{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:26:54Z","timestamp":1789810014963,"version":"4.0.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0170236","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T18:44:16Z","timestamp":1486061056000},"page":"e0170236","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Characteristics of Staphylococcus aureus Bacteraemia and Predictors of Early and Late Mortality"],"prefix":"10.1371","volume":"12","author":[{"given":"Matteo","family":"Bassetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Peghin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Maria","family":"Trecarichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Carnelutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Del Giacomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Ansaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Trucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Alicino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cauda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Sartor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Spanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Scarparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Tumbarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"ref1","unstructured":"2014. EAArotEARSNE-N."},{"key":"ref2","unstructured":"Center for Disease Dynamics EP. State of the World\u2019s Antibiotics CW, DC 2015."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1469-0691.2012.03903.x","article-title":"The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study","volume":"19","author":"KB Laupland","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1017\/ice.2015.213","article-title":"Evolving Epidemiology of Staphylococcus aureus Bacteremia","volume":"36","author":"Y Rhee","year":"2015","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"O630","DOI":"10.1111\/1469-0691.12564","article-title":"Case fatality ratio and mortality rate trends of community-onset Staphylococcus aureus bacteraemia","volume":"20","author":"S Tom","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jinf.2013.10.015","article-title":"Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies","volume":"68","author":"AJ Kaasch","year":"2014","journal-title":"J Infect"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12941-016-0122-8","article-title":"Mortality predictors of Staphylococcus aureus bacteremia: a prospective multicenter study","volume":"15","author":"M Yilmaz","year":"2016","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/cid\/cit499","article-title":"Impact of an evidence-based bundle intervention in the quality-of-care management and outcome of Staphylococcus aureus bacteremia","volume":"57","author":"LE Lopez-Cortes","year":"2013","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jinf.2015.09.037","article-title":"Infectious disease consultation for Staphylococcus aureus bacteremia\u2014A systematic review and meta-analysis","volume":"72","author":"M Vogel","year":"2016","journal-title":"J Infect"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/jac\/dkt016","article-title":"Predictive factors for early mortality among patients with methicillin-resistant Staphylococcus aureus bacteraemia","volume":"68","author":"O Gasch","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jinf.2014.05.004","article-title":"Mandatory infectious diseases consultation for MRSA bacteremia is associated with reduced mortality","volume":"69","author":"F Tissot","year":"2014","journal-title":"J Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/345476","article-title":"Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis","volume":"36","author":"SE Cosgrove","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","article-title":"CDC definitions for nosocomial infections, 1988","volume":"16","author":"JS Garner","year":"1988","journal-title":"Am J Infect Control"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"791","DOI":"10.7326\/0003-4819-137-10-200211190-00007","article-title":"Health care\u2014associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections","volume":"137","author":"ND Friedman","year":"2002","journal-title":"Ann Intern Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/cid\/civ1199","article-title":"A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit","volume":"62","author":"A Tabah","year":"2016","journal-title":"Clin Infect Dis"},{"key":"ref16","unstructured":"(EUCAST). TECoAST. Breakpoint tables for interpretation of MICs and zone diameters. 2016 Version 6.0. Available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eucast.org\/clinical_breakpoints\/\" xlink:type=\"simple\">http:\/\/www.eucast.org\/clinical_breakpoints\/<\/ext-link>. Accessed May 16."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/cid\/civ777","article-title":"Risk Factors for Invasive Methicillin-Resistant Staphylococcus aureus Infection After Recent Discharge From an Acute-Care Hospitalization, 2011\u20132013","volume":"62","author":"L Epstein","year":"2016","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1469-0691.2011.03679.x","article-title":"Risk factors and mortality of healthcare-associated and community-acquired Staphylococcus aureus bacteraemia","volume":"18","author":"M Bassetti","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1128\/AAC.01157-10","article-title":"Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections","volume":"55","author":"ME de Kraker","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/cid\/ciu583","article-title":"Avoiding the perfect storm: the biologic and clinical case for reevaluating the 7-day expectation for methicillin-resistant Staphylococcus aureus bacteremia before switching therapy","volume":"59","author":"R Kullar","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/jac\/dkq424","article-title":"Mortality associated with in-hospital bacteraemia caused by Staphylococcus aureus: a multistate analysis with follow-up beyond hospital discharge","volume":"66","author":"M Wolkewitz","journal-title":"J Antimicrob Chemother"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1086\/313650","article-title":"Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia","volume":"30","author":"A Soriano","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1093\/jac\/dkq373","article-title":"Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia","volume":"65","author":"M Paul","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/cid\/civ120","article-title":"Impact of Infectious Disease Consultation on Quality of Care, Mortality, and Length of Stay in Staphylococcus aureus Bacteremia: Results From a Large Multicenter Cohort Study","volume":"60","author":"AD Bai","year":"2015","journal-title":"Clin Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.amjmed.2010.01.015","article-title":"The value of infectious diseases consultation in Staphylococcus aureus bacteremia","volume":"123","author":"H Honda","year":"2010","journal-title":"Am J Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jhin.2010.07.015","article-title":"Mortality in patients with meticillin-resistant Staphylococcus aureus bacteraemia, England 2004\u20132005","volume":"77","author":"TL Lamagni","year":"2011","journal-title":"J Hosp Infect"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jhin.2006.07.001","article-title":"Increased mortality among elderly patients with meticillin-resistant Staphylococcus aureus bacteraemia","volume":"64","author":"E Tacconelli","year":"2006","journal-title":"J Hosp Infect"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1016\/j.ijid.2010.09.012","article-title":"Clinical features and outcome of Staphylococcus aureus infection in elderly versus younger adult patients","volume":"15","author":"CI Kang","year":"2011","journal-title":"Int J Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1086\/502156","article-title":"Role of comorbidity in mortality related to Staphylococcus aureus bacteremia: a prospective study using the Charlson weighted index of comorbidity","volume":"24","author":"O Lesens","year":"2003","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/MD.0b013e31824d7ed2","article-title":"Metastatic infectious disease and clinical outcome in Staphylococcus aureus and Streptococcus species bacteremia","volume":"91","author":"FJ Vos","year":"2012","journal-title":"Medicine (Baltimore)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/cid\/civ808","article-title":"Combination of Vancomycin and beta-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial","volume":"62","author":"JS Davis","year":"2016","journal-title":"Clin Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jceh.2012.11.002","article-title":"Model for End- Stage Liver Disease","volume":"3","author":"HK Singal","year":"2013","journal-title":"J Clin Exp Hepatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0170236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:10:48Z","timestamp":1589001048000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0170236"}},"subtitle":[],"editor":[{"given":"Karsten","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0170236","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}