{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:30:34Z","timestamp":1773685834678,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RSA5880019"],"award-info":[{"award-number":["RSA5880019"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","award":["RES5829130016"],"award-info":[{"award-number":["RES5829130016"]}],"id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research University Project, Office of Higher Education Commission","award":["NRU59-056-AS"],"award-info":[{"award-number":["NRU59-056-AS"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169306","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T22:21:48Z","timestamp":1484000508000},"page":"e0169306","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between Promoter Hypomethylation and Overexpression of Autotaxin with Outcome Parameters in Biliary Atresia"],"prefix":"10.1371","volume":"12","author":[{"given":"Wanvisa","family":"Udomsinprasert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakarin","family":"Kitkumthorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apiwat","family":"Mutirangura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Voranush","family":"Chongsrisawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Poovorawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sittisak","family":"Honsawek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/hep.21790","article-title":"Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop","volume":"46","author":"RJ Sokol","year":"2007","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","article-title":"Biliary atresia","volume":"374","author":"JL Hartley","year":"2009","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cld.2005.10.001","article-title":"Pathogenesis and treatment opportunities for biliary atresia","volume":"10","author":"C Petersen","year":"2006","journal-title":"Clin Liver Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/SLA.0b013e3182300950","article-title":"The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival","volume":"254","author":"R Superina","year":"2011","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"39436","DOI":"10.1074\/jbc.M205623200","article-title":"Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase","volume":"277","author":"A Tokumura","year":"2002","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200204026","article-title":"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production","volume":"158","author":"M Umezu-Goto","year":"2002","journal-title":"J Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e103532","DOI":"10.1371\/journal.pone.0103532","article-title":"Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis\u2014a prospective cohort study","volume":"25","author":"T Pleli","year":"2014","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2014.03.006","article-title":"Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma","volume":"433","author":"M Kondo","year":"2014","journal-title":"Clin Chim Acta"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"G880","DOI":"10.1152\/ajpgi.00039.2003","article-title":"Involvement of Rho\/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells","volume":"285","author":"H Ikeda","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.cca.2012.07.014","article-title":"Autotaxin in liver fibrosis","volume":"413","author":"H Ikeda","year":"2012","journal-title":"Clin Chim Acta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cca.2011.03.014","article-title":"Autotaxin as a novel serum marker of liver fibrosis","volume":"412","author":"H Nakagawa","year":"2011","journal-title":"Clin Chim Acta"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/01.mcg.0000225642.90898.0e","article-title":"Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C","volume":"41","author":"N Watanabe","year":"2007","journal-title":"J Clin Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/onc.2010.517","article-title":"Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression","volume":"30","author":"SY Park","year":"2011","journal-title":"Oncogene"},{"key":"ref14","first-page":"71","article-title":"Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma","volume":"31","author":"JM Wu","year":"2010","journal-title":"Mol Cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/hep.24106","article-title":"DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia","volume":"53","author":"RP Matthews","year":"2011","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00018-002-8420-z","article-title":"DNA methylation and the regulation of gene transcription","volume":"59","author":"JT Attwood","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/sj.onc.1209950","article-title":"Viral oncoproteins target the DNA methyltransferases","volume":"26","author":"WA Burgers","year":"2007","journal-title":"Oncogene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/hmg\/2.9.1377","article-title":"Modification of 15q11-q13 DNA methylation imprints in unique Angelman and Prader-Willi patients","volume":"2","author":"CC Glenn","year":"1993","journal-title":"Hum Mol Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/art.1780331109","article-title":"Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis","volume":"33","author":"B Richardson","year":"1990","journal-title":"Arthritis Rheum"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1002\/art.25018","article-title":"DNA hypomethylation in rheumatoid arthritis synovial fibroblasts","volume":"60","author":"E Karouzakis","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.bbrc.2011.12.054","article-title":"Abnormal DNA methylation of ITGAL (CD11a) in CD4+ T cells from infants with biliary atresia","volume":"417","author":"R Dong","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1203\/PDR.0b013e318232a949","article-title":"Changes in epigenetic regulation of CD4+ T lymphocytesin biliary atresia","volume":"70","author":"R Dong","year":"2011","journal-title":"Pediatr Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/1354750X.2014.994564","article-title":"Serum autotaxin levels correlate with hepatic dysfunction and severity in postoperative biliary atresia","volume":"20","author":"W Udomsinprasert","year":"2015","journal-title":"Biomarkers"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-4274(95)03486-2","article-title":"A microassay for measuring cytosine DNA methyltransferase activity during tumor progression","volume":"82\u201383","author":"SA Belinsky","year":"1995","journal-title":"Toxicol Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10060","DOI":"10.1073\/pnas.152121799","article-title":"Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis","volume":"99","author":"Y Saito","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cellsig.2012.10.007","article-title":"DNA methylation: new therapeutic implications for hepatic fibrosis","volume":"25","author":"EB Bian","year":"2013","journal-title":"Cell Signal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/bbrc.1998.8983","article-title":"Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture","volume":"248","author":"H Ikeda","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1007\/s11605-007-0322-9","article-title":"Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer?","volume":"11","author":"AB Cooper","year":"2007","journal-title":"J. Gastrointest Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/oby.20960","article-title":"Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity","volume":"23","author":"VP Rachakonda","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/MPG.0000000000001044","article-title":"Serum autotaxin activity correlates with pruritus in pediatric cholestatic disorders","volume":"62","author":"AE Kremer","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"30847","DOI":"10.1038\/srep30847","article-title":"Serum Autotaxin is a Marker of the Severity of Liver Injury and Overall Survival in Patients with Cholestatic Liver Diseases","volume":"6","author":"E Wunsch","year":"2016","journal-title":"Sci Rep"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.canlet.2009.04.029","article-title":"Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells","volume":"284","author":"S Jansen","year":"2009","journal-title":"Cancer Lett"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbrc.2010.09.114","article-title":"Autotaxin: a protein with two faces","volume":"401","author":"M Tania","year":"2010","journal-title":"Biochem Biophys Res Commun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:23:19Z","timestamp":1588994599000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169306"}},"subtitle":[],"editor":[{"given":"Gianfranco D.","family":"Alpini","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,4]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169306","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,4]]}}}