2"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0167455","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T20:20:38Z","timestamp":1481314838000},"page":"e0167455","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Large-Scale Analysis of Gene Expression Data Reveals a Novel Gene Expression Signature Associated with Colorectal Cancer Distant Recurrence"],"prefix":"10.1371","volume":"11","author":[{"given":"Nehad M.","family":"Alajez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0029-1242458","article-title":"Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors","volume":"22","author":"FA Haggar","year":"2009","journal-title":"Clinics in colon and rectal surgery"},{"issue":"2","key":"ref2","first-page":"104","article-title":"Colorectal cancer statistics, 2014","volume":"64","author":"R Siegel","year":"2014","journal-title":"CA: a cancer journal for clinicians"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jso.20942","article-title":"Prognostic significance of depth of invasion, vascular invasion and numbers of lymph node retrievals in combination for patients with stage II colorectal cancer undergoing radical resection","volume":"97","author":"HL Tsai","year":"2008","journal-title":"Journal of surgical oncology"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/PAS.0000000000000518","article-title":"Perineural Invasion is a Strong Prognostic Factor in Colorectal Cancer: A Systematic Review","volume":"40","author":"N Knijn","year":"2016","journal-title":"The American journal of surgical pathology"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1056\/NEJM200104193441603","article-title":"Molecular predictors of survival after adjuvant chemotherapy for colon cancer","volume":"344","author":"T Watanabe","year":"2001","journal-title":"The New England journal of medicine"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1200\/JCO.2010.30.1077","article-title":"Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer","volume":"29","author":"R Salazar","year":"2011","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"e1001453","DOI":"10.1371\/journal.pmed.1001453","article-title":"Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value","volume":"10","author":"L Marisa","year":"2013","journal-title":"PLoS medicine"},{"issue":"269","key":"ref8","first-page":"pl1","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"J Gao","year":"2013","journal-title":"Science signaling"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"E Cerami","year":"2012","journal-title":"Cancer discovery"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/1319-3767.187602","article-title":"Significance of BMI1 and FSCN1 expression in colorectal cancer","volume":"22","author":"NM Alajez","year":"2016","journal-title":"Saudi J Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1186\/s12885-015-1783-y","article-title":"Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer","volume":"15","author":"H Takahashi","year":"2015","journal-title":"BMC cancer"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1158\/1078-0432.CCR-10-2884","article-title":"Clinical significance of osteoprotegerin expression in human colorectal cancer","volume":"17","author":"S Tsukamoto","year":"2011","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13287-015-0123-0","article-title":"CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells","volume":"6","author":"M Al-Toub","year":"2015","journal-title":"Stem cell research & therapy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1038\/cddis.2010.64","article-title":"Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98","volume":"1","author":"NM Alajez","year":"2010","journal-title":"Cell death & disease"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/scrt325","article-title":"Pleiotropic effects of cancer cells&apos; secreted factors on human stromal (mesenchymal) stem cells","volume":"4","author":"M Al-toub","year":"2013","journal-title":"Stem cell research & therapy"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1614","DOI":"10.1038\/cddis.2014.556","article-title":"Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer","volume":"6","author":"R Vishnubalaji","year":"2015","journal-title":"Cell death & disease"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"S Ramaswamy","year":"2003","journal-title":"Nat Genet"},{"issue":"7123","key":"ref18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature05372","article-title":"A human colon cancer cell capable of initiating tumour growth in immunodeficient mice","volume":"445","author":"CA O'Brien","year":"2007","journal-title":"Nature"},{"issue":"7123","key":"ref19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature05384","article-title":"Identification and expansion of human colon-cancer-initiating cells","volume":"445","author":"L Ricci-Vitiani","year":"2007","journal-title":"Nature"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.stem.2011.02.020","article-title":"The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse","volume":"8","author":"A Merlos-Suarez","year":"2011","journal-title":"Cell stem cell"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3892\/ijo.2016.3329","article-title":"Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer","volume":"48","author":"T Masuda","year":"2016","journal-title":"International journal of oncology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12967-014-0369-9","article-title":"Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients","volume":"13","author":"M Kumar","year":"2015","journal-title":"Journal of translational medicine"},{"issue":"16","key":"ref23","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/pros.23065","article-title":"The role of HOXC6 in prostate cancer development","volume":"75","author":"AR Hamid","year":"2015","journal-title":"The Prostate"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"e34004","DOI":"10.1371\/journal.pone.0034004","article-title":"Oncogenic function of DACT1 in colon cancer through the regulation of beta-catenin","volume":"7","author":"G Yuan","year":"2012","journal-title":"PloS one"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1158\/0008-5472.CAN-05-4610","article-title":"Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis","volume":"66","author":"CS Schuetz","year":"2006","journal-title":"Cancer research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0167455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:24:12Z","timestamp":1589034252000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0167455"}},"subtitle":[],"editor":[{"given":"Gianpaolo","family":"Papaccio","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,9]]},"references-count":25,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0167455","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,9]]}}}