{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:54:27Z","timestamp":1784058867028,"version":"3.55.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1193- B05"],"award-info":[{"award-number":["CRC1193- B05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1193-B05"],"award-info":[{"award-number":["CRC 1193-B05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168652","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T13:45:14Z","timestamp":1482155114000},"page":"e0168652","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy"],"prefix":"10.1371","volume":"11","author":[{"given":"Hanganu","family":"Alexandru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthuraman","family":"Muthuraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Chaitanya","family":"Chirumamilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabin","family":"Koirala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Paktas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten E.","family":"Zeuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiu","family":"Groppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1212\/01.WNL.0000027361.73814.0E","article-title":"Blepharospasm recent advances","volume":"59","author":"M Hallett","year":"2002","journal-title":"Neurology"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3171\/jns.1995.82.2.0201","article-title":"Microvascular decompression for hemifacial spasm","volume":"82","author":"FG Barker","year":"1995","journal-title":"Journal of Neurosurgery"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/brain\/108.3.593","article-title":"Pathophysiology of blepharospasm and oromandibular dystonia","volume":"108","author":"A Berardelli","year":"1985","journal-title":"Brain"},{"issue":"16","key":"ref4","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1212\/01.wnl.0000327601.46315.85","article-title":"Update on blepharospasm Report from the BEBRF International Workshop","volume":"71","author":"M Hallett","year":"2008","journal-title":"Neurology"},{"issue":"05","key":"ref5","first-page":"145","article-title":"Observations on the etiology of trigeminal neuralgia, hemifacial spasm, acoustic nerve dysfunction and glossopharyngeal neuralgia. Definitive microsurgical treatment and results in 117 patients","volume":"20","author":"PJ Jannetta","year":"1977","journal-title":"Neurochirurgia"},{"issue":"19","key":"ref6","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1212\/01.wnl.0000311389.26145.95","article-title":"Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review) Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology","volume":"70","author":"D Simpson","year":"2008","journal-title":"Neurology"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/jnnp.2007.131524","article-title":"Tactile temporal discrimination in patients with blepharospasm","volume":"79","author":"M Fiorio","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/brain\/awg219","article-title":"Abnormalities of spatial discrimination in focal and generalized dystonia","volume":"126","author":"F Molloy","year":"2003","journal-title":"Brain"},{"issue":"10","key":"ref9","first-page":"2697","article-title":"The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer's cramp","volume":"129","author":"M Peller","year":"2006","journal-title":"The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer's cramp"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1136\/jnnp.2005.087148","article-title":"Bilateral grey-matter increase in the putamen in primary blepharospasm","volume":"77","author":"T Etgen","year":"2006","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/mds.21495","article-title":"Morphometric changes of sensorimotor structures in focal dystonia","volume":"22","author":"M Obermann","year":"2007","journal-title":"Movement disorders"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/mds.23724","article-title":"Cortical gray matter changes in primary blepharospasm: A voxel-based morphometry study","volume":"26","author":"D Martino","year":"2011","journal-title":"Movement Disorders"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1468-1331.2008.02196.x","article-title":"Increased basal-ganglia activation performing a non-dystonia-related task in focal dystonia","volume":"15","author":"M Obermann","year":"2008","journal-title":"European journal of neurology"},{"key":"ref14","first-page":"97","article-title":"Rating scales for blepharospasm","volume":"4","author":"S Fahn","year":"1985","journal-title":"Adv Ophthal Plast Reconstr Surg"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0003-9993(96)90254-3","article-title":"Supervision rating scale: A measure of functional outcome from brain injury","volume":"77","author":"C Boake","year":"1996","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"issue":"1","key":"ref16","first-page":"332","article-title":"Classification and investigation of dystonia","volume":"2","author":"S Fahn","year":"1987","journal-title":"Movement disorders"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.neuroimage.2004.03.032","article-title":"A hybrid approach to the skull stripping problem in MRI","volume":"22","author":"F S\u00e9gonne","year":"2004","journal-title":"NeuroImage"},{"issue":"Supplement 1","key":"ref18","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","article-title":"Sequence-independent segmentation of magnetic resonance images","volume":"23","author":"B Fischl","year":"2004","journal-title":"NeuroImage"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1109\/42.668698","article-title":"A nonparametric method for automatic correction of intensity nonuniformity in MRI data","volume":"17","author":"JG Sled","year":"1998","journal-title":"IEEE Transactions on Medical Imaging"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1109\/TMI.2006.887364","article-title":"Geometrically accurate topology-correction of cortical surfaces using nonseparating loops","volume":"26","author":"F S\u00e9gonne","year":"2007","journal-title":"IEEE Transactions on Medical Imaging"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis: I. Segmentation and surface reconstruction","volume":"9","author":"AM Dale","year":"1999","journal-title":"NeuroImage"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"M Reuter","year":"2012","journal-title":"NeuroImage"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.neuroimage.2010.07.020","article-title":"Highly accurate inverse consistent registration: A robust approach","volume":"53","author":"M Reuter","year":"2010","journal-title":"NeuroImage"},{"issue":"4","key":"ref24","first-page":"1159","article-title":"Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia","volume":"130","author":"AT Du","year":"2007","journal-title":"Brain"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1523\/JNEUROSCI.3948-05.2006","article-title":"Enhanced Long-Term Potentiation-Like Plasticity of the Trigeminal Blink Reflex Circuit in Blepharospasm","volume":"26","author":"A Quartarone","year":"2006","journal-title":"The Journal of Neuroscience"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/mds.23497","article-title":"Botulinum toxin modulates basal ganglia but not deficient somatosensory activation in orofacial dystonia","volume":"26","author":"C Dresel","year":"2011","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.clinph.2003.10.035","article-title":"Cortical control of voluntary blinking: a transcranial magnetic stimulation study","volume":"115","author":"YH Sohn","year":"2004","journal-title":"Clinical Neurophysiology"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2047-9158-1-12","article-title":"Anatomical correlates of blepharospasm","volume":"1","author":"S Horovitz","year":"2012","journal-title":"Translational Neurodegeneration"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroimage.2010.08.013","article-title":"Manual activity shapes structure and function in contralateral human motor hand area","volume":"54","author":"O Granert","year":"2011","journal-title":"NeuroImage"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/cercor\/bhr120","article-title":"Abnormal Structure\u2013Function Relationship in Spasmodic Dysphonia","volume":"22","author":"K Simonyan","year":"2012","journal-title":"Cerebral Cortex"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/brain\/awt302","article-title":"The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome","volume":"137","author":"N Wolpe","year":"2014","journal-title":"Brain"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ana.24138","article-title":"The acute brain response to levodopa heralds dyskinesias in Parkinson disease","volume":"75","author":"DM Herz","year":"2014","journal-title":"Annals of Neurology"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1523\/JNEUROSCI.11-11-03656.1991","article-title":"Functional organization of human supplementary motor cortex studied by electrical stimulation","volume":"11","author":"I Fried","year":"1991","journal-title":"The Journal of neuroscience"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/cercor\/bhi011","article-title":"Canceling Planned Action: An fMRI Study of Countermanding Saccades","volume":"15","author":"CE Curtis","year":"2005","journal-title":"Cerebral Cortex"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1152\/jn.1998.80.5.2671","article-title":"Neuronal activity in medial frontal cortex during learning of sequential procedures","volume":"80","author":"K Nakamura","year":"1998","journal-title":"Journal of Neurophysiology"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nrn2478","article-title":"Functional role of the supplementary and pre-supplementary motor areas","volume":"9","author":"P Nachev","year":"2008","journal-title":"Nature Reviews Neuroscience"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0172374","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T14:34:48Z","timestamp":1568644488000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168652"}},"subtitle":[],"editor":[{"given":"Lutz","family":"Jaencke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168652","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0172374","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}