{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:05:07Z","timestamp":1791993907265,"version":"4.4.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Genzyme (US)"},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","award":["Start-up fund"],"award-info":[{"award-number":["Start-up fund"]}],"id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168346","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T13:42:20Z","timestamp":1482154940000},"page":"e0168346","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy"],"prefix":"10.1371","volume":"11","author":[{"given":"Brent","family":"Fall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ronald","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Shankland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Pippin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Jefferson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Warnock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Najafian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/GIM.0b013e3181f13b75","article-title":"Effects of enzyme replacement therapy in Fabry disease\u2014a comprehensive review of the medical literature","volume":"12","author":"O Lidove","year":"2010","journal-title":"Genet Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13023-015-0253-6","article-title":"Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document","volume":"10","author":"M Biegstraaten","year":"2015","journal-title":"Orphanet J Rare Dis"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ki.2010.484","article-title":"Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease","volume":"79","author":"B Najafian","year":"2011","journal-title":"Kidney Int"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000369309","article-title":"Foot process effacement is an early marker of nephropathy in young classic Fabry patients without albuminuria","volume":"129","author":"C Tondel","year":"2015","journal-title":"Nephron"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/ndt\/gfr420","article-title":"Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation","volume":"27","author":"DG Warnock","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.semnephrol.2014.06.008","article-title":"Progenitor cells and podocyte regeneration","volume":"34","author":"SJ Shankland","year":"2014","journal-title":"Semin Nephrol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jemt.10072","article-title":"Podocyte is the major culprit accounting for the progression of chronic renal disease","volume":"57","author":"W Kriz","year":"2002","journal-title":"Microsc Res Tech"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1046\/j.1523-1755.2002.00675.x","article-title":"Globotriaosylceramide accumulation in the Fabry kidney is cleared from multiple cell types after enzyme replacement therapy","volume":"62","author":"BL Thurberg","year":"2002","journal-title":"Kidney Int"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1681\/ASN.2006080816","article-title":"Sustained, long-term renal stabilization after 54 months of agalsidase beta therapy in patients with Fabry disease","volume":"18","author":"DP Germain","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1681\/ASN.2012030316","article-title":"Agalsidase benefits renal histology in young patients with Fabry disease","volume":"24","author":"C Tondel","year":"2013","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"e92693","DOI":"10.1371\/journal.pone.0092693","article-title":"Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury","volume":"9","author":"WM White","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"ref12","first-page":"1709","article-title":"Urinary podocyte can be an indicator for the pathogenetic condition of patients with IgA nephropathy","volume":"60","author":"P Shen","year":"2014","journal-title":"Clin Lab"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10157-013-0814-8","article-title":"Urinary and glomerular podocytes in patients with chronic kidney diseases","volume":"18","author":"K Hanamura","year":"2014","journal-title":"Clin Exp Nephrol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000046097","article-title":"Urinary podocytes in primary focal segmental glomerulosclerosis","volume":"89","author":"M Hara","year":"2001","journal-title":"Nephron"},{"key":"ref15","article-title":"Podocyturia is significantly elevated in untreated vs treated Fabry adult patients","author":"H Trimarchi","year":"2016","journal-title":"J Nephrol"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"AS Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/oxfordjournals.ndt.a027660","article-title":"Progressive renal failure\u2014inability of podocytes to replicate and the consequences for development of glomerulosclerosis","volume":"11","author":"W Kriz","year":"1996","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1447-0756.1985.tb00045.x","article-title":"Early prenatal diagnosis of inborn error of metabolism: a case report of a fetus affected with Fabry's disease","volume":"11","author":"O Tsutsumi","year":"1985","journal-title":"Asia Oceania J Obstet Gynaecol"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.2337\/db07-0019","article-title":"Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy","volume":"56","author":"M Toyoda","year":"2007","journal-title":"Diabetes"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1681\/ASN.2014080752","article-title":"Glomerular Aging and Focal Global Glomerulosclerosis: A Podometric Perspective","volume":"26","author":"JB Hodgin","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/ndt\/gfr084","article-title":"Targeted urine microscopy in Anderson-Fabry disease: a cheap, sensitive and specific diagnostic technique","volume":"26","author":"M Selvarajah","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5935\/0101-2800.20160008","article-title":"Podocyturia in Fabry disease","volume":"38","author":"EM Pereira","year":"2016","journal-title":"J Bras Nefrol"},{"key":"ref23","first-page":"257628","article-title":"Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease","volume":"2015","author":"H Trimarchi","year":"2015","journal-title":"Case Rep Nephrol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jmedgenet-2014-102797","article-title":"Ten-year outcome of enzyme replacement therapy with agalsidase beta in patients with Fabry disease","volume":"52","author":"DP Germain","year":"2015","journal-title":"J Med Genet"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/cge.12261","article-title":"Intrafamilial phenotypic variability in four families with Anderson-Fabry disease","volume":"86","author":"M Rigoldi","year":"2014","journal-title":"Clin Genet"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1681\/ASN.2013121322","article-title":"Fabry disease: dose matters","volume":"25","author":"DG Warnock","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"e112188","DOI":"10.1371\/journal.pone.0112188","article-title":"Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease","volume":"9","author":"M Mauer","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/ndt\/gfq006","article-title":"Differential expression of claudin tight junction proteins in the human cortical nephron","volume":"25","author":"A Kirk","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00467-016-3387-4","article-title":"Significant improvement in Fabry disease podocytopathy after 3 years of treatment with agalsidase beta","volume":"31","author":"S Ito","year":"2016","journal-title":"Pediatr Nephrol"},{"key":"ref30","article-title":"Reaccumulation of globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients","author":"R Skrunes","year":"2016","journal-title":"Nephrol Dial Transplant"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2215\/CJN.08110811","article-title":"Relationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy","volume":"7","author":"R Asao","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2215\/CJN.01470506","article-title":"Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schonlein-Henoch purpura nephritis","volume":"2","author":"M Hara","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000013302","article-title":"Urinary excretion of podocytes reflects disease activity in children with glomerulonephritis","volume":"18","author":"M Hara","year":"1998","journal-title":"Am J Nephrol"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/0886022X.2011.649627","article-title":"Relationship between urinary podocytes and kidney diseases","volume":"34","author":"D Sun","year":"2012","journal-title":"Ren Fail"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI200112367","article-title":"Apoptosis in podocytes induced by TGF-beta and Smad7","volume":"108","author":"M Schiffer","year":"2001","journal-title":"J Clin Invest"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"F40","DOI":"10.1152\/ajprenal.00404.2002","article-title":"Urinary excretion of viable podocytes in health and renal disease","volume":"285","author":"SU Vogelmann","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"e63506","DOI":"10.1371\/journal.pone.0063506","article-title":"Dysregulated autophagy contributes to podocyte damage in Fabry's disease","volume":"8","author":"MC Liebau","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1046\/j.1523-1755.2003.00032.x","article-title":"Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening","volume":"63","author":"A Melk","year":"2003","journal-title":"Kidney Int"},{"issue":"2","key":"ref39","first-page":"341","article-title":"The declaration of Helsinki 2000: ethical principles and the dignity of difference","volume":"25","author":"SE Salako","year":"2006","journal-title":"Med Law"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1083\/jcb.98.4.1591","article-title":"Identification and characterization of podocalyxin\u2014the major sialoprotein of the renal glomerular epithelial cell","volume":"98","author":"D Kerjaschki","year":"1984","journal-title":"J Cell Biol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.preghy.2011.09.004","article-title":"The role of podocytes in the early detection of pre-eclampsia","volume":"2","author":"D Ramsuran","year":"2012","journal-title":"Pregnancy Hypertens"},{"issue":"10","key":"ref42","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1681\/ASN.2006040325","article-title":"Parietal podocytes in normal human glomeruli","volume":"17","author":"J Bariety","year":"2006","journal-title":"J Am Soc Nephrol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T14:34:34Z","timestamp":1568644474000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168346"}},"subtitle":[],"editor":[{"given":"Hideharu","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":42,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168346","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}