{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:03:43Z","timestamp":1790521423609,"version":"4.1.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kakenhi Grant for scientific research by the Japan Society for the Promotion of Science","award":["No. 25462466, 26670695 and 16H02679"],"award-info":[{"award-number":["No. 25462466, 26670695 and 16H02679"]}]},{"name":"Japan Agency for Medical Research and Development (JP)"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171615","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T18:32:54Z","timestamp":1486578774000},"page":"e0171615","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the \u201cobesity paradox\u201d"],"prefix":"10.1371","volume":"12","author":[{"given":"Ryuichi","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingguo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Nara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Numakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Maeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Habuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/jnci\/djt310","article-title":"An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma","volume":"105","author":"AA Hakimi","year":"2013","journal-title":"Journal of the National Cancer Institute"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM","volume":"17","author":"SB Edge","year":"2010","journal-title":"Annals of surgical oncology"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00000478-198210000-00007","article-title":"Prognostic significance of morphologic parameters in renal cell carcinoma","volume":"6","author":"SA Fuhrman","year":"1982","journal-title":"The American journal of surgical pathology"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.juro.2009.06.015","article-title":"Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness","volume":"182","author":"DS Finley","year":"2009","journal-title":"J Urol"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/carcin\/bgr182","article-title":"Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome","volume":"32","author":"M Huang","year":"2011","journal-title":"Carcinogenesis"},{"issue":"20","key":"ref7","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1021\/jf102669p","article-title":"The flavonol isorhamnetin exhibits cytotoxic effects on human colon cancer cells","volume":"58","author":"S Jaramillo","year":"2010","journal-title":"Journal of agricultural and food chemistry"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/cc2857","article-title":"Statistics review 10: further nonparametric methods","volume":"8","author":"V Bewick","year":"2004","journal-title":"Critical care (London, England)"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2337\/diabetes.52.3.667","article-title":"Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy","volume":"52","author":"SA Phillips","year":"2003","journal-title":"Diabetes"},{"issue":"6941","key":"ref10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature01705","article-title":"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects","volume":"423","author":"T Yamauchi","year":"2003","journal-title":"Nature"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.eururo.2008.02.044","article-title":"Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney","volume":"54","author":"JH Pinthus","year":"2008","journal-title":"Eur Urol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12672-010-0017-7","article-title":"Adiponectin receptor expression in human malignant tissues","volume":"1","author":"SH Chou","year":"2010","journal-title":"Hormones & cancer"},{"issue":"3","key":"ref13","first-page":"2823","article-title":"Combination of metformin and valproic acid synergistically induces cell cycle arrest and apoptosis in clear cell renal cell carcinoma","volume":"8","author":"X Zhang","year":"2015","journal-title":"International journal of clinical and experimental pathology"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ijc.27639","article-title":"Body mass index and survival in patients with renal cell carcinoma: a clinical-based cohort and meta-analysis","volume":"132","author":"Y Choi","year":"2013","journal-title":"International journal of cancer"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1158\/1055-9965.EPI-16-0226","article-title":"Body Mass Index and Survival in a Prospective Randomized Trial of Localized High-Risk Renal Cell Carcinoma","volume":"25","author":"NM Donin","year":"2016","journal-title":"Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/jjco\/hym158","article-title":"Decreased serum adiponectin levels in patients with metastatic renal cell carcinoma","volume":"38","author":"A Horiguchi","year":"2008","journal-title":"Japanese journal of clinical oncology"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.euf.2015.06.012","article-title":"Serum Adiponectin Predicts Cancer-specific Survival of Patients with Renal Cell Carcinoma","volume":"2","author":"M de Martino","year":"2016","journal-title":"European Urology Focus"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1210\/jc.2002-021721","article-title":"Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns","volume":"88","author":"A Gavrila","year":"2003","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8746268","DOI":"10.1155\/2016\/8746268","article-title":"Racial Differences in Serum Adipokine and Insulin Levels in a Matched Osteoarthritis Sample: A Pilot Study","volume":"2016","author":"R Gandhi","year":"2016","journal-title":"Journal of obesity"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1038\/ncomms10230","article-title":"Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity","volume":"7","author":"V Laurent","year":"2016","journal-title":"Nature communications"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/sj.bjc.6603051","article-title":"Adiponectin and cancer: a systematic review","volume":"94","author":"I Kelesidis","year":"2006","journal-title":"Br J Cancer"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cellsig.2009.01.035","article-title":"A guide and guard: the many faces of T-cadherin","volume":"21","author":"M Philippova","year":"2009","journal-title":"Cellular signalling"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"s858","DOI":"10.1093\/ajcn\/86.3.858S","article-title":"Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence","volume":"86","author":"D Barb","year":"2007","journal-title":"The American journal of clinical nutrition"},{"issue":"2\u20133","key":"ref24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.regpep.2006.02.001","article-title":"Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells","volume":"134","author":"OO Ogunwobi","year":"2006","journal-title":"Regulatory peptides"},{"issue":"44","key":"ref25","doi-asserted-by":"crossref","first-page":"11682","DOI":"10.1021\/bi801451f","article-title":"The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1\/2 through a Src\/Ras-dependent pathway and stimulate cell growth","volume":"47","author":"MH Lee","year":"2008","journal-title":"Biochemistry"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/biof.83","article-title":"Effect of adiponectin on apoptosis: proapoptosis or antiapoptosis?","volume":"36","author":"Y Sun","year":"2010","journal-title":"BioFactors (Oxford, England)"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.yjmcc.2007.03.808","article-title":"Adiponectin protects against the development of systolic dysfunction following myocardial infarction","volume":"42","author":"R Shibata","year":"2007","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1541-7786.MCR-15-0068","article-title":"Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies","volume":"13","author":"G Zadra","year":"2015","journal-title":"Molecular cancer research: MCR"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1081\/CNV-120001177","article-title":"Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas","volume":"20","author":"G Gobe","year":"2002","journal-title":"Cancer investigation"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/carcin\/bgr021","article-title":"2&apos;-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma","volume":"32","author":"LD Nagaprashantha","year":"2011","journal-title":"Carcinogenesis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T12:41:03Z","timestamp":1568810463000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171615"}},"subtitle":[],"editor":[{"given":"Jung Weon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,8]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171615","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,8]]}}}