{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:45:56Z","timestamp":1790826356867,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009342","name":"Aeras Global Tuberculosis Vaccine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009342","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dartmouth College (US)"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168521","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T18:42:32Z","timestamp":1482259352000},"page":"e0168521","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["Immunogenicity and Protective Efficacy of the DAR-901 Booster Vaccine in a Murine Model of Tuberculosis"],"prefix":"10.1371","volume":"11","author":[{"given":"Timothy","family":"Lahey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick","family":"Laddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Keeble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Dagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Mei","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Arbeit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Fordham","family":"von Reyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"ref1","article-title":"Global Tuberculosis Report 2014","year":"2014"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJMra1200894","article-title":"Tuberculosis","volume":"368","author":"A Zumla","year":"2013","journal-title":"The New England journal of medicine"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/thoraxjnl-2013-203456","article-title":"Tuberculosis vaccines: time to reset the paradigm?","volume":"68","author":"A Lalvani","year":"2013","journal-title":"Thorax"},{"issue":"8794","key":"ref4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0140-6736(92)90794-4","article-title":"Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi","volume":"339","author":"JM Ponnighaus","year":"1992","journal-title":"Lancet"},{"issue":"9493","key":"ref5","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0140-6736(05)67145-0","article-title":"Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: the BCG-REVAC cluster-randomised trial","volume":"366","author":"LC Rodrigues","year":"2005","journal-title":"Lancet"},{"issue":"9731","key":"ref6","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/S0140-6736(10)60393-5","article-title":"New vaccines for tuberculosis","volume":"375","author":"SH Kaufmann","year":"2010","journal-title":"Lancet"},{"issue":"43","key":"ref7","doi-asserted-by":"crossref","first-page":"15520","DOI":"10.1073\/pnas.1404386111","article-title":"Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countries","volume":"111","author":"GM Knight","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Suppl 3","key":"ref8","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.1086\/313880","article-title":"Safety and immunogenicity of a five-dose series of inactivated Mycobacterium vaccae vaccination for the prevention of HIV-associated tuberculosis","volume":"30","author":"RD Waddell","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"16","key":"ref9","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1097\/00002030-200311070-00010","article-title":"Immunogenicity of an inactivated mycobacterial vaccine for the prevention of HIV-associated tuberculosis: a randomized, controlled trial","volume":"17","author":"JM Vuola","year":"2003","journal-title":"Aids"},{"issue":"48","key":"ref10","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1016\/j.vaccine.2010.09.041","article-title":"Immunogenicity of a protective whole cell mycobacterial vaccine in HIV-infected adults: a phase III study in Tanzania","volume":"28","author":"T Lahey","year":"2010","journal-title":"Vaccine"},{"issue":"24","key":"ref11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/QAD.0b013e3283350f1b","article-title":"Prevention of tuberculosis in Bacille Calmette-Guerin-primed, HIV-infected adults boosted with an inactivated whole-cell mycobacterial vaccine","volume":"13","author":"CF von Reyn","year":"2010","journal-title":"Aids"},{"issue":"2","key":"ref12","first-page":"103","article-title":"Improving on BCG. APMIS: acta pathologica, microbiologica, et immunologica","volume":"99","author":"JL Stanford","year":"1991","journal-title":"Scandinavica"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"e2517","DOI":"10.1371\/journal.pone.0002517","article-title":"Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens","volume":"3","author":"DJ Laddy","year":"2008","journal-title":"PloS one"},{"issue":"26","key":"ref14","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1056\/NEJM199612263352604","article-title":"Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection","volume":"335","author":"E Jouanguy","year":"1996","journal-title":"The New England journal of medicine"},{"issue":"26","key":"ref15","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJM199612263352602","article-title":"A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection","volume":"335","author":"MJ Newport","year":"1996","journal-title":"The New England journal of medicine"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1086\/656332","article-title":"Interferon gamma responses to mycobacterial antigens protect against subsequent HIV-associated tuberculosis","volume":"202","author":"T Lahey","year":"2010","journal-title":"The Journal of infectious diseases"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"e22074","DOI":"10.1371\/journal.pone.0022074","article-title":"Polyantigenic interferon-gamma responses are associated with protection from TB among HIV-infected adults with childhood BCG immunization","volume":"6","author":"T Lahey","year":"2011","journal-title":"PloS one"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1164\/rccm.201003-0334OC","article-title":"Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns","volume":"182","author":"BM Kagina","year":"2010","journal-title":"American journal of respiratory and critical care medicine"},{"issue":"9871","key":"ref19","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(13)60177-4","article-title":"Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial","volume":"381","author":"MD Tameris","year":"2013","journal-title":"Lancet"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.chom.2013.02.009","article-title":"Antibody-mediated immunity against tuberculosis: implications for vaccine development","volume":"13","author":"JM Achkar","year":"2013","journal-title":"Cell host & microbe"},{"key":"ref21","article-title":"Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis","author":"AK Khera","year":"2015","journal-title":"Journal of immunology"},{"key":"ref22","article-title":"A Functional Role for Antibodies in Tuberculosis","author":"LL Lu","year":"2016","journal-title":"Cell"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2016.08.072","article-title":"A Functional Role for Antibodies in Tuberculosis","volume":"167","author":"LL Lu","year":"2016","journal-title":"Cell"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2008-0154TR","article-title":"What animal models teach humans about tuberculosis","volume":"39","author":"AS Dharmadhikari","year":"2008","journal-title":"American journal of respiratory cell and molecular biology"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/eji.200939542","article-title":"Animal models of tuberculosis","volume":"39","author":"D Young","year":"2009","journal-title":"European journal of immunology"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1128\/IAI.00287-09","article-title":"Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis","volume":"77","author":"HM Vordermeier","year":"2009","journal-title":"Infect Immun"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"e5264","DOI":"10.1371\/journal.pone.0005264","article-title":"MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques","volume":"4","author":"FA Verreck","year":"2009","journal-title":"PloS one"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.4049\/jimmunol.171.3.1602","article-title":"Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara","volume":"171","author":"NP Goonetilleke","year":"2003","journal-title":"Journal of immunology"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tube.2013.11.003","article-title":"A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data","volume":"94","author":"H McShane","year":"2014","journal-title":"Tuberculosis"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1128\/IAI.65.11.4525-4530.1997","article-title":"Immunization with heat-killed Mycobacterium vaccae stimulates CD8+ cytotoxic T cells specific for macrophages infected with Mycobacterium tuberculosis","volume":"65","author":"MA Skinner","year":"1997","journal-title":"Infect Immun"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1128\/IAI.65.5.1856-1862.1997","article-title":"Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae","volume":"65","author":"C Abou-Zeid","year":"1997","journal-title":"Infect Immun"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S2213-2600(14)70033-5","article-title":"Progress in tuberculosis vaccine development and host-directed therapies\u2014a state of the art review","volume":"2","author":"SH Kaufmann","year":"2014","journal-title":"The Lancet Respiratory medicine"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.TNMI7-0003-2016","article-title":"Mycobacterium bovis BCG and New Vaccines for the Prevention of Tuberculosis","volume":"4","author":"T Lahey","year":"2016","journal-title":"Microbiol Spectr"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T03:45:06Z","timestamp":1601264706000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168521"}},"subtitle":[],"editor":[{"given":"Thomas Jens","family":"Scriba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168521","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}