{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:59:56Z","timestamp":1787021996303,"version":"build-2736575974"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169743","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T13:42:03Z","timestamp":1484142123000},"page":"e0169743","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combined Inhibition of the Renin-Angiotensin System and Neprilysin Positively Influences Complex Mitochondrial Adaptations in Progressive Experimental Heart Failure"],"prefix":"10.1371","volume":"12","author":[{"given":"Laura","family":"Grois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hupf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Reinders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dietl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Jungbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Resch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars S.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Luchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Birner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,11]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1042\/CS20130294","article-title":"The central renin-angiotensin system and sympathetic nerve activity in chronic heart failure","volume":"126","author":"IH Zucker","year":"2014","journal-title":"Clinical science (London, England: 1979)"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccl.2013.09.010","article-title":"The sympathetic nervous system and heart failure","volume":"32","author":"DY Zhang","year":"2014","journal-title":"Cardiology clinics"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/CIRCRESAHA.113.300308","article-title":"Adrenergic nervous system in heart failure: pathophysiology and therapy","volume":"113","author":"A Lymperopoulos","year":"2013","journal-title":"Circulation research"},{"issue":"9146","key":"ref4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)11181-9","article-title":"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial","volume":"353","year":"1999","journal-title":"Lancet (London, England)"},{"issue":"22","key":"ref5","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJM200105313442201","article-title":"Effect of carvedilol on survival in severe chronic heart failure","volume":"344","author":"M Packer","year":"2001","journal-title":"The New England journal of medicine"},{"issue":"9169","key":"ref6","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure: Metoprolol CR\/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)","volume":"353","year":"1999","journal-title":"Lancet (London, England)"},{"issue":"23","key":"ref7","first-page":"1429","article-title":"Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group","volume":"316","year":"1987","journal-title":"The New England journal of medicine"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","article-title":"Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association","volume":"129","author":"AS Go","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/ejhf.250","article-title":"Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances","volume":"17","author":"JJV McMurray","year":"2015","journal-title":"European journal of heart failure"},{"issue":"1","key":"ref10","first-page":"2","article-title":"Vasopeptidase inhibitors: potential role in the treatment of heart failure","volume":"2","author":"PT RJL Trindade","year":"2001","journal-title":"Heart Fail Monit"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000029801.86489.50","article-title":"Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE)","volume":"106","author":"M Packer","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0735-1097(00)00741-5","article-title":"The clinical, cardiac, renal, arterial and neurohormonal effects of omapatrilat, a vasopeptidase inhibitor, in patients with chronic heart failure","volume":"36","author":"DR McClean","year":"2000","journal-title":"Journal of the American College of Cardiology"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00005344-199912000-00003","article-title":"Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril","volume":"34","author":"NC Trippodo","year":"1999","journal-title":"Journal of cardiovascular pharmacology"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"JJV McMurray","year":"2014","journal-title":"The New England journal of medicine"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00210-012-0791-6","article-title":"Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure","volume":"385","author":"C Birner","year":"2012","journal-title":"Naunyn-Schmiedeberg's archives of pharmacology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10741-007-9079-1","article-title":"Mitochondrial centrality in heart failure","volume":"13","author":"J Mar\u00edn-Garc\u00eda","year":"2008","journal-title":"Heart failure reviews"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cardfail.2012.06.418","article-title":"Proteomic profiling implies mitochondrial dysfunction in tachycardia-induced heart failure","volume":"18","author":"C Birner","year":"2012","journal-title":"Journal of cardiac failure"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/ejhf.122","article-title":"Interatrial differences of basal molecular set-up and changes in tachycardia-induced heart failure-a proteomic profiling study","volume":"16","author":"A Dietl","year":"2014","journal-title":"European journal of heart failure"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1159\/000358645","article-title":"Experimental heart failure induces alterations of the lung proteome\u2014insight into molecular mechanisms","volume":"33","author":"C Birner","year":"2014","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00210-011-0723-x","article-title":"Differential expression of potassium channels and abnormal conduction in experimental tachycardia-induced heart failure","volume":"385","author":"C Birner","year":"2012","journal-title":"Naunyn-Schmiedeberg's archives of pharmacology"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cyto.2007.08.009","article-title":"Head-to-head comparison of BNP and IL-6 as markers of clinical and experimental heart failure: Superiority of BNP","volume":"40","author":"CM Birner","year":"2007","journal-title":"Cytokine"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0008-6363(01)00316-9","article-title":"Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction","volume":"51","author":"A Luchner","year":"2001","journal-title":"Cardiovascular research"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"H977","DOI":"10.1152\/ajpheart.2001.280.3.H977","article-title":"Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart","volume":"280","author":"EA Boehm","year":"2001","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"ref24","unstructured":"Srere PA (1973) [1] Citrate synthase. In: Lowenstein JM, editor. Citric acid cycle. New York: Academic Press. pp. 3\u201311."},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1373\/clinchem.2005.050146","article-title":"Automated spectrophotometric analysis of mitochondrial respiratory chain complex enzyme activities in cultured skin fibroblasts","volume":"51","author":"KA Kramer","year":"2005","journal-title":"Clinical chemistry"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nprot.2011.333","article-title":"Monitoring protein expression in whole-cell extracts by targeted label- and standard-free LC-MS\/MS","volume":"6","author":"K Bluemlein","year":"2011","journal-title":"Nature protocols"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4939-3341-9_8","article-title":"Testing Suitability of Cell Cultures for SILAC-Experiments Using SWATH-Mass Spectrometry","volume":"1394","author":"Y Reinders","year":"2016","journal-title":"Methods in molecular biology (Clifton, N.J.)"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardfail.2004.03.004","article-title":"Dilated versus nondilated cardiomyopathy in the elderly population treated with guideline-based medical therapy for systolic chronic heart failure","volume":"10","author":"G Cioffi","year":"2004","journal-title":"Journal of cardiac failure"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1378\/chest.107.3.680","article-title":"An echocardiographic evaluation of patients with idiopathic heart failure","volume":"107","author":"B Andersson","year":"1995","journal-title":"Chest"},{"issue":"9851","key":"ref30","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0140-6736(12)61227-6","article-title":"The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial","volume":"380","author":"SD Solomon","year":"2012","journal-title":"Lancet (London, England)"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0008-6363(01)00368-6","article-title":"Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure","volume":"52","author":"J Mar\u00edn-Garc\u00eda","year":"2001","journal-title":"Cardiovascular research"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"H1813","DOI":"10.1152\/ajpheart.00036.2004","article-title":"In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure","volume":"287","author":"GW Moe","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.cardfail.2009.04.010","article-title":"Regional distribution of mitochondrial dysfunction and apoptotic remodeling in pacing-induced heart failure","volume":"15","author":"J Mar\u00edn-Garc\u00eda","year":"2009","journal-title":"Journal of cardiac failure"},{"key":"ref34","article-title":"Post-translational modifications of the cardiac proteome in diabetes and heart failure","author":"AR Wende","year":"2015","journal-title":"Proteomics. Clinical applications"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvn184","article-title":"Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation","volume":"80","author":"MG Rosca","year":"2008","journal-title":"Cardiovascular research"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"T Doenst","year":"2013","journal-title":"Circulation research"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/CIRCIMAGING.114.001857","article-title":"Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy","volume":"7","author":"MS Dodd","year":"2014","journal-title":"Circulation. Cardiovascular imaging"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","article-title":"Oxidative stress and heart failure","volume":"301","author":"H Tsutsui","year":"2011","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ajmg.a.35714","article-title":"Complex II deficiency\u2014a case report and review of the literature","volume":"161A","author":"S Jain-Ghai","year":"2013","journal-title":"American journal of medical genetics. Part A"},{"issue":"3","key":"ref40","first-page":"487","article-title":"A point mutation in the cytb gene of cardiac mtDNA associated with complex III deficiency in ischemic cardiomyopathy","volume":"40","author":"J Marin-Garcia","year":"1996","journal-title":"Biochemistry and molecular biology international"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/CIRCGENETICS.109.871236","article-title":"Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts","volume":"3","author":"G Agnetti","year":"2010","journal-title":"Circulation. Cardiovascular genetics"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"E243","DOI":"10.1152\/ajpendo.00044.2013","article-title":"Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice","volume":"305","author":"VW Dolinsky","year":"2013","journal-title":"American journal of physiology. Endocrinology and metabolism"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yjmcc.2013.01.016","article-title":"Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure","volume":"59","author":"EN Dedkova","year":"2013","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCGENETICS.113.000404","article-title":"Mechanical unloading promotes myocardial energy recovery in human heart failure","volume":"7","author":"AA Gupte","year":"2014","journal-title":"Circulation. Cardiovascular genetics"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"H2098","DOI":"10.1152\/ajpheart.00471.2008","article-title":"Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure","volume":"295","author":"K Qanud","year":"2008","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2353\/ajpath.2006.050137","article-title":"Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor","volume":"168","author":"S Miyata","year":"2006","journal-title":"The American journal of pathology"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s10517-008-0287-z","article-title":"Ultrastructural signs of cyclophosphamide-induced damage to cardiomyocytes","volume":"146","author":"EL Lushnikova","year":"2008","journal-title":"Bulletin of experimental biology and medicine"},{"key":"ref48","author":"CJ Duncan","year":"1991"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2012.04.006","article-title":"Lipid metabolism and toxicity in the heart","volume":"15","author":"IJ Goldberg","year":"2012","journal-title":"Cell metabolism"},{"issue":"4","key":"ref50","first-page":"385","article-title":"Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management","volume":"40","author":"DE Meyers","year":"2013","journal-title":"Texas Heart Institute journal \/ from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/ejhf.76","article-title":"Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial","volume":"16","author":"PS Jhund","year":"2014","journal-title":"European journal of heart failure"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T07:57:33Z","timestamp":1568707053000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169743"}},"subtitle":[],"editor":[{"given":"Edward J.","family":"Lesnefsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,11]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169743","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,11]]}}}