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Guidelines for the clinical care of patients with thalassemia in Canada. Thalassemia.ca. 2009. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.thalassemia.ca\/resources\/\" xlink:type=\"simple\">http:\/\/www.thalassemia.ca\/resources\/<\/ext-link>"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/GIM.0b013e3181cd68ed","article-title":"Beta-thalassemia","volume":"12","author":"A Cao","year":"2010","journal-title":"Genetics in Medicine"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3324\/haematol.2011.055962","article-title":"Beta-thalassemia: From genotype to phenotype","volume":"96","author":"F Danjou","year":"2011","journal-title":"Haematologica"},{"issue":"22","key":"ref4","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1182\/blood-2010-01-251348","article-title":"The inherited diseases of hemoglobin are an emerging global health burden","volume":"115","author":"D Weatherall","year":"2010","journal-title":"Blood"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1196\/annals.1345.003","article-title":"Changing patterns of thalassemia worldwide","volume":"1054","author":"E Vichinsky","year":"2005","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2471\/BLT.06.036673","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators","volume":"86","author":"B Modell","year":"2008","journal-title":"Bulletin of the World Health Organization"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2010.05546.x","article-title":"Thalassemia as a global health problem: Recent progress toward its control in the developing countries","volume":"1202","author":"D Weatherall","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000086764","article-title":"United Arab Emirates: Communities and community genetics","volume":"8","author":"L Al-Gazali","year":"2005","journal-title":"Public Health Genomics"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/humu.21232","article-title":"Mutations of a country: A mutation review of single gene disorders in the United Arab Emirates (UAE)","volume":"31","author":"L Al-Gazali","year":"2010","journal-title":"Human Mutation"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1399-0004.2001.600201.x","article-title":"Consanguinity and its relevance to clinical genetics","volume":"60","author":"A Bittles","year":"2008","journal-title":"Clinical Genetics"},{"issue":"5007","key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.2028254","article-title":"Reproductive 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Health statistics 2013. Haad.ae. 2013. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.haad.ae\" xlink:type=\"simple\">http:\/\/www.haad.ae<\/ext-link>"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/03630269.2013.791627","article-title":"Hemoglobinopathy carrier prevalence in the United Arab Emirates: First analysis of the Dubai health authority premarital screening program results","volume":"37","author":"K Belhoul","year":"2013","journal-title":"Hemoglobin"},{"key":"ref21","unstructured":"Sheikh Saud bin Saqr Al Qasimi Foundation for Policy Research. Public health in the United Arab Emirates and Ras Al Khaimah. 2015. Availablefrom: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.alqasimifoundation.com\/admin\/Content\/File-1312201511130.pdf\" xlink:type=\"simple\">http:\/\/www.alqasimifoundation.com\/admin\/Content\/File-1312201511130.pdf<\/ext-link>"},{"issue":"2","key":"ref22","first-page":"a011775","article-title":"The Prevention of thalassemia","volume":"3","author":"A Cao","year":"2013","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"ref23","unstructured":"Statistics Center Abu Dhabi. Statistical yearbook of Abu Dhabi 2013. Government.ae. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/government.ae\/documents\/10138\/3525509\/SYB+2013+English+-full+version.pdf\/324407c4-8e0d-4d09-abab-6983547234c8;jsessionid=23GI0V7f+yzLK2zWOB7DJQgI.undefined\" xlink:type=\"simple\">http:\/\/government.ae\/documents\/10138\/3525509\/SYB+2013+English+-full+version.pdf\/324407c4-8e0d-4d09-abab-6983547234c8;jsessionid=23GI0V7f+yzLK2zWOB7DJQgI.undefined<\/ext-link>"},{"key":"ref24","unstructured":"Federal Competitiveness and Statistics Authority. Statistics by subjects. 2015. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/fcsa.gov.ae\" xlink:type=\"simple\">http:\/\/fcsa.gov.ae<\/ext-link>"},{"key":"ref25","unstructured":"WHO. Genes and human disease. Who.int. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/genomics\/public\/geneticdiseases\/en\/index2.html\" xlink:type=\"simple\">http:\/\/www.who.int\/genomics\/public\/geneticdiseases\/en\/index2.html<\/ext-link>"},{"key":"ref26","article-title":"R: A language and environment for statistical computing","year":"2016"},{"issue":"no. 3","key":"ref27","first-page":"1","article-title":"Karline Soetaert and Thomas Petzoldt, Inverse modeling, sensitivity and Monte Carlo analysis in R using package FME","volume":"33","year":"2010","journal-title":"Journal of Statistical Software"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1258\/jms.2008.008029","article-title":"Premarital screening programs for haemoglobinopathies, HIV and hepatitis viruses: Review and factors affecting their success","volume":"16","author":"FM Alswaidi","year":"2009","journal-title":"Journal of Medical Screen"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000430837","article-title":"Exploring the effectiveness of mandatory premarital screening and genetic counseling programs for beta-thalassemia in the Middle East: A scoping review","volume":"18","author":"M Saffi","year":"2015","journal-title":"Public Health Genomics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0170485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:35:08Z","timestamp":1589013308000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0170485"}},"subtitle":[],"editor":[{"given":"Michela","family":"Grosso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,30]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0170485","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,30]]}}}