{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:10:00Z","timestamp":1791861000966,"version":"4.3.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371763"],"award-info":[{"award-number":["81371763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Program of China","award":["2015CB554203"],"award-info":[{"award-number":["2015CB554203"]}]},{"name":"National key basic research program of China","award":["2015CB554201"],"award-info":[{"award-number":["2015CB554201"]}]},{"name":"priority project from the Ministry of Health of China","award":["2016YFC1200103"],"award-info":[{"award-number":["2016YFC1200103"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI120489"],"award-info":[{"award-number":["R01AI120489"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171201","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T18:54:24Z","timestamp":1486061664000},"page":"e0171201","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["OxyR-activated expression of Dps is important for Vibrio cholerae oxidative stress resistance and pathogenesis"],"prefix":"10.1371","volume":"12","author":[{"given":"Xiaoyun","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Larios-Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-3599","authenticated-orcid":true,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/MMBR.62.4.1301-1314.1998","article-title":"Epidemiology, Genetics, and Ecology of ToxigenicVibrio cholerae","volume":"62","author":"SM Faruque","year":"1998","journal-title":"Microbiology and molecular biology reviews"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/S0140-6736(12)60436-X","article-title":"Cholera","volume":"379","author":"J. F Harris","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"e1004787","DOI":"10.1371\/journal.ppat.1004787","article-title":"Intestinal colonization dynamics of Vibrio cholerae","volume":"11","author":"S Almagro-Moreno","year":"2015","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1574-6976.2002.tb00605.x","article-title":"Vibrio cholerae and cholera: out of the water and into the host","volume":"26","author":"J Reidl","year":"2002","journal-title":"FEMS microbiology reviews"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1073\/pnas.1014640108","article-title":"Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB","volume":"108","author":"Z Liu","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1073\/pnas.1218039110","article-title":"Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence","volume":"110","author":"M Yang","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2015.12.038","article-title":"Differential Thiol-Based Switches Jump-Start Vibrio cholerae Pathogenesis","volume":"14","author":"Z Liu","year":"2016","journal-title":"Cell reports"},{"issue":"22","key":"ref8","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1128\/JB.01824-14","article-title":"Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters","volume":"196","author":"JJ Thomson","year":"2014","journal-title":"J Bacteriol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbagen.2003.10.016","article-title":"Role of the W07-toxin on Vibrio cholerae-induced diarrhoea","volume":"1670","author":"S Bhattacharyya","year":"2004","journal-title":"Biochimica et biophysica acta"},{"issue":"2","key":"ref10","first-page":"221","article-title":"Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139","volume":"9","author":"F Qadri","year":"2002","journal-title":"Clinical and diagnostic laboratory immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.physiol.68.040104.110001","article-title":"Oxidative stress in marine environments: biochemistry and physiological ecology","volume":"68","author":"MP Lesser","year":"2006","journal-title":"Annual review of physiology"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"e53383","DOI":"10.1371\/journal.pone.0053383","article-title":"Catalases promote resistance of oxidative stress in Vibrio cholerae","volume":"7","author":"H Wang","year":"2012","journal-title":"PloS one"},{"key":"ref13","article-title":"Thiol-based switch mechanism of virulence regulator AphB modulates oxidative stress response in Vibrio cholerae","author":"Z Liu","year":"2016","journal-title":"Molecular microbiology"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1073\/pnas.052694299","article-title":"Quorum-sensing regulators control virulence gene expression in Vibrio cholerae","volume":"99","author":"J Zhu","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/AEM.02804-06","article-title":"Quorum sensing enhances the stress response in Vibrio cholerae","volume":"73","author":"A Joelsson","year":"2007","journal-title":"Applied and environmental microbiology"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.marpolbul.2006.04.011","article-title":"Salinity-induced survival strategy of Vibrio cholerae associated with copepods in Cochin backwaters","volume":"52","author":"KU Thomas","year":"2006","journal-title":"Marine pollution bulletin"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1369-5274(99)80033-2","article-title":"Oxidative stress","volume":"2","author":"G Storz","year":"1999","journal-title":"Current opinion in microbiology"},{"issue":"12B","key":"ref18","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1101\/gad.6.12b.2646","article-title":"A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli","volume":"6","author":"M Almiron","year":"1992","journal-title":"Genes Dev"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2672.2010.04890.x","article-title":"Structure, function and regulation of the DNA-binding protein Dps and its role in acid and oxidative stress resistance in Escherichia coli: a review","volume":"110","author":"LN Calhoun","year":"2011","journal-title":"J Appl Microbiol"},{"issue":"20","key":"ref20","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1128\/JB.181.20.6361-6370.1999","article-title":"Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid","volume":"181","author":"T Ali Azam","year":"1999","journal-title":"J Bacteriol"},{"issue":"13","key":"ref21","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1128\/jb.176.13.3928-3935.1994","article-title":"Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB","volume":"176","author":"O Lomovskaya","year":"1994","journal-title":"Journal of bacteriology"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2958.1994.tb00421.x","article-title":"The dps promoter is activated by OxyR during growth and by IHF and \u03c3S in stationary phase","volume":"13","author":"S Altuvia","year":"1994","journal-title":"Molecular microbiology"},{"issue":"31","key":"ref23","doi-asserted-by":"crossref","first-page":"27689","DOI":"10.1074\/jbc.M202094200","article-title":"Iron and hydrogen peroxide detoxification properties of DNA-binding protein from starved cells. A ferritin-like DNA-binding protein of Escherichia coli","volume":"277","author":"G Zhao","year":"2002","journal-title":"J Biol Chem"},{"issue":"16","key":"ref24","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1128\/jb.179.16.5188-5194.1997","article-title":"Protection of DNA during oxidative stress by the nonspecific DNA-binding protein Dps","volume":"179","author":"A Martinez","year":"1997","journal-title":"Journal of bacteriology"},{"issue":"13","key":"ref25","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1128\/JB.186.13.4192-4198.2004","article-title":"Dps protects cells against multiple stresses during stationary phase","volume":"186","author":"S Nair","year":"2004","journal-title":"Journal of bacteriology"},{"issue":"31","key":"ref26","doi-asserted-by":"crossref","first-page":"27689","DOI":"10.1074\/jbc.M202094200","article-title":"Iron and hydrogen peroxide detoxification properties of DNA-binding protein from starved cells A ferritin-like DNA-binding protein of Escherichia coli","volume":"277","author":"G Zhao","year":"2002","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1471-2180-8-181","article-title":"Acid stress damage of DNA is prevented by Dps binding in Escherichia coli O157: H7","volume":"8","author":"KC Jeong","year":"2008","journal-title":"BMC microbiology"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.micres.2008.12.003","article-title":"The Dps protein of Escherichia coli is involved in copper homeostasis","volume":"165","author":"D Thieme","year":"2010","journal-title":"Microbiological research"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bbagen.2010.01.013","article-title":"The multifaceted capacity of Dps proteins to combat bacterial stress conditions: detoxification of iron and hydrogen peroxide and DNA binding","volume":"1800","author":"E Chiancone","year":"2010","journal-title":"Biochimica et Biophysica Acta (BBA)-General Subjects"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1128\/IAI.72.2.1155-1158.2004","article-title":"The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress resistance and virulence","volume":"72","author":"TA Halsey","year":"2004","journal-title":"Infection and immunity"},{"issue":"22","key":"ref31","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1128\/AEM.01742-10","article-title":"Ralstonia solanacearum Dps contributes to oxidative stress tolerance and to colonization of and virulence on tomato plants","volume":"76","author":"JM Colburn-Clifford","year":"2010","journal-title":"Applied and environmental microbiology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1128\/IAI.74.2.1141-1147.2006","article-title":"Genetic and phenotypic diversity of quorum-sensing systems in clinical and environmental isolates of Vibrio cholerae","volume":"74","author":"A Joelsson","year":"2006","journal-title":"Infection and immunity"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/plas.1996.0001","article-title":"Conditionally Replicative and Conjugative Plasmids CarryinglacZ\u03b1 for Cloning, Mutagenesis, and Allele Replacement in Bacteria","volume":"35","author":"WW Metcalf","year":"1996","journal-title":"Plasmid"},{"issue":"27","key":"ref34","doi-asserted-by":"crossref","first-page":"11145","DOI":"10.1073\/pnas.0703860104","article-title":"Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae","volume":"104","author":"BK Hammer","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"28","key":"ref35","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1073\/pnas.0802241105","article-title":"Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing","volume":"105","author":"Z Liu","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"14","key":"ref36","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/jb.177.14.4121-4130.1995","article-title":"Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter","volume":"177","author":"L-M Guzman","year":"1995","journal-title":"Journal of bacteriology"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1348-0421.1986.tb03037.x","article-title":"Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor","volume":"30","author":"M Iwanaga","year":"1986","journal-title":"Microbiology and immunology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mimet.2015.05.016","article-title":"Enumeration of viable non-culturable Vibrio cholerae using propidium monoazide combined with quantitative PCR","volume":"115","author":"B Wu","year":"2015","journal-title":"Journal of microbiological methods"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1128\/IAI.64.6.2246-2255.1996","article-title":"Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression","volume":"64","author":"CL Gardel","year":"1996","journal-title":"Infection and immunity"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2164-6-115","article-title":"Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide","volume":"6","author":"W Chang","year":"2005","journal-title":"BMC Genomics"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1128\/IAI.01094-07","article-title":"Regulatory networks controlling Vibrio cholerae virulence gene expression","volume":"75","author":"JS Matson","year":"2007","journal-title":"Infect Immun"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"e00013","DOI":"10.1128\/mBio.00013-12","article-title":"The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines","volume":"3","author":"AM Stern","year":"2012","journal-title":"mBio"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"M Krzywinski","year":"2009","journal-title":"Genome Res"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2958.1994.tb00421.x","article-title":"The dps promoter is activated by OxyR during growth and by IHF and sigma S in stationary phase","volume":"13","author":"S Altuvia","year":"1994","journal-title":"Mol Microbiol"},{"issue":"19","key":"ref45","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1128\/JB.00475-15","article-title":"The DNA-Binding Protein from Starved Cells (Dps) Utilizes Dual Functions To Defend Cells against Multiple Stresses","volume":"197","author":"VO Karas","year":"2015","journal-title":"J Bacteriol"},{"issue":"19","key":"ref46","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1128\/JB.00475-15","article-title":"The DNA-binding protein from starved cells (Dps) utilizes dual functions to defend cells against multiple stresses","volume":"197","author":"VO Karas","year":"2015","journal-title":"Journal of bacteriology"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1128\/MMBR.51.3.365-379.1987","article-title":"Survival strategies of bacteria in the natural environment","volume":"51","author":"DB Roszak","year":"1987","journal-title":"Microbiol Rev"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1462-2920.2006.01206.x","article-title":"Gene expression profile of Vibrio cholerae in the cold stress-induced viable but non-culturable state","volume":"9","author":"H Asakura","year":"2007","journal-title":"Environ Microbiol"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1128\/IAI.64.6.2246-2255.1996","article-title":"Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression","volume":"64","author":"CL Gardel","year":"1996","journal-title":"Infect Immun"},{"issue":"9","key":"ref50","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1073\/pnas.84.9.2833","article-title":"Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin","volume":"84","author":"RK Taylor","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"e00430","DOI":"10.1128\/mBio.00430-13","article-title":"Streptomycin-Induced Inflammation Enhances Escherichia coli Gut Colonization Through Nitrate Respiration","volume":"4","author":"AM Spees","year":"2013","journal-title":"mBio"},{"key":"ref52","article-title":"Thiol-based switch mechanism of virulence regulator AphB modulates oxidative stress response in Vibrio cholerae","author":"Z Liu","year":"2016","journal-title":"Molecular Microbiology"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions. Cellular and molecular life sciences","volume":"60","author":"M Zafarullah","year":"2003","journal-title":"CMLS"},{"issue":"1\u20133","key":"ref54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejphar.2012.06.014","article-title":"N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice","volume":"691","author":"I Amrouche-Mekkioui","year":"2012","journal-title":"European journal of pharmacology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T16:08:39Z","timestamp":1601568519000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171201"}},"subtitle":[],"editor":[{"given":"Michael R.","family":"Volkert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171201","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}