{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:08:51Z","timestamp":1768982931130,"version":"3.49.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169789","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T18:41:51Z","timestamp":1484246511000},"page":"e0169789","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis"],"prefix":"10.1371","volume":"12","author":[{"given":"Zhengju","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengwei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangqing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengzhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhufeng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/and.12380","article-title":"The relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkey","volume":"47","author":"H Gurkan","year":"2015","journal-title":"Andrologia"},{"issue":"2","key":"ref2","first-page":"139","article-title":"Sperm DNA damage and its clinical relevance in assessing reproductive outcome","volume":"6","author":"RK Sharma","year":"2004","journal-title":"Asian journal of andrology"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.gene.2012.02.023","article-title":"Follicle stimulating hormone receptor G-29A, 919A&gt;G, 2039A&gt;G polymorphism and the risk of male infertility: a meta-analysis","volume":"505","author":"W Wu","year":"2012","journal-title":"Gene"},{"issue":"8","key":"ref4","first-page":"2810","article-title":"Significance of mutations in the androgen receptor gene in males with idiopathic infertility","volume":"85","author":"O Hiort","year":"2000","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/molehr\/gam031","article-title":"Mutations in the protamine 1 gene associated with male infertility","volume":"13","author":"C Ravel","year":"2007","journal-title":"Molecular human reproduction"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/jhg.2010.59","article-title":"The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility","volume":"55","author":"MR Safarinejad","year":"2010","journal-title":"J Hum Genet"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate&apos;s role","volume":"3","author":"KS Crider","year":"2012","journal-title":"Advances in nutrition"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1093\/humrep\/del280","article-title":"Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility","volume":"21","author":"HC Lee","year":"2006","journal-title":"Human reproduction"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fertnstert.2013.09.014","article-title":"Polymorphisms in folate-metabolizing genes and risk of idiopathic male infertility: a study on a Russian population and a meta-analysis","volume":"101","author":"AS Weiner","year":"2014","journal-title":"Fertility and sterility"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1207\/S15327914NC372_18","article-title":"Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells","volume":"37","author":"SJ Duthie","year":"2000","journal-title":"Nutr Cancer"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15027631","article-title":"Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis","volume":"15","author":"Y Yang","year":"2016","journal-title":"Genetics and molecular research: GMR"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/0886022X.2015.1111086","article-title":"Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis","volume":"38","author":"X Zhu","year":"2016","journal-title":"Renal failure"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15548","DOI":"10.1038\/srep15548","article-title":"Role of genetic mutations in folate-related enzyme genes on Male Infertility","volume":"5","author":"K Liu","year":"2015","journal-title":"Scientific reports"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2016.02.012","article-title":"Methionine synthase A2756G transition might be a risk factor for male infertility: Evidences from seven case-control studies","volume":"425","author":"M Karimian","year":"2016","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"e0121147","DOI":"10.1371\/journal.pone.0121147","article-title":"MTHFR 677C&gt;T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies","volume":"10","author":"M Gong","year":"2015","journal-title":"PloS one"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"A Stang","year":"2010","journal-title":"European journal of epidemiology"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.4238\/2014.March.24.26","article-title":"Prospective study of MTHFR genetic polymorphisms as a possible etiology of male infertility. Genetics and molecular research","volume":"13","author":"SS Li","year":"2014","journal-title":"GMR"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.4238\/2015.April.15.13","article-title":"Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males. Genetics and molecular research","volume":"14","author":"XY Li","year":"2015","journal-title":"GMR"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10815-014-0423-9","article-title":"Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population","volume":"32","author":"W Ni","year":"2015","journal-title":"Journal of assisted reproduction and genetics"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1745-7262.2007.00225.x","article-title":"Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia","volume":"9","author":"Z-C A","year":"2007","journal-title":"Asian journal of andrology"},{"issue":"10","key":"ref21","first-page":"1054","article-title":"Association of MTHFR C677T and MS A2756G polymorphism with semen quality","volume":"37","author":"L L","year":"2012","journal-title":"J Cent South Univ"},{"issue":"7","key":"ref22","first-page":"625","article-title":"Association between MethyIenterahydrofolate Reductase Gene C677 T Polymorphism and Male Infertility with Azoospermia or Severe oligozoospermia and Asthenospermia in Ningxia Han Population","volume":"33","author":"XF Q","year":"2011","journal-title":"Journal of Ningxia Medical University"},{"issue":"7","key":"ref23","first-page":"443","article-title":"Associated of the Methylenetetrahydrofolate Reductase Gene C677T Polymorphism with Male Infertility","volume":"27","author":"HT S","year":"2007","journal-title":"Reproduction & Contraception"},{"key":"ref24","first-page":"629","article-title":"Association between MTHFR C677T Polymorphism and Male Infertility in Han Population of He Nan China","volume":"7","author":"P J","year":"2013","journal-title":"China Hwalth Care & Nutrition"},{"issue":"1","key":"ref25","first-page":"5","article-title":"Association of methylenetetrahydrofolate reductase gene C677T polymorphism with asthenospermia in Han population of South Anhui","volume":"29","author":"BH Y","year":"2010","journal-title":"J of Wannan Medical University"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1071\/RD14186","article-title":"Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility","volume":"28","author":"M Karimian","year":"2016","journal-title":"Reproduction, Fertility and Development"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"e22277","DOI":"10.1371\/journal.pone.0022277","article-title":"Strong Association of 677 C&gt;T Substitution in the MTHFR Gene with Male Infertility\u2014A Study on an Indian Population and a Meta-Analysis","volume":"6","author":"M Xiong","year":"2011","journal-title":"PloS one"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.rbmo.2015.07.015","article-title":"MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis","volume":"31","author":"H Nikzad","year":"2015","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1590\/S1415-475738120140179","article-title":"Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population","volume":"38","author":"M Kurzawski","year":"2015","journal-title":"Genetics and molecular biology"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gene.2013.12.001","article-title":"Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population","volume":"536","author":"DS Mfady","year":"2014","journal-title":"Gene"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1469-1809.2011.00691.x","article-title":"Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertility: a meta-analysis","volume":"76","author":"O Shen","year":"2012","journal-title":"Annals of human genetics"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s11033-011-0946-4","article-title":"MTHFR 677C&gt;T and 1298A&gt;C polymorphisms and male infertility risk: a meta-analysis","volume":"39","author":"B Wei","year":"2012","journal-title":"Mol Biol Rep"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ajhg.2009.10.015","article-title":"Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies","volume":"85","author":"S Xu","year":"2009","journal-title":"The American Journal of Human Genetics"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"e57917","DOI":"10.1371\/journal.pone.0057917","article-title":"Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality","volume":"8","author":"B Yang","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/humupd\/dml063","article-title":"Impact of folate and homocysteine metabolism on human reproductive health","volume":"13","author":"T Forges","year":"2007","journal-title":"Human reproduction update"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:31:41Z","timestamp":1588991501000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169789"}},"subtitle":[],"editor":[{"given":"Hao","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169789","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}