{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:47:22Z","timestamp":1793314042555,"version":"4.5.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI033144"],"award-info":[{"award-number":["AI033144"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI048793"],"award-info":[{"award-number":["AI048793"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171261","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T13:46:25Z","timestamp":1486129585000},"page":"e0171261","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses"],"prefix":"10.1371","volume":"12","author":[{"given":"Inna G.","family":"Ovsyannikova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Schaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth R.","family":"Larrabee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iana H.","family":"Haralambieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/S0264-410X(00)00468-0","article-title":"Twin studies of immunogenicity\u2014determining the genetic contribution to vaccine failure","volume":"19","author":"PL Tan","year":"2001","journal-title":"Vaccine"},{"issue":"6","key":"ref2","first-page":"653","article-title":"Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics","volume":"82","author":"GA Poland","year":"2007","journal-title":"Clin PharmacolTher"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0092-8674(94)90336-0","article-title":"MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation","volume":"76","author":"RN Germain","year":"1994","journal-title":"Cell"},{"issue":"3\u20134","key":"ref4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0264-410X(01)00346-2","article-title":"Identification of an association between HLA class II alleles and low antibody levels after measles immunization","volume":"20","author":"GA Poland","year":"2001","journal-title":"Vaccine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.vaccine.2003.11.016","article-title":"Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination","volume":"22","author":"IG Ovsyannikova","year":"2004","journal-title":"Vaccine"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1086\/500144","article-title":"Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine","volume":"193","author":"IG Ovsyannikova","year":"2006","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cyto.2006.12.001","article-title":"Human Leukocyte Antigen and Interleukin 2, 10 and 12p40 cytokine responses to measles: Is there evidence of the HLA effect?","volume":"36","author":"IG Ovsyannikova","year":"2006","journal-title":"Cytokine"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.vaccine.2012.01.038","article-title":"Consistency of HLA associations between two independent measles vaccine cohorts: a replication study","volume":"30","author":"IG Ovsyannikova","year":"2012","journal-title":"Vaccine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-9-1","article-title":"HLA class I supertypes: a revised and updated classification","volume":"9","author":"J Sidney","year":"2008","journal-title":"BMC Immunol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000331585","article-title":"The association of CD46, SLAM, and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses\u2014a replication study and examination of novel polymorphisms","volume":"72","author":"IG Ovsyannikova","year":"2011","journal-title":"Human Hered"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00439-011-0977-x","article-title":"The role of polymorphisms in toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity","volume":"130","author":"IG Ovsyannikova","year":"2011","journal-title":"Hum Genet"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/FPC.0b013e32834df186","article-title":"Effects of vitamin A and D receptor gene polymorphisms\/haplotypes on immune responses to measles vaccine","volume":"22","author":"IG Ovsyannikova","year":"2012","journal-title":"Pharmacogenet Genomics"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.humimm.2013.01.031","article-title":"Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity","volume":"74","author":"IG Ovsyannikova","year":"2013","journal-title":"Hum Immunol"},{"issue":"5","key":"ref14","first-page":"704","article-title":"CD46 measles virus receptor polymorphisms influence receptor protein expression and primary measles vaccine responses in naive Australian children","volume":"19","author":"HD Clifford","year":"2012","journal-title":"ClinVaccine Immunol"},{"issue":"43","key":"ref15","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1016\/j.vaccine.2012.07.063","article-title":"Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique","volume":"30","author":"HD Clifford","year":"2012","journal-title":"Vaccine"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00251-011-0574-0","article-title":"Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine","volume":"64","author":"HD Clifford","year":"2012","journal-title":"Immunogenetics"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1034\/j.1399-0039.2003.00126.x","article-title":"Immunogenetics of killer-cell immunoglobulin-like receptors","volume":"62","author":"P Parham","year":"2003","journal-title":"Tissue Antigens"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00251-012-0623-3","article-title":"Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections","volume":"64","author":"S Aranda-Romo","year":"2012","journal-title":"Immunogenetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"298348","DOI":"10.1155\/2011\/298348","article-title":"KIR\/HLA interactions and pathogen immunity","volume":"2011","author":"KM Jamil","year":"2011","journal-title":"J Biomed Biotechnol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1744-313X.2007.00739.x","article-title":"Killer cell immunoglobulin-like receptors on NK cells: the how, where and why","volume":"35","author":"CM Gardiner","year":"2008","journal-title":"Int J Immunogenet"},{"issue":"3","key":"ref21","first-page":"1017","article-title":"Distinct KIR\/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses","volume":"118","author":"G Ahlenstiel","year":"2008","journal-title":"J Clin Invest"},{"issue":"286","key":"ref22","article-title":"Editorial: Role of HLA and KIR in Viral Infections","volume":"7","author":"J de Wit","year":"2016","journal-title":"Front Immunol"},{"issue":"28","key":"ref23","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1016\/j.vaccine.2012.04.055","article-title":"Genome-wide association study of antibody response to smallpox vaccine","volume":"30","author":"IG Ovsyannikova","year":"2012","journal-title":"Vaccine"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00439-014-1449-x","article-title":"HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study","volume":"133","author":"IG Ovsyannikova","year":"2014","journal-title":"Hum Genet"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00439-012-1174-2","article-title":"Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients","volume":"131","author":"RB Kennedy","year":"2012","journal-title":"Hum Genet"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","article-title":"Inference of population structure using multilocus genotype data","volume":"155","author":"JK Pritchard","year":"2000","journal-title":"Genetics"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1128\/CVI.00008-08","article-title":"Development of a novel efficient fluorescence-based plaque reduction microneutralization assay for measles immunity","volume":"15","author":"IH Haralambieva","year":"2008","journal-title":"Clin Vaccine Immunol"},{"issue":"27","key":"ref28","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1016\/j.vaccine.2011.04.037","article-title":"A large observational study to concurrently assess persistence of measles specific B-cell and T-cell immunity in individuals following two doses of MMR vaccine","volume":"29","author":"IH Haralambieva","year":"2011","journal-title":"Vaccine"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s00251-005-0061-6","article-title":"Immunologic significance of HLA class I genes in measles virus-specific IFN-gamma and IL-4 cytokine immune responses","volume":"57","author":"IG Ovsyannikova","year":"2005","journal-title":"Immunogenetics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s00251-004-0756-0","article-title":"HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine","volume":"56","author":"IG Ovsyannikova","year":"2005","journal-title":"Immunogenetics"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/infdis\/jir167","article-title":"Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine","volume":"203","author":"IG Ovsyannikova","year":"2011","journal-title":"J InfectDis"},{"issue":"22","key":"ref32","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1073\/pnas.1206614109","article-title":"High-throughput, high-fidelity HLA genotyping with deep sequencing","volume":"109","author":"C Wang","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"e64683","DOI":"10.1371\/journal.pone.0064683","article-title":"Imputing amino acid polymorphisms in human leukocyte antigens","volume":"8","author":"X Jia","year":"2013","journal-title":"PLos ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-065X.2006.00459.x","article-title":"KIR and disease: a model system or system of models?","volume":"214","author":"SI Khakoo","year":"2006","journal-title":"Immunological Reviews"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ajhg.2015.09.005","article-title":"Imputation of KIR Types from SNP Variation Data","volume":"97","author":"D Vukcevic","year":"2015","journal-title":"Am J Hum Genet"},{"issue":"7218","key":"ref36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature07331","article-title":"Genes mirror geography within Europe","volume":"456","author":"J Novembre","year":"2008","journal-title":"Nature"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nature Genet"},{"key":"ref38","unstructured":"EMBL-EBI. IPD-IMGT\/HLA Database. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ebi.ac.uk\/ipd\/imgt\/hla\/\" xlink:type=\"simple\">http:\/\/www.ebi.ac.uk\/ipd\/imgt\/hla\/<\/ext-link>. Wellcome Genome Campus, Hinxton, Cabridgeshire, United Kingdom; 2016. Date accessed: June 13, 2016."},{"issue":"3\u20134","key":"ref39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s002510050594","article-title":"Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism","volume":"50","author":"A Sette","year":"1999","journal-title":"Immunogenetics"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.hdy.6800717","article-title":"Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix","volume":"95","author":"J Li","year":"2005","journal-title":"Heredity (Edinb)"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00251-008-0331-1","article-title":"Methods for assessing gene content diversity of KIR with examples from a global set of populations","volume":"60","author":"RM Single","year":"2008","journal-title":"Immunogenetics"},{"issue":"16","key":"ref43","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1016\/j.vaccine.2007.01.020","article-title":"HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design","volume":"25","author":"IG Ovsyannikova","year":"2007","journal-title":"Vaccine"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.4049\/jimmunol.173.3.1987","article-title":"Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II","volume":"173","author":"D SenGupta","year":"2004","journal-title":"J Immunol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/JVI.78.1.42-51.2004","article-title":"Identification and characterization of novel, naturally processed measles virus class II HLA-DRB1 peptides","volume":"78","author":"IG Ovsyannikova","year":"2004","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/pr0501416","article-title":"Identification of class II HLA-DRB1*03-bound measles virus peptides by 2D-liquid chromatography tandem mass spectrometry","volume":"4","author":"KL Johnson","year":"2005","journal-title":"J Proteome Res"},{"issue":"2","key":"ref47","first-page":"e01047","article-title":"Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA","volume":"5","author":"WH Lin","year":"2014","journal-title":"MBio"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/infdis\/168.4.1020","article-title":"Comparison of measles virus-specific antibodies with antibody-dependent cellular cytotoxicity and neutralizing functions","volume":"168","author":"DN Forthal","year":"1993","journal-title":"J Infect Dis"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0732-8893(98)00069-8","article-title":"Measurement of measles virus-specific neutralizing antibodies: evaluation of the syncytium inhibition assay in comparison with the plaque reduction neutralization test","volume":"33","author":"BJ Ward","year":"1999","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:27:00Z","timestamp":1658564820000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171261"}},"subtitle":[],"editor":[{"given":"G\u00fcher","family":"Saruhan-Direskeneli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,3]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171261","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,3]]}}}