{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:30:31Z","timestamp":1789194631034,"version":"build-2803163510"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01504"],"award-info":[{"award-number":["01E01504"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01004"],"award-info":[{"award-number":["01E01004"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01004"],"award-info":[{"award-number":["01E01004"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01004"],"award-info":[{"award-number":["01E01004"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ED 266\/1-1"],"award-info":[{"award-number":["ED 266\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01504"],"award-info":[{"award-number":["01E01504"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01504"],"award-info":[{"award-number":["01E01504"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01E01004"],"award-info":[{"award-number":["01E01004"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ED 266\/1-1"],"award-info":[{"award-number":["ED 266\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168446","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T18:59:19Z","timestamp":1482173959000},"page":"e0168446","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["TRPC4\u03b1 and TRPC4\u03b2 Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation"],"prefix":"10.1371","volume":"11","author":[{"given":"Nadine","family":"Kirschmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bandleon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"von Ehrlich-Treuenst\u00e4tt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Schaaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karina","family":"Lamprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Miranda-Laferte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Langsenlehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Eder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/CIRCRESAHA.110.225888","article-title":"TRPC channels as effectors of cardiac hypertrophy","volume":"108","author":"P Eder","year":"2011","journal-title":"Circ Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCRESAHA.115.303831","article-title":"Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction","volume":"115","author":"CA Makarewich","year":"2014","journal-title":"Circ Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00441-013-1733-4","article-title":"Expression and localization of TRPC proteins in rat ventricular myocytes at various developmental stages","volume":"355","author":"Y Jiang","year":"2014","journal-title":"Cell Tissue Res"},{"key":"ref4","first-page":"1660","article-title":"Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart","volume":"20","author":"H Nakayama","year":"2006","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1073\/pnas.1001825107","article-title":"TRPC channels are necessary mediators of pathologic cardiac hypertrophy","volume":"107","author":"X Wu","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/CIRCRESAHA.109.206581","article-title":"TRPC1 channels are critical for hypertrophic signaling in the heart","volume":"105","author":"M Seth","year":"2009","journal-title":"Circ Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/eurheartj\/ehv250","article-title":"A background Ca2+ entry pathway mediated by TRPC1\/TRPC4 is critical for development of pathological cardiac remodelling","volume":"36","author":"JE Camacho Londo\u00f1o","year":"2015","journal-title":"Eur Heart J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1074\/jbc.M109850200","article-title":"Functional differences between TRPC4 splice variants","volume":"277","author":"M Schaefer","year":"2002","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-3-642-54215-2_5","article-title":"TRPC4- and TRPC4-containing channels","volume":"222","author":"M Freichel","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10026","DOI":"10.1074\/jbc.M707306200","article-title":"Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate","volume":"283","author":"K Otsuguro","year":"2008","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/mol.114.093690","article-title":"The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4\u03b1 is critical for its contribution to cardiomyocyte hypertrophy","volume":"86","author":"N Cooley","year":"2014","journal-title":"Mol Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/CIRCRESAHA.111.260729","article-title":"Interaction between NF\u03baB and NFAT coordinates cardiac hypertrophy and pathological remodeling","volume":"110","author":"Q Liu","year":"2012","journal-title":"Circ Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/CIRCRESAHA.114.302293","article-title":"Overexpression of the Na+\/K+ ATPase \u03b12 but not \u03b11 isoform attenuates pathological cardiac hypertrophy and remodeling","volume":"114","author":"RN Correll","year":"2014","journal-title":"Circ Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.yjmcc.2012.02.010","article-title":"Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity","volume":"52","author":"E Camors","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/S0006-3495(95)80378-4","article-title":"Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytes","volume":"68","author":"RA Bassani","year":"1995","journal-title":"Biophys J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cardiores.2006.10.016","article-title":"Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex","volume":"73","author":"P Eder","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00395-010-0097-0","article-title":"Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia\/reoxygenation","volume":"105","author":"A Gorbe","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1172\/JCI27702","article-title":"TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling","volume":"116","author":"K Kuwahara","year":"2006","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"33487","DOI":"10.1074\/jbc.M605536200","article-title":"Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling","volume":"281","author":"EW Bush","year":"2006","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e802","DOI":"10.1371\/journal.pone.0000802","article-title":"TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size","volume":"2","author":"JS Brenner","year":"2007","journal-title":"PloS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3940(00)01033-8","article-title":"Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells","volume":"285","author":"H Yamada","year":"2000","journal-title":"Neurosci Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"47842","DOI":"10.1074\/jbc.M302983200","article-title":"N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity","volume":"278","author":"A Dietrich","year":"2003","journal-title":"J Biol Chem"},{"issue":"Pt 3","key":"ref23","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1042\/bj3510735","article-title":"Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3","volume":"351","author":"RR McKay","year":"2000","journal-title":"Biochem J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"10997","DOI":"10.1074\/jbc.M411797200","article-title":"A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2","volume":"280","author":"L-P He","year":"2005","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1074\/jbc.M309297200","article-title":"Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2","volume":"279","author":"C Zitt","year":"2004","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.yjmcc.2012.08.005","article-title":"Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling","volume":"53","author":"H Gao","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jcp.20057","article-title":"TRPC5 activation kinetics are modulated by the scaffolding protein ezrin\/radixin\/moesin-binding phosphoprotein-50 (EBP50)","volume":"201","author":"AG Obukhov","year":"2004","journal-title":"J Cell Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1242\/jcs.115.17.3497","article-title":"The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells","volume":"115","author":"L Mery","year":"2002","journal-title":"J Cell Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"10140","DOI":"10.1073\/pnas.95.17.10140","article-title":"Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure","volume":"95","author":"JW Adams","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1128\/MCB.26.10.3785-3797.2006","article-title":"Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth","volume":"26","author":"Q Liu","year":"2006","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"34528","DOI":"10.1074\/jbc.M002844200","article-title":"beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes","volume":"275","author":"S Saito","year":"2000","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.RES.86.3.255","article-title":"Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure","volume":"86","author":"LJ De Windt","year":"2000","journal-title":"Circ Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"39171","DOI":"10.1074\/jbc.M110.149690","article-title":"Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes","volume":"285","author":"H Li","year":"2010","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1074\/jbc.M115.693911","article-title":"Transient Receptor Potential Canonical (TRPC)\/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES","volume":"291","author":"J Sabourin","year":"2016","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11010-006-9261-0","article-title":"Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis","volume":"294","author":"S Satoh","year":"2007","journal-title":"Mol Cell Biochem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T15:53:40Z","timestamp":1658159620000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168446"}},"subtitle":[],"editor":[{"given":"Alexander G","family":"Obukhov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":35,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168446","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}