{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:31:42Z","timestamp":1790728302041,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH grant","award":["1RO1DK109408-01A1"],"award-info":[{"award-number":["1RO1DK109408-01A1"]}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR130106"],"award-info":[{"award-number":["PR130106"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169137","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T14:05:57Z","timestamp":1484229957000},"page":"e0169137","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study"],"prefix":"10.1371","volume":"12","author":[{"given":"Masanari","family":"Kuwabara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Hisatome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Roncal-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Andres-Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Bjornstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Milagres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Cicerchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura G.","family":"S\u00e1nchez-Lozada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Lanaspa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1053\/j.ajkd.2013.10.062","article-title":"CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy","volume":"63","author":"R Correa-Rotter","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1053\/j.ajkd.2009.12.012","article-title":"Decreased kidney function of unknown cause in Nicaragua: a community-based survey","volume":"55","author":"C Torres","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"ref3","article-title":"Climate Change and the Emergent Epidemic of Chronic Kidney Disease from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy","author":"J Glaser","year":"2016","journal-title":"CJASN"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/j.ajkd.2015.08.021","article-title":"Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy","volume":"67","author":"C Roncal-Jimenez","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ki.2013.492","article-title":"Fructokinase activity mediates dehydration-induced renal injury","volume":"86","author":"CA Roncal Jimenez","year":"2014","journal-title":"Kidney international"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1152\/ajpregu.00354.2015","article-title":"Rehydration with Soft Drink-like Beverages Exacerbates Dehydration and Worsens Dehydration-associated Renal Injury","volume":"311","author":"FE Garc\u00eda-Arroyo","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrneph.2014.76","article-title":"Hyperosmolarity drives hypertension and CKD\u2014water and salt revisited","volume":"10","author":"RJ Johnson","year":"2014","journal-title":"Nature reviews Nephrology"},{"key":"ref8","article-title":"Metabolic and kidney diseases in the setting of climate change, water shortage, and survival factors","author":"RJ Johnson","year":"2016","journal-title":"JASN"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1440-1797.2010.01415.x","article-title":"Fluid and nutrient intake and risk of chronic kidney disease","volume":"16","author":"GF Strippoli","year":"2011","journal-title":"Nephrology (Carlton)"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.2215\/CJN.01990211","article-title":"Urine volume and change in estimated GFR in a community-based cohort study","volume":"6","author":"WF Clark","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000445959","article-title":"Hydration and Chronic Kidney Disease Progression: A Critical Review of the Evidence","volume":"43","author":"WF Clark","year":"2016","journal-title":"Am J Nephrol"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000350377","article-title":"Association between Water Intake, Chronic Kidney Disease, and Cardiovascular Disease: A Cross-Sectional Analysis of NHANES Data","volume":"37","author":"JM Sontrop","year":"2013","journal-title":"Am J Nephrol"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/ndt\/gft507","article-title":"Fluid intake and all-cause mortality, cardiovascular mortality and kidney function: a population-based longitudinal cohort study","volume":"29","author":"SC Palmer","year":"2014","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0272-6386(03)00193-8","article-title":"High urine volume and low urine osmolality are risk factors for faster progression of renal disease","volume":"41","author":"LA Hebert","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"ref15","first-page":"F973","article-title":"Effect of water intake on the progression of chronic renal failure in the 5\/6 nephrectomized rat","volume":"258","author":"N Bouby","year":"1990","journal-title":"Am J Physiol"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"S Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1080\/15257770.2011.596496","article-title":"Japanese guideline for the management of hyperuricemia and gout: second edition","volume":"30","author":"H Yamanaka","year":"2011","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/clinchem\/30.10.1703","article-title":"Calculated vs measured plasma osmolalities revisited","volume":"30","author":"CI Bhagat","year":"1984","journal-title":"Clin Chem"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2008060576","article-title":"Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells","volume":"20","author":"P Cirillo","year":"2009","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/oby.20026","article-title":"Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology","volume":"21","author":"RJ Johnson","year":"2013","journal-title":"Obesity"},{"issue":"16","key":"ref21","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.106.685503","article-title":"C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study","volume":"115","author":"SQ Khan","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/TP.0b013e3181b11ae4","article-title":"Copeptin, a surrogate marker of vasopressin, is associated with accelerated renal function decline in renal transplant recipients","volume":"88","author":"E Meijer","year":"2009","journal-title":"Transplantation"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ki.2009.397","article-title":"Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort","volume":"77","author":"E Meijer","year":"2010","journal-title":"Kidney international"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ijo.2012.88","article-title":"Copeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malmo Diet and Cancer Study cardiovascular cohort","volume":"37","author":"S Enhorning","year":"2013","journal-title":"International journal of obesity"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nrneph.2013.22","article-title":"Vasopressin: a novel target for the prevention and retardation of kidney disease?","volume":"9","author":"L Bankir","year":"2013","journal-title":"Nature reviews Nephrology"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/ndt\/18.3.497","article-title":"Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin-angiotensin system","volume":"18","author":"P Bardoux","year":"2003","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1179\/2049396714Y.0000000102","article-title":"Changes in kidney function among Nicaraguan sugarcane workers","volume":"21","author":"RL Laws","year":"2015","journal-title":"International journal of occupational and environmental health"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.ajkd.2015.08.022","article-title":"Biomarkers of Kidney Injury Among Nicaraguan Sugarcane Workers","volume":"67","author":"RL Laws","year":"2016","journal-title":"American journal of kidney diseases: the official journal of the National Kidney Foundation"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.envres.2015.07.007","article-title":"Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador\u2014A cross-shift study of workers at risk of Mesoamerican nephropathy","volume":"142","author":"R Garcia-Trabanino","year":"2015","journal-title":"Environmental research"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"e003666","DOI":"10.1136\/bmjopen-2013-003666","article-title":"The chronic kidney disease Water Intake Trial (WIT): results from the pilot randomised controlled trial","volume":"3","author":"WF Clark","year":"2013","journal-title":"BMJ open"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.ki.5002017","article-title":"Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study","volume":"71","author":"K Yamagata","year":"2007","journal-title":"Kidney international"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1097\/01.ASN.0000095249.99803.85","article-title":"Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland","volume":"14","author":"MK Haroun","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1592\/phco.23.10.1085.32751","article-title":"Osmolality and osmolarity: narrowing the terminology gap","volume":"23","author":"BL Erstad","year":"2003","journal-title":"Pharmacotherapy"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ki.2011.369","article-title":"Dietary salt influences postprandial plasma sodium concentration and systolic blood pressure","volume":"81","author":"RJ Suckling","year":"2012","journal-title":"Kidney international"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0197941","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T19:09:18Z","timestamp":1601320158000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169137"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Remuzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169137","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}