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Diseases"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3181\/00379727-136-35455","article-title":"A permanent heteroploid human cell line with type B glucose-6-phosphate dehydrogenase","volume":"136","author":"WD Peterson Jr.","year":"1971","journal-title":"Proceedings of the Society for Experimental Biology and Medicine Society for Experimental Biology and Medicine (New York, NY)"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1086\/381271","article-title":"Neisseria meningitidis undergoes PilC phase variation and PilE sequence variation during invasive disease","volume":"189","author":"A Rytkonen","year":"2004","journal-title":"The Journal of infectious diseases"},{"issue":"12","key":"ref56","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1128\/IAI.00584-16","article-title":"Impact of Moderate Temperature Changes on Neisseria meningitidis Adhesion Phenotypes and 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Bartley","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1462-5822.2011.01586.x","article-title":"Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells","volume":"13","author":"MP Jennings","year":"2011","journal-title":"Cellular microbiology"},{"issue":"9","key":"ref76","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1128\/JCM.36.9.2465-2470.1998","article-title":"Necessity of molecular techniques to distinguish between Neisseria meningitidis strains isolated from patients with meningococcal disease and from their healthy contacts","volume":"36","author":"U Vogel","year":"1998","journal-title":"Journal of clinical microbiology"},{"issue":"22","key":"ref77","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1128\/JB.00851-07","article-title":"A functional two-partner secretion system contributes to adhesion of 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Wright","year":"2006"},{"issue":"10","key":"ref81","doi-asserted-by":"crossref","first-page":"e26907","DOI":"10.1371\/journal.pone.0026907","article-title":"Rates of mutation and host transmission for an Escherichia coli clone over 3 years","volume":"6","author":"PR Reeves","year":"2011","journal-title":"PloS one"},{"issue":"12","key":"ref82","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1073\/pnas.1113219109","article-title":"Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease","volume":"109","author":"BC Young","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nrmicro.2015.13","article-title":"Within-host evolution of bacterial pathogens","volume":"14","author":"X Didelot","year":"2016","journal-title":"Nature reviews Microbiology"},{"issue":"3","key":"ref84","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2958.2000.01873.x","article-title":"Phase variation of the gonococcal siderophore receptor FetA","volume":"36","author":"SD Carson","year":"2000","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/j.1460-2075.1991.tb07970.x","article-title":"Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly","volume":"10","author":"AB Jonsson","year":"1991","journal-title":"The EMBO journal"},{"issue":"9","key":"ref86","doi-asserted-by":"crossref","first-page":"e76932","DOI":"10.1371\/journal.pone.0076932","article-title":"The distribution and &apos;in vivo&apos; phase variation status of haemoglobin receptors in invasive meningococcal serogroup B disease: genotypic and phenotypic analysis","volume":"8","author":"J Lucidarme","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"ref87","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1574-6976.2006.00052.x","article-title":"Lessons from meningococcal carriage studies","volume":"31","author":"DA Caugant","year":"2007","journal-title":"FEMS microbiology reviews"},{"issue":"10","key":"ref88","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.ebiom.2015.09.007","article-title":"Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis","volume":"2","author":"MM Mustapha","year":"2015","journal-title":"EBioMedicine"},{"issue":"5","key":"ref89","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/jama.1997.03540290041030","article-title":"School-based clusters of meningococcal disease in the United States. 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