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Intelligent Data Engineering and Automated Learning\u2014IDEAL 2009. 2009;Proceedings 5788(641\u2013648).","DOI":"10.1007\/978-3-642-04394-9_78"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroimage.2013.06.058","article-title":"Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly","volume":"83","author":"T Liu","year":"2013","journal-title":"NeuroImage"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neubiorev.2004.03.004","article-title":"Regional dissociations within the hippocampus\u2014memory and anxiety","volume":"28","author":"DM Bannerman","year":"2004","journal-title":"Neurosci Biobehav R"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","article-title":"The human hippocampus and spatial and episodic memory","volume":"35","author":"N Burgess","year":"2002","journal-title":"Neuron"},{"key":"ref52","unstructured":"Cohen NJ, Eichenbaum H. Memory, amnesia, and the hippocampal system. 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