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Meeting, Montreal, 2011, p. 3285."},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1137\/0914036","article-title":"On Row Relaxation Methods for Large Constrained Least Squares Problems","volume":"14","author":"A Dax","year":"1993","journal-title":"SIAM Journal on Scientific Computing"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"McAuliffe MJ, Lalonde FM, McGarry D, Gandler W, Csaky K, Trus BL, editors. Medical Image Processing, Analysis and Visualization in clinical research. 14th IEEE Symp. 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