{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:45:33Z","timestamp":1791942333548,"version":"4.3.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573509"],"award-info":[{"award-number":["81573509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0167930","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T19:03:09Z","timestamp":1481742189000},"page":"e0167930","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb\/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance"],"prefix":"10.1371","volume":"11","author":[{"given":"Huqun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maosheng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"JA Lieberman","year":"2005","journal-title":"N Engl J Med"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbr.2010.08.046","article-title":"Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone","volume":"216","author":"M Shobo","year":"2011","journal-title":"Behav Brain Res"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00213-005-2224-4","article-title":"A parametric analysis of olanzapine-induced weight gain in female rats","volume":"181","author":"GD Cooper","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00023210-200822060-00003","article-title":"Pharmacological management of atypical antipsychotic-induced weight gain","volume":"22","author":"T Baptista","year":"2008","journal-title":"CNS Drugs"},{"issue":"1\u20133","key":"ref5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.schres.2011.06.004","article-title":"Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: an animal model","volume":"131","author":"M Hahn","year":"2011","journal-title":"Schizophr Res"},{"issue":"Suppl 1","key":"ref6","first-page":"1","article-title":"Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review","volume":"19","author":"JW Newcomer","year":"2005","journal-title":"CNS Drugs"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/sj.npp.1301541","article-title":"Effects of olanzapine and ziprasidone on glucose tolerance in healthy volunteers","volume":"33","author":"J Sacher","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1210\/jc.2008-1815","article-title":"Effects of olanzapine and haloperidol on the metabolic status of healthy man","volume":"95","author":"S Vidarsdottir","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"e22662","DOI":"10.1371\/journal.pone.0022662","article-title":"A double blind,placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers","volume":"6","author":"VL Albaugh","year":"2011","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.2337\/db13-0430","article-title":"Antipsychotic-Induced Insulin Resistance and Postprandial Hormonal Dysregulation Independent of Weight Gain or Psychiatric Disease","volume":"62","author":"KL Teff","year":"2013","journal-title":"Diabetes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"23873","DOI":"10.1038\/srep23873","article-title":"Adiposetissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance","volume":"6","author":"CY Tan","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/nu8030128","article-title":"An increase in the omega-6\/omega-3 fatty acid ratio increases the risk for obesity","volume":"8","author":"AP Simopoulos","year":"2016","journal-title":"Nutrient"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"21454","DOI":"10.1038\/srep21454","article-title":"Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance","volume":"6","author":"X Chen","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"e0154683","DOI":"10.1371\/journal.pone.0154683","article-title":"Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia","volume":"11","author":"E Han","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/ijerph13010052","article-title":"The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes","volume":"13","author":"LM Salto","year":"2016","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2337\/diabetes.51.1.7","article-title":"Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes","volume":"51","author":"JD McGarry","year":"2002","journal-title":"Diatbete"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.2337\/diabetes.52.10.2461","article-title":"A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes","volume":"52","author":"S Kashyap","year":"2003","journal-title":"Diabetes"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.2337\/db12-0662","article-title":"Does endurance training protect from lipotoxicity?","volume":"61","author":"M Roden","year":"2012","journal-title":"Diabetes"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/112_2013_13","article-title":"Free fatty acid receptors and their role in regulation of energy metabolism","volume":"164","author":"T Hara","year":"2013","journal-title":"Reviews of physiology, biochemistry and pharmacology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12944-015-0123-1","article-title":"The role of fatty acids in insulin resistance","volume":"14","author":"B Sears","year":"2015","journal-title":"Lipids in Health and Disease"},{"key":"ref21","first-page":"703","article-title":"Role of hepatic desaturases in obesity-related metabolic disorders","volume":"13","author":"H Bjermo","year":"2010","journal-title":"CurrOpinClinNutrMetab Care"},{"key":"ref22","first-page":"4","article-title":"Recent insights into the relation of D5 desaturase and D6 desaturase activity to the development of type 2 diabetes","volume":"23","author":"J Kroger","year":"2012","journal-title":"CurrOpinLipidol"},{"key":"ref23","first-page":"503","article-title":"Fatty acid profile of the erythrocyte membrane preceding development of type 2 diabetes mellitus","volume":"18","author":"B Krachler","year":"2008","journal-title":"NutrMetabCardiovasc Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.metabol.2012.06.004","article-title":"Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study","volume":"62","author":"LS Chow","year":"2013","journal-title":"Metabolism"},{"key":"ref25","first-page":"155","article-title":"Evaluation of various biomarkers as potential mediators of the association between D5 desaturase, D6 desaturase, and stearoyl-CoA desaturase activity and incident type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition\u2013Potsdam Study","volume":"102","author":"S Jacobs","year":"2015","journal-title":"Am J ClinNutr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.clnu.2013.03.001","article-title":"Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease","volume":"33","author":"J Mayneris-Perxachs","year":"2014","journal-title":"Clinical Nutrition"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.plipres.2008.10.002","article-title":"Dietary fats and prevention of type 2 diabetes","volume":"48","author":"U Ris\u00e9rus","year":"2009","journal-title":"Prog Lipid Res"},{"key":"ref28","first-page":"128","article-title":"Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women","volume":"16","author":"E Warensj\u00f6","year":"2006","journal-title":"NutrMetabCardiovasc Dis"},{"key":"ref29","first-page":"436","article-title":"Plasma palmitoleic acid, a product of stearoyl-coAdesaturase activity, is an independent marker of triglyceridemia and abdominal adiposity","volume":"18","author":"F Paillard","year":"2008","journal-title":"NutrMetabCardiovasc Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.plipres.2008.01.004","article-title":"Dietary fatty acids and cardiovascular disease: an epidemiological approach","volume":"47","author":"A Erkkil\u00e4","year":"2008","journal-title":"Prog Lipid Res"},{"issue":"2\u20133","key":"ref31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2008.09.027","article-title":"Chronic Risperidone Treatment Preferentially Increases Rat Erythrocyte and Prefrontal Cortex Omega-3 Fatty Acid Composition: Evidence for Augmented Biosynthesis","volume":"107","author":"RK McNamara","year":"2009","journal-title":"Schizophr Res"},{"issue":"1","key":"ref32","first-page":"90","article-title":"Plasma fatty acid composition, estimated desaturase activities, andtheir relation with the metabolic syndrome in a population at highrisk of cardiovascular disease","volume":"33","author":"J Mayneris-Perxachs","year":"2014","journal-title":"ClinNutr"},{"key":"ref33","first-page":"18","article-title":"Weight gain with atypical antipsychotics: evidence and insights","volume":"68","author":"DC Henderson","year":"2007","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.schres.2011.03.016","article-title":"Atypical Antipsychotic Medications Increase Postprandial Triglyceride and Glucose Levels in Male Rats: Relationship with Stearoyl-CoA Desaturase Activity","volume":"129","author":"RK McNamara","year":"2011","journal-title":"Schizophr Res"},{"key":"ref35","first-page":"153","article-title":"Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study","volume":"101","author":"W Ma","year":"2015","journal-title":"Am J ClinNutr"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00125-015-3730-5","article-title":"Plasma fatty acids as predictors of glycaemia and type 2 diabetes","volume":"58","author":"MA Lankinen","year":"2015","journal-title":"Diabetologia"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s001250100547","article-title":"Diet and risk of Type II diabetes: the role of types of fat and carbohydrate","volume":"44","author":"FB Hu","year":"2001","journal-title":"Diabetologia"},{"issue":"17","key":"ref38","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1074\/jbc.M708700200","article-title":"Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells","volume":"283","author":"T Coll","year":"2008","journal-title":"J Biol Chem"},{"issue":"37","key":"ref39","doi-asserted-by":"crossref","first-page":"26865","DOI":"10.1074\/jbc.M513304200","article-title":"Toll-like receptor-2 is essential for the development of palmitate -induced insulin resistance in myotubes","volume":"281","author":"JJ Senn","year":"2006","journal-title":"J Biol Chem"},{"issue":"18","key":"ref40","doi-asserted-by":"crossref","first-page":"11663","DOI":"10.1074\/jbc.M115.649483","article-title":"Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation","volume":"290","author":"V Pardo","year":"2015","journal-title":"J Biol Chem"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2003.08.020","article-title":"Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes","volume":"419","author":"JA Chavez","year":"2003","journal-title":"Arch BiochemBiophys"},{"issue":"Suppl 1","key":"ref42","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ejphar.2011.05.085","article-title":"Fatty acids and inflammation: the cutting edge between food and pharma","volume":"668","author":"PC Calder","year":"2011","journal-title":"European journal of pharmacology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"539426","DOI":"10.1155\/2012\/539426","article-title":"Health implications of high dietary omega-6 polyunsaturated Fatty acids","volume":"2012","author":"E Patterson","year":"2012","journal-title":"J Nutr and Metab"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.schres.2011.03.006","article-title":"Differential Effects of Antipsychotic Medications on Polyunsaturated Fatty Acid Biosynthesis in Rats: Relationship with Liver Delta6-Desaturase Expression","volume":"129","author":"RK McNamara","year":"2011","journal-title":"Schizophr Res"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.mp.4002000","article-title":"Metabolomic mapping of atypical antipsychotic effects in schizophrenia","volume":"12","author":"R Kaddurah-Daouk","year":"2007","journal-title":"Mol Psychiatry"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.plefa.2011.06.006","article-title":"Plasma fatty acids profile and estimated elongase and desaturases activities in Tunisian patients with the metabolic syndrome","volume":"85","author":"MM Sethom","year":"2011","journal-title":"Prostaglandins LeukotEssent Fatty Acids"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/oby.2009.379","article-title":"Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients","volume":"18","author":"J Araya","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0022-2275(20)33401-5","article-title":"Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol","volume":"40","author":"JM Ntambi","year":"1999","journal-title":"J Lipid Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"29854","DOI":"10.1074\/jbc.271.47.29854","article-title":"Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes","volume":"271","author":"AM Sessler","year":"1996","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.nutr.24.121803.063211","article-title":"Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases","volume":"24","author":"MT Nakamura","year":"2004","journal-title":"Annu Rev Nutr"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/1099-081X(199911)20:8<369::AID-BDD200>3.0.CO;2-6","article-title":"Pharmacokinetics and tissue distribution of olanzapine in rats","volume":"20","author":"M Aravagiri","year":"1999","journal-title":"Biopharm Drug Dispos"},{"issue":"4","key":"ref52","first-page":"717","article-title":"Chronic olanzapine administration in rats: effect of route of administration on weight, food intake and body composition","volume":"103","author":"S Mann","year":"2013","journal-title":"PharmacolBiochemBehav"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"e53459","DOI":"10.1371\/journal.pone.0053459","article-title":"Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine","volume":"8","author":"HN Boyda","year":"2013","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0167930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T05:53:41Z","timestamp":1658037221000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0167930"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0167930","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,14]]}}}