{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:28:55Z","timestamp":1780432135837,"version":"3.54.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171416","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T13:59:10Z","timestamp":1486043950000},"page":"e0171416","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["No neuronal loss, but alterations of the GDNF system in asymptomatic diverticulosis"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-9333","authenticated-orcid":true,"given":"Martina","family":"Barrenschee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Wedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Hohmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cossais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ebsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"B\u00f6ttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"issue":"9409","key":"ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(04)15597-9","article-title":"Diverticular disease of the colon","volume":"363","author":"N Stollman","year":"2004","journal-title":"Lancet"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1053\/gast.2002.32978","article-title":"The burden of selected digestive diseases in the United States","volume":"122","author":"RS Sandler","year":"2002","journal-title":"Gastroenterology"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/1756283X15621228","article-title":"Diverticulosis today: unfashionable and still under-researched","volume":"9","author":"A Tursi","year":"2016","journal-title":"Therap Adv Gastroenterol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000335699","article-title":"Abnormalities of neuromuscular anatomy in diverticular disease","volume":"30","author":"M B\u00f6ttner","year":"2012","journal-title":"Dig Dis"},{"key":"ref5","article-title":"Diverticulosis and Diverticulitis","author":"JD Feuerstein","year":"2016","journal-title":"Mayo Clin Proc"},{"issue":"9373","key":"ref6","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/S0140-6736(03)13583-0","article-title":"Smooth muscle cholinergic denervation hypersensitivity in diverticular disease","volume":"361","author":"M Golder","year":"2003","journal-title":"Lancet"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2982.2009.01445.x","article-title":"Diverticular disease is associated with an enteric neuropathy as revealed by morphometric analysis","volume":"22","author":"T Wedel","year":"2010","journal-title":"Neurogastroenterol Motil"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1136\/gutjnl-2012-302660","article-title":"The enteric serotonergic system is altered in patients with diverticular disease","volume":"62","author":"M B\u00f6ttner","year":"2013","journal-title":"Gut"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1007\/BF02234460","article-title":"Twenty-four hour recordings of colonic motility in patients with diverticular disease: evidence for abnormal motility and propulsive activity","volume":"44","author":"G Bassotti","year":"2001","journal-title":"Dis Colon Rectum"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF02050595","article-title":"Usefulness of colonic motility study in identifying patients at risk for complicated diverticular disease","volume":"34","author":"C Cortesini","year":"1991","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000381431","article-title":"Morphologic Basis for Developing Diverticular Disease, Diverticulitis, and Diverticular Bleeding","volume":"31","author":"T Wedel","year":"2015","journal-title":"Viszeralmedizin"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/gut.2009.200444","article-title":"The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group","volume":"59","author":"CH Knowles","year":"2010","journal-title":"Gut"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s004410050686","article-title":"GDNF: a cytokine at the interface of TGF-betas and neurotrophins","volume":"286","author":"K Unsicker","year":"1996","journal-title":"Cell Tissue Res"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2982.2008.01256.x","article-title":"Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung&apos;s disease","volume":"21","author":"G Burzynski","year":"2009","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1111\/j.1365-2982.2010.01626.x","article-title":"Glial cell line-derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system","volume":"23","author":"DM Rodrigues","year":"2011","journal-title":"Neurogastroenterol Motil"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s002210050702","article-title":"The GDNF-induced neurite outgrowth and neuronal survival in dissociated myenteric plexus cultures of the rat small intestine decreases postnatally","volume":"125","author":"KH Sch\u00e4fer","year":"1999","journal-title":"Exp Brain Res"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"e66290","DOI":"10.1371\/journal.pone.0066290","article-title":"The GDNF System Is Altered in Diverticular Disease\u2014Implications for Pathogenesis","volume":"8","author":"M B\u00f6ttner","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-013-1690-y","article-title":"Site-specific gene expression and localization of growth factor ligand receptors RET, GFRalpha1 and GFRalpha2 in human adult colon","volume":"354","author":"M Barrenschee","year":"2013","journal-title":"Cell Tissue Res"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00401-009-0527-y","article-title":"Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group","volume":"118","author":"CH Knowles","year":"2009","journal-title":"Acta Neuropathol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s11948-010-9201-y","article-title":"Avoiding twisted pixels: ethical guidelines for the appropriate use and manipulation of scientific digital images","volume":"16","author":"DW Cromey","year":"2010","journal-title":"Sci Eng Ethics"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1365-2982.2009.01424.x","article-title":"Laser microdissection as a new tool to investigate site-specific gene expression in enteric ganglia of the human intestine","volume":"22","author":"M B\u00f6ttner","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"ref23","article-title":"R: A Language and Environment for Statistical Computing","year":"2012"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.aanat.2008.09.002","article-title":"Morphologic pattern of myenteric neural plexus in colonic diverticular disease. A whole-mount study employing histochemical staining for acetylcholinesterase","volume":"190","author":"O Deduchovas","year":"2008","journal-title":"Ann Anat"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/01.mcg.0000173856.84814.37","article-title":"Morphology of myenteric plexuses in the human large intestine: comparison between large intestines with and without colonic diverticula","volume":"39","author":"H Iwase","year":"2005","journal-title":"J Clin Gastroenterol"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1542-3565(04)00614-7","article-title":"Alterations in colonic motility and relationship to pain in colonic diverticulosis","volume":"3","author":"G Bassotti","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00384-013-1716-7","article-title":"In vitro motor patterns and electrophysiological changes in patients with colonic diverticular disease","volume":"28","author":"D Gallego","year":"2013","journal-title":"Int J Colorectal Dis"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/nmo.12407","article-title":"Nitrergic neuro-muscular transmission is up-regulated in patients with diverticulosis","volume":"26","author":"F Espin","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"ref29","article-title":"SNAP-25 is abundantly expressed in enteric neuronal networks and upregulated by the neurotrophic factor GDNF","author":"M Barrenschee","year":"2015","journal-title":"Histochem Cell Biol"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1365-2982.2009.01308.x","article-title":"Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms","volume":"21","author":"J Simpson","year":"2009","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF00841669","article-title":"Comparative evaluation of anticonvulsant and anti-arrhythmic effects of phenazepam, a benzodiazepine receptor agonist","volume":"109","author":"TA Voronina","year":"1990","journal-title":"Biull Eksp Biol Med"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pneurobio.2008.09.006","article-title":"Driving GDNF expression: the green and the red traffic lights","volume":"86","author":"A Saavedra","year":"2008","journal-title":"Prog Neurobiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-230X-11-3","article-title":"Distribution of enteric glia and GDNF during gut inflammation","volume":"11","author":"GB von Boyen","year":"2011","journal-title":"BMC Gastroenterol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T20:25:43Z","timestamp":1540239943000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171416"}},"subtitle":[],"editor":[{"given":"Xuan-Zheng","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171416","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}