{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:33:31Z","timestamp":1790627611314,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169976","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T18:11:57Z","timestamp":1484244717000},"page":"e0169976","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability"],"prefix":"10.1371","volume":"12","author":[{"given":"Marjory B.","family":"Brooks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma K.","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Besteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy E.","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol L.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidrun","family":"Ellinger-Ziegelbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B.","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Paulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Y.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert E.","family":"Schultze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2013.01.008","article-title":"Innate immunity","volume":"25","author":"J Hoffmann","year":"2013","journal-title":"Current opinion in immunology"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ni.2666","article-title":"Platelet-macrophage partnership in innate immunity and inflammation","volume":"14","author":"A Mantovani","year":"2013","journal-title":"Nature immunology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0031-1276586","article-title":"The plasma contact system 2.0.","volume":"37","author":"C Maas","year":"2011","journal-title":"Seminars in thrombosis and hemostasis"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.thromres.2011.10.013","article-title":"Sepsis, thrombosis and organ dysfunction","volume":"129","author":"N Semeraro","year":"2012","journal-title":"Thromb Res"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"7997","DOI":"10.4049\/jimmunol.0802884","article-title":"Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4\/MyD88 and the cGMP-dependent protein kinase pathway","volume":"182","author":"G Zhang","year":"2009","journal-title":"Journal of immunology"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.mbc.0000061290.28953.57","article-title":"Pathophysiology of disseminated intravascular coagulation (DIC) progresses at a different rate in tissue factor-induced and lipopolysaccharide-induced DIC models in rats","volume":"14","author":"H Asakura","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.thromres.2010.12.002","article-title":"Animal models of DIC and their relevance to human DIC: a systematic review","volume":"128","author":"LO Berthelsen","year":"2011","journal-title":"Thrombosis research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1097\/00003246-200009001-00003","article-title":"Pathophysiology of disseminated intravascular coagulation in sepsis","volume":"28","author":"H ten Cate","year":"2000","journal-title":"Crit Care Med"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/01.mbc.0000240916.63521.2e","article-title":"International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients","volume":"17","author":"C Voves","year":"2006","journal-title":"Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00003246-200009001-00004","article-title":"Description of compensated and uncompensated disseminated intravascular coagulation (DIC) responses (non-overt and overt DIC) in baboon models of intravenous and intraperitoneal Escherichia coli sepsis and in the human model of endotoxemia: toward a better definition of DIC","volume":"28","author":"FB Taylor Jr.","year":"2000","journal-title":"Crit Care Med"},{"issue":"1","key":"ref11","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"JP Bastard","year":"2006","journal-title":"European cytokine network"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ahj.2013.03.018","article-title":"Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis","volume":"166","author":"BM Everett","year":"2013","journal-title":"American heart journal"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/CIRCULATIONAHA.107.709204","article-title":"Cardiovascular risk factors and venous thromboembolism: a meta-analysis","volume":"117","author":"W Ageno","year":"2008","journal-title":"Circulation"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1476-5381.2011.01255.x","article-title":"How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?","volume":"163","author":"H Laverty","year":"2011","journal-title":"British journal of pharmacology"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/0192623312460924","article-title":"Current practices in preclinical drug development: gaps in hemostasis testing to assess risk of thromboembolic injury","volume":"41","author":"AE Schultze","year":"2013","journal-title":"Toxicologic pathology"},{"key":"ref16","article-title":"High sensitivity flow cytometry of membrane vesicles","author":"SA Stoner","year":"2015","journal-title":"Cytometry Part A: the journal of the International Society for Analytical Cytology"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v2i0.19671","article-title":"Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis","volume":"2","author":"C Gardiner","year":"2013","journal-title":"Journal of extracellular vesicles"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1373\/clinchem.2007.097972","article-title":"Detection and characterization of placental microRNAs in maternal plasma","volume":"54","author":"SS Chim","year":"2008","journal-title":"Clinical chemistry"},{"key":"ref19","unstructured":"Goni R, Garcia P, Foissac S. The qPCR data statistical analysis. Integromics White Paper. 2009:1\u20139."},{"issue":"3\u20134","key":"ref20","first-page":"591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"S SS","year":"1965","journal-title":"Biometrika"},{"key":"ref21","first-page":"278","article-title":"Contributions to Probability and Statistics","author":"H Levene","year":"1960"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1373\/clinchem.2010.157198","article-title":"Analysis of circulating microRNA: preanalytical and analytical challenges","volume":"57","author":"JS McDonald","year":"2011","journal-title":"Clinical chemistry"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/09537104.2011.560305","article-title":"Characterization of human platelet microRNA by quantitative PCR coupled with an annotation network for predicted target genes","volume":"22","author":"A Osman","year":"2011","journal-title":"Platelets"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCRESAHA.111.300539","article-title":"Circulating microRNAs as novel biomarkers for platelet activation","volume":"112","author":"P Willeit","year":"2013","journal-title":"Circulation research"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/ATVBAHA.110.218123","article-title":"The many faces of endothelial microparticles","volume":"31","author":"F Dignat-George","year":"2011","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk\u2014database: prediction of possible miRNA binding sites by &quot;walking&quot; the genes of three genomes","volume":"44","author":"H Dweep","year":"2011","journal-title":"Journal of biomedical informatics"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.bbadis.2014.07.021","article-title":"Role of extracellular and intracellular microRNAs in sepsis","volume":"1842","author":"K Essandoh","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/emmm.201202318","article-title":"MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways","volume":"5","author":"HS Cheng","year":"2013","journal-title":"EMBO molecular medicine"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3892\/etm.2015.2224","article-title":"microRNA-23b regulates the expression of inflammatory factors in vascular endothelial cells during sepsis","volume":"9","author":"M Wu","year":"2015","journal-title":"Experimental and therapeutic medicine"},{"issue":"19","key":"ref30","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1182\/blood-2012-10-461798","article-title":"Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression","volume":"121","author":"O Gidlof","year":"2013","journal-title":"Blood"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.0902369","article-title":"Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation","volume":"184","author":"Y Suarez","year":"2010","journal-title":"Journal of immunology"},{"issue":"14","key":"ref32","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1182\/blood-2010-02-268011","article-title":"Regulation of fibrinogen production by microRNAs","volume":"116","author":"A Fort","year":"2010","journal-title":"Blood"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"e44532","DOI":"10.1371\/journal.pone.0044532","article-title":"miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells","volume":"7","author":"A Marchand","year":"2012","journal-title":"PloS one"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.molcel.2014.03.012","article-title":"A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide","volume":"54","author":"Y Tan","year":"2014","journal-title":"Molecular cell"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1189\/jlb.0607373","article-title":"Inflammation, endothelium, and coagulation in sepsis","volume":"83","author":"M Schouten","year":"2008","journal-title":"Journal of leukocyte biology"},{"issue":"6214","key":"ref36","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1256478","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume":"346","author":"V Sreeramkumar","year":"2014","journal-title":"Science"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: Exosomes, microvesicles, and friends","volume":"200","author":"G Raposo","year":"2013","journal-title":"The Journal of cell biology"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"C Th\u00e9ry","year":"2002","journal-title":"Nature Reviews Immunology"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"J Krol","year":"2010","journal-title":"Nature reviews Genetics"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00011-014-0747-z","article-title":"Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88\/TAK1\/IKKbeta\/IkappaB-alpha\/NF-kappaB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock","volume":"63","author":"AN Sari","year":"2014","journal-title":"Inflamm Res"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.4049\/jimmunol.0801613","article-title":"Bruton&apos;s tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes","volume":"182","author":"G Alsaleh","year":"2009","journal-title":"Journal of immunology"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.20101823","article-title":"miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice","volume":"208","author":"MP Boldin","year":"2011","journal-title":"J Exp Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-511X-13-27","article-title":"miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease","volume":"13","author":"J Feng","year":"2014","journal-title":"Lipids Health Dis"},{"issue":"25","key":"ref44","doi-asserted-by":"crossref","first-page":"10355","DOI":"10.1073\/pnas.1107052108","article-title":"MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation","volume":"108","author":"J Zhou","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1083\/jcb.201105013","article-title":"PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy","volume":"196","author":"E Ardite","year":"2012","journal-title":"J Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T09:19:38Z","timestamp":1568711978000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169976"}},"subtitle":[],"editor":[{"given":"Hugo","family":"ten Cate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169976","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}