{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:10:10Z","timestamp":1790021410485,"version":"4.0.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Duchenne Alliance","award":["100065"],"award-info":[{"award-number":["100065"]}]},{"name":"Duchenne Alliance","award":["100065"],"award-info":[{"award-number":["100065"]}]},{"name":"Duchenne Alliance","award":["100071"],"award-info":[{"award-number":["100071"]}]},{"name":"Duchenne Alliance","award":["100071"],"award-info":[{"award-number":["100071"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168293","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T19:02:41Z","timestamp":1481828561000},"page":"e0168293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Long-Term Quercetin Dietary Enrichment Partially Protects Dystrophic Skeletal Muscle"],"prefix":"10.1371","volume":"11","author":[{"given":"Hannah R.","family":"Spaulding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Ballmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Quindry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Selsby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"issue":"2\u20133","key":"ref1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-5793(94)00748-9","article-title":"Alpha-dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy","volume":"350","author":"JM Ervasti","year":"1994","journal-title":"FEBS Lett"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1073\/pnas.90.8.3710","article-title":"Dystrophin protects the sarcolemma from stresses developed during muscle contraction","volume":"90","author":"BJ Petrof","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6607","key":"ref3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/384349a0","article-title":"Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene","volume":"384","author":"JM Tinsley","year":"1996","journal-title":"Nature"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/4033","article-title":"Expression of full-length utrophin prevents muscular dystrophy in mdx mice","volume":"4","author":"J Tinsley","year":"1998","journal-title":"Nat Med"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.gt.3301066","article-title":"Prevention of the dystrophic phenotype in dystrophin\/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene","volume":"7","author":"PM Wakefield","year":"2000","journal-title":"Gene Ther"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/sj.gt.3301941","article-title":"Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer","volume":"10","author":"M Cerletti","year":"2003","journal-title":"Gene Ther"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/hmg\/ddv444","article-title":"Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles","volume":"25","author":"C Peladeau","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clnu.2012.06.003","article-title":"Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of Duchenne muscular dystrophy","volume":"32","author":"BS Gordon","year":"2013","journal-title":"Clin Nutr"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"C908","DOI":"10.1152\/ajpcell.00196.2005","article-title":"Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction","volume":"289","author":"LM Angus","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3233\/JND-150106","article-title":"Comparison of Experimental Protocols of Physical Exercise for mdx Mice and Duchenne Muscular Dystrophy Patients","volume":"2","author":"J Hyzewicz","year":"2015","journal-title":"Journal of Neuromuscular Diseases"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1152\/japplphysiol.00252.2013","article-title":"Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse","volume":"115","author":"JT Selsby","year":"2013","journal-title":"J Appl Physiol (1985)"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.ajpath.2013.01.020","article-title":"Voluntary physical activity protects from susceptibility to skeletal muscle contraction-induced injury but worsens heart function in mdx mice","volume":"182","author":"C Hourde","year":"2013","journal-title":"Am J Pathol"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/joa.12443","article-title":"Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy","volume":"228","author":"IC Barbin","year":"2016","journal-title":"J Anat"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"e30063","DOI":"10.1371\/journal.pone.0030063","article-title":"Rescue of dystrophic skeletal muscle by PGC-1alpha involves a fast to slow fiber type shift in the mdx mouse","volume":"7","author":"JT Selsby","year":"2012","journal-title":"PLoS One"},{"issue":"Pt 21","key":"ref15","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1113\/jphysiol.2012.240390","article-title":"Peroxisome proliferator-activated receptor \u03b3 coactivator 1-\u03b1 gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necrotic mdx mouse skeletal muscle","volume":"590","author":"R Godin","year":"2012","journal-title":"J Physiol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1152\/ajpregu.00221.2012","article-title":"Rescue of dystrophic skeletal muscle by PGC-1 alpha involves restored expression of dystrophin-associated protein complex components and satellite cell signaling","volume":"305","author":"K Hollinger","year":"2013","journal-title":"American Journal of Physiology-Regulatory Integrative and Comparative Physiology"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1113\/EP085339","article-title":"PGC-1alpha gene transfer improves muscle function in dystrophic muscle following prolonged disease progress","volume":"100","author":"K Hollinger","year":"2015","journal-title":"Experimental physiology"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1101\/gad.1525107","article-title":"PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy","volume":"21","author":"C Handschin","year":"2007","journal-title":"Genes & development"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.clnu.2011.01.010","article-title":"Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis","volume":"30","author":"AW Boots","year":"2011","journal-title":"Clin Nutr"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Nemoto S, Fergusson MM, Finkel T. SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1\u03b1. 2005.","DOI":"10.1074\/jbc.M501485200"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.bbadis.2013.04.005","article-title":"Lysine deacetylases and mitochondrial dynamics in neurodegeneration","volume":"1832","author":"P Guedes-Dias","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"29","key":"ref22","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"S Jager","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.clnu.2014.06.008","article-title":"Long-term quercetin dietary enrichment decreases muscle injury in mdx mice","volume":"34","author":"K Hollinger","year":"2015","journal-title":"Clin Nutr"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1113\/expphysiol.2014.083360","article-title":"Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment","volume":"100","author":"C Ballmann","year":"2015","journal-title":"Exp Physiol"},{"key":"ref25","article-title":"Oral quercetin administration transiently protects respiratory function in dystrophin deficient mice","author":"JT Selsby","year":"2016","journal-title":"J Physiol"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511810893","article-title":"Measuring Behaviour","author":"P Martin","year":"2007"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"R1192","DOI":"10.1152\/ajpregu.00586.2009","article-title":"Leupeptin-based inhibitors do not improve the mdx phenotype","volume":"299","author":"J Selsby","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1113\/expphysiol.2010.054379","article-title":"Increased catalase expression improves muscle function in mdx mice","volume":"96","author":"JT Selsby","year":"2011","journal-title":"Exp Physiol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"e30063","DOI":"10.1371\/journal.pone.0030063","article-title":"Rescue of dystrophic skeletal muscle by PGC-1\u03b1 involves a fast to slow fiber type shift in the mdx mouse","volume":"7","author":"J Selsby","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1113\/jphysiol.1988.sp017279","article-title":"Contractile properties of skeletal muscles from young, adult and aged mice","volume":"404","author":"SV Brooks","year":"1988","journal-title":"J Physiol"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"R1071","DOI":"10.1152\/ajpregu.90925.2008","article-title":"Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance","volume":"296","author":"JM Davis","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1194\/jlr.M038786","article-title":"Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1\/SIRT1","volume":"55","author":"J Dong","year":"2014","journal-title":"J Lipid Res"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3892\/ijmm.2014.1852","article-title":"Quercetin protects against high glucose-induced damage in bone marrow-derived endothelial progenitor cells","volume":"34","author":"LR Zhao","year":"2014","journal-title":"Int J Mol Med"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbrc.2008.06.077","article-title":"The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways","volume":"373","author":"J Ahn","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbrc.2008.11.130","article-title":"Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells","volume":"378","author":"G Suchankova","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"6954","key":"ref36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"KT Howitz","year":"2003","journal-title":"Nature"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC-1alpha","volume":"26","author":"Z Gerhart-Hines","year":"2007","journal-title":"The EMBO journal"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"e1004490","DOI":"10.1371\/journal.pgen.1004490","article-title":"Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy","volume":"10","author":"A Chalkiadaki","year":"2014","journal-title":"PLoS Genet"},{"issue":"6771","key":"ref39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"S Imai","year":"2000","journal-title":"Nature"},{"key":"ref40","article-title":"NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice","author":"H Zhang","year":"2016","journal-title":"Science"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/ptr.1975","article-title":"Flavonoids as antagonists at A1 adenosine receptors","volume":"20","author":"SP Alexander","year":"2006","journal-title":"Phytother Res"},{"issue":"21","key":"ref42","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/hmg\/ddu287","article-title":"Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical-metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy","volume":"23","author":"GM Camerino","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00002060-199801000-00004","article-title":"Effects of aging and voluntary exercise on the function of dystrophic muscle from mdx mice","volume":"77","author":"MA Wineinger","year":"1998","journal-title":"Am J Phys Med Rehabil"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"e45699","DOI":"10.1371\/journal.pone.0045699","article-title":"Combined effect of AMPK\/PPAR agonists and exercise training in mdx mice functional performance","volume":"7","author":"CR Bueno Junior","year":"2012","journal-title":"PLoS One"},{"issue":"Pt 2","key":"ref45","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1469-7793.2001.00591.x","article-title":"Force and power output of fast and slow skeletal muscles from mdx mice 6\u201328 months old","volume":"535","author":"GS Lynch","year":"2001","journal-title":"J Physiol"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0022-510X(94)00276-T","article-title":"mdx mice show progressive weakness and muscle deterioration with age","volume":"129","author":"C Pastoret","year":"1995","journal-title":"J Neurol Sci"},{"issue":"6335","key":"ref47","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/352536a0","article-title":"The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy","volume":"352","author":"HH Stedman","year":"1991","journal-title":"Nature"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/BF01738755","article-title":"Functional regeneration in the hindlimb skeletal muscle of the mdx mouse","volume":"9","author":"JE Anderson","year":"1988","journal-title":"J Muscle Res Cell Motil"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T16:11:46Z","timestamp":1568650306000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168293"}},"subtitle":[],"editor":[{"given":"Ashok","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168293","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,15]]}}}