{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T05:10:07Z","timestamp":1749877807883,"version":"3.41.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_135272, 320030_156193"],"award-info":[{"award-number":["32003B_135272, 320030_156193"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168541","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T21:06:55Z","timestamp":1483996015000},"page":"e0168541","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs"],"prefix":"10.1371","volume":"11","author":[{"given":"Pranitha","family":"Kamat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Christen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan K.","family":"Bongoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rieben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCULATIONAHA.109.192667","article-title":"Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association","volume":"121","author":"D Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/jama.297.17.1892","article-title":"Decline in rates of death and heart failure in acute coronary syndromes, 1999\u20132006","volume":"297","author":"KA Fox","year":"2007","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/jama.2009.1178","article-title":"Reduction in acute myocardial infarction mortality in the United States: risk-standardized mortality rates from 1995\u20132006","volume":"302","author":"HM Krumholz","year":"2009","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.CIR.82.3.723","article-title":"Mechanism of myocardial "stunning"","volume":"82","author":"R Bolli","year":"1990","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0022-4804(92)90070-G","article-title":"Recent advances in the role of reactive oxygen intermediates in ischemic injury. I. Evidence demonstrating presence of reactive oxygen intermediates; II. Role of metals in site-specific formation of radicals","volume":"53","author":"SR Powell","year":"1992","journal-title":"J Surg Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/01.CIR.80.5.1115","article-title":"Deleterious effects of oxygen radicals in ischemia\/reperfusion. Resolved and unresolved issues","volume":"80","author":"RA Kloner","year":"1989","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1073\/pnas.86.12.4695","article-title":"Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog","volume":"86","author":"R Bolli","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbadis.2005.10.001","article-title":"Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition","volume":"1762","author":"AJ Tompkins","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0022-2828(84)80011-5","article-title":"Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia\/reperfusion injury","volume":"16","author":"ML Hess","year":"1984","journal-title":"J Mol Cell Cardiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"H2649","DOI":"10.1152\/ajpheart.2001.280.6.H2649","article-title":"Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia","volume":"280","author":"C Duilio","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/01.CIR.73.5.1077","article-title":"Protective effects of N-2-mercaptopropionyl glycine against myocardial reperfusion injury after neutrophil depletion in the dog: evidence for the role of intracellular-derived free radicals","volume":"73","author":"SE Mitsos","year":"1986","journal-title":"Circulation"},{"key":"ref12","first-page":"265","article-title":"Endothelial dysfunction and reactive oxygen species production in ischemia\/reperfusion and nitrate tolerance","volume":"23","author":"K Szocs","year":"2004","journal-title":"Gen Physiol Biophys"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1096\/fj.06-6188fje","article-title":"Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia\/reperfusion injury","volume":"20","author":"J McCormick","year":"2006","journal-title":"FASEB J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1254\/jphs.FP0070186","article-title":"Edaravone preserves coronary microvascular endothelial function after ischemia\/reperfusion on the beating canine heart in vivo","volume":"104","author":"R Sukmawan","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10715768909087964","article-title":"Effects of free radicals on the fluidity of myocardial membranes","volume":"7","author":"M Bagchi","year":"1989","journal-title":"Free Radic Res Commun"},{"key":"ref16","first-page":"1","article-title":"The mechanism of "Fenton-like" reactions and their importance for biological systems. A biologist's view","volume":"36","author":"SI Liochev","year":"1999","journal-title":"Met Ions Biol Syst"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1006\/jmcc.1997.0535","article-title":"Patterns of mobilization of copper and iron following myocardial ischemia: possible predictive criteria for tissue injury","volume":"29","author":"E Berenshtein","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1067\/mtc.2001.113325","article-title":"The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection","volume":"121","author":"M Karck","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1113\/jphysiol.1994.sp020147","article-title":"Changes in mitochondrial function induced in isolated guinea-pig ventricular myocytes by calcium overload","volume":"476","author":"KK Minezaki","year":"1994","journal-title":"J Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1536\/ihj.39.707","article-title":"Na+\/Ca++ exchanger and myocardial ischemia\/reperfusion","volume":"39","author":"S Mochizuki","year":"1998","journal-title":"Jpn Heart J"},{"key":"ref21","first-page":"3436","article-title":"Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+\/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187)","volume":"41","author":"EH Herman","year":"1981","journal-title":"Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2165\/00003495-200565070-00008","article-title":"Dexrazoxane: a review of its use for cardioprotection during anthracycline chemotherapy","volume":"65","author":"RS Cvetkovic","year":"2005","journal-title":"Drugs"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1634\/theoncologist.2007-0247","article-title":"Dexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy","volume":"13","author":"RC Kane","year":"2008","journal-title":"Oncologist"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0929867305666220314194045","article-title":"Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines","volume":"5","author":"BB Hasinoff","year":"1998","journal-title":"Curr Med Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0090-9556(25)08496-X","article-title":"The hydrolysis activation of the doxorubicin cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane)","volume":"18","author":"BB Hasinoff","year":"1990","journal-title":"Drug Metab Dispos"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jps.2600830115","article-title":"Pharmacodynamics of the hydrolysis-activation of the cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane","volume":"83","author":"BB Hasinoff","year":"1994","journal-title":"J Pharm Sci"},{"key":"ref27","first-page":"3","article-title":"Chemistry of dexrazoxane and analogues","volume":"25","author":"BB Hasinoff","year":"1998","journal-title":"Semin Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/mol.64.3.670","article-title":"The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity","volume":"64","author":"BB Hasinoff","year":"2003","journal-title":"Mol Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1385\/CT:2:2:111","article-title":"Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage","volume":"2","author":"BB Hasinoff","year":"2002","journal-title":"Cardiovasc Toxicol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/1357-2725(94)00055-7","article-title":"Relationship between severity of ischemia and oxidant scavenger enzyme activities in the isolated rat heart","volume":"27","author":"C Coudray","year":"1995","journal-title":"Int J Biochem Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000336485","article-title":"Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs","volume":"121","author":"Y Banz","year":"2012","journal-title":"Cardiology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.cardiores.2007.07.016","article-title":"Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1","volume":"76","author":"Y Banz","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1093\/eurheartj\/ehi421","article-title":"Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia\/reperfusion injury","volume":"26","author":"Y Banz","year":"2005","journal-title":"Eur Heart J"},{"key":"ref34","article-title":"Circulating CD31+\/Annexin V+ microparticles correlate with cardiovascular outcomes","author":"JM Sinning","year":"2011","journal-title":"Eur Heart J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/01.ATV.0000191634.13057.15","article-title":"Circulating CD31+\/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease","volume":"26","author":"N Werner","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/01.CIR.95.3.693","article-title":"Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium","volume":"95","author":"AG Kumar","year":"1997","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"32910","DOI":"10.1074\/jbc.272.52.32910","article-title":"Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells","volume":"272","author":"V Lakshminarayanan","year":"1997","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/cyto.1995.0037","article-title":"Expression of leukocyte chemotactic cytokines in myocardial tissue","volume":"7","author":"Y Seino","year":"1995","journal-title":"Cytokine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9440(10)62517-5","article-title":"Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia","volume":"159","author":"V Lakshminarayanan","year":"2001","journal-title":"Am J Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1096\/fasebj.8.13.7926371","article-title":"Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes","volume":"8","author":"P Loetscher","year":"1994","journal-title":"FASEB J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"H1001","DOI":"10.1152\/ajpheart.00716.2003","article-title":"Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase","volume":"286","author":"XL Chen","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10557-006-0497-4","article-title":"Dexrazoxane prevents myocardial ischemia\/reperfusion-induced oxidative stress in the rat heart","volume":"20","author":"E Ramu","year":"2006","journal-title":"Cardiovasc Drugs Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1139\/y2012-096","article-title":"Protective effects of dexrazoxane against acute ischaemia\/reperfusion injury of rat hearts","volume":"90","author":"J Neckar","year":"2012","journal-title":"Can J Physiol Pharmacol"},{"key":"ref44","first-page":"69","article-title":"Influence of vitamin E and ICRF-187 on chronic doxorubicin cardiotoxicity in miniature swine","volume":"49","author":"EH Herman","year":"1983","journal-title":"Lab Invest"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1124\/dmd.105.005546","article-title":"Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat","volume":"33","author":"PE Schroeder","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/j.2040-4603.2015.tb00664.x","article-title":"Pathophysiology of Myocardial Infarction","volume":"5","author":"NG Frangogiannis","journal-title":"Compr Physiol"},{"journal-title":"J Thromb Thrombolysis","article-title":"Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction","author":"S van Diepen","key":"ref47"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T04:29:13Z","timestamp":1749875353000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168541"}},"subtitle":[],"editor":[{"given":"Marc W.","family":"Merx","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168541","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}