{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:03:58Z","timestamp":1790327038914,"version":"4.1.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/02397-0"],"award-info":[{"award-number":["2015\/02397-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["470070\/2012-9"],"award-info":[{"award-number":["470070\/2012-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0170317","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T19:33:28Z","timestamp":1484940808000},"page":"e0170317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Environmental Enrichment Blunts Ethanol Consumption after Restraint Stress in C57BL\/6 Mice"],"prefix":"10.1371","volume":"12","author":[{"given":"Priscila","family":"Marianno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Possa","family":"Abrahao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-6108","authenticated-orcid":true,"given":"Rosana","family":"Camarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: a systems approach from molecular physiology to addictive behavior","volume":"89","author":"R Spanagel","year":"2009","journal-title":"Physiol Rev"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1111\/acer.12145","article-title":"Repeated cycles of binge-like ethanol (EtOH)\u2014drinking in male C57BL\/6J mice augments subsequent voluntary EtOH intake but not other dependence-like phenotypes","volume":"37","author":"BR Cox","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1006\/nbdi.2000.0351","article-title":"Drug addiction","volume":"7","author":"G Koob","year":"2000","journal-title":"Neurobiol Dis"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1369-1600.2006.00012.x","article-title":"Behavioural assessment of drug reinforcement and addictive features in rodents: an overview","volume":"11","author":"C Sanchis-Segura","year":"2006","journal-title":"Addict Biol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.alcohol.2006.12.003","article-title":"Characterization of the ethanol-deprivation effect in substrains of C57BL\/6 mice","volume":"40","author":"RT Khisti","year":"2006","journal-title":"Alcohol"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/j.1530-0277.2006.00248.x","article-title":"Development of an alcohol deprivation and escalation effect in C57BL\/6J mice","volume":"30","author":"RI Melendez","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1530-0277.2000.tb04546.x","article-title":"Alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations","volume":"24","author":"ZA Rodd-Henricks","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.alcohol.2014.03.002","article-title":"The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice","volume":"48","author":"V Vengeliene","year":"2014","journal-title":"Alcohol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/alcalc\/34.2.231","article-title":"Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism?","volume":"34","author":"R Spanagel","year":"1999","journal-title":"Alcohol Alcohol"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.biopsych.2008.11.002","article-title":"A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication","volume":"65","author":"JC Crabbe","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"J Nithianantharajah","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbr.2011.04.002","article-title":"The impact of environmental enrichment in laboratory rats\u2014Behavioural and neurochemical aspects","volume":"222","author":"J Simpson","year":"2011","journal-title":"Behav Brain Res"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2004.10.018","article-title":"Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding","volume":"159","author":"KG Hellemans","year":"2005","journal-title":"Behav Brain Res"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbr.2008.04.019","article-title":"Impulsive choice and environmental enrichment: effects of d-amphetamine and methylphenidate","volume":"193","author":"JL Perry","year":"2008","journal-title":"Behav Brain Res"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.pbb.2009.01.016","article-title":"Neurobehavioral effects of environmental enrichment and drug abuse vulnerability","volume":"92","author":"DJ Stairs","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/mp.2009.151","article-title":"The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1","volume":"15","author":"Y Sztainberg","year":"2010","journal-title":"Mol Psychiatry"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/FBP.0b013e32834eb060","article-title":"Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue","volume":"23","author":"MD Puhl","year":"2012","journal-title":"Behav Pharmacol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00213-002-1134-y","article-title":"Environmental enrichment decreases intravenous amphetamine self-administration in rats: dose-response functions for fixed- and progressive-ratio schedules","volume":"162","author":"TA Green","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"issue":"44","key":"ref19","doi-asserted-by":"crossref","first-page":"17145","DOI":"10.1073\/pnas.0806889105","article-title":"Reversal of cocaine addiction by environmental enrichment","volume":"105","author":"M Solinas","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1369-1600.2011.00408.x","article-title":"Environmental enrichment blocks ethanol-induced locomotor sensitization and decreases BDNF levels in the prefrontal cortex in mice","volume":"17","author":"AV Rueda","year":"2012","journal-title":"Addict Biol"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0091-3057(89)90545-5","article-title":"Effects of environmental enrichment on voluntary ethanol intake in rats","volume":"34","author":"GE Rockman","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1037\/a0022627","article-title":"Differential rearing conditions and alcohol-preferring rats: consumption of and operant responding for ethanol","volume":"125","author":"GA Deehan Jr","year":"2011","journal-title":"Behav Neurosci"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2009.11.043","article-title":"Environmental enrichment reduces the impact of novelty and motivational properties of ethanol in spontaneously hypertensive rats","volume":"208","author":"CR de Carvalho","year":"2010","journal-title":"Behav Brain Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2015.05.035","article-title":"Environmental enrichment blocks reinstatement of ethanol-induced conditioned place preference in mice","volume":"599","author":"X Li","year":"2015","journal-title":"Neurosci Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.physbeh.2014.11.012","article-title":"Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL\/6J mice","volume":"148","author":"MF Lopez","year":"2015","journal-title":"Physiol Behav"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1124\/jpet.301.3.785","article-title":"Stress and cocaine addiction","volume":"301","author":"NE Goeders","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"ref27","first-page":"391","article-title":"Stress and alcohol: epidemiologic evidence","volume":"34","author":"KM Keyes","year":"2012","journal-title":"Alcohol Res"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s002130050498","article-title":"Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats","volume":"135","author":"AD L\u00ea","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00213-011-2443-9","article-title":"Effects of stress on alcohol drinking: a review of animal studies","volume":"218","author":"HC Becker","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"issue":"13","key":"ref30","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1038\/npp.2009.127","article-title":"Environmental enrichment reduces cocaine seeking and reinstatement induced by cues and stress but not by cocaine","volume":"34","author":"C Chauvet","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2006.08.016","article-title":"Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress","volume":"175","author":"C Fox","year":"2006","journal-title":"Behav Brain Res"},{"issue":"18","key":"ref32","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1523\/JNEUROSCI.22-18-07840.2002","article-title":"Environmental enrichment reverses the effects of maternal separation on stress reactivity","volume":"22","author":"DD Francis","year":"2002","journal-title":"J Neurosci"},{"issue":"16","key":"ref33","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1523\/JNEUROSCI.0577-11.2011","article-title":"Environmental enrichment confers stress resiliency to social defeat through an infralimbic cortex-dependent neuroanatomical pathway","volume":"31","author":"ML Lehmann","year":"2011","journal-title":"J Neurosci"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.physbeh.2004.10.007","article-title":"Evaluation of a simple model of ethanol drinking to intoxication in C57BL\/6J mice","volume":"84","author":"JS Rhodes","year":"2005","journal-title":"Physiol Behav"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/laban1005-39","article-title":"A rapid, simple, humane method for submandibular bleeding of mice using a lancet","volume":"34","author":"WT Golde","year":"2005","journal-title":"Lab Animal (NY)"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.alcohol.2014.07.015","article-title":"Environmental stressors influence limited-access ethanol consumption by C57BL\/6J mice in a sex-dependent manner","volume":"48","author":"DK Cozzoli","year":"2014","journal-title":"Alcohol"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pbb.2007.04.001","article-title":"Zonisamide decreases ethanol intake in rats and mice","volume":"87","author":"CM Knapp","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1601-183X.2006.00210.x","article-title":"Mouse inbred strain differences in ethanol drinking to intoxication","volume":"6","author":"JS Rhodes","year":"2007","journal-title":"Genes Brain Behav"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neubiorev.2014.11.017","article-title":"Inoculation stress hypothesis of environmental enrichment","volume":"49","author":"EJ Crofton","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"ref40","first-page":"314","article-title":"Environmental enrichment of laboratory rodents: The answer depends on the question","volume":"61","author":"LA Toth","year":"2011","journal-title":"Comp Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.59.103006.093548","article-title":"Addiction and the brain antireward system","volume":"59","author":"GF Koob","year":"2008","journal-title":"Annu Rev Psychol"},{"issue":"4","key":"ref42","first-page":"427","article-title":"Environmental-enrichment-related variations in behavioral, biochemical, and physiologic responses of Sprague-Dawley and Long Evans rats","volume":"49","author":"ATM Konkle","year":"2010","journal-title":"J Am Assoc Lab Anim Sci"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1523\/JNEUROSCI.3878-12.2013","article-title":"Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis","volume":"33","author":"ML Lehmann","year":"2013","journal-title":"J Neurosci"},{"issue":"6","key":"ref44","first-page":"692","article-title":"The evolution of the stress concept","volume":"61","author":"H Selye","year":"1973","journal-title":"Am Sci"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"e0127945","DOI":"10.1371\/journal.pone.0127945","article-title":"Environmental enrichment reduces anxiety by differentially activating serotonergic and neuropeptide Y (NPY)-ergic system in indian field mouse (<italic>Mus booduga<\/italic>): an animal model of post-traumatic stress disorder","volume":"10","author":"D Ragu Varman","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<28::AID-SYN4>3.0.CO;2-J","article-title":"Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies","volume":"23","author":"JD Bremner","year":"1996","journal-title":"Synapse"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10253890701200997","article-title":"GABA(A) receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders","volume":"10","author":"K Matsumoto","year":"2007","journal-title":"Stress"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.pbb.2011.10.010","article-title":"Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats","volume":"100","author":"EI Varlinskaya","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"issue":"Pt A","key":"ref49","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neuropharm.2016.10.026","article-title":"Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala","volume":"113","author":"LS Novaes","year":"2017","journal-title":"Neuropharmacology"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuron.2016.09.029","article-title":"Stress increases ethanol self-administration via a shift toward excitatory GABA signaling in the ventral tegmental area","volume":"92","author":"A Ostroumov","year":"2016","journal-title":"Neuron"},{"issue":"3","key":"ref51","first-page":"143","article-title":"Effect of acute and repeated immobilization stress on food and water intake, urine output and vasopressin changes in rats","volume":"22","author":"N Michajlovskij","year":"1988","journal-title":"Endocrinol Exp"},{"key":"ref52","first-page":"1","article-title":"The physiological regulation of thirst and fluid intake","volume":"19","author":"MJ McKinley","year":"2004","journal-title":"News Physiol Sci"},{"issue":"1\u20132","key":"ref53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-4328(00)00377-6","article-title":"Enrichment-dependent differences in novelty exploration in rats can be explained by habituation","volume":"121","author":"A Zimmermann","year":"2001","journal-title":"Behav Brain Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0170317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T23:29:53Z","timestamp":1719012593000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0170317"}},"subtitle":[],"editor":[{"given":"Andrey E","family":"Ryabinin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,20]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0170317","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,20]]}}}