{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:44:59Z","timestamp":1790196299298,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0170083","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T18:39:37Z","timestamp":1484159977000},"page":"e0170083","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice"],"prefix":"10.1371","volume":"12","author":[{"given":"Lyvianne","family":"Decourtye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Mire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Clemessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Heurtier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Ledent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain C.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Mollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Epelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Meaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Le Bouc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Kappeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming","volume":"85","author":"IC McMillen","year":"2005","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1210\/jc.2008-2489","article-title":"Infancy weight gain predicts childhood body fat and age at menarche in girls","volume":"94","author":"KK Ong","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature02725","article-title":"Developmental plasticity and human health","volume":"430","author":"P Bateson","year":"2004","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.1095292","article-title":"Living with the past: evolution, development, and patterns of disease","volume":"305","author":"PD Gluckman","year":"2004","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The thrifty phenotype hypothesis","volume":"60","author":"CN Hales","year":"2001","journal-title":"Br Med Bull"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/en.2008-0981","article-title":"Early postnatal nutrition determines somatotropic function in mice","volume":"150","author":"L Kappeler","year":"2009","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1371\/journal.pbio.0060254","article-title":"Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism","volume":"6","author":"L Kappeler","year":"2008","journal-title":"PLoS Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jcp.21295","article-title":"GHRH proliferative action on somatotrophs is cell-type specific and dependent on Pit-1\/GHF-1 expression","volume":"215","author":"A Solloso","year":"2008","journal-title":"J Cell Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02935589","article-title":"Insulin and insulin-like growth factor receptors in the nervous system","volume":"3","author":"M Adamo","year":"1989","journal-title":"Mol Neurobiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrn3209","article-title":"The many faces of insulin-like peptide signalling in the brain","volume":"13","author":"AM Fernandez","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnins.2016.00052","article-title":"IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain","volume":"10","author":"V Nieto-Estevez","year":"2016","journal-title":"Front Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1523\/JNEUROSCI.2270-05.2005","article-title":"Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway","volume":"25","author":"J Jaworski","year":"2005","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"21268","DOI":"10.1074\/jbc.272.34.21268","article-title":"Insulin-like Growth Factor-I-mediated Neurite Outgrowth in Vitro Requires Mitogen-activated Protein Kinase Activation","volume":"272","author":"B Kim","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1523\/JNEUROSCI.20-11-04165.2000","article-title":"Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex","volume":"20","author":"MM Niblock","year":"2000","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1242\/jcs.02490","article-title":"PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone","volume":"118","author":"L Laurino","year":"2005","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nn1742","article-title":"IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity","volume":"9","author":"L Sosa","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1242\/jcs.00285","article-title":"Regulation of membrane expansion at the nerve growth cone","volume":"116","author":"KH Pfenninger","year":"2003","journal-title":"J Cell Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuron.2008.01.027","article-title":"Role of IGF signaling in olfactory sensory map formation and axon guidance","volume":"57","author":"JA Scolnick","year":"2008","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nn1789","article-title":"IGF-I specifically enhances axon outgrowth of corticospinal motor neurons","volume":"9","author":"PH Ozdinler","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.expneurol.2008.09.014","article-title":"IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury","volume":"215","author":"ER Hollis 2nd","year":"2009","journal-title":"Exp Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1210\/en.2003-0006","article-title":"Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: a ventral hypothalamic network","volume":"144","author":"N Balthasar","year":"2003","journal-title":"Endocrinology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1365-2826.2008.01780.x","article-title":"Sexually dimorphic distribution of sst2A receptors on growth hormone-releasing hormone neurones in mice: modulation by gonadal steroids","volume":"20","author":"K Bouyer","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2006.10.002","article-title":"Multiple co-localizations in arcuate GHRH-eGFP neurons in the mouse hypothalamus","volume":"33","author":"K Bouyer","year":"2007","journal-title":"J Chem Neuroanat"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1210\/en.2010-0298","article-title":"Specific involvement of gonadal hormones in the functional maturation of growth hormone releasing hormone (GHRH) neurons","volume":"151","author":"LA Gouty-Colomer","year":"2010","journal-title":"Endocrinology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e51135","DOI":"10.1371\/journal.pone.0051135","article-title":"A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice","volume":"7","author":"R Hassouna","year":"2012","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1210\/en.2010-0798","article-title":"Novel ontogenetic patterns of sexual differentiation in arcuate nucleus GHRH neurons revealed in GHRH-enhanced green fluorescent protein transgenic mice","volume":"152","author":"S McArthur","year":"2011","journal-title":"Endocrinology"},{"key":"ref27","first-page":"R1104","article-title":"Intake and use of milk nutrients by rat pups suckled in small, medium, or large litters","volume":"260","author":"ML Fiorotto","year":"1991","journal-title":"Am J Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2006.01.042","article-title":"Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation","volume":"125","author":"G Lopez-Bendito","year":"2006","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.mcn.2007.09.009","article-title":"Modulating Sema3A signal with a L1 mimetic peptide is not sufficient to promote motor recovery and axon regeneration after spinal cord injury","volume":"37","author":"E Mire","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0513","article-title":"The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor","volume":"369","author":"IC Weaver","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/nn.3160","article-title":"Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth","volume":"15","author":"E Mire","year":"2012","journal-title":"Nat Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.4155\/fmc.09.89","article-title":"Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor","volume":"1","author":"MJ Mulvihill","year":"2009","journal-title":"Future Med Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.1095004","article-title":"Trophic action of leptin on hypothalamic neurons that regulate feeding","volume":"304","author":"SG Bouret","year":"2004","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1523\/JNEUROSCI.3215-12.2013","article-title":"Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice","volume":"33","author":"K Bouyer","year":"2013","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fncel.2013.00194","article-title":"Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway","volume":"7","author":"ME Bernis","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"ref36","first-page":"3","article-title":"Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling","volume":"5","author":"CM Liu","year":"2012","journal-title":"Front Mol Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0896-6273(02)00686-4","article-title":"Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB","volume":"34","author":"BE Lonze","year":"2002","journal-title":"Neuron"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(02)00752-3","article-title":"Raf and akt mediate distinct aspects of sensory axon growth","volume":"35","author":"A Markus","year":"2002","journal-title":"Neuron"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"11486","DOI":"10.1523\/JNEUROSCI.6074-11.2012","article-title":"Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function","volume":"32","author":"E Caron","year":"2012","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cell.2014.01.008","article-title":"Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding","volume":"156","author":"MC Vogt","year":"2014","journal-title":"Cell"},{"key":"ref41","first-page":"80","article-title":"Nutritional regulation of the insulin-like growth factors","volume":"15","author":"JP Thissen","year":"1994","journal-title":"Endocr Rev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01298","article-title":"IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice","volume":"421","author":"M Holzenberger","year":"2003","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/gerona\/glp051","article-title":"Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age","volume":"64","author":"L Sun","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0172915","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0170083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:21:07Z","timestamp":1588990867000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0170083"}},"subtitle":[],"editor":[{"given":"Raul M.","family":"Luque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,11]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0170083","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0172915","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,11]]}}}