{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:59:47Z","timestamp":1792000787896,"version":"4.4.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP568746"],"award-info":[{"award-number":["APP568746"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1045400"],"award-info":[{"award-number":["APP1045400"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171887","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T13:39:18Z","timestamp":1488807558000},"page":"e0171887","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Cognitive change trajectories in virally suppressed HIV-infected individuals indicate high prevalence of disease activity"],"prefix":"10.1371","volume":"12","author":[{"given":"Chloe","family":"Gott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadene","family":"Dermody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Brew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-6373","authenticated-orcid":true,"given":"Lucette A.","family":"Cysique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"ref1","unstructured":"The Kirby Institute. HIV, viral hepatitis and sexually transmissible infections in Australia. Annual Surveillance Reports 2015 [Internet]. 2015. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.kirby.unsw.edu.au\/surveillance\/Annual-Surveillance-Reports\" xlink:type=\"simple\">http:\/\/www.kirby.unsw.edu.au\/surveillance\/Annual-Surveillance-Reports<\/ext-link>"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1212\/01.WNL.0000287431.88658.8b","article-title":"Updated research nosology for HIV-associated neurocognitive disorders","volume":"69","author":"a Antinori","year":"2007","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s11065-009-9102-5","article-title":"Cognitive neuropsychology of HIV-associated neurocognitive disorders","volume":"19","author":"SP Woods","year":"2009","journal-title":"Neuropsychol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1017\/S1355617702813212","article-title":"A meta-analysis of the neuropsychological sequelae of HIV infection","volume":"8","author":"M Reger","year":"2002","journal-title":"J Int Neuropsychol Soc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/09540260701877894","article-title":"Neurocognitive disturbances in HIV","volume":"20","author":"I Grant","year":"2008","journal-title":"Int Rev Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/09540260701877894","article-title":"Neurocognitive disturbances in HIV","volume":"20","author":"I Grant","year":"2008","journal-title":"Int Rev Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11481-008-9143-1","article-title":"Neurodegeneration and ageing in the HAART era","volume":"4","author":"BJ Brew","year":"2009","journal-title":"J neuroimmune Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/cid\/ciu862","article-title":"Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study","volume":"60","author":"RK Heaton","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/QAD.0b013e32833336c8","article-title":"Incidence and nature of cognitive decline over 1 year among HIV-infected former plasma donors in China","volume":"24","author":"L a Cysique","year":"2010","journal-title":"AIDS"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1212\/01.wnl.0000210477.63851.d3","article-title":"Variable benefit in neuropsychological function in HIV- infected HAART-treated patients","volume":"66","author":"LAJ Cysique","year":"2006","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study","volume":"75","author":"RK Heaton","year":"2010","journal-title":"Neurology"},{"key":"ref12","first-page":"1","article-title":"Identifying Neurocognitive Decline at 36 months among HIV-positive participants in the CHARTER cohort using Group-Based Trajectory Analysis","author":"M-J Brouillette","year":"2016","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1212\/WNL.0000000000002277","article-title":"Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study","volume":"86","author":"N Sacktor","year":"2016","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1080\/13854046.2015.1077995","article-title":"Does Older Age Confer an Increased Risk of Incident Neurocognitive Disorders Among Persons Living with HIV Disease?","volume":"29","author":"DP Sheppard","year":"2015","journal-title":"Clin Neuropsychol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/13803395.2014.892061","article-title":"Verbal memory declines more rapidly with age in HIV infected versus uninfected adults","volume":"36","author":"TR Seider","year":"2014","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1212\/01.WNL.0000277520.94788.82","article-title":"Longitudinally preserved psychomotor performance in long-term asymptomatic HIV-infected individuals","volume":"69","author":"MA Cole","year":"2007","journal-title":"Neurology"},{"key":"ref17","unstructured":"Dore GJ, Mcdonald A, Li Y, Kaldor JM, Brew BJ, Surveillance HI V. Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. 2010"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s40263-015-0302-7","article-title":"The Chronicity of HIV Infection Should Drive the Research Strategy of NeuroHIV Treatment Studies: A Critical Review","volume":"30","author":"TM Gates","year":"2016","journal-title":"CNS Drugs"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s13365-015-0368-5","article-title":"The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults","volume":"22","author":"LA Cysique","year":"2016","journal-title":"J Neurovirol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1037\/a0029964","article-title":"Facial emotional processing in HIV infection: relation to neurocognitive and neuropsychiatric status","volume":"26","author":"T a Lane","year":"2012","journal-title":"Neuropsychology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s13365-014-0242-x","article-title":"HIV-associated neurocognitive disorder in Australia: A case of a high-functioning and optimally treated cohort and implications for international neuroHIV research","volume":"20","author":"L a Cysique","year":"2014","journal-title":"J Neurovirol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/13803395.2010.535504","article-title":"Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change","volume":"33","author":"L a Cysique","year":"2011","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1017\/S1355617700000230","article-title":"The HNRC 500\u2014neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center","volume":"1","author":"RK Heaton","year":"1995","journal-title":"J Int Neuropsychol Soc"},{"key":"ref24","article-title":"Revised Comprehensive Norms for an Expanded Halstead-Reitan Battery (HRB): Demographically Adjusted Neuropsychological Norms for African American and Caucasian Adults","author":"RK Heaton","year":"2004"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/NBHIV.S30466","article-title":"Management issues in HIV-associated neurocognitive disorders","author":"L Cysique","year":"2012","journal-title":"Neurobehav HIV Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1212\/WNL.41.6.778","article-title":"Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection","volume":"41","year":"1991","journal-title":"Neurology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/13803390490510031","article-title":"Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection","volume":"26","author":"CL Carey","year":"2004","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1080\/13854046.2012.694479","article-title":"Defining neurocognitive impairment in HIV: deficit scores versus clinical ratings","volume":"26","author":"K Blackstone","year":"2012","journal-title":"Clin Neuropsychol"},{"key":"ref29","first-page":"95","article-title":"Advances in Clinical Neuropsychology","author":"GJ Chelune","year":"1986"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1080\/13803395.2014.943696","article-title":"Effects of information processing speed on learning, memory, and executive functioning in people living with HIV\/AIDS","volume":"36","author":"RP Fellows","year":"2014","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061738","article-title":"HIV, vascular and aging injuries in the brain of clinically stable HIV-infected adults: a (1)H MRS study","volume":"8","author":"L a Cysique","year":"2013","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s13365-014-0246-6","article-title":"Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART","volume":"20","author":"J Harezlak","year":"2014","journal-title":"J Neurovirol. Springer"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Bischof GN, Rodrigue KM, Kennedy KM, Devous MD, Park DC. Amyloid deposition in younger adults is linked to episodic memory performance. 2016;","DOI":"10.1212\/WNL.0000000000003425"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Cysique LA, Hewitt T, Croitoru-lamoury J, Taddei K, Martins RN, Chew CSN, et al. APOE \u03b5 4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV + individuals\u2013a cross-sectional observational study. 2015; 4\u201311.","DOI":"10.1186\/s12883-015-0298-0"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s13365-012-0094-1","article-title":"Impact of HIV and aging on neuropsychological function","volume":"18","author":"L a Wendelken","year":"2012","journal-title":"J Neurovirol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T06:19:28Z","timestamp":1568873968000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171887"}},"subtitle":[],"editor":[{"given":"Stephen D.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,6]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171887","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,6]]}}}