{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:25:41Z","timestamp":1778628341816,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Healthy Aging, Faculty of Health Sciences at the University of Copenhagen"},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["VELUX26145"],"award-info":[{"award-number":["VELUX26145"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["VELUX31539"],"award-info":[{"award-number":["VELUX31539"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169912","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T16:11:11Z","timestamp":1484669471000},"page":"e0169912","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men"],"prefix":"10.1371","volume":"12","author":[{"given":"Otto M\u00f8lby","family":"Henriksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naja Liv","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"Osler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik Lykke","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte Merete","family":"Hallam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben Thade","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Johannes","family":"Lauritzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egill","family":"Rostrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"ref1","year":"2012"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrneurol.2013.107","article-title":"Ushering in the study and treatment of preclinical Alzheimer disease","volume":"9","author":"JB Langbaum","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-2012-120793","article-title":"Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer&apos;s disease","volume":"32","author":"JC de la Torre","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.arcmed.2012.10.018","article-title":"Contribution of neuroimaging to the diagnosis of Alzheimer&apos;s disease and vascular dementia","volume":"43","author":"G Roman","year":"2012","journal-title":"Arch Med Res"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"e000368","DOI":"10.1136\/bmjopen-2011-000368","article-title":"Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI","volume":"2","author":"L Lunau","year":"2012","journal-title":"BMJ Open"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archneurol.2009.913","article-title":"APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging","volume":"67","author":"M Thambisetty","year":"2010","journal-title":"Arch Neurol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/cercor\/bhs381","article-title":"Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer&apos;s disease","volume":"24","author":"OC Okonkwo","year":"2014","journal-title":"Cereb Cortex"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00415-004-0569-y","article-title":"High total cerebral blood flow is associated with a decrease of white matter lesions","volume":"251","author":"RH Bisschops","year":"2004","journal-title":"J Neurol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.jcbfm.9600563","article-title":"Total cerebral blood flow, white matter lesions and brain atrophy: the SMART-MR study","volume":"28","author":"AP Appelman","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/sj.jcbfm.9600526","article-title":"Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study","volume":"28","author":"MW Vernooij","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","article-title":"Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study","volume":"57","author":"A Ruitenberg","year":"2005","journal-title":"Ann Neurol"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e97363","DOI":"10.1371\/journal.pone.0097363","article-title":"Resting brain perfusion and selected vascular risk factors in healthy elderly subjects","volume":"9","author":"OM Henriksen","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1161\/STROKEAHA.112.666727","article-title":"Cardiovascular disease risk and cerebral blood flow velocity","volume":"43","author":"MP Pase","year":"2012","journal-title":"Stroke"},{"issue":"11","key":"ref14","first-page":"1842","article-title":"Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction","volume":"41","author":"CC Meltzer","year":"2000","journal-title":"J Nucl Med"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1038\/jcbfm.2015.157","article-title":"The bidirectional association between reduced cerebral blood flow and brain atrophy in the general population","volume":"35","author":"HI Zonneveld","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/mrm.24372","article-title":"Comparing model-based and model-free analysis methods for QUASAR arterial spin labeling perfusion quantification","volume":"69","author":"MA Chappell","year":"2013","journal-title":"Magn Reson Med"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroimage.2009.07.068","article-title":"The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study","volume":"49","author":"ET Petersen","year":"2010","journal-title":"Neuroimage"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/eurpub\/cks140","article-title":"Socio-economic position early in life, cognitive development and cognitive change from young adulthood to middle age","volume":"23","author":"M Osler","year":"2013","journal-title":"Eur J Public Health"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/ije\/dyi300","article-title":"Cohort profile: the Metropolit 1953 Danish male birth cohort","volume":"35","author":"M Osler","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1002\/hbm.22489","article-title":"Subclinical cognitive decline in middle-age is associated with reduced task-induced deactivation of the brain&apos;s default mode network","volume":"35","author":"NL Hansen","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1467-9450.2009.00789.x","article-title":"The Danish draft board&apos;s intelligence test, Borge Priens Prove: psychometric properties and research applications through 50 years","volume":"50","author":"TW Teasdale","year":"2009","journal-title":"Scand J Psychol"},{"key":"ref22","unstructured":"Amthauer R, Brocke B, Liepmann D. IST 2000R. Intelligenz-Struktur test 2000Rxg. Hogrefe Verlag; 2001."},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/mrm.20784","article-title":"Model-free arterial spin labeling quantification approach for perfusion MRI","volume":"55","author":"ET Petersen","year":"2006","journal-title":"Magn Reson Med"},{"issue":"Suppl 1","key":"ref24","first-page":"1","article-title":"Physiological correlates of cerebral blood flow measurements using arterial spin labeling and phase contrast mapping","volume":"25","author":"OM Henriksen","year":"2012","journal-title":"Abstracts of ESMRMB (European Society for Magnetic Resonance in Medicine and Biology) 2012, the 29th Annual Scientific Meeting.Lisbon, Portugal.October 4\u20136, 2012. MAGMA"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/jmri.23579","article-title":"Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography","volume":"35","author":"OM Henriksen","year":"2012","journal-title":"J Magn Reson Imaging"},{"issue":"1\u20132","key":"ref26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000081050","article-title":"Impact of age-related cerebral white matter changes on the transition to disability\u2014the LADIS study: rationale, design and methodology","volume":"24","author":"L Pantoni","year":"2005","journal-title":"Neuroepidemiology"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"SM Smith","year":"2009","journal-title":"Neuroimage"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"AM Winkler","year":"2014","journal-title":"Neuroimage"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3233\/JAD-2010-091504","article-title":"Pre-clinical detection of Alzheimer&apos;s disease using FDG-PET, with or without amyloid imaging","volume":"20","author":"L Mosconi","year":"2010","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.neuroimage.2010.08.009","article-title":"Differential effects of the APOE genotype on brain function across the lifespan","volume":"54","author":"N Filippini","year":"2011","journal-title":"Neuroimage"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jmri.24090","article-title":"Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2","volume":"38","author":"BP Thomas","year":"2013","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuroimage.2010.12.032","article-title":"Age-associated reductions in cerebral blood flow are independent from regional atrophy","volume":"55","author":"JJ Chen","year":"2011","journal-title":"Neuroimage"},{"issue":"3","key":"ref34","first-page":"199","article-title":"Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements","volume":"12","author":"K Nilsson","year":"2000","journal-title":"Aging (Milano)"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1161\/STROKEAHA.113.001716","article-title":"Use of total cerebral blood flow as an imaging biomarker of known cardiovascular risks","volume":"44","author":"JR Jennings","year":"2013","journal-title":"Stroke"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia","volume":"73","author":"DC Alsop","year":"2015","journal-title":"Magn Reson Med"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/STROKEAHA.114.008030","article-title":"Longitudinal relationship between cerebral small-vessel disease and cerebral blood flow: the second manifestations of arterial disease-magnetic resonance study","volume":"46","author":"PH van der Veen","year":"2015","journal-title":"Stroke"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jdiacomp.2012.03.021","article-title":"Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes","volume":"26","author":"M Brundel","year":"2012","journal-title":"J Diabetes Complications"},{"issue":"22","key":"ref39","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1212\/01.wnl.0000436618.48402.da","article-title":"Total cerebral blood flow and mortality in old age: a 12-year follow-up study","volume":"81","author":"B Sabayan","year":"2013","journal-title":"Neurology"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer&apos;s disease","volume":"11","author":"Y Stern","year":"2012","journal-title":"Lancet Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T13:31:00Z","timestamp":1568727060000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169912"}},"subtitle":[],"editor":[{"given":"Jean-Claude","family":"Baron","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169912","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]}}}