{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:37:55Z","timestamp":1768700275576,"version":"3.49.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2013\/17887-8"],"award-info":[{"award-number":["2013\/17887-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2014\/04638-2"],"award-info":[{"award-number":["2014\/04638-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169870","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T13:59:19Z","timestamp":1485179959000},"page":"e0169870","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional Haplotypes in Interleukin 4 Gene Associated with Periodontitis"],"prefix":"10.1371","volume":"12","author":[{"given":"Giovana","family":"Anovazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell Costa de","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzane Cristina","family":"Pigossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia Sertori","family":"Finoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Pinto Alves","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Rossa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-0268","authenticated-orcid":false,"given":"Raquel Mantuaneli","family":"Scarel-Caminaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"issue":"Suppl 6","key":"ref1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1600-051X.2005.00803.x","article-title":"Disease progression: identification of high-risk groups and individuals for periodontitis","volume":"32","author":"LJ Heitz-Mayfield","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1399-302X.2009.00544.x","article-title":"Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque","volume":"24","author":"SJ Byrne","year":"2009","journal-title":"Oral microbiology and immunology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0757.2006.00179.x","article-title":"Toll-like receptors and their role in periodontal health and disease","volume":"43","author":"R Mahanonda","year":"2007","journal-title":"Periodontology 2000"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1399-302X.2007.00410.x","article-title":"Lack of Toll-like receptor 4 decreases lipopolysaccharide-induced bone resorption in C3H\/HeJ mice in vivo","volume":"23","author":"H Nakamura","year":"2008","journal-title":"Oral microbiology and immunology"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1902\/jop.2009.090198","article-title":"The role of toll-like receptor 2 in the recognition of Aggregatibacter actinomycetemcomitans","volume":"80","author":"V Gelani","year":"2009","journal-title":"Journal of periodontology"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-051X.2009.01531.x","article-title":"The essential role of toll like receptor-4 in the control of Aggregatibacter actinomycetemcomitans infection in mice","volume":"37","author":"HR Lima","year":"2010","journal-title":"Journal of clinical periodontology"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/154411130201300104","article-title":"Destructive periodontitis lesions are determined by the nature of the lymphocytic response","volume":"13","author":"E Gemmell","year":"2002","journal-title":"Critical reviews in oral biology and medicine: an official publication of the American Association of Oral Biologists"},{"issue":"8","key":"ref8","first-page":"1036","article-title":"Genetic risk factors for the periodontal diseases","volume":"15","author":"BS Michalowicz","year":"1994","journal-title":"Compendium"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1177\/00220345010800080301","article-title":"Polymorphisms of the interleukin-1 gene family, oral microbial pathogens, and smoking in adult periodontitis","volume":"80","author":"ML Laine","year":"2001","journal-title":"Journal of dental research"},{"issue":"6812","key":"ref10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/35046183","article-title":"Evolutionary biology. The problem of variation","volume":"408","author":"DL Stern","year":"2000","journal-title":"Nature"},{"issue":"Suppl 6","key":"ref11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-051X.2005.00806.x","article-title":"Identification of genetic risk factors for periodontitis and possible mechanisms of action","volume":"32","author":"BG Loos","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"Suppl 6","key":"ref12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-051X.2005.00810.x","article-title":"Effect of genetic variability on the inflammatory response to periodontal infection","volume":"32","author":"L Shapira","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1902\/jop.2009.090392","article-title":"Polymorphisms and haplotypes in the interleukin-4 gene are associated with chronic periodontitis in a Brazilian population","volume":"81","author":"G Anovazzi","year":"2010","journal-title":"Journal of periodontology"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.humimm.2013.08.286","article-title":"Interleukin 4 haplotypes of susceptibility to chronic periodontitis are associated with IL-4 protein levels but not with clinical outcomes of periodontal therapy","volume":"74","author":"G Anovazzi","year":"2013","journal-title":"Human immunology"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10096-013-1903-z","article-title":"Periodontopathogens levels and clinical response to periodontal therapy in individuals with the interleukin-4 haplotype associated with susceptibility to chronic periodontitis","volume":"32","author":"LS Finoti","year":"2013","journal-title":"European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0165-6147(03)00131-7","article-title":"Cytokine gene polymorphisms in multifactorial diseases: gateways to novel targets for immunotherapy?","volume":"24","author":"K Vandenbroeck","year":"2003","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/sj.gene.6363830","article-title":"Association between IL-4 genotype and IL-4 production in the Japanese population","volume":"3","author":"H Nakashima","year":"2002","journal-title":"Genes Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"185757","DOI":"10.1155\/2014\/185757","article-title":"The effect of IL-4 gene polymorphisms on cytokine production in patients with chronic periodontitis and in healthy controls","volume":"2014","author":"J Bartova","year":"2014","journal-title":"Mediators of inflammation"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1172\/JCI114265","article-title":"Neutrophil-activating peptide-1\/interleukin 8, a novel cytokine that activates neutrophils","volume":"84","author":"M Baggiolini","year":"1989","journal-title":"The Journal of clinical investigation"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/0022034510376402","article-title":"Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints","volume":"89","author":"GP Garlet","year":"2010","journal-title":"Journal of dental research"},{"issue":"3\u20134","key":"ref21","first-page":"297","article-title":"Tumor necrosis factors in 1998","volume":"9","author":"H Wajant","year":"1998","journal-title":"Cytokine & growth factor reviews"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2302\/kjm.54.127","article-title":"TNF-alpha and pathologic bone resorption","volume":"54","author":"BF Boyce","year":"2005","journal-title":"The Keio journal of medicine"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1002\/eji.201545800","article-title":"IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23","volume":"45","author":"HM Grifka-Walk","year":"2015","journal-title":"European journal of immunology"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/jre.12169","article-title":"Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease","volume":"49","author":"VP Parachuru","year":"2014","journal-title":"Journal of periodontal research"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/jre.12270","article-title":"T-lymphocyte phenotype and function triggered by Aggregatibacter actinomycetemcomitans is serotype-dependent","volume":"50","author":"J Diaz-Zuniga","year":"2015","journal-title":"Journal of periodontal research"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jaut.2012.03.003","article-title":"Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis","volume":"39","author":"NM Moutsopoulos","year":"2012","journal-title":"Journal of autoimmunity"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1189\/jlb.1RU0114-010RR","article-title":"IL-17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells","volume":"96","author":"R Du","year":"2014","journal-title":"Journal of leukocyte biology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"M Saraiva","year":"2010","journal-title":"Nature reviews Immunology"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"KN Couper","year":"2008","journal-title":"Journal of immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:31:38Z","timestamp":1588959098000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169870"}},"subtitle":[],"editor":[{"given":"\u00d6zlem","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169870","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}