{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:48:20Z","timestamp":1790135300432,"version":"4.0.1"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Health and Medical Research Council (AU)","award":["APP1005315"],"award-info":[{"award-number":["APP1005315"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)-Brazil","award":["248427\/2013-0"],"award-info":[{"award-number":["248427\/2013-0"]}]},{"name":"National Health and Medical Research Council (AU)","award":["APP1052464"],"award-info":[{"award-number":["APP1052464"]}]},{"name":"Australian Research Council (AU)","award":["FT110101048"],"award-info":[{"award-number":["FT110101048"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0167732","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T05:13:19Z","timestamp":1481346799000},"page":"e0167732","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased Age, but Not Parity Predisposes to Higher Bacteriuria Burdens Due to Streptococcus Urinary Tract Infection and Influences Bladder Cytokine Responses, Which Develop Independent of Tissue Bacterial Loads"],"prefix":"10.1371","volume":"11","author":[{"given":"Matthew J.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie Y.","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee K.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9638-8091","authenticated-orcid":true,"given":"Glen C.","family":"Ulett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"issue":"Suppl 1","key":"ref1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1086\/318850","article-title":"Urinary tract infections: disease panorama and challenges","volume":"183","author":"WE Stamm","year":"2001","journal-title":"J Infect Dis"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2105\/AJPH.80.3.331","article-title":"Recurring urinary tract infection: incidence and risk factors","volume":"80","author":"B Foxman","year":"1990","journal-title":"Am J Public Health"},{"issue":"Suppl 1A","key":"ref3","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/S0002-9343(02)01054-9","article-title":"Epidemiology of urinary tract infections: incidence, morbidity, and economic costs","volume":"113","author":"B Foxman","year":"2002","journal-title":"Am J Med"},{"key":"ref4","first-page":"397","article-title":"Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care: Partial Update of NICE Clinical Guideline 2","year":"2012"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/1471-2334-12-273","article-title":"Prognostic value of semi-quantitative bacteruria counts in the diagnosis of group B streptococcus urinary tract infection: a 4-year retrospective study in adult patients","volume":"12","author":"CK Tan","year":"2012","journal-title":"BMC Infect Dis"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1128\/JCM.00154-09","article-title":"Diversity of group B streptococcus serotypes causing urinary tract infection in adults","volume":"47","author":"KB Ulett","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.UTI-0012-2012","article-title":"Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract","volume":"4","author":"KA Kline","year":"2016","journal-title":"Microbiol Spectr"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"524 e1","DOI":"10.1016\/j.ajog.2007.01.006","article-title":"Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery","volume":"196","author":"BL Anderson","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1080\/00016340600780508","article-title":"Morbidity related to maternal group B streptococcal infections","volume":"85","author":"AE Muller","year":"2006","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1086\/432804","article-title":"Group B streptococcal infections in elderly adults","volume":"41","author":"MS Edwards","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1086\/650696","article-title":"Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1alpha","volume":"201","author":"GC Ulett","year":"2010","journal-title":"J Infect Dis"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1128\/IAI.00023-12","article-title":"Genome-wide mapping of cystitis due to <italic>Streptococcus agalactiae<\/italic> and <italic>Escherichia coli<\/italic> in mice identifies a unique bladder transcriptome that signifies pathogen-specific antimicrobial defense against urinary tract infection","volume":"80","author":"CK Tan","year":"2012","journal-title":"Infect Immun"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1128\/IAI.00122-11","article-title":"Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection","volume":"79","author":"KA Kline","year":"2011","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"29000","DOI":"10.1038\/srep29000","article-title":"Pathogenesis of <italic>Streptococcus<\/italic> urinary tract infection depends on bacterial strain and beta-hemolysin\/cytolysin that mediates cytotoxicity, cytokine synthesis, inflammation and virulence","volume":"6","author":"SY Leclercq","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1128\/IAI.00938-15","article-title":"Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing <italic>Streptococcus agalactiae<\/italic>","volume":"84","author":"DS Ipe","year":"2015","journal-title":"Infect Immun"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrurol.2010.190","article-title":"The epidemiology of urinary tract infection","volume":"7","author":"B Foxman","year":"2010","journal-title":"Nat Rev Urol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0891-5520(03)00005-9","article-title":"Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs","volume":"17","author":"B Foxman","year":"2003","journal-title":"Infect Dis Clin North Am"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1574-6968.12204","article-title":"Asymptomatic bacteriuria: prevalence rates of causal microorganisms, etiology of infection in different patient populations, and recent advances in molecular detection","volume":"346","author":"DS Ipe","year":"2013","journal-title":"FEMS Microbiol Lett"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-0029-1239485","article-title":"Asymptomatic bacteriuria in pregestational diabetic pregnancies and the role of group B streptococcus","volume":"27","author":"JR Alvarez","year":"2010","journal-title":"Am J Perinatol"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1099\/00222615-47-7-649","article-title":"Group B streptococcal bacteraemia in the elderly","volume":"47","author":"C Trivalle","year":"1998","journal-title":"J Med Microbiol"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1128\/IAI.00684-12","article-title":"Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic <italic>Escherichia coli<\/italic>","volume":"80","author":"KA Kline","year":"2012","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/1040841X.2015.1028885","article-title":"Urinary tract infection of mice to model human disease: Practicalities, implications and limitations","author":"AJ Carey","year":"2015","journal-title":"Crit Rev Microbiol"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mib.2013.01.005","article-title":"Uropathogenic <italic>Escherichia coli<\/italic> virulence and innate immune responses during urinary tract infection","volume":"16","author":"GC Ulett","year":"2013","journal-title":"Curr Opin Microbiol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"e97798","DOI":"10.1371\/journal.pone.0097798","article-title":"Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model","volume":"9","author":"KA Kline","year":"2014","journal-title":"PLoS ONE"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1128\/JB.00122-08","article-title":"UpaG, a new member of the trimeric autotransporter family of adhesins in uropathogenic <italic>Escherichia coli<\/italic>","volume":"190","author":"J Valle","year":"2008","journal-title":"J Bacteriol"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"e1001042","DOI":"10.1371\/journal.ppat.1001042","article-title":"Early severe inflammatory responses to uropathogenic <italic>E<\/italic>. <italic>coli<\/italic> predispose to chronic and recurrent urinary tract infection","volume":"6","author":"TJ Hannan","year":"2010","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4049\/jimmunol.1101231","article-title":"Innate transcriptional networks activated in bladder in response to uropathogenic <italic>Escherichia coli<\/italic> drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection","volume":"188","author":"BL Duell","year":"2012","journal-title":"J Immunol"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1128\/IAI.66.6.2798-2802.1998","article-title":"Time course and host responses to <italic>Escherichia coli<\/italic> urinary tract infection in genetically distinct mouse strains","volume":"66","author":"WJ Hopkins","year":"1998","journal-title":"Infect Immun"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.clp.2010.02.002","article-title":"Group B streptococcal disease in infants: progress in prevention and continued challenges","volume":"37","author":"JR Verani","year":"2010","journal-title":"Clin Perinatol"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"e109321","DOI":"10.1371\/journal.pone.0109321","article-title":"Asymptomatic bacteriuria <italic>Escherichia coli<\/italic> are live biotherapeutics for UTI","volume":"9","author":"CN Rudick","year":"2014","journal-title":"PLoS ONE"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/infdis\/jis493","article-title":"<italic>Escherichia coli<\/italic> 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic <italic>E<\/italic>. <italic>coli<\/italic>","volume":"206","author":"RE Watts","year":"2012","journal-title":"J Infect Dis"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/IAI.74.1.615-624.2006","article-title":"The asymptomatic bacteriuria <italic>Escherichia coli<\/italic> strain 83972 outcompetes uropathogenic <italic>E<\/italic>. <italic>coli<\/italic> strains in human urine","volume":"74","author":"V Roos","year":"2006","journal-title":"Infect Immun"},{"key":"ref33","first-page":"14","article-title":"The Basics of Bacteriuria: Strategies of Microbes for Persistence in Urine","volume":"6","author":"DS Ipe","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.juro.2013.07.060","article-title":"Rare emergence of symptoms during long-term asymptomatic <italic>Escherichia coli<\/italic> 83972 carriage without an altered virulence factor repertoire","volume":"191","author":"B Koves","year":"2014","journal-title":"J Urol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens5010021","article-title":"Asymtomatic Bacteriuria as a Model to Study the Coevolution of Hosts and Bacteria","volume":"5","author":"U Dobrindt","year":"2016","journal-title":"Pathogens"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0022-5347(05)67823-8","article-title":"Urinary tract infection prophylaxis using <italic>Escherichia coli<\/italic> 83972 in spinal cord injured patients","volume":"163","author":"R Hull","year":"2000","journal-title":"J Urol"},{"issue":"2","key":"ref37","first-page":"51S","article-title":"Urinary tract infections in the elderly","volume":"13","author":"JD McCue","year":"1993","journal-title":"Pharmacotherapy"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.coi.2010.05.003","article-title":"Aging of the innate immune system","volume":"22","author":"AC Shaw","year":"2010","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11934-001-0073-1","article-title":"Urinary tract infections in the elderly","volume":"2","author":"T Matsumoto","year":"2001","journal-title":"Curr Urol Rep"},{"issue":"5","key":"ref40","article-title":"Urinary tract infection in older adults","volume":"9","author":"TA Rowe","year":"2013","journal-title":"Aging health"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/end.2014.0002","article-title":"Age-related changes in 24-hour urine composition must be considered in the medical management of nephrolithiasis","volume":"28","author":"JI Friedlander","year":"2014","journal-title":"J Endourol"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0749-0690(18)30122-8","article-title":"Renal stone disease in older adults","volume":"14","author":"DS Goldfarb","year":"1998","journal-title":"Clin Geriatr Med"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.juro.2012.09.023","article-title":"Effect of age on the clinical presentation of incident symptomatic urolithiasis in the general population","volume":"189","author":"AE Krambeck","year":"2013","journal-title":"J Urol"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.6061\/clinics\/2012(05)09","article-title":"Metabolic assessment of elderly men with urolithiasis","volume":"67","author":"CH Freitas Junior","year":"2012","journal-title":"Clinics (Sao Paulo)"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1128\/IAI.01234-12","article-title":"Estrogenic modulation of uropathogenic <italic>Escherichia coli<\/italic> infection pathogenesis in a murine menopause model","volume":"81","author":"C Wang","year":"2013","journal-title":"Infect Immun"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/sji.12413","article-title":"Effects of Ageing on the Immune System: Infants to Elderly","volume":"83","author":"R Valiathan","year":"2016","journal-title":"Scand J Immunol"},{"issue":"1\u20133","key":"ref47","first-page":"37","article-title":"Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians","volume":"121","author":"R Gerli","year":"2000","journal-title":"Mech Ageing Dev"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/107999099313127","article-title":"Increase in circulating levels of monocyte chemoattractant protein-1 with aging","volume":"19","author":"H Inadera","year":"1999","journal-title":"J Interferon Cytokine Res"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0002-9343(02)01484-5","article-title":"Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly","volume":"114","author":"HJ Cohen","year":"2003","journal-title":"Am J Med"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1532-5415.1999.tb01583.x","article-title":"Serum IL-6 level and the development of disability in older persons","volume":"47","author":"L Ferrucci","year":"1999","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.4049\/jimmunol.1401174","article-title":"Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories","volume":"193","author":"J Nikolich-Zugich","year":"2014","journal-title":"J Immunol"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.anai.2009.11.009","article-title":"Innate and adaptive immunosenescence","volume":"104","author":"S Agarwal","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nri3547","article-title":"Age-dependent dysregulation of innate immunity","volume":"13","author":"AC Shaw","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.smim.2012.04.007","article-title":"Translational research in immune senescence: assessing the relevance of current models","volume":"24","author":"KP High","year":"2012","journal-title":"Semin Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.exger.2013.12.009","article-title":"Role of dendritic cells in innate and adaptive immune response in human aging","volume":"54","author":"S Gupta","year":"2014","journal-title":"Exp Gerontol"},{"issue":"16","key":"ref56","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0264-410X(99)00494-6","article-title":"Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells","volume":"18","author":"TL Lung","year":"2000","journal-title":"Vaccine"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"e59091","DOI":"10.1371\/journal.pone.0059091","article-title":"beta-Hemolysin\/cytolysin of Group B Streptococcus enhances host inflammation but is dispensable for establishment of urinary tract infection","volume":"8","author":"R Kulkarni","year":"2013","journal-title":"PLoS ONE"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0167732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T21:36:18Z","timestamp":1601242578000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0167732"}},"subtitle":[],"editor":[{"given":"Jayoung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,9]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0167732","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,9]]}}}