{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:22:54Z","timestamp":1784287374203,"version":"3.55.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169884","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T18:24:13Z","timestamp":1485282253000},"page":"e0169884","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Adjuvant Acid Suppression on the Outcomes of Bleeding Esophageal Varices after Endoscopic Variceal Ligation"],"prefix":"10.1371","volume":"12","author":[{"given":"Cheng-Kun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ning","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Hsing","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Ting","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Howe","family":"Nguang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Lun","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Kun","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-I","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-Chyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Kee","family":"Chuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJM198810133191505","article-title":"The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study","volume":"319","year":"1988","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e61666","DOI":"10.1371\/journal.pone.0061666","article-title":"The Outcome of Prophylactic Intravenous Cefazolin and Ceftriaxone in Different Clinical Stages of Cirrhotic Patients after Endoscopic Interventions for Acute Variceal Hemorrhage","volume":"8","author":"CK Wu","year":"2013","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00464-011-1642-0","article-title":"The effects of cefazolin on cirrhotic patients with acute variceal hemorrhage after endoscopic interventions","volume":"25","author":"HW Xu","year":"2011","journal-title":"Surg Endosc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.gie.2013.07.023","article-title":"The role of endoscopy in the management of variceal hemorrhage","volume":"80","author":"JH Hwang","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying riskand individualizing care for portal hypertension","volume":"63","author":"R de Franchis","year":"2015","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1136\/gutjnl-2015-309262","article-title":"U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients","volume":"64","author":"D Tripathi","year":"2015","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1572-0241.2003.07294.x","article-title":"Improved patient survival after acute variceal bleeding: a multicenter, cohort study","volume":"98","author":"N Chalasani","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/hep.21089","article-title":"Improved prognosis for patients hospitalized with esophageal varices in Sweden 1969\u20132002","volume":"43","author":"K Stokkeland","year":"2006","journal-title":"Hepatology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/MEG.0b013e32830280c7","article-title":"Decreasing in-hospital mortality for oesophageal variceal hemorrhage in the USA","volume":"20","author":"MM Jamal","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cld.2010.03.012","article-title":"Refractory acute variceal bleeding: what to do next?","volume":"14","author":"M D\u2019Amico","year":"2010","journal-title":"Clin Liver Dis"},{"key":"ref11","first-page":"103","article-title":"Portal Hypertension V","author":"L Laine","year":"2011"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1055\/s-0032-1301734","article-title":"Acute variceal bleeding","volume":"33","author":"JC Garc\u0131a-Pagan","year":"2012","journal-title":"Semin Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1592\/phco.29.3.248","article-title":"Continuous infusion of pantoprazole with octreotide does not improve management of variceal hemorrhage","volume":"29","author":"C Alaniz","year":"2009","journal-title":"Pharmacotherapy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.cgh.2016.05.040","article-title":"Use of Antibiotics Among Patients With Cirrhosis and Upper Gastrointestinal Bleeding Is Associated With Reduced Mortality","volume":"14","author":"AM Moon","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0889-8553(21)00593-8","article-title":"Complications of esophageal variceal sclerotherapy","volume":"20","author":"RA Truesdale Jr","year":"1991","journal-title":"Gastroenterol Clin North Am"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/hep.20593","article-title":"Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: a randomized, controlled trial","volume":"41","author":"NJ Shaheen","year":"2005","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00535-011-0472-0","article-title":"Long-term administration of PPI reduces treatment failures after esophageal variceal band ligation: a randomized, controlled trial","volume":"47","author":"H Hidaka","year":"2012","journal-title":"J Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/jgh.12107","article-title":"Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding","volume":"28","author":"GH Lo","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/j.gastro.2016.09.007","article-title":"Proton pump inhibitors increase risk for hepatic encephalopathy in patients with cirrhosis in population study","volume":"152","author":"CF Tsai","year":"2016","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e944","DOI":"10.1097\/MD.0000000000000944","article-title":"Risk of spontaneous bacterial peritonitis associated with gastric Acid suppression","volume":"94","author":"SS Chang","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/1060028014559244","article-title":"Use of proton pump inhibitors in the management of gastroesophageal varices: a systematic review","volume":"49","author":"EA Lo","year":"2015","journal-title":"Ann Pharmacother"},{"key":"ref22","unstructured":"Health and National Health Insurance Annual Statistics Information Services. National Health Insurance Research Database, Taiwan. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nhri.org.tw\/nhird\/en\/index.htm\" xlink:type=\"simple\">http:\/\/www.nhri.org.tw\/nhird\/en\/index.htm<\/ext-link>, accessed on 30 July, 2015."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"RA Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1440-1746.2006.04177.x","article-title":"Proton pump inhibitors in acute non-variceal upper gastrointestinal bleeding","volume":"21","author":"GI Leontiadis","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0016-5107(93)70049-8","article-title":"Comparison and characterization of ulcerations induced by endoscopic ligation of esophageal varices versus endoscopic sclerotherapy","volume":"39","author":"MF Young","year":"1993","journal-title":"Gastrointest Endosc"},{"key":"ref26","first-page":"2281","article-title":"Natural history of postligation ulcers","volume":"89","author":"S Nijhawan","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2036.2010.04331.x","article-title":"Predictive factors of bleeding related to post-banding ulcer following endoscopic variceal ligation in cirrhotic patients: a case-control study","volume":"32","author":"G Vanbiervliet","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"ref28","first-page":"483","article-title":"Effect of proton pump inhibitor (PPI: Rabeprazole) on reflux esophagitis after endoscopic injection sclerotherapy (EIS), a randomized control study (24 hour-pH monitoring)","volume":"104","author":"T Akahoshi","year":"2013","journal-title":"Fukuoka Igaku Zasshi"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ajg.2009.615","article-title":"Clostridium difficile is associated with poor outcomes in patients with cirrhosis: A national and tertiary center perspective","volume":"105","author":"JS Bajaj","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/jgh.12065","article-title":"Acid-suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis","volume":"28","author":"A Deshpande","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/MOG.0b013e32833ea9d9","article-title":"Adverse effects of proton pump inhibitor drugs: clues and conclusions","volume":"26","author":"DM McCarthy","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.3748\/wjg.14.2980","article-title":"Proton pump inhibitors in cirrhosis: tradition or evidence based practice?","volume":"14","author":"F Lodato","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/hep.22341","article-title":"Comorbidity and survival of Danish cirrhosis patients: a nationwide population-based cohort study","volume":"48","author":"P Jepsen","year":"2008","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1034\/j.1600-0676.2003.01804.x","article-title":"Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic hepatitis, smoking and abstinence","volume":"23","author":"F Pessione","year":"2003","journal-title":"Liver Int"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0899-9007(01)00521-4","article-title":"Nutrition and survival in patients with liver cirrhosis","volume":"17","author":"F Alberino","year":"2001","journal-title":"Nutrition"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T17:51:18Z","timestamp":1658512278000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169884"}},"subtitle":[],"editor":[{"given":"John","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169884","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}