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Canine Lymphomas. 2015; <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/vet.purdue.edu\/pcop\/canine-lymphoma-research.php\" xlink:type=\"simple\">https:\/\/vet.purdue.edu\/pcop\/canine-lymphoma-research.php<\/ext-link>."},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jgm.1100","article-title":"Gene therapy clinical trials worldwide to 2007\u2014an update","volume":"9","author":"ML Edelstein","year":"2007","journal-title":"J Gene Med"},{"issue":"5304","key":"ref5","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"JM Bergelson","year":"1997","journal-title":"Science"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-E","article-title":"Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment","volume":"73","author":"TJ Wickham","year":"1993","journal-title":"Cell"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1128\/JVI.70.7.4502-4508.1996","article-title":"Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells","volume":"70","author":"S Huang","year":"1996","journal-title":"J Virol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cgt.7700174","article-title":"Adenovirus as a gene therapy vector for hematopoietic cells","volume":"7","author":"FC Marini 3rd","year":"2000","journal-title":"Cancer Gene Ther"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.32607\/20758251-2011-3-3-100-106","article-title":"An Efficient Method for the Delivery of the Interleukin-2 Gene to Human Hematopoietic Cells using the Fiber-Modified Recombinant Adenovirus","volume":"3","author":"VN Rogozhin","year":"2011","journal-title":"Acta Naturae"},{"issue":"16","key":"ref10","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1089\/hum.1998.9.16-2363","article-title":"The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures","volume":"9","author":"S Hemmi","year":"1998","journal-title":"Hum Gene Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1476-4598-10-105","article-title":"A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors","volume":"10","author":"E Grellier","year":"2011","journal-title":"Mol Cancer"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4161\/cbt.11.7.14690","article-title":"Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins","volume":"11","author":"AM O'Neill","year":"2011","journal-title":"Cancer Biol Ther"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s11626-007-9060-2","article-title":"Species identification in cell culture: a two-pronged molecular approach","volume":"43","author":"JK Cooper","year":"2007","journal-title":"In vitro cellular & developmental biology Animal"},{"issue":"1","key":"ref14","first-page":"115","article-title":"The polypeptides of adenovirus. 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