{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:06:22Z","timestamp":1763766382190,"version":"3.37.3"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31302077"],"award-info":[{"award-number":["31302077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572019"],"award-info":[{"award-number":["81572019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)"},{"name":"the Starting Foundation for Talents of Xuzhou Medical College","award":["53591317"],"award-info":[{"award-number":["53591317"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171005","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T13:50:40Z","timestamp":1486043440000},"page":"e0171005","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased hepatic Th2 and Treg subsets are associated with biliary fibrosis in different strains of mice caused by Clonorchis sinensis"],"prefix":"10.1371","volume":"12","author":[{"given":"Bei-Bei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Xian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui-Yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"issue":"10020","key":"ref1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0140-6736(15)60313-0","article-title":"Clonorchiasis","volume":"387","author":"MB Qian","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4174\/astr.2014.87.2.104","article-title":"Acute cholecystitis associated with <italic>Clonorchis sinensis<\/italic> infection","volume":"87","author":"JT Oh","year":"2014","journal-title":"Ann Surg Treat Res"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"e42471","DOI":"10.1371\/journal.pone.0042471","article-title":"Cholecystolithiasis is associated with <italic>Clonorchis sinensis<\/italic> infection","volume":"7","author":"T Qiao","year":"2012","journal-title":"PloS one"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1245\/s10434-014-3710-x","article-title":"Identification of risk and prognostic factors for patients with clonorchiasis-associated intrahepatic cholangiocarcinoma","volume":"21","author":"GW Zhang","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2049-9957-1-4","article-title":"The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma","volume":"1","author":"MB Qian","year":"2012","journal-title":"Infect Dis Poverty"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrm2455","article-title":"Cancer as an overhealing wound: an old hypothesis revisited","volume":"9","author":"M Schafer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"ref7","first-page":"65","article-title":"Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms","volume":"57","author":"F Okada","year":"2014","journal-title":"Yonago Acta Med"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Yan C, Wang L, Li B, Zhang BB, Zhang B, Wang YH, et al. The expression dynamics of transforming growth factor-\u03b2\/Smad signaling in the liverHYPERLINK &quot;javascript:;&quot; HYPERLINK &quot;javascript:;&quot;fibrosis HYPERLINK &quot;javascript:;&quot;experimentally caused byHYPERLINK &quot;javascript:;&quot; HYPERLINK &quot;javascript:;&quot;Clonorchis sinensisHYPERLINK &quot;javascript:;&quot;. Parasit Vectors. 2015;4:70.","DOI":"10.1186\/s13071-015-0675-y"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182016000111","article-title":"<italic>Strongyloides<\/italic> infection in rodents: immune response and immune regulation","volume":"24","author":"M Breloer","year":"2016","journal-title":"Parasitology"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tree.2008.02.011","article-title":"Parasite immune evasion: a momentous molecular war","volume":"23","author":"P Schmid-Hempel","year":"2008","journal-title":"Trends Ecol Evol"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.mib.2005.06.011","article-title":"Parasite immune escape: new views into host-parasite interactions","volume":"8","author":"S Gupta","year":"2005","journal-title":"Curr Opin Microbiol"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2016.0189","article-title":"Effects of protein malnutrition on tolerance to helminth infection","volume":"12","author":"D Clough","year":"2016","journal-title":"Biol Lett"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.parint.2011.07.001","article-title":"Cyst formation, increased anti-inflammatory cytokines and expression of chemokines support for <italic>Clonorchis sinensis<\/italic> infection in FVB mice","volume":"61","author":"EM Kim","year":"2012","journal-title":"Parasitol Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fimmu.2014.00487","article-title":"The differentiation of CD4<sup>+<\/sup>T-helper cell subsets in the context of helminth parasite infection","volume":"5","author":"T Bouchery","year":"2014","journal-title":"Front Immunol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/eji.201343746","article-title":"IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo","volume":"44","author":"KA Smith","year":"2014","journal-title":"Eur J Immunol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.4049\/jimmunol.0802767","article-title":"Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival","volume":"182","author":"R D'Elia","year":"2009","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13071-015-0650-7","article-title":"An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with <italic>Schistosoma japonicum<\/italic>","volume":"8","author":"W Zhang","year":"2015","journal-title":"Parasit Vectors"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/CMR.05040-11","article-title":"Helminth infections and host immune regulation","volume":"25","author":"HJ McSorley","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4<sup>+<\/sup> effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"LE Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.jaci.2013.03.015","article-title":"Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease","volume":"131","author":"K Hirahara","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4049\/jimmunol.1500745","article-title":"Parasite Antigen-Specific Regulation of Th1, Th2, and Th17 Responses in <italic>Strongyloides stercoralis<\/italic> Infection","volume":"195","author":"R Anuradha","year":"2015","journal-title":"J immuno"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the TH1\/TH2 paradigm","volume":"4","author":"TA Wynn","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/infdis\/jis654","article-title":"T-helper 17 cells are associated with pathology in human schistosomiasis","volume":"207","author":"M Mbow","year":"2013","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/eji.200737063","article-title":"Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2","volume":"37","author":"LE Layland","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref25","first-page":"1187","article-title":"Th1\/Th2 cytokine profile in spleen mononuclear cells of mice infected with <italic>Clonorchis<\/italic> stimulated by excretory-secretory antigen","volume":"9","author":"QQ Guo","year":"2009","journal-title":"Journal of Tropical Medicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e0143217","DOI":"10.1371\/journal.pone.0143217","article-title":"The dynamics of Treg\/Th17 and the imbalance of Treg\/Th17 in <italic>Clonorchis sinensis<\/italic>-infected mice","volume":"10","author":"C Yan","year":"2015","journal-title":"Plos One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"29844","DOI":"10.1038\/srep29844","article-title":"IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages","volume":"6","author":"H Peng","year":"2016","journal-title":"Scientific Reports"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s00436-016-5012-7","article-title":"Interleukin-13 is involved in the formation of liver fibrosis in <italic>Clonorchis sinensis<\/italic>-infected mice","volume":"115","author":"Y Xu","year":"2016","journal-title":"Parasitol Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.parint.2011.07.002","article-title":"Strain variation in the susceptibility and immune response to <italic>Clonorchis sinensis<\/italic> infection in mice","volume":"61","author":"MH Uddin","year":"2012","journal-title":"Parasitol Int"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijpara.2015.11.003","article-title":"Oxidative stress-mediated mouse liver lesions caused by <italic>Clonorchis sinensis<\/italic> infection","volume":"46","author":"S Maeng","year":"2016","journal-title":"Int J Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3347\/kjp.2015.53.6.777","article-title":"Pathological lesions and inducible nitric oxide synthase expressions in the liver of mice experimentally infected with <italic>Clonorchis sinensis<\/italic>","volume":"53","author":"QL Yang","year":"2015","journal-title":"Korean J Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1046\/j.1365-2168.2002.02143.x","article-title":"Liver fluke-associated cholangiocarcinoma","volume":"89","author":"P Watanapa","year":"2002","journal-title":"Br J Surg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.4049\/jimmunol.0900579","article-title":"The MHC haplotype H2b converts two pure nonlupus mouse strains to producers of antinuclear antibodies","volume":"183","author":"K Hannestad","year":"2009","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e5113","DOI":"10.1371\/journal.pone.0005113","article-title":"The MHC gene region of murine hosts influences the differential tissue tropism of infecting <italic>Trypanosoma cruzi<\/italic> strains","volume":"4","author":"JM Freitas","year":"2009","journal-title":"PloS one"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/CIRCGENETICS.110.957449","article-title":"Genes within the MHC region have a dramatic influence on radiation-enhanced atherosclerosis in mice","volume":"3","author":"W Shi","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e733","DOI":"10.1371\/journal.pntd.0000733","article-title":"Specific humoral immunity versus polyclonal B cell activation in <italic>Trypanosoma cruzi<\/italic> infection of susceptible and resistant mice","volume":"4","author":"MA Bryan","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.imbio.2015.11.012","article-title":"Susceptibility and resistance to <italic>Echinococcus granulosus<\/italic> infection: Associations between mouse strains and early peritoneal immune responses","volume":"221","author":"G Mourglia-Ettlin","year":"2016","journal-title":"Immunobiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00436-003-0934-2","article-title":"Cytokine responses in mice infected with <italic>Clonorchis sinensis<\/italic>","volume":"91","author":"YK Choi","year":"2003","journal-title":"Parasitol Res"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exppara.2011.09.003","article-title":"Over expression of IL-10 by macrophages overcomes resistance to murine filariasis","volume":"132","author":"S Specht","year":"2012","journal-title":"Exp Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0031182008005192","article-title":"FVB\/N mice are highly resistant to primary infection with <italic>Nippostrongylus brasiliensis<\/italic>","volume":"136","author":"ML Knott","year":"2009","journal-title":"Parasitology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1164\/rccm.201410-1820OC","article-title":"The Causal Role of IL-4 and IL-13 in S<italic>chistosoma mansoni<\/italic> Pulmonary Hypertension","volume":"192","author":"R Kumar","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"416480","DOI":"10.1155\/2015\/416480","article-title":"T helper 17\/Regulatory T cell balance and experimental models of peritoneal dialysis-induced damage","volume":"2015","author":"G Liappas","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e15404","DOI":"10.1371\/journal.pone.0015404","article-title":"CD4<sup>+<\/sup>CD25<sup>+<\/sup>Foxp3<sup>+<\/sup> regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice","volume":"5","author":"P Martin","year":"2010","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e74955","DOI":"10.1371\/journal.pone.0074955","article-title":"Adoptive transfer of regulatory T cells protects against Coxsackievirus B3-induced cardiac fibrosis","volume":"8","author":"P Martin","year":"2013","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/jcmm.12806","article-title":"Atopic dermatitis induces the expansion of thymus-derived regulatory T cells exhibiting a Th2-like phenotype in mice","volume":"20","author":"V Moosbrugger-Martinz","year":"2016","journal-title":"J Cell Mol Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.ajpath.2016.03.020","article-title":"CD4<sup>+<\/sup>CD25<sup>hi<\/sup>Foxp3<sup>+<\/sup> cells exacerbate bleomycin-induced pulmonary fibrosis","volume":"186","author":"SZ Birjandi","year":"2016","journal-title":"Am J Pathol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T02:14:57Z","timestamp":1568772897000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171005"}},"subtitle":[],"editor":[{"given":"Patricia","family":"Talamas-Rohana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171005","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}