{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:51:55Z","timestamp":1789678315913,"version":"4.0.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health of the United States","award":["A135969 and K01TW000001"],"award-info":[{"award-number":["A135969 and K01TW000001"]}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["176W009"],"award-info":[{"award-number":["176W009"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["55000632"],"award-info":[{"award-number":["55000632"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Mexican Council of Science and Technology","award":["SALUD 2003-C01-132, SEP-2004-C01-47499\/A1, FOSSIS 2005-03 (15203], FOSSIS 2005-2 14475, SALUD-2008-C01-87332, SALUD-2010-01-140178]"],"award-info":[{"award-number":["SALUD 2003-C01-132, SEP-2004-C01-47499\/A1, FOSSIS 2005-03 (15203], FOSSIS 2005-2 14475, SALUD-2008-C01-87332, SALUD-2010-01-140178]"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0168955","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T21:46:45Z","timestamp":1483998405000},"page":"e0168955","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Isoniazid Mono-Resistant Tuberculosis: Impact on Treatment Outcome and Survival of Pulmonary Tuberculosis Patients in Southern Mexico 1995-2010"],"prefix":"10.1371","volume":"11","author":[{"given":"Renata","family":"B\u00e1ez-Salda\u00f1a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Delgado-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Pablo","family":"Cruz-Hervert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Montesinos-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Ferreyra-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bobadilla-del-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Canizales-Quintero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ferreira-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"T\u00e9llez-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Montero-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Yanes-Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Mongua-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Areli","family":"Mart\u00ednez-Gamboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Sifuentes-Osornio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ponce-de-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Global tuberculosis report 2016. [Accessed November 2016]. Available in URL: http:\/\/reliefweb.int\/sites\/reliefweb.int\/files\/resources\/gtbr2016_main_text.pdf<\/ext-link>."},{"key":"ref2","unstructured":"Wright A, Zignol M. WHO\/IUATLD. Anti-tuberculosis Drug Resistance in the world: fourth global report.2002-2007. Geneva, Switzerland: World Health Organization; 2008. [Accessed November 2016]. Available URL: http:\/\/www.who.int\/tb\/publications\/2008\/drs_report4_26feb08.pdf<\/ext-link>."},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.5588\/ijtld.12.0167","article-title":"Drug resistance in Mexico: results from the National Survey on Drug-Resistant Tuberculosis","volume":"17","author":"I Bojorquez-Chapela","year":"2013","journal-title":"The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease"},{"issue":"Pt 1","key":"ref4","first-page":"700","article-title":"Controlled trial of 2, 4, and 6 months of pyrazinamide in 6-month, three-times-weekly regimens for smear-positive pulmonary tuberculosis, including an assessment of a combined preparation of isoniazid, rifampin, and pyrazinamide. Results at 30 months. Hong Kong Chest Service\/British Medical Research Council","volume":"143","year":"1991","journal-title":"Am Rev Respir Dis"},{"issue":"19","key":"ref5","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1001\/jama.283.19.2537","article-title":"Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries","volume":"283","author":"MA Espinal","year":"2000","journal-title":"Jama"},{"key":"ref6","unstructured":"WHO Treatment guidelines for drug resistant tuberculosis. 2016 update.[Accessed November, 2016]. Available in URL http:\/\/www.who.int\/tb\/MDRTBguidelines2016.pdf<\/ext-link>."},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1086\/595689","article-title":"Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis","volume":"48","author":"A Cattamanchi","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cmi.2014.08.008","article-title":"Treatment outcome of patients with isoniazid mono-resistant tuberculosis","volume":"21","author":"JY Chien","year":"2015","journal-title":"Clin Microbiol Infect"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e1000150","DOI":"10.1371\/journal.pmed.1000150","article-title":"Standardized treatment of active tuberculosis in patients with previous treatment and\/or with mono-resistance to isoniazid: a systematic review and meta-analysis","volume":"6","author":"D Menzies","year":"2009","journal-title":"PLoS Med"},{"issue":"3","key":"ref10","first-page":"423","article-title":"Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis","volume":"133","author":"DA Mitchison","year":"1986","journal-title":"Am Rev Respir Dis"},{"issue":"9466","key":"ref11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0140-6736(05)74812-1","article-title":"Does DOTS work in populations with drug-resistant tuberculosis?","volume":"365","author":"K DeRiemer","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"ref12","first-page":"630","article-title":"Clinical consequences and transmissibility of drug-resistant tuberculosis in southern Mexico","volume":"160","author":"ML Garcia-Garcia","year":"2000","journal-title":"Archives of internal medicine"},{"issue":"1","key":"ref13","first-page":"12","article-title":"The role of core groups in transmitting Mycobacterium tuberculosis in a high prevalence community in Southern Mexico","volume":"4","author":"M Garcia-Garcia","year":"2000","journal-title":"The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/thoraxjnl-2012-201756","article-title":"Association of diabetes and tuberculosis: impact on treatment and post-treatment outcomes","volume":"68","author":"ME Jimenez-Corona","year":"2013","journal-title":"Thorax"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/thx.2005.049452","article-title":"Gender differentials of pulmonary tuberculosis transmission and reactivation in an endemic area","volume":"61","author":"ME Jimenez-Corona","year":"2006","journal-title":"Thorax"},{"key":"ref16","unstructured":""Modificaci\u00f3n a la Norma Oficial Mexicana NOM 006-SSA-1993, para la prevenci\u00f3n y control de la tuberculosis en la atenci\u00f3n primaria a la salud". Norma Oficial Mexicana NOM-006-SSA-1993. Diario Oficial de la Federaci\u00f3n, 31 de enero de 2005."},{"key":"ref17","unstructured":""Modificaci\u00f3n a la Norma Oficial Mexicana NOM 006-SSA-1993, para la prevenci\u00f3n y control de la tuberculosis en la atenci\u00f3n primaria a la salud". Norma Oficial Mexicana NOM-006-SSA-1993. Diario Oficial de la Federaci\u00f3n, 18 de Agosto de 2000."},{"issue":"3","key":"ref18","first-page":"213","article-title":"Revised international definitions in tuberculosis control","volume":"5","year":"2001","journal-title":"The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease"},{"key":"ref19","unstructured":"Instituto Nacional de Estad\u00edstica, Geograf\u00eda, e Inform\u00e1tica (INEGI). Censo de poblaci\u00f3n y vivienda 2010-Glosario. [Accessed Noviembre 2016]. Available in URL: http:\/\/www.beta.inegi.org.mx\/app\/glosario\/default.html?p=ENVI2014<\/ext-link>."},{"key":"ref20","unstructured":"Secretar\u00eda de Salud. Encuesta Nacional de Adicciones 2008. M\u00e9xico 2009 [Accessed Noviembre 2016]. Available in URL: http:\/\/www.conadic.salud.gob.mx\/pdfs\/ena08\/ENA08_NACIONAL.pdf<\/ext-link>."},{"key":"ref21","unstructured":""Modificacion a la Norma Oficial Mexicana NOM-015-SSA2-1994, Para la prevenci\u00f3n, tratamiento y control de la diabetes mellitus en la atenci\u00f3n primaria" Norma Oficial Mexicana NOM-015-SSA2-1994, Para la prevenci\u00f3n, tratamiento y control de la diabetes: Secretaria de Salud, Diario Oficial de la Federaci\u00f3n, Mexico, 2001."},{"key":"ref22","unstructured":"World Health Organization. Guidance on provider-initiated HIV testing and counselling in health facilities. 2007. [Accessed July, 2015]. Available URL: http:\/\/www.who.int\/hiv\/pub\/guidelines\/9789241595568_en.pdf<\/ext-link>."},{"key":"ref23","first-page":"472","article-title":"Manual of Clinical Microbiology","volume":"1","author":"G Pfyffer","year":"2011"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/JCM.40.1.150-154.2002","article-title":"Multicenter evaluation of fully automated BACTEC Mycobacteria Growth Indicator Tube 960 system for susceptibility testing of Mycobacterium tuberculosis","volume":"40","author":"P Bemer","year":"2002","journal-title":"Journal of clinical microbiology"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1128\/JCM.39.7.2453-2457.2001","article-title":"Comparison of variable number tandem repeat and IS6110-restriction fragment length polymorphism analyses for discrimination of high- and low-copy-number IS6110 Mycobacterium tuberculosis isolates","volume":"39","author":"RE Barlow","year":"2001","journal-title":"Journal of clinical microbiology"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1128\/CMR.00061-05","article-title":"Molecular epidemiology of tuberculosis: current insights","volume":"19","author":"B Mathema","year":"2006","journal-title":"Clinical microbiology reviews"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"e50551","DOI":"10.1371\/journal.pone.0050551","article-title":"High isoniazid resistance rates in rifampicin susceptible Mycobacterium tuberculosis pulmonary isolates from Pakistan","volume":"7","author":"N Fasih","year":"2012","journal-title":"PloS one"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4067\/S0716-10182015000500002","article-title":"Primary resistance to anti tuberculosis drugs in Chile 2011\u20132012","volume":"32","author":"F Arias","year":"2015","journal-title":"Revista chilena de infectologia: organo oficial de la Sociedad Chilena de Infectologia"},{"issue":"6","key":"ref29","first-page":"745","article-title":"First national survey of Mycobacterium tuberculosis drug resistance, Madagascar, 2005\u20132006","volume":"14","author":"H Ramarokoto","year":"2010","journal-title":"The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jinf.2010.03.017","article-title":"Isoniazid-resistant tuberculosis in Denmark: mutations, transmission and treatment outcome","volume":"60","author":"D Bang","year":"2010","journal-title":"The Journal of infection"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874285801408010001","article-title":"A retrospective analysis of isoniazid-monoresistant tuberculosis: among Iranian pulmonary tuberculosis patients","volume":"8","author":"M Varahram","year":"2013","journal-title":"The open microbiology journal"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10096-011-1167-4","article-title":"Comparison of isoniazid monoresistant tuberculosis with drug-susceptible tuberculosis and multidrug-resistant tuberculosis","volume":"30","author":"L Fox","year":"2011","journal-title":"European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1756-0500-5-225","article-title":"Relatively low primary drug resistant tuberculosis in southwestern Ethiopia","volume":"5","author":"G Abebe","year":"2012","journal-title":"BMC research notes"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"e0152933","DOI":"10.1371\/journal.pone.0152933","article-title":"Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru","volume":"11","author":"L Villegas","year":"2016","journal-title":"PloS one"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"e86316","DOI":"10.1371\/journal.pone.0086316","article-title":"Clinical characteristics and treatment outcomes of patients with low- and high-concentration isoniazid-monoresistant tuberculosis","volume":"9","author":"TY Wang","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.21149\/spm.v57i2.7414","article-title":"Primary drug resistance in a region with high burden of tuberculosis. A critical problem","volume":"57","author":"C Villa-Rosas","year":"2015","journal-title":"Salud Publica Mex"},{"issue":"13","key":"ref37","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.13.19830-en","article-title":"Large outbreak of isoniazid-monoresistant tuberculosis in London, 1995 to 2006: case-control study and recommendations","volume":"16","author":"H Maguire","year":"2011","journal-title":"Euro Surveill"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0002-9343(96)00402-0","article-title":"Nonadherence in tuberculosis treatment: predictors and consequences in New York City","volume":"102","author":"A Pablos-Mendez","year":"1997","journal-title":"The American journal of medicine"},{"key":"ref39","unstructured":"World Health Organization. Framework of indicators and targets for laboratory strengthening under the End TB Strategy.2016. [Accessed on November, 2016]. Available in URL: http:\/\/apps.who.int\/iris\/bitstream\/10665\/250307\/1\/9789241511438-eng.pdf<\/ext-link>."},{"key":"ref40","unstructured":"World Health Organization. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB\/RIF assay for the diagnosis of pulmonary and extra-pulmonary TB in adults and children. Policy update.2013. [Accessed November, 2016]. Available in URL: http:\/\/apps.who.int\/iris\/bitstream\/10665\/112472\/1\/9789241506335_eng.pdf<\/ext-link>."},{"key":"ref41","unstructured":"UNAIDS. HIV and AIDS estimates 2015. M\u00e9xico. [Accessed on December 2016]. Available URL: http:\/\/www.unaids.org\/en\/regionscountries\/countries\/mexico<\/ext-link>."},{"key":"ref42","unstructured":"DGE, INDRE, RLSP. Lineamientos para la vigilancia epidemiol\u00f3gica de la tuberculosis por laboratorio. 1 ed. 1, editor. M\u00e9xico, D. F.2015. [Accessed December 2016]. Available on URL: https:\/\/www.google.com.mx\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=0ahUKEwiy1ZXQ19_QAhVox1QKHZb0BkYQFgg0MAQ&url=https%3A%2F%2Fwww.gob.mx%2Fcms%2Fuploads%2Fattachment%2Ffile%2F66202%2FLineamientos_para_vigilancia_por_laboratorio_de_tuberculosis.pdf&usg=AFQjCNEezhmQolZIRxrSLKXxkV2pnfi5pw&sig2=RGqF7Xt2KWRctPy-3iLrkA<\/ext-link>."},{"issue":"7","key":"ref43","first-page":"631","article-title":"Drug resistance among failure and relapse cases of tuberculosis: is the standard re-treatment regimen adequate","volume":"7","author":"HT Quy","year":"2003","journal-title":"Drug resistance among failure and relapse cases of tuberculosis: is the standard re-treatment regimen adequate"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1086\/517536","article-title":"Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance","volume":"44","author":"HS Cox","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1086\/425005","article-title":"The effect of initial drug resistance on treatment response and acquired drug resistance during standardized short-course chemotherapy for tuberculosis","volume":"39","author":"KJ Seung","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/ageing\/afs028","article-title":"Tuberculosis in ageing: high rates, complex diagnosis and poor clinical outcomes","volume":"41","author":"LP Cruz-Hervert","year":"2012","journal-title":"Age and ageing"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3201\/eid0811.020021","article-title":"Tuberculosis-related deaths within a well-functioning DOTS control program","volume":"8","author":"L Garcia-Garcia Mde","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"ref48","first-page":"129","article-title":"Treatment of drug-resistant tuberculosis","volume":"4","author":"L Pinto","year":"2011","journal-title":"Infect Drug Resist"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0168955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T02:36:02Z","timestamp":1658370962000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0168955"}},"subtitle":[],"editor":[{"given":"Madhukar","family":"Pai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0168955","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}