{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:20:37Z","timestamp":1763202037420,"version":"3.37.3"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["ZCSPP100ANL07T"],"award-info":[{"award-number":["ZCSPP100ANL07T"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169258","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T18:24:16Z","timestamp":1485282256000},"page":"e0169258","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Direct Renin Blockade on Renal &amp; Systemic Hemodynamics and on RAAS Activity, in Weight Excess and Hypertension: A Randomized Clinical Trial"],"prefix":"10.1371","volume":"12","author":[{"given":"A. J.","family":"Kwakernaak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Roksnoer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Lambers Heerspink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"van den Berg-Garrelds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Lochorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"van Embden Andres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Klijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kobori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H. J.","family":"Danser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D.","family":"Laverman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Navis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.295.13.1549","article-title":"Prevalence of overweight and obesity in the United States, 1999\u20132004","volume":"295","author":"CL Ogden","year":"2006","journal-title":"JAMA"},{"key":"ref2","unstructured":"International Obesity Task Force EU Platform Briefing Paper; prepared in collaboration with the European Association for the Study of Obesity; March 15 2005 Brussels."},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1001\/archinte.162.16.1867","article-title":"Overweight and obesity as determinants of cardiovascular risk: the Framingham experience","volume":"162","author":"PW Wilson","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1056\/NEJM199910073411501","article-title":"Body-mass index and mortality in a prospective cohort of U.S. adults","volume":"341","author":"EE Calle","year":"1999","journal-title":"N Engl J Med"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1681\/ASN.2005060638","article-title":"Obesity and risk for chronic renal failure","volume":"17","author":"E Ejerblad","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM199601043340103","article-title":"Blood pressure and end-stage renal disease in men","volume":"334","author":"MJ Klag","year":"1996","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"S Lewington","year":"2002","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1161\/01.HYP.26.4.610","article-title":"Combined renal effects of overweight and hypertension","volume":"26","author":"J Ribstein","year":"1995","journal-title":"Hypertension"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/01.ASN.0000046029.53933.09","article-title":"Insulin resistance and risk of chronic kidney disease in nondiabetic US adults","volume":"14","author":"J Chen","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archinte.1981.00340010073016","article-title":"Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity","volume":"141","author":"FH Messerli","year":"1981","journal-title":"Arch Intern Med"},{"key":"ref11","first-page":"228","article-title":"Effects of enalaprilic acid on sodium excretion and renal hemodynamics in essential hypertension","volume":"1","author":"G Navis","year":"1985","journal-title":"J Clin Hypertens"},{"journal-title":"Nephrol Dial Transplant","article-title":"Body mass index and body fat distribution as renal risk fctors: a focus on the role of renl hemodynamics","author":"AJ Kwakernaak","key":"ref12"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ki.1983.72","article-title":"Hemodynamically mediated glomerular injury and the progressive nature of kidney disease","volume":"23","author":"BM Brenner","year":"1983","journal-title":"Kidney Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1600-6143.2006.01672.x","article-title":"Body mass index and glomerular hyperfiltration in renal transplant recipients: cross-sectional analysis and long-term impact","volume":"7","author":"RJ Bosma","year":"2007","journal-title":"Am J Transplant"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/clpt.1994.190","article-title":"Discordant effects of enalapril and lisinopril on systemic and renal hemodynamics","volume":"56","author":"AJ Apperloo","year":"1994","journal-title":"Clin Pharmacol Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0140-6736(96)11445-8","article-title":"Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia)","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1161\/01.HYP.0000190819.07663.da","article-title":"Body mass index and angiotensin-dependent control of the renal circulation in healthy humans","volume":"46","author":"SB Ahmed","year":"2005","journal-title":"Hypertension"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.HYP.23.1.44","article-title":"Responses to converting enzyme and renin inhibition. Role of angiotensin II in humans","volume":"23","author":"ND Fisher","year":"1994","journal-title":"Hypertension"},{"key":"ref19","first-page":"151","article-title":"1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee","volume":"17","year":"1999","journal-title":"J Hypertens"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1681\/ASN.V74567","article-title":"Precision of glomerular filtration rate determinations for long-term slope calculations is improved by simultaneous infusion of 125I-iothalamate and 131I-hippuran","volume":"7","author":"AJ Apperloo","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"ref21","first-page":"97","article-title":"A radioisotope method for simultaneous determination of the glomerular filtration rate and the effective renal plasma flow","volume":"20","author":"AJ Donker","year":"1977","journal-title":"Neth J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.2215\/CJN.05501207","article-title":"Feasibility and impact of the measurement of extracellular fluid volume simultaneous with GFR by <sup>125<\/sup>I-iothalamate","volume":"3","author":"FW Visser","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref23","first-page":"303","article-title":"A formula to estimate the approximate surface area if height and weight be known. 1916","volume":"5","author":"D DuBois","year":"1989","journal-title":"Nutrition"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1161\/CIRCULATIONAHA.108.767202","article-title":"Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans","volume":"117","author":"ND Fisher","year":"2008","journal-title":"Circulation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0009-9236(95)90160-4","article-title":"Renal vascular responses to renin inhibition with zankiren in men","volume":"57","author":"ND Fisher","year":"1995","journal-title":"Clin Pharmacol Ther"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1046\/j.1365-2362.1999.00573.x","article-title":"Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension","volume":"29","author":"P van Paassen","year":"1999","journal-title":"Eur J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1681\/ASN.V11101813","article-title":"Renin inhibition improves pressure natriuresis in essential hypertension","volume":"11","author":"P van Paassen","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00005344-199507000-00007","article-title":"Renal and systemic effects of the renin inhibitor remikiren in patients with essential hypertension","volume":"26","author":"P van Paasen","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/ndt\/15.5.637","article-title":"Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function","volume":"15","author":"P van Paassen","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2337\/dc09-1303","article-title":"Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study","volume":"33","author":"DZ Cherney","year":"2010","journal-title":"Diabetes Care"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/HYPERTENSIONAHA.106.084301","article-title":"Direct Renin inhibition with aliskiren in obese patients with arterial hypertension","volume":"49","author":"J Jordan","year":"2007","journal-title":"Hypertension"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.amjhyper.2006.06.003","article-title":"Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan","volume":"20","author":"JL Pool","year":"2007","journal-title":"Am J Hypertens"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/HJH.0b013e32832be593","article-title":"Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, double-blind trial","volume":"27","author":"RE Schmieder","year":"2009","journal-title":"J Hypertens"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/01.CIR.0000156466.02908.ED","article-title":"Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients","volume":"111","author":"AH Gradman","year":"2005","journal-title":"Circulation"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1161\/01.HYP.0000101688.17370.87","article-title":"Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren","volume":"42","author":"A Stanton","year":"2003","journal-title":"Hypertension"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/HJH.0b013e3282f3ad9a","article-title":"Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial","volume":"26","author":"K Andersen","year":"2008","journal-title":"J Hypertens"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF03256921","article-title":"Long-term safety and tolerability of the oral direct renin inhibitor aliskiren with optional add-on hydrochlorothiazide in patients with hypertension: a randomized, open-label, parallel-group, multicentre, dose-escalation study with an extension phase","volume":"31","author":"D Sica","year":"2011","journal-title":"Clin Drug Investig"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1161\/HYPERTENSIONAHA.115.07012","article-title":"On the Origin of Urinary Renin: A Translational Approach","volume":"67","author":"LC Roksnoer","year":"2016","journal-title":"Hypertension"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/01.HYP.0000135678.20725.54","article-title":"Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats","volume":"44","author":"MC Prieto-Carrasquero","year":"2004","journal-title":"Hypertension"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"F632","DOI":"10.1152\/ajprenal.00462.2004","article-title":"AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats","volume":"289","author":"MC Prieto-Carrasquero","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1681\/ASN.2009030300","article-title":"The biology of the (pro)renin receptor","volume":"21","author":"G Nguyen","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/ATVBAHA.108.164210","article-title":"Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells","volume":"28","author":"WW Batenburg","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/HYPERTENSIONAHA.111.180737","article-title":"Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?","volume":"58","author":"WW Batenburg","year":"2011","journal-title":"Hypertension"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/CS20120042","article-title":"(Pro)renin and its receptors: pathophysiological implications","volume":"123","author":"WW Batenburg","year":"2012","journal-title":"Clin Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/CIRCRESAHA.110.224667","article-title":"The (pro)renin receptor\/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes","volume":"107","author":"K Kinouchi","year":"2010","journal-title":"Circ Res"},{"key":"ref46","article-title":"Renal Atp6ap2\/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System","author":"F Trepiccione","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"ref47","first-page":"222","article-title":"Low-Density Lipoprotein Metabolism","volume":"118","author":"X Lu","year":"2016","journal-title":"Circ Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/ajh\/hpv045","article-title":"The Role of the (Pro)renin Receptor in Hypertensive Disease","volume":"28","author":"AH Danser","year":"2015","journal-title":"Am J Hypertens"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1097\/HJH.0b013e32834bbcbf","article-title":"Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney","volume":"29","author":"M van den Heuvel","year":"2011","journal-title":"J Hypertens"},{"key":"ref50","first-page":"108","article-title":"Urinary Angiotensinogen as a Novel Biomarker of Intrarenal Renin-Angiotensin System in Chronic Kidney Disease","volume":"6","author":"H Kobori","year":"2011","journal-title":"Int Rev Thromb"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1097\/HJH.0b013e328362217c","article-title":"Urinary renin and angiotensinogen in type 2 diabetes: added value beyond urinary albumin?","volume":"31","author":"F Persson","year":"2013","journal-title":"J Hypertens"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1681\/ASN.2011121159","article-title":"Liver angiotensinogen is the primary source of renal angiotensin II","volume":"23","author":"T Matsusaka","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ki.2013.440","article-title":"Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen","volume":"85","author":"DI Ortiz-Melo","year":"2014","journal-title":"Kidney Int"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3317\/jraas.2007.028","article-title":"Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension","volume":"8","author":"Y Uresin","year":"2007","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/01.HYP.17.4.510","article-title":"Renal and endocrine responses to a renin inhibitor, enalkiren, in normal humans","volume":"17","author":"P Cordero","year":"1991","journal-title":"Hypertension"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/01.hjh.0000202812.72341.99","article-title":"Renin inhibition with aliskiren: where are we now, and where are we going?","volume":"24","author":"M Azizi","year":"2006","journal-title":"J Hypertens"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/HYPERTENSIONAHA.107.108845","article-title":"Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats","volume":"52","author":"DL Feldman","year":"2008","journal-title":"Hypertension"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/HJH.0b013e32834f6b43","article-title":"Aliskiren penetrates adipose and skeletal muscle tissue and reduces renin-angiotensin system activity in obese hypertensive patients","volume":"30","author":"M Boschmann","year":"2012","journal-title":"J Hypertens"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/ki.1987.71","article-title":"Moderate sodium restriction in hypertensive subjects: renal effects of ACE-inhibition","volume":"31","author":"G Navis","year":"1987","journal-title":"Kidney Int"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1046\/j.1523-1755.2003.00239.x","article-title":"Renal hemodynamic and tubular responses to salt in women using oral contraceptives","volume":"64","author":"A Pechere-Bertschi","year":"2003","journal-title":"Kidney Int"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/01.CIR.95.1.39","article-title":"Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women","volume":"95","author":"H Schunkert","year":"1997","journal-title":"Circulation"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T17:51:22Z","timestamp":1658512282000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169258"}},"subtitle":[],"editor":[{"given":"Yoshitaka","family":"Isaka","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169258","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}