{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:34:48Z","timestamp":1789400088435,"version":"build-2803163510"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0170676","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T19:26:23Z","timestamp":1485458783000},"page":"e0170676","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessing the Genotypic Differences between Strains of Corynebacterium pseudotuberculosis biovar equi through Comparative Genomics"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-7380","authenticated-orcid":true,"given":"Rafael A.","family":"Bara\u00fana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel T. J.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adonney A. O.","family":"Veras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny C.","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro J.","family":"Benevides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-6437","authenticated-orcid":true,"given":"Marcus V. C.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-9448","authenticated-orcid":true,"given":"Lu\u00eds C.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy M.","family":"Edman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Spier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.2460\/javma.1996.209.04.804","article-title":"Retrospective study of <italic>Corynebacterium pseudotuberculosis<\/italic> infection in horses: 538 cases","volume":"209","author":"M Aleman","year":"1996","journal-title":"J Am Vet Med Ass"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/vr.100543","article-title":"Survival of <italic>Corynebacterium pseudotuberculosis<\/italic> biovar <italic>equi<\/italic> in soil","volume":"170","author":"SJ Spier","year":"2012","journal-title":"Vet Rec"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/01652176.1996.9694623","article-title":"Mastitis in dairy cattle caused by <italic>Corynebacterium pseudotuberculosis<\/italic> and the feasibility of transmission by houseflies","volume":"18","author":"I Yeruham","year":"1996","journal-title":"Vet Q"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2460\/ajvr.2004.65.829","article-title":"Use of a real-time polymerase chain reaction-based fluorogenic 5\u2019 nuclease assay to evaluate insect vectors of <italic>Corynebacterium pseudotuberculosis<\/italic> infections in horses","volume":"65","author":"SJ Spier","year":"2004","journal-title":"Am J Vet Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40793-016-0149-7","article-title":"The genome anatomy of <italic>Corynebacterium pseudotuberculosis<\/italic> VD57 a high virulent strain causing Caseous lymphadenitis","volume":"11","author":"S Almeida","year":"2016","journal-title":"Stand Genomic Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/vr.89.26.691","article-title":"Two biotypes of <italic>Corynebacterium pseudotuberculosis<\/italic>","volume":"89","author":"EL Biberstein","year":"1971","journal-title":"Vet Rec"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-1135(95)00146-8","article-title":"Genetic differences between nitrate-negative and nitrate-positive <italic>C<\/italic>. <italic>pseudotuberculosis<\/italic> strains using restriction fragment length polymorphisms","volume":"49","author":"SS Sutherland","year":"1996","journal-title":"Vet Microbiol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2460\/javma.245.3.309","article-title":"Frequency of <italic>Corynebacterium pseudotuberculosis<\/italic> infection in horses across the United States during a 10-year period","volume":"245","author":"I Kilcoyne","year":"2014","journal-title":"J Am Vet Med Assoc"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jevs.2013.06.006","article-title":"Re-emergence of Pigeon Fever (<italic>Corynebacterium pseudotuberculosis<\/italic>) infection in Texas horses: epidemiologic investigation of laboratory-diagnosed cases","volume":"34","author":"B Szonyi","year":"2014","journal-title":"J Equine Vet Sci"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"e0140666","DOI":"10.1371\/journal.pone.0140666","article-title":"Bayesian geostatistical analysis and ecoclimate determinants of <italic>Corynebacterium pseudotuberculosis<\/italic> infection among horses","volume":"10","author":"C Boysen","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0737-0806(01)70058-5","article-title":"<italic>Corynebacterium pseudotuberculosis<\/italic> infection (Pigeon Fever) in horses in Western Colorado: an epidemiological investigation","volume":"21","author":"K Hall","year":"2001","journal-title":"J Equine Vet Sci"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0167-5877(98)00071-3","article-title":"Risk factors associated with <italic>Corynebacterium pseudotuberculosis<\/italic> infection in California horses","volume":"35","author":"MG Doherr","year":"1998","journal-title":"Prev Vet Med"},{"issue":"6","key":"ref13","first-page":"e01385","article-title":"Complete genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> strain E19, isolated from a horse in Chile","volume":"3","author":"ALQ Cavalcante","year":"2015","journal-title":"Genome Announc"},{"issue":"23","key":"ref14","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1128\/JB.01782-12","article-title":"Complete genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> Cp31, isolated from a Egyptian buffalo","volume":"194","author":"A Silva","year":"2012","journal-title":"J Bacteriol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.tvjl.2014.03.009","article-title":"The relationship between <italic>Corynebacterium pseudotuberculosis<\/italic> biovar <italic>equi<\/italic> phenotype with location and extent of lesions in horses","volume":"200","author":"E Britz","year":"2014","journal-title":"Vet J"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"e00977","DOI":"10.1128\/genomeA.00977-14","article-title":"Genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> MB20 bv. <italic>equi<\/italic> isolated from a pectoral abscesso f na Oldenburg horse in California","volume":"2","author":"RA Bara\u00fana","year":"2014","journal-title":"Genome Announc"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"e00176","DOI":"10.1128\/genomeA.00176-16","article-title":"Whole-genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> 262 biovar <italic>equi<\/italic> isolated from Cow milk","volume":"4","author":"CL Ara\u00fajo","year":"2016","journal-title":"Genome Announc"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"e54287","DOI":"10.1371\/journal.pone.0054287","article-title":"Evolution of a Pathogen: a comparative genomic analysis identifies a genetic pathway to pathogenesis in <italic>Acinetobacter<\/italic>","volume":"8","author":"JW Sahl","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"e53818","DOI":"10.1371\/journal.pone.0053818","article-title":"The pan-genome of the animal pathogen <italic>Corynebacterium pseudotuberculosis<\/italic> reveals differences in genome plasticity between the biovar <italic>ovis<\/italic> and <italic>equi<\/italic> strains","volume":"8","author":"SC Soares","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref20","first-page":"323","article-title":"Complete genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> I19, a strain isolated from a cow in Israel with bovine mastitis","volume":"193","author":"A Silva","year":"2011","journal-title":"Genome Announc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1186\/1471-2164-11-728","article-title":"The complete genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> FRC41 isolated from a 12-year old girl with necrotizing lymphadenitis reveals insights into the gene-regulatory networks contributing to virulence","volume":"11","author":"E Trost","year":"2010","journal-title":"BMC Genomics"},{"issue":"16","key":"ref22","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/bioinformatics\/btp356","article-title":"Reordering contigs of draft genomes using the Mauve aligner","volume":"25","author":"AI Rissman","year":"2009","journal-title":"Bioinformatics"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/nar\/25.5.0955","article-title":"tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequences","volume":"25","author":"TM Lowe","year":"1997","journal-title":"Nucl Acids Res"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/bioinformatics\/btr703","article-title":"Artemis: an integrated platform for visualization and analysis of high-throughput sequence-based experimental data","volume":"28","author":"T Carver","year":"2012","journal-title":"Bioinformatics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1471-2164-12-402","article-title":"BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons","volume":"12","author":"NF Alikhan","year":"2011","journal-title":"BMC Genomics"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1099\/00207713-45-4-740","article-title":"Phylogeny of the genus <italic>Corynebacterium<\/italic> deduced from analysis of small-subunit ribosomal DNA sequences","volume":"45","author":"R Ruimy","year":"1995","journal-title":"Int J Syst Bacteriol"},{"key":"ref27","article-title":"GIPSy: Genomic island prediction software","author":"SC Soares","year":"2015","journal-title":"J Biotechnol"},{"issue":"16","key":"ref28","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1093\/bioinformatics\/bti553","article-title":"ACT: the Artemis comparison tool","volume":"21","author":"TJ Carver","year":"2005","journal-title":"Bioinformatics"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1128\/IAI.73.5.2881-2890.2005","article-title":"Effects of Oligopeptide Permease in group A Streptococcal infection","volume":"73","author":"CH Wang","year":"2005","journal-title":"Infect Immun"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.1365-2958.2001.02440.x","article-title":"Oligopeptide permeases is required for expression of the <italic>Bacillus thuringiensis plcR<\/italic> regulon and for virulence","volume":"40","author":"M Gorminet","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/jvim.12534","article-title":"Minimum Inhibitory Concentrations of equine <italic>Corynebacterium pseudotuberculosis<\/italic> isolates (1996\u20132012)","volume":"29","author":"DM Rhodes","year":"2015","journal-title":"J Vet Intern Med"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"e39107","DOI":"10.1371\/journal.pone.0039107","article-title":"Gegenees: Fragmented alignment of multiple genomes for determining phylogenomic distances and genetic signatures unique for specified target groups","volume":"7","author":"J \u00c2gren","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/molbev\/msj030","article-title":"Application of phylogenetic networks in evolutionary studies","volume":"23","author":"DH Huson","year":"2006","journal-title":"Mol Biol Evol"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1046\/j.1365-2958.2003.03782.x","article-title":"Assembly of pili on the surface of <italic>Corynebacterium diphtheriae<\/italic>","volume":"50","author":"H Ton-That","year":"2003","journal-title":"Mol Microbiol"},{"issue":"W1","key":"ref35","doi-asserted-by":"crossref","first-page":"W41","DOI":"10.1093\/nar\/gkw330","article-title":"Simple Synteny: a web-based tool for visualization of microsynteny across multiple species","volume":"44","author":"D Veltri","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1365-2958.2007.05968.x","article-title":"Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in <italic>Corynebacterium diphtheriae<\/italic>","volume":"66","author":"A Swaminathan","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref37","article-title":"PHAST: a fast phage search tool","author":"Y Zhou","year":"2011","journal-title":"Nucl Acids Res"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1042\/bst0320214","article-title":"Habitat, applications and genomics of the aerobic, thermophilic genus <italic>Geobacillus<\/italic>","volume":"32","author":"G McMullan","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"14833","DOI":"10.1038\/srep14833","article-title":"High resolution structure of an M23 peptidase with a substrate analogue","volume":"5","author":"M Grabowska","year":"2015","journal-title":"Sci Rep"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/bioinformatics\/btr655","article-title":"PGAP: pan-genomes analysis pipeline","volume":"28","author":"Y Zhao","year":"2012","journal-title":"Bioinformatics"},{"issue":"24","key":"ref41","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1128\/JB.06293-11","article-title":"Complete genome sequence of <italic>Corynebacterium pseudotuberculosis<\/italic> strain CIP 52.97, isolated from a horse in Kenya","volume":"193","author":"LT Cerdeira","year":"2011","journal-title":"J Bacteriol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1471-2105-10-154","article-title":"EDGAR: a software framework for the comparative analysis of prokaryotic genomes","volume":"10","author":"J Blom","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1128\/JB.00619-08","article-title":"The pangenome structure of <italic>Escherichia coli<\/italic>: comparative genomic analysis of <italic>E<\/italic>. <italic>coli<\/italic> commensal and pathogenic isolates","volume":"190","author":"DA Rasko","year":"2008","journal-title":"J Bacteriol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1002132","DOI":"10.1371\/journal.ppat.1002132","article-title":"Dynamic evolution of pathogenicity revealed by sequencing and comparative genomics of 19 <italic>Pseudomonas syringae<\/italic> isolates","volume":"7","author":"DA Baltrus","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2010-11-10-r107","article-title":"Structure and dynamics of the pan-genome of <italic>Streptococcus pneumoniae<\/italic> and closely related species","volume":"11","author":"C Donati","year":"2010","journal-title":"Genome Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/1471-2164-11-500","article-title":"Probing the pangenome of <italic>Listeria monocytogenes<\/italic>: new insights into intraspecific niche expansion and genomic diversification","volume":"11","author":"X Deng","year":"2010","journal-title":"BMC Genomics"},{"issue":"10","key":"ref47","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1073\/pnas.93.10.4787","article-title":"Targeted replacement of the mycocerosic acid synthase gene in <italic>Mycobacterium bovis<\/italic> BCG produces a mutant that lacks mycosides","volume":"93","author":"AK Azad","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gki442","article-title":"InterProScan: protein domains identifier","volume":"33","author":"E Quevillon","year":"2005","journal-title":"Nucl Acids Res"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0966-842X(02)02307-7","article-title":"Bacteria killing their own kind: novel bacteriocins of <italic>Pseudomonas<\/italic> and other \u03b3-proteobacteria","volume":"10","author":"AHA Parret","year":"2002","journal-title":"Trends Microbiol"},{"key":"ref50","article-title":"Survival of <italic>Corynebacterium pseudotuberculosis<\/italic> biovar <italic>equi<\/italic> in soil","author":"SJ Spier","year":"2012","journal-title":"Vet Rec"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1099\/jmm.0.46997-0","article-title":"Multiplex PCR assay for identification of <italic>Corynebacterium pseudotuberculosis<\/italic> from pure cultures and for rapid detection of this pathogen in clinical samples","volume":"56","author":"LGC Pacheco","year":"2007","journal-title":"J Med Microbiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1101\/gr.1917404","article-title":"Using the miraEST assembler for reliable and automated mRNA transcript assembly and SNP detection in sequenced ESTs","volume":"14","author":"B Chevreux","year":"2004","journal-title":"Genome Res"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.4238\/2013.August.16.2","article-title":"Pannotator: an automated tool for annotation of pan-genomes","volume":"12","author":"AR Santos","year":"2013","journal-title":"Genet Mol Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"W181","DOI":"10.1093\/nar\/gkn179","article-title":"The CGView Server: a comparative genomics tool for circular genomes","volume":"36","author":"JR Grant","year":"2008","journal-title":"Nucl Acids Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0170676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T02:48:01Z","timestamp":1719024481000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0170676"}},"subtitle":[],"editor":[{"given":"Ulrike Gertrud","family":"Munderloh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,26]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0170676","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,26]]}}}