{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:59:45Z","timestamp":1790402385701,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26293206"],"award-info":[{"award-number":["26293206"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0109025"],"award-info":[{"award-number":["15ek0109025"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0109048"],"award-info":[{"award-number":["15ek0109048"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26293206"],"award-info":[{"award-number":["26293206"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26670440"],"award-info":[{"award-number":["26670440"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["15K15337"],"award-info":[{"award-number":["15K15337"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["16K15480"],"award-info":[{"award-number":["16K15480"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168846","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T21:34:58Z","timestamp":1483997698000},"page":"e0168846","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Decreased Peak Expiratory Flow Associated with Muscle Fiber-Type Switching in Spinal and Bulbar Muscular Atrophy"],"prefix":"10.1371","volume":"11","author":[{"given":"Shinichiro","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Hijikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohide","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Banno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Halievski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1212\/WNL.18.7.671","article-title":"Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait","volume":"18","author":"WR Kennedy","year":"1968","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.pneurobio.2012.05.007","article-title":"Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)","volume":"99","author":"M Katsuno","year":"2012","journal-title":"Prog Neurobiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jns.2007.08.012","article-title":"Spinal and bulbar muscular atrophy: skeletal muscle pathology in male patients and heterozygous females","volume":"264","author":"G Sorar\u00f9","year":"2008","journal-title":"J Neurol Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/352077a0","article-title":"Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy","volume":"352","author":"AR La Spada","year":"1991","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1212\/01.WNL.0000151978.74467.E7","article-title":"Laryngospasm: an underdiagnosed symptom of X-linked spinobulbar muscular atrophy","volume":"64","author":"AD Sperfeld","year":"2005","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jns.2013.12.010","article-title":"Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm","volume":"337","author":"S Tanaka","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/brain\/awl096","article-title":"Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients","volume":"129","author":"N Atsuta","year":"2006","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1212\/01.wnl.0000227785.73714.64","article-title":"Noninvasive positive-pressure ventilation in ALS: predictors of tolerance and survival","volume":"67","author":"D Lo Coco","year":"2006","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","article-title":"Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"73","author":"RG Miller","year":"2009","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"BR Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00005792-194809000-00001","article-title":"Pulmonary insufficiency; physiological classification, clinical methods of analysis, standard values in normal subjects","volume":"27","author":"ED Baldwin","year":"1948","journal-title":"Medicine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.0954-6820.1963.tb16520.x","article-title":"Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age","volume":"173","author":"E Berglund","year":"1963","journal-title":"Acta Med Scand"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.nmd.2015.03.008","article-title":"A functional scale for spinal and bulbar muscular atrophy: Cross-sectional and longitudinal study","volume":"25","author":"A Hashizume","year":"2015","journal-title":"Neuromuscul Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00415-015-7680-0","article-title":"Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy","volume":"262","author":"S Maeshima","year":"2015","journal-title":"J Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e35273","DOI":"10.1371\/journal.pone.0035273","article-title":"Rapid determination of myosin heavy chain expression in rat, mouse, and human skeletal muscle using multicolor immunofluorescence analysis","volume":"7","author":"D Bloemberg","year":"2012","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ana.410320517","article-title":"Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene","volume":"32","author":"M Doyu","year":"1992","journal-title":"Ann Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1474-4422(10)70182-4","article-title":"Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"9","author":"M Katsuno","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(10)70321-5","article-title":"Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial","volume":"10","author":"LE Fern\u00e1ndez-Rhodes","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1093\/brain\/aws170","article-title":"Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy","volume":"135","author":"A Hashizume","year":"2012","journal-title":"Brain"},{"key":"ref20","first-page":"9S","article-title":"The Peak Flow Working Group: the definition of peak expiratory flow","volume":"24","author":"OF Pedersen","year":"1997","journal-title":"Eur Respir J Suppl"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature00904","article-title":"Transcriptional co-activator PGC-1\u03b1 drives the formation of slow-twitch muscle fibres","volume":"418","author":"J Lin","year":"2002","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1371\/journal.pbio.0020294","article-title":"Regulation of muscle fiber type and running endurance by PPARdelta","volume":"2","author":"YX Wang","year":"2004","journal-title":"PLoS Biol"},{"key":"ref23","first-page":"427","article-title":"The value of cough peak flow in the assessment of cough efficacy in neuromuscular patients. A cross sectional study","volume":"50","author":"P Tzani","year":"2014","journal-title":"Eur J Phys Rehabil Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/j.2040-4603.2013.tb00531.x","article-title":"Mechanical properties of respiratory muscles","volume":"3","author":"GC Sieck","year":"2013","journal-title":"Compr Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/ije\/dyt079","article-title":"Peak flow as a predictor of cause-specific mortality in China: results from a 15-year prospective study of ~170,000 men","volume":"42","author":"M Smith","year":"2013","journal-title":"Int J Epidemiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ppul.23172","article-title":"Characterization of pulmonary function in Duchenne Muscular Dystrophy","volume":"50","author":"OH Mayer","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.sc.3100370","article-title":"Cough in spinal cord injured patients: the relationship between motor level and peak expiratory flow","volume":"35","author":"AY Wang","year":"1997","journal-title":"Spinal Cord"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1212\/WNL.0000000000000507","article-title":"Correlation of clinical and molecular features in spinal bulbar muscular atrophy","volume":"82","author":"P Fratta","year":"2014","journal-title":"Neurology"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"C1723","DOI":"10.1152\/ajpcell.1994.267.6.C1723","article-title":"Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle","volume":"267","author":"V Smerdu","year":"1994","journal-title":"Am J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"S Schiaffino","year":"2011","journal-title":"Physiol Rev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/mus.23813","article-title":"Androgen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy","volume":"47","author":"K Oki","year":"2013","journal-title":"Muscle Nerve"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1152\/japplphysiol.00886.2014","article-title":"Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy","volume":"118","author":"K Oki","year":"2015","journal-title":"J Appl Physiol (1985)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00401-016-1550-4","article-title":"Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet","volume":"132","author":"A Rocchi","year":"2016","journal-title":"Acta Neuropathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.2337\/db07-0255","article-title":"Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift","volume":"56","author":"KS R\u00f6ckl","year":"2007","journal-title":"Diabetes"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/hmg\/ddn310","article-title":"Mitochondrial abnormalities in spinal and bulbar muscular atrophy","volume":"18","author":"S Ranganathan","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jcp.24494","article-title":"The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells","volume":"229","author":"M Shen","year":"2014","journal-title":"J Cell Physiol"},{"key":"ref37","first-page":"3893","article-title":"A comprehensive endocrine description of Kennedy's disease revealing androgen insensitivity linked to CAG repeat length","volume":"87","author":"S Dejager","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1152\/japplphysiol.01122.2012","article-title":"Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and\/or IIb fibers","volume":"114","author":"CB Mantilla","year":"2013","journal-title":"J Appl Physiol (1985)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1365-2990.2008.00950.x","article-title":"Childhood spinal muscular atrophy induces alterations in contractile and regulatory protein isoform expressions","volume":"34","author":"L Stevens","year":"2008","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T04:30:18Z","timestamp":1749875418000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168846"}},"subtitle":[],"editor":[{"given":"Yoshitaka","family":"Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168846","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}