{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:12:01Z","timestamp":1789143121714,"version":"build-2803163510"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373608"],"award-info":[{"award-number":["81373608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171878","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T15:20:04Z","timestamp":1487172004000},"page":"e0171878","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Chinese patent medicine Si-Mo-Tang oral liquid for functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1371","volume":"12","author":[{"given":"Yunxia","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"issue":"19","key":"ref1","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional Dyspepsia","volume":"373","author":"NJ Talley","year":"2015","journal-title":"The New England journal of medicine"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1016\/j.jval.2011.05.021","article-title":"Influence of organic and functional dyspepsia on work productivity: the HEROES-DIP study","volume":"14","author":"G Sander","year":"2011","journal-title":"Value Health"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/apt.12355","article-title":"Functional dyspepsia: the economic impact to patients","volume":"38","author":"B Lacy","year":"2013","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3904\/kjim.2016.091","article-title":"Functional dyspepsia: new insights into pathogenesis and therapy","volume":"31","author":"NJ Talley","year":"2016","journal-title":"The Korean Journal of Internal Medicine"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/2050640613499567","article-title":"A survey of pharmacological and nonpharmacological treatment of functional gastrointestinal disorders","volume":"1","author":"E Lahner","year":"2013","journal-title":"United European Gastroenterology Journal"},{"issue":"27","key":"ref6","doi-asserted-by":"crossref","first-page":"e1111","DOI":"10.1097\/MD.0000000000001111","article-title":"Common Mechanism of Pathogenesis in Gastrointestinal Diseases Implied by Consistent Efficacy of Single Chinese Medicine Formula","volume":"94","author":"W Ling","year":"2015","journal-title":"Medicine"},{"key":"ref7","unstructured":"Sheng YZ, Wang WT, Wei C. Si-Mo-Tang oral liquid: China, 94110842.2. 1995-08-09."},{"key":"ref8","article-title":"Theory & practice of systematic review\/meat-analysis","author":"Luo Jie","year":"2013"},{"key":"ref9","article-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"JP Higgins","year":"2016"},{"issue":"7414","key":"ref10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JPT Higgins","year":"2003","journal-title":"BMJ (Clinical research ed.)"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"e0122397","DOI":"10.1371\/journal.pone.0122397","article-title":"The efficacy of Shugan Jianpi Zhixie therapy for diarrhea-predominant irritable bowel syndrome: a meta-analysis of randomized, double-blind, placebo-controlled trials","volume":"10","author":"Y Xiao","year":"2015","journal-title":"PloS one"},{"issue":"6","key":"ref12","first-page":"856","article-title":"Clinical efficacy of Si-Mo-Tang on functional dyspepsia with syndrome of incoordination between the liver and spleen and its effect on motilin and substance P in plasma","volume":"25","author":"GX Cai","year":"2010","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"29","key":"ref13","first-page":"157","article-title":"Evaluation of the effect of Si-Mo-Tang on functional dyspepsia in children","volume":"48","author":"XH Ji","year":"2010","journal-title":"Chinese Modern Doctor"},{"issue":"21","key":"ref14","first-page":"316","article-title":"Clinical efficacy of Si-Mo-Tang in 92 cases of functional dyspepsia","author":"ZD Shen","year":"2012","journal-title":"Frontiers of Medicine"},{"issue":"6","key":"ref15","first-page":"50","article-title":"Si-Mo-Tang oral liquid in the treatment of 55 cases of functional dyspepsia","volume":"40","author":"Y Tu","year":"2009","journal-title":"Jiangxi Journal of traditional Chinese Medicine"},{"issue":"1","key":"ref16","first-page":"33","article-title":"Si-Mo-Tang oral liquid in the treatment of 62 cases of functional dyspepsia","volume":"3","author":"JH Wang","year":"2003","journal-title":"Clinical Journal of Practical Integrated Traditional Chinese and Western Medicine"},{"issue":"1","key":"ref17","first-page":"29","article-title":"Clinical effect of Si-Mo-Tang and Cisapride on functional dyspepsia","volume":"8","author":"QZ Wang","year":"2000","journal-title":"Chinese Journal of Spleen and Stomach"},{"issue":"6","key":"ref18","first-page":"758","article-title":"The effect of Si-Mo-Tang and Cisapride in the treatment of functional dyspepsia","volume":"12","author":"SH Wei","year":"1999","journal-title":"Acta Medicinae Sinica"},{"issue":"2","key":"ref19","first-page":"14","article-title":"Clinical observation of Si-Mo-Tang in the treatment of 60 cases of functional dyspepsia","volume":"34","author":"ZH Xiao","year":"2012","journal-title":"Journal of Guiyang College of Traditional Chinese Medicine"},{"issue":"11","key":"ref20","first-page":"815","article-title":"The effect of Si-Mo-Tang on functional dyspepsia in 98 cases","volume":"27","author":"Y Zheng","year":"2005","journal-title":"Hebei Journal of Traditional Chinese Medicine"},{"issue":"29","key":"ref21","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.11569\/wcjd.v17.i29.3028","article-title":"Combined use of Si-Mo-Tang, Domperidone and Amitriptyline to treat functional dyspepsia: a report of 60 cases","volume":"17","author":"YL Zhu","year":"2009","journal-title":"World Chinese Journal of Digestology"},{"issue":"8","key":"ref22","first-page":"679","article-title":"Treatment of 50 patients with dyskinetic functional dyspepsia with Si-Mo-Tang oral liquid","volume":"24","author":"S Ye","year":"2005","journal-title":"Herald of Medicine"},{"issue":"10","key":"ref23","first-page":"1791","article-title":"Clinical efficacy of Si-Mo-Tang on functional dyspepsia with Qi stagnancy of both liver and spleen and its effect on Nitrie Oxide, Acetylcholinesterase, Cholecystokinin and substance P in serum","volume":"23","author":"SN Zhou","year":"2014","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"issue":"13","key":"ref24","first-page":"22","article-title":"Clinical observation of Cisapride combined with Si-Mo-Tang on functional dyspepsia","volume":"06","author":"Y Zhang","year":"2011","journal-title":"China Healthcare Innovation"},{"key":"ref25","unstructured":"Li YJ. The Meta-analysis of Si-Mo-Tang on patients with functionaldyspepsia and the study on clinical efficacy of Si-Mo-Tang onpatients with functional dyspepsia with qi stagnancy of both liverand spleen.M.Sc. Thesis, Hunan University of Traditional Chinese Medicine. 2012. Available:http:\/\/www.cnki.net\/KCMS\/detail\/detail.aspx?QueryID=17&CurRec=1&recid=&filename=1012401545.nh&dbname=CMFD2012&dbcode=CMFD&pr=&urlid=&yx=&v=MjA1MzdJUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSTHlmWU9SbkZDbmxWTDNCVkYyNkhMZTRIOVRJcXBFYlA=<\/ext-link>"},{"issue":"10","key":"ref26","first-page":"65","article-title":"Si-Mo-Tang oral liquid in the treatment of dyspepsia in 60 cases of children","volume":"30","author":"FC Meng","year":"2014","journal-title":"Hunan Journal of Traditional Chinese Medicine"},{"issue":"04","key":"ref27","first-page":"211","article-title":"Si-Mo-Tang combined with Lactobacillinin the treatment of dyspepsia in children","author":"YB Xie","year":"2016","journal-title":"Strait Pharmaceutical Journal"},{"issue":"05","key":"ref28","first-page":"83","article-title":"Clinical observation of functions dyspepsia combined Si-Mo-Tang oral liquid with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules","author":"MM Zhang","year":"2016","journal-title":"New traditional Chinese Medicine"},{"issue":"9","key":"ref29","first-page":"222","article-title":"Combination of Traditional Chinese and Western Medicine in the treatment of functional dyspepsia in 30 cases of children","volume":"27","author":"LX Tian","year":"2014","journal-title":"Medicine & People"},{"issue":"5","key":"ref30","first-page":"60","article-title":"Clinical observation on 108 cases of children with functional dyspepsia treated by integrated Traditional Chinese and Western Medicine","volume":"24","author":"H Wen","year":"2011","journal-title":"The Medical Journal of Industrial Enterprise"},{"issue":"23","key":"ref31","first-page":"59","article-title":"Clinical research of treating functional dyspepsia with Domperidone and Si-Mo-Tang oral liquid","volume":"03","author":"SX Li","year":"2011","journal-title":"Clinical Journal of Chinese Medicine"},{"issue":"19","key":"ref32","first-page":"126","article-title":"Effect of Si-Mo-Tang and Trimebutine in treating postprandial distress syndrome of functional dyspepsia","author":"K Zhang","year":"2015","journal-title":"Chinese Medical Innovation"},{"issue":"17","key":"ref33","first-page":"187","article-title":"The effect and nursing strategy of Si-Mo-Tangassociated with Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines in treating functional dyspepsia","volume":"04","author":"HS Jiang","year":"2010","journal-title":"Chinese Journal of Modern Drug Application"},{"issue":"14","key":"ref34","first-page":"148","article-title":"Effect of Domperidone and Si-Mo-Tang oral liquid in 68 cases with dyskinetic functional dyspepsia","volume":"13","author":"DH Yu","year":"2011","journal-title":"Chinese Community Physicians (Medical)"},{"issue":"12","key":"ref35","first-page":"92","article-title":"Clinical research of Traditional Chinese and Western Medicine in the treatment of children with functional dyspepsia","author":"L Wu","year":"2014","journal-title":"Journal of North Pharmacy"},{"issue":"24","key":"ref36","first-page":"143","article-title":"Clinical observation of Si-Mo-Tang combined with Mosapride in the treatment of 60 cases of functional dyspepsia","volume":"9","author":"P Hu","year":"2015","journal-title":"Chinese Journal of Modern Drug Application"},{"issue":"13","key":"ref37","first-page":"2853","article-title":"Si-Mo-Tang, Dmperidone and Amitriptyline in the treatment of functional dyspepsia in 35 cases","volume":"32","author":"L Li","year":"2012","journal-title":"Chinese Journal of Gerontology"},{"issue":"10","key":"ref38","first-page":"33","article-title":"Clinical observation of Si-Mo-Tang oral liquid in the treatment of 27 cases of neonatal functional dyspepsia","volume":"16","author":"W Tang","year":"2010","journal-title":"Guiding Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"ref39","unstructured":"Longstreth GF, Lacy BE. Functional dyspepsia in adults. Up To Date. 2016. Available: http:\/\/www.uptodate.com\/contents\/functional-dyspepsia-in-adults?source=search_result&search=Functional+dyspepsia+in+adults&selectedTitle=2~150<\/ext-link>"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/2050640614563373","article-title":"Changes in serum ghrelin level in relation to meal-time in patients with functional dyspepsia","volume":"3","author":"M Kazemi","year":"2015","journal-title":"United European gastroenterology journal"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/820794","article-title":"The roles of motilin and ghrelin in gastrointestinal motility","volume":"2010","author":"T Ohno","year":"2010","journal-title":"International Journal of Peptides"},{"issue":"3","key":"ref42","first-page":"222","article-title":"Effect of Si-Mo-Tang on the expression of Ghrelin both in the plasma and gastric mucosal of functional dyspepsia patients","volume":"20","author":"H Li","year":"2013","journal-title":"Chinese Journal of Traditional Medical Science and Technology"},{"issue":"21","key":"ref43","first-page":"4341","article-title":"Effect of Si-Mo-Tang on the expression of Ghrelin and Nitric Oxide in plasma of the patients with functional dyspepsia","author":"JD Huang","year":"2015","journal-title":"Journal of Clinical Medicine"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3109\/13880209.2011.637505","article-title":"Simultaneous determination of synephrine, arecoline, and norisoboldine in Chinese patent medicine Si-Mo-Tang oral liquid preparation by strong cation exchange high performance liquid chromatography","volume":"50","author":"Y Yi","year":"2012","journal-title":"Pharmaceutical biology"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3109\/13880209.2013.879601","article-title":"Gastrointestinal effect of methanol extract of Radix Aucklandiae and selected active substances on the transit activity of rat isolated intestinal strips","volume":"52","author":"H Guo","year":"2014","journal-title":"Pharmaceutical biology"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3109\/13880209.2013.854396","article-title":"The effects of Fructus Aurantii extract on the 5-hydroxytryptamine and vasoactive intestinal peptide contents of the rat gastrointestinal tract","volume":"52","author":"Y Jiang","year":"2014","journal-title":"Pharmaceutical biology"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.femsim.2004.09.008","article-title":"Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants","volume":"43","author":"Y Wang","year":"2005","journal-title":"FEMS immunology and medical microbiology"},{"issue":"01","key":"ref48","first-page":"56","article-title":"The influence of the extraction of Lindera aggregata (Sims) Kosterm on the isolated ileum of guinea pigs","author":"JS Guo","year":"2012","journal-title":"Lishizhen Medicine and Materia Medica Research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T23:55:17Z","timestamp":1540338917000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171878"}},"subtitle":[],"editor":[{"given":"Craig","family":"Meyers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171878","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}