{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:06:09Z","timestamp":1791273969516,"version":"4.1.0"},"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF 2015-71208-R"],"award-info":[{"award-number":["SAF 2015-71208-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["CSD-2007-00020"],"award-info":[{"award-number":["CSD-2007-00020"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["GV PROMETEO II 2014-056"],"award-info":[{"award-number":["GV PROMETEO II 2014-056"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF 2015- 65267-R"],"award-info":[{"award-number":["SAF 2015- 65267-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BFU2010-17850"],"award-info":[{"award-number":["BFU2010-17850"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ERC 294665"],"award-info":[{"award-number":["ERC 294665"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171738","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T19:08:26Z","timestamp":1486408106000},"page":"e0171738","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["p38\u03b1 regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging"],"prefix":"10.1371","volume":"12","author":[{"given":"Ana M.","family":"Tormos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rius-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Jorques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Rada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela M.","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel R.","family":"Nebreda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-9693","authenticated-orcid":true,"given":"Raquel","family":"Tal\u00e9ns-Visconti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"282430","DOI":"10.1155\/2012\/282430","article-title":"Hepatocytes polyploidization and cell cycle control in liver physiopathology","volume":"2012","author":"G Gentric","year":"2012","journal-title":"Int J Hepatol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clinre.2011.05.011","article-title":"Polyploidy and liver proliferation","volume":"36","author":"G Gentric","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ajpath.2013.06.035","article-title":"Polyploidization in liver tissue","volume":"184","author":"G Gentric","year":"2014","journal-title":"Am J Pathol"},{"issue":"Pt 20","key":"ref4","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1242\/jcs.016907","article-title":"Liver tetraploidization is controlled by a new process of incomplete cytokinesis","volume":"120","author":"G Margall-Ducos","year":"2007","journal-title":"J Cell Sci"},{"issue":"7","key":"ref5","first-page":"1880","article-title":"The insulin\/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents","volume":"119","author":"S Celton-Morizur","year":"2009","journal-title":"J Clin Invest"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/scbi.2000.0317","article-title":"Hepatic polyploidy and liver growth control","volume":"10","author":"S Gupta","year":"2000","journal-title":"Semin Cancer Biol"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1096\/fasebj.14.9.1073","article-title":"Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21","volume":"14","author":"F Nunez","year":"2000","journal-title":"FASEB J"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.semcdb.2013.01.003","article-title":"Aneuploidy, polyploidy and ploidy reversal in the liver","volume":"24","author":"AW Duncan","year":"2013","journal-title":"Semin Cell Dev Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.cellbio.17.1.351","article-title":"Animal cell cytokinesis","volume":"17","author":"M Glotzer","year":"2001","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"13","key":"ref10","doi-asserted-by":"crossref","first-page":"R514","DOI":"10.1016\/S0960-9822(01)00307-4","article-title":"Animal cytokinesis: breaking up is hard to do","volume":"11","author":"SG Zeitlin","year":"2001","journal-title":"Curr Biol"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/MMBR.66.2.155-178.2002","article-title":"Cytokinesis in eukaryotes","volume":"66","author":"DA Guertin","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2007.11.011","article-title":"Cytokinesis: placing and making the final cut","volume":"131","author":"FA Barr","year":"2007","journal-title":"Cell"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.biocel.2010.04.007","article-title":"Actin cytoskeleton dynamics and the cell division cycle","volume":"42","author":"YW Heng","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1100\/tsw.2010.129","article-title":"Making the final cut\u2014mechanisms mediating the abscission step of cytokinesis","volume":"10","author":"JA Schiel","year":"2010","journal-title":"ScientificWorldJournal"},{"issue":"Pt 8","key":"ref15","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1242\/jcs.02335","article-title":"Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy","volume":"118","author":"PP D'Avino","year":"2005","journal-title":"J Cell Sci"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.tcb.2005.10.006","article-title":"Cytokinesis: welcome to the Rho zone","volume":"15","author":"A Piekny","year":"2005","journal-title":"Trends Cell Biol"},{"issue":"Pt 5","key":"ref17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/jcs.064964","article-title":"Rho GTPases and their role in organizing the actin cytoskeleton","volume":"124","author":"ST Sit","year":"2011","journal-title":"J Cell Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-4419-6199-0_3","article-title":"Understanding cytokinesis failure","volume":"676","author":"G Normand","year":"2010","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1083\/jcb.147.7.1519","article-title":"Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2","volume":"147","author":"T Sumi","year":"1999","journal-title":"J Cell Biol"},{"issue":"7316","key":"ref20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09414","article-title":"The ploidy conveyor of mature hepatocytes as a source of genetic variation","volume":"467","author":"AW Duncan","journal-title":"Nature"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1006\/excr.1994.1293","article-title":"Ploidy-dependent growth and binucleation in cultured rat hepatocytes","volume":"214","author":"L Mossin","year":"1994","journal-title":"Exp Cell Res"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/hep.26174","article-title":"Liver-specific p38alpha deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice","volume":"57","author":"AM Tormos","year":"2013","journal-title":"Hepatology"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"A Cuadrado","year":"2010","journal-title":"Biochem J"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.bbamcr.2007.03.010","article-title":"p38 MAP-kinases pathway regulation, function and role in human diseases","volume":"1773","author":"A Cuenda","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.biocel.2010.08.002","article-title":"Inactivation of p38 MAPK during liver regeneration","volume":"43","author":"JS Campbell","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1002\/art.22080","article-title":"Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis","volume":"54","author":"A Korb","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"30","key":"ref27","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.3748\/wjg.v12.i30.4807","article-title":"Etiopathogenesis of inflammatory bowel diseases","volume":"12","author":"S Danese","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.4049\/jimmunol.177.5.2926","article-title":"The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner","volume":"177","author":"G Pongratz","year":"2006","journal-title":"J Immunol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1183\/09031936.00170711","article-title":"Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs","volume":"42","author":"K Gaffey","year":"2013","journal-title":"Eur Respir J"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1111\/bph.12901","article-title":"p38 MAPK in cardioprotection\u2014are we there yet?","volume":"172","author":"ED Martin","year":"2015","journal-title":"Br J Pharmacol"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s40256-014-0063-6","article-title":"Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease","volume":"14","author":"M Fisk","year":"2014","journal-title":"Am J Cardiovasc Drugs"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1002\/cncr.11425","article-title":"Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma","volume":"97","author":"K Iyoda","year":"2003","journal-title":"Cancer"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/sj.leu.2404200","article-title":"Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo","volume":"20","author":"TA Navas","year":"2006","journal-title":"Leukemia"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neulet.2004.12.064","article-title":"Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38","volume":"379","author":"CI Svensson","year":"2005","journal-title":"Neurosci Lett"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.expneurol.2006.11.016","article-title":"p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury","volume":"204","author":"JT Xu","year":"2007","journal-title":"Exp Neurol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1124\/jpet.108.139006","article-title":"Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity","volume":"327","author":"RJ Hill","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1021\/ml2001455","article-title":"The Discovery of VX-745: A Novel and Selective p38alpha Kinase Inhibitor","volume":"2","author":"JP Duffy","year":"2011","journal-title":"ACS Med Chem Lett"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/art.24485","article-title":"Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies","volume":"60","author":"N Damjanov","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1177\/0091270011405496","article-title":"Novel p38alpha mitogen-activated protein kinase inhibitor shows analgesic efficacy in acute postsurgical dental pain","volume":"52","author":"SE Tong","year":"2012","journal-title":"J Clin Pharmacol"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3899\/jrheum.100602","article-title":"A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis","volume":"38","author":"MC Genovese","year":"2011","journal-title":"J Rheumatol"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cgh.2005.11.013","article-title":"Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn&apos;s disease: a randomized, double-blind, placebo-controlled trial","volume":"4","author":"S Schreiber","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9949","key":"ref42","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0140-6736(14)60417-7","article-title":"Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial","volume":"384","author":"LK Newby","year":"2014","journal-title":"Lancet"},{"issue":"49","key":"ref43","doi-asserted-by":"crossref","first-page":"38716","DOI":"10.1074\/jbc.M008040200","article-title":"Growth regulation via p38 mitogen-activated protein kinase in developing liver","volume":"275","author":"MM Awad","year":"2000","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"ref44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0248-4900(01)01124-8","article-title":"Cell cycle regulation by p38 MAP kinases","volume":"93","author":"C Ambrosino","year":"2001","journal-title":"Biol Cell"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.7150\/ijbs.5.44","article-title":"Non-classical p38 map kinase functions: cell cycle checkpoints and survival","volume":"5","author":"TM Thornton","year":"2009","journal-title":"Int J Biol Sci"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2694","article-title":"Signal integration by JNK and p38 MAPK pathways in cancer development","volume":"9","author":"EF Wagner","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"20","key":"ref47","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.4161\/cc.6.20.4774","article-title":"p38alpha: a suppressor of cell proliferation and tumorigenesis","volume":"6","author":"L Hui","year":"2007","journal-title":"Cell Cycle"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ng2033","article-title":"p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway","volume":"39","author":"L Hui","year":"2007","journal-title":"Nat Genet"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/ng2037","article-title":"p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation","volume":"39","author":"JJ Ventura","year":"2007","journal-title":"Nat Genet"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cbf.290060403","article-title":"Epidermal growth factor receptor numbers in male and female mouse primary hepatocyte cultures","volume":"6","author":"R Benveniste","year":"1988","journal-title":"Cell Biochem Funct"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Graham JM. Isolation of nuclei and nuclear membranes from animal tissues. Curr Protoc Cell Biol. 2001;Chapter 3:Unit 3 10. Epub 2008\/01\/30.","DOI":"10.1002\/0471143030.cb0310s12"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1185504","article-title":"p27Kip1 modulates cell migration through the regulation of RhoA activation","volume":"18","author":"A Besson","year":"2004","journal-title":"Genes Dev"},{"issue":"19","key":"ref53","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/sj.onc.1209322","article-title":"Stability of p21Waf1\/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton","volume":"25","author":"ML Coleman","year":"2006","journal-title":"Oncogene"},{"issue":"23","key":"ref54","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1073\/pnas.0805057106","article-title":"RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility","volume":"106","author":"MD Larrea","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 12","key":"ref55","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1242\/jcs.058081","article-title":"MNK1 kinase activity is required for abscission","volume":"125","author":"Y Rannou","year":"2012","journal-title":"J Cell Sci"},{"issue":"11","key":"ref56","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/ncb1183","article-title":"Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive","volume":"6","author":"E Jacinto","year":"2004","journal-title":"Nat Cell Biol"},{"issue":"17","key":"ref57","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.4161\/cc.7.17.6514","article-title":"PI3-K and GSK-3: Akt-ing together with microtubules","volume":"7","author":"GJ Buttrick","year":"2008","journal-title":"Cell Cycle"},{"issue":"Pt 3","key":"ref58","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1242\/jcs.110.3.357","article-title":"Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27","volume":"110","author":"J Guay","year":"1997","journal-title":"J Cell Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4615-5873-6_5","article-title":"A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry","volume":"2","author":"JN Lavoie","year":"1996","journal-title":"Prog Cell Cycle Res"},{"issue":"12","key":"ref60","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.febslet.2010.03.044","article-title":"Cytokinesis and cancer","volume":"584","author":"AP Sagona","year":"2010","journal-title":"FEBS Lett"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4419-6199-0_8","article-title":"Polyploidization of liver cells","volume":"676","author":"S Celton-Morizur","year":"2010","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1101\/gad.1785209","article-title":"Mechanisms for concentrating Rho1 during cytokinesis","volume":"23","author":"S Yoshida","year":"2009","journal-title":"Genes Dev"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/cc.2.4.433","article-title":"Multiple roles of the PI3K\/PKB (Akt) pathway in cell cycle progression","volume":"2","author":"J Liang","year":"2003","journal-title":"Cell Cycle"},{"issue":"14","key":"ref64","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"DD Sarbassov","year":"2004","journal-title":"Curr Biol"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/35000065","article-title":"A conserved docking motif in MAP kinases common to substrates, activators and regulators","volume":"2","author":"T Tanoue","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0092-8674(05)80019-4","article-title":"Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs","volume":"81","author":"A Minden","year":"1995","journal-title":"Cell"},{"issue":"2","key":"ref67","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ceb.2006.02.002","article-title":"Rho GTPases in animal cell mitosis","volume":"18","author":"S Narumiya","year":"2006","journal-title":"Curr Opin Cell Biol"},{"issue":"Pt 23","key":"ref68","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1242\/jcs.01582","article-title":"Rho signalling at a glance","volume":"117","author":"M Schwartz","year":"2004","journal-title":"J Cell Sci"},{"issue":"27","key":"ref69","doi-asserted-by":"crossref","first-page":"25066","DOI":"10.1074\/jbc.M010892200","article-title":"BetaPix-enhanced p38 activation by Cdc42\/Rac\/PAK\/MKK3\/6-mediated pathway. Implication in the regulation of membrane ruffling","volume":"276","author":"SH Lee","year":"2001","journal-title":"J Biol Chem"},{"issue":"5","key":"ref70","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.201207197","article-title":"Stuck in the middle: Rac, adhesion, and cytokinesis","volume":"198","author":"T Davies","year":"2012","journal-title":"J Cell Biol"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.201301090","article-title":"Inhibition of Cdc42 during mitotic exit is required for cytokinesis","volume":"202","author":"BD Atkins","year":"2013","journal-title":"J Cell Biol"},{"issue":"Pt 17","key":"ref72","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1242\/jcs.097667","article-title":"Cofilin nuclear-cytoplasmic shuttling affects cofilin-actin rod formation during stress","volume":"125","author":"LN Munsie","year":"2012","journal-title":"J Cell Sci"},{"issue":"2","key":"ref73","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00418-014-1243-9","article-title":"Nuclear actin filaments recruit cofilin and actin-related protein 3, and their formation is connected with a mitotic block","volume":"142","author":"A Kalendova","year":"2014","journal-title":"Histochem Cell Biol"},{"issue":"6134","key":"ref74","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1235038","article-title":"Nuclear actin network assembly by formins regulates the SRF coactivator MAL","volume":"340","author":"C Baarlink","year":"2013","journal-title":"Science"},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1083\/jcb.200709082","article-title":"As functional nuclear actin comes into view, is it globular, filamentous, or both?","volume":"180","author":"T Pederson","year":"2008","journal-title":"J Cell Biol"},{"issue":"10","key":"ref76","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/j.1742-4658.2009.06986.x","article-title":"Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression","volume":"276","author":"B Zheng","year":"2009","journal-title":"FEBS J"},{"issue":"6","key":"ref77","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1083\/jcb.200710058","article-title":"Actin-dependent intranuclear repositioning of an active gene locus in vivo","volume":"179","author":"M Dundr","year":"2007","journal-title":"J Cell Biol"},{"issue":"32","key":"ref78","doi-asserted-by":"crossref","first-page":"20780","DOI":"10.1016\/S0021-9258(17)32060-4","article-title":"Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity","volume":"269","author":"R Benndorf","year":"1994","journal-title":"J Biol Chem"},{"issue":"5","key":"ref79","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/hep.23566","article-title":"miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway","volume":"51","author":"F Yang","year":"2010","journal-title":"Hepatology"},{"issue":"3","key":"ref80","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1349-7006.2007.00702.x","article-title":"Involvement of protein kinase C beta-extracellular signal-regulating kinase 1\/2\/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion","volume":"99","author":"K Guo","year":"2008","journal-title":"Cancer Sci"},{"issue":"5","key":"ref81","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.HYP.0000164582.63421.2d","article-title":"Involvement of RhoA\/Rho kinase pathway in myogenic tone in the rabbit facial vein","volume":"45","author":"C Dubroca","year":"2005","journal-title":"Hypertension"},{"issue":"41","key":"ref82","doi-asserted-by":"crossref","first-page":"23934","DOI":"10.1074\/jbc.270.41.23934","article-title":"Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1","volume":"270","author":"S Zhang","year":"1995","journal-title":"J Biol Chem"},{"issue":"4","key":"ref83","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3892\/etm_00000091","article-title":"Rho-kinase regulates prostaglandin D(2)-stimulated heat shock protein 27 induction in osteoblasts","volume":"1","author":"K Kato","year":"2010","journal-title":"Exp Ther Med"},{"issue":"1","key":"ref84","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1152\/jappl.2002.92.1.41","article-title":"HSP27 modulates agonist-induced association of translocated RhoA and PKC-alpha in muscle cells of the colon","volume":"92","author":"KN Bitar","year":"2002","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"ref85","doi-asserted-by":"crossref","first-page":"G635","DOI":"10.1152\/ajpgi.00261.2003","article-title":"Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCalpha","volume":"286","author":"SB Patil","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5","key":"ref86","doi-asserted-by":"crossref","first-page":"G894","DOI":"10.1152\/ajpgi.00141.2001","article-title":"HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction","volume":"282","author":"KN Bitar","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"37","key":"ref87","doi-asserted-by":"crossref","first-page":"24173","DOI":"10.1074\/jbc.273.37.24173","article-title":"A role for the p38 mitogen-activated protein kinase\/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini","volume":"273","author":"C Schafer","year":"1998","journal-title":"J Biol Chem"},{"issue":"20","key":"ref88","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1021\/bi9928389","article-title":"Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes","volume":"39","author":"D Chevalier","year":"2000","journal-title":"Biochemistry"},{"issue":"45","key":"ref89","doi-asserted-by":"crossref","first-page":"42596","DOI":"10.1074\/jbc.M205863200","article-title":"Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2","volume":"277","author":"US Kayyali","year":"2002","journal-title":"J Biol Chem"},{"issue":"2","key":"ref90","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1124\/mol.113.090365","article-title":"Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: role and targeting","volume":"85","author":"FM Gurgis","year":"2014","journal-title":"Mol Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T16:53:32Z","timestamp":1658595212000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171738"}},"subtitle":[],"editor":[{"given":"Matias A","family":"Avila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171738","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}